Clinical trials: Neurocognitive Development
Iron Deficiency, Anemia of Prematurity
Neurodevelopment After Early Iron Supplementation
Background: Iron deficiency in early childhood may impair neurodevelopment. Aim: To examine whether early iron supplementation improved neurodevelopment in preterm infants.
- Conditions
- Iron Deficiency, Anemia of Prematurity, Neurodevelopmental Delay
- Trial name
- NCT00457990
- Testing
- Oral administration of ferrous sulphate
- Where
- Germany
- Volunteers
- 204 people
- Sponsor
- University of Ulm
Cognitive Impairment, Child Autism
Exercise and Cognition in Children With ASD
Physical exercise is widely reported to be beneficial to executive functions (EFs) in children with autism spectrum disorder (ASD).
- Trial name
- NCT05503459
- Testing
- Bicycle learning, Stationary cycling
- Where
- Hong Kong
- Volunteers
- 82 people
- Sponsor
- Education University of Hong Kong
Dyslexia
Validating a Neurocognitive Remediation Model for Visual-Attentional Pathway in Chinese Developmental Dyslexia
Developmental dyslexia is a common and serious specific learning disability affecting up to one in eight children in Hong Kong, with profound consequences for academic success and personal well-being.
- Trial name
- NCT07707700
- Testing
- Action video game intervention group, Active Control (Non-Action Video Game) Group
- Where
- Hong Kong
- Volunteers
- 76 people
- Sponsor
- The Hong Kong Polytechnic University
Cerebral Palsy, Cerebral Palsy (CP)
Assessing Intellectual and Motor Outcomes in High-risk Infants
Cerebral palsy (CP) is a condition when a baby has a brain injury that affects their movement and muscle tone. Some people with CP can have other developmental issues, like learning impairments, but many do not and have isolated…
- Conditions
- Cerebral Palsy, Cerebral Palsy (CP), Cerebral Palsy Children, High-risk Infants
- Trial name
- AIM-High (NCT06857539)
- Where
- 4 sites in Ireland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University College Cork
Infant Malnutrition, Malnutrition in Pregnancy
Supplementing Maternal and Infant Diet With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS)
The use of lipid-based nutrients (LNS), such as Nutributter or fortified spread (FS), have been associated with improved growth and development outcomes among infants in Ghana and Malawi.
- Trial name
- iLiNS-DYAD-M (NCT01239693)
- Testing
- IFA, MMN, LNS
- Where
- Malawi
- Volunteers
- 1,391 people, healthy volunteers welcome
- Sponsor
- Tampere University
Zika Virus Infection, Neurocognitive Deficit
Zika and Neurodevelopment Among Infants in Grenada
Implement a randomized controlled trial, evidence-based, culturally adapted, environmental enrichment intervention for the purpose of enhancing neurocognitive outcomes among Zika Exposed Children.
- Conditions
- Zika Virus Infection, Neurocognitive Deficit, Development, Child, Neurodevelopmental Abnormality
- Trial name
- NCT04697147
- Testing
- Conscious Discipline-Based Environmental Enrichment Intervention
- Where
- Grenada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Windward Islands Research and Education Foundation
Neurocognitive Dysfunction, Language Development
Can Singing Kangaroo Improve Outcome of Preterm Infants
To assess whether a musical intervention (maternal/paternal singing) during the skin-to-skin sessions (Kangaroo care) would improve the language development of the preterm infant.
- Trial name
- SingKang (NCT03795454)
- Testing
- Singing
- Volunteers
- 140 people
- Sponsor
- University of Helsinki
Premature Infant
Psychomotor Therapy for Very Premature Infants
Our current reflexion is that sensory dys-stimulations, including vestibule-proprioceptive disorders and unbalanced between brain and brainstem maturation of the neonatal period involve an early deviant development for immature…
- Trial name
- VPI (NCT03093337)
- Testing
- Early post hospital discharge psychomotor therapy
- Where
- 10 sites in France
- Volunteers
- 162 people
- Sponsor
- University Hospital, Toulouse
Mild Cognitive Impairment
Tailored Mediterranean Lifestyle Education in Patients With Mild Cognitive Impairment
Evidence suggests that a Mediterranean diet can have a beneficial effect on brain health. Mild cognitive impairment (MCI) describes problems with brain function such as difficulty with day-to-day memory and concentration.
- Trial name
- NCT03265522
- Testing
- "ThinkMed" resource at baseline, Standard Care Control, "ThinkMed" resource (staged)
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Queen's University, Belfast
Huntington's Disease
Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease
Huntington's Disease (HD) is an autosomal dominant disease manifested in a triad of cognitive, psychiatric, and motor signs and symptoms. HD is caused by a triplet repeat (CAG)expansion in the gene Huntingtin (HTT).
- Trial name
- ChANGE HD (NCT01860339)
- Where
- 6 sites in United States
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Peggy C Nopoulos
Alzheimer's Disease
Development and Decline of Brain and Cognition Through the Life Span
The protocol objectives are to enable prospective IRB review of research using human MRI scans and data collected under other branch protocols or extramural sources.
- Trial name
- NCT00880451
- Where
- United States
- Sponsor
- National Institute of Mental Health (NIMH)
Mild Cognitive Impairment, Attention Impaired
The Effect of Body Percussion Training on Neuromotor Performance, Attention, and Functionality in Adolescents With Mild Intellectual Disability
The aim of this randomized controlled trial is to investigate the effects of group-based rhythm-based body percussion training on neuromotor performance, attention, and functionality in adolescents with mild intellectual…
- Conditions
- Mild Cognitive Impairment, Attention Impaired, Adolescent Development
- Trial name
- NCT07554144
- Testing
- Rhythm-based body percussion training group, Control group (passive listening) group
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Kutahya Health Sciences University
Obesity, Genetic Disorder
Brain-Derived Neurotrophic Factor in Obesity and Brain Function
Background: Prader-Willi syndrome (PWS) and MC4R genetic mutations are two conditions that can cause problems with appetite regulation. People with PWS often have behavior and thinking problems.
- Conditions
- Obesity, Genetic Disorder, Mental Retardation, Developmental Delay
- Trial name
- NCT01517048
- Where
- 2 sites in United States, Canada
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Creation of an Italian Network of Biobanks of Rare Diseases
ScATtEred Rare Disease Biobanks: a Model of Sample/Data Collection With susTainablE and Shared Criteria
Rare diseases (RDs) have been defined by the European Union (EU) as life-threatening or chronically debilitating conditions affecting less than 1 person in 2000.
- Trial name
- SATELLITES (NCT06782230)
- Where
- Italy
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
HIV, HIV-uninfected Children
A Cross Sectional Evaluation of the Development in Children Age 4 to 7 Infected or Exposed to HIV From the ANRS 12140 Cohort (Pediacam)
This study aims to perform a comprehensive neuro-cognitive evaluation of the 4-7 year old children from the Pediacam cohort (ANRS 12140 /12225, NCT02043418).
- Conditions
- HIV, HIV-uninfected Children, Children Exposed to HIV
- Trial name
- PediacamDEV (NCT02570334)
- Testing
- HIV-infected children initiated antiretroviral treatment within the first 7 months of life
- Where
- 3 sites in Cameroon
- Volunteers
- 400 people
- Sponsor
- ANRS, Emerging Infectious Diseases