Clinical trials: HIV Antiretroviral Therapy (ART) Adherence
Adherence
Positive Steps to Enhance Problem Solving Skills
This randomized control trial is to test the efficacy of a stepped-care "adaptive" Antiretroviral Therapy (ART) adherence intervention ("Positive STEPS") for HIV infected adolescents and young adults, ages 16 to 29.
- Trial name
- STEPS (NCT03092531)
- Testing
- Positive STEPS
- Where
- 4 sites in United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV Infection
Typology of Adherence in Adolescents: Phase II
A number of factors influence HIV-positive adolescents' acceptance of and willingness to continue taking anti-HIV medicines. These factors include mental health and substance abuse issues, barriers such as lack of medical…
- Trial name
- NCT00106678
- Where
- 17 sites in United States, Puerto Rico
- Volunteers
- 1,200 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV - Human Immunodeficiency Virus, HIV Antiretroviral Therapy (ART) Adherence
Improving the HIV Care Continuum With mHealth Technology
Youth living with HIV (YLHIV) face barriers to engagement and retention in HIV care, show poor medication adherence, and often fail to achieve and maintain viral suppression.
- Conditions
- HIV - Human Immunodeficiency Virus, HIV Antiretroviral Therapy (ART) Adherence, mHealth Application, mHealth Intervention
- Trial name
- NCT07631104
- Testing
- MindBodyU Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Carolina
HIV-1-infection
Group-Based Intervention to Improve Mental Health and Adherence Among Youth Living With HIV in Low Resource Settings
IMPAACT 2016 was a multi-site, two-arm, individually randomized, controlled study to evaluate whether an Indigenous Leader Outreach Model (ILOM) of trauma-informed cognitive behavioral therapy (TI-CBT) delivered by Indigenous…
- Trial name
- NCT04024488
- Testing
- Youth TI-CBT Intervention Arm, Youth Discussion Control Arm, Caregiver TI-CBT Intervention Arm
- Where
- 8 sites in Botswana, Malawi and 2 more
- Volunteers
- 484 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
HIV/AIDS
Contribution of "Praise Messages" to HIV Treatment Retention and Adherence Among Female Sex Workers in Ethiopia
This study evaluates the effects of praise message phone calls on antiretroviral therapy (ART) initiation, adherence, and prescription refills.
- Trial name
- NCT03127397
- Testing
- Praise message phone call
- Where
- Ethiopia
- Volunteers
- 810 people
- Sponsor
- Reed College
HIV Antiretroviral Therapy (ART) Adherence, PMTCT
Optimizing Prevention and Care for Pregnant and Postpartum Adolescent Girls and Young Women With HIV in Tanzania
The goal of this clinical trial is to find better ways to care for pregnant and postpartum adolescent girls and young women (AGYW) aged 15-24 years with HIV in Tanzania, and to prevent them from passing HIV to their babies.
- Conditions
- HIV Antiretroviral Therapy (ART) Adherence, PMTCT, Pregnancy, Retention in Care
- Trial name
- ENGAGE (NCT06605053)
- Testing
- Co-produced intervention to optimize PMTCT care engagement
- Where
- 2 sites in Tanzania
- Volunteers
- 222 people
- Sponsor
- Karolinska Institutet
HIV Infections, Adherence, Medication
Technology Based Community Health Nursing to Improve Combination Anti-Retroviral Therapy (cART) Adherence and Virologic Suppression in Youth Living With HIV
Human immunodeficiency virus (HIV) infection has disproportionately persisted as a public health threat to adolescents and young adults (AYA) from minority communities in the United States.
- Trial name
- Tech2Check (NCT03600103)
- Testing
- Tech2Check
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Johns Hopkins University
Human Immunodeficiency Virus
Optimizing Retention in Care and Adherence to Anti-retroviral Therapy Amongst Adolescents Living With HIV in Rwanda
HIV has now become the leading cause of death amongst adolescents in Africa with over 2.1 million adolescents (aged 10-19 years old) living with HIV today.
- Trial name
- NCT04531605
- Testing
- YBank program
- Volunteers
- 72 people
- Sponsor
- Youth Development Labs, Inc dba YLabs
HIV/AIDS
Adolescents Living With HIV (ALWH): Social Networks, Adherence and Retention
human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) is the second leading cause of death in Africa. Adolescents living with HIV (ALWH) are at increased risk for HIV-related morbidity and mortality due to…
- Trial name
- NCT04077047
- Testing
- iEngage
- Where
- 2 sites in United States, South Africa
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
HIV Infections
The Mochudi Prevention Project ART Protocol
The goal of the "Mochudi Prevention Project" is to reduce the number of new HIV infections in the village of Mochudi, Botswana by promoting a comprehensive package of interventions that have proven to be effective in preventing…
- Trial name
- NCT01583439
- Testing
- highly active antiretroviral therapy: Lopinavir/Ritonavir, Lamivudine, Zidovudine, Efavirenz, Tenofovir Disoproxil Fumarate, Emtricitabine
- Where
- Botswana
- Volunteers
- 11 people
- Sponsor
- Harvard School of Public Health (HSPH)
