Clinical trials: Intestinal Infection, open to volunteers
Microsporidiosis Intestinal, Heart Transplant Infection
Intestinal Microsporidiosis in French Heart Transplant Recipients (CARMIC)
The investigators propose to carry out a national retrospective study to collect epidemiological, biological, clinical and therapeutic data on microsporidiosis among heart transplant patients.
- Trial name
- CARMIC (NCT06986980)
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cryptosporidiosis
Nitazoxanide for Treatment of Cryptosporidium in Children
The goal of this clinical trial is to learn if nitazoxanide (NTZ) can treat Cryptosporidium infection in children age 6-12 months.
- Trial name
- NCT06600711
- Testing
- Nitazoxanide
- Volunteers
- 480 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Appendicitis Acute, Acute Abdomen in Children
The Impact of a Diagnostic Strategy for Acute Appendicitis in Children With Acute Abdominal Pain in Primary Care
BACKGROUND Acute appendicitis (AA) in an early stage is difficult to distinguish from other (self-limiting) causes of acute abdominal pain (e.g.
- Trial name
- ISAAK (NCT06762275)
- Testing
- Diagnostic strategy
- Where
- Netherlands
- Volunteers
- 566 people
- Sponsor
- University Medical Center Groningen
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Appendicitis, Acute, Appendectomy
Video-Based Grading of Intraoperative Adverse Events in Pediatric Laparoscopic Appendectomy
Acute appendicitis is the most common surgical emergency in children, and laparoscopic appendectomy is its standard treatment. Although intraoperative adverse events (iAEs) are recognized as an important determinant of surgical…
- Conditions
- Appendicitis, Acute, Appendectomy, Intraoperative Complications, Patient Safety
- Trial name
- PedAppy-iAE (NCT07794618)
- Testing
- Laparoscopic appendectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ahmet Burak Doğan, MD
Shigella Infection
Safety and Immunogenicity Study of IP-QSV Vaccine in Healthy Adults/Adolescents, Children and Infants
The goal of this phase 1/2a, randomized, observer-blind, age-descending, dose-finding trial is to evaluate the safety and immunogenicity of a quadrivalent synthetic oligosaccharide-based Shigella vaccine (adjuvanted IP-QSV) in…
- Trial name
- NCT07666750
- Testing
- 30μg IP-QSV, 10μg IP-QSV, 2μg IP-QSV
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Chronic Disease, HIV/AIDS
Observational Pharmaco-Epidemiology Research & Analysis
Greater advances are needed in two separate but related areas in healthcare: 1) the Clinical Decision Support Systems that complement the EHR use in support of routine patient care, population management and disease management…
- Conditions
- Chronic Disease, HIV/AIDS, Liver Diseases, Inflammatory Bowel Diseases
- Trial name
- OPERA (NCT03813862)
- Testing
- Non-interventional (observational only)
- Where
- United States
- Volunteers
- 2,000,000 people, healthy volunteers welcome
- Sponsor
- Epividian
Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness
Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy
Abstract Objective: The aim of this study is to compare two different ways of adjusting the air-filled cushion (cuff) of the breathing tube used during general anesthesia in children undergoing laparoscopic appendectomy (closed…
- Conditions
- Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness, Airway Complications, Respiratory Complications
- Trial name
- NCT07678086
- Testing
- Pressure Transducer, Traditional Palpation Method
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Acute Pain, Abdomen, Acute
Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain
Appendicitis is a common condition in children 6-17 years of age, and the top reason for emergency surgery in Canada. Children with appendicitis can have very bad pain in their belly.
- Conditions
- Acute Pain, Abdomen, Acute, Abdominal Pain, Appendicitis
- Trial name
- KETOAPP (NCT06160778)
- Testing
- Ketorolac Tromethamine, Morphine Sulfate, normal saline
- Where
- Canada
- Volunteers
- 495 people
- Sponsor
- University of Calgary
Rhinitis
Washed Microbiota Transplantation for Rhinitis
The common symptoms of rhinitis include nasal itching, sneezing, anterior or posterior nasal leakage, and nasal congestion. Rhinitis can be classified as allergic rhinitis (AR) and non-allergic rhinitis (NAR) based on the…
- Trial name
- NCT06350448
- Testing
- Washed Microbiota Transplantation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Laparoscopic Appendectomy
Comparison Between Metallic Clip Ligation and Suture Ligation of Appendicular Stump in Laparoscopic Appendectomy
Laparoscopic appendectomy is the standard procedure for acute appendicitis. Among the various steps of the procedure one of the rate limiting step is the ligation of the appendicular stump which can be done using suture material…
- Trial name
- NCT07129746
- Testing
- Metallic clip ligation of the appendicular stump, Suture ligation of appendicular stump
- Where
- Pakistan
- Volunteers
- 10 people
- Sponsor
- Jinnah Hospital
Gut Microbiome
Developing Interventions for Protecting HIV-Exposed Uninfected Infants Against Severe Infections
Research has shown that babies who are exposed to HIV, but are uninfected (negative HIV status), have a bigger risk of developing severe infections.
- Trial name
- NCT07052409
- Testing
- Inkomazi
- Where
- South Africa
- Volunteers
- 72 people
- Sponsor
- University of Colorado, Denver
COVID-19-Associated Encephalitis, Long COVID
Longterm Influence of Pediatric Long COVID Syndrome
We enroll pediatric patients who were diagnosed COVID-19 for main observation target. We will perform brain MRI and neuropsychiatric evaluation 4-6 months after COVID-19 diagnosed.
- Trial name
- NCT05566392
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Respiratory Syncytial Virus Infection, Bronchiolitis
Gut Microbiome and Immune Response in Severe RSV Infection in Vietnamese Infants
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in young children, and a substantial proportion of severe cases occur in previously healthy infants.
- Conditions
- Respiratory Syncytial Virus Infection, Bronchiolitis, Viral Lower Respiratory Tract Infection (LRTI)
- Trial name
- GUT-LUNG RSV (NCT07417657)
- Where
- Vietnam
- Volunteers
- 250 people
- Sponsor
- Phuc Huu Phan
Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock
Artificial Intelligence-driven Virtual Standardized Pediatric Patients Trial
Background: China's healthcare system for children faces significant challenges, particularly due to the limited pediatric service capacity of primary healthcare institutions.
- Conditions
- Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock, Hand-foot-and-mouth Disease, Acute Appendicitis
- Trial name
- NCT06699433
- Testing
- Virtual standardized patients (VSPs), Case teaching manuals, Case teaching videos
- Where
- 3 sites in China
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- Southern Medical University, China
Intra Abdominal Infections, Appendicitis Acute
Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study
The NATURAL Study is a prospective, observational, pragmatic study of RNA biomarkers of infections to aid in the diagnosis of abdominal pain.
- Conditions
- Intra Abdominal Infections, Appendicitis Acute, Pyelonephritis, Diverticulitis
- Trial name
- NATURAL (NCT07579312)
- Testing
- TruNAV, an RNA-based blood test for host immune activation by infections
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- True Bearing Diagnostics, Inc.
Acute Appendicitis
TACTILE : Validation of a Teleconsultation-Based Predictive Score for the Diagnosis of Acute Appendicitis in Children Using Artificial Intelligence Methods
Acute appendicitis is the most common abdominal surgical emergency in children and a frequent cause of pediatric emergency department visits.
- Trial name
- TACTILE (NCT07479849)
- Testing
- Score-based appendicitis risk classification in teleconsultation
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Angers
Diarrhea Infectious, Cholera
Testing a Scalable Model of the Cholera Hospital-Based Intervention for 7 Days (CHoBI7)
The findings from previous recent randomized controlled trials of The Cholera Hospital Based Intervention for 7 Days (CHoBI7) demonstrated that this intervention was effective in significantly reducing symptomatic cholera…
- Trial name
- CHoBI7 (NCT06498817)
- Testing
- Standard Recommendation, CHoBI7 Scale-Up Program
- Where
- Bangladesh
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Growth Failure, Intestinal Infection
MAL-ED Metabolic: A Follow-Up of Chronic Disease at Puberty
The concept that the roots of cardiometabolic disease start in early life was established by Dr. David Barker, who documented relationships between low birthweight (as a marker for challenges during gestation) and later…
- Conditions
- Growth Failure, Intestinal Infection, Metabolic Syndrome, Glucose Intolerance
- Trial name
- NCT05121935
- Volunteers
- 254 people
- Sponsor
- University of Virginia
Cholera, Water-Related Diseases
Preventative Intervention for Cholera for 7 Days
The first objective of our study is to develop a theory-driven evidence-based targeted water, sanitation, and hygiene (WASH) intervention for household members of diarrhea patients in South Kivu, Democratic Republic of the Congo…
- Conditions
- Cholera, Water-Related Diseases, Diarrhea Infectious
- Trial name
- PICHA-7 (NCT05166850)
- Testing
- PICHA7 mHealth program, Standard Arm
- Where
- 2 sites in Democratic Republic of the Congo
- Volunteers
- 2,900 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health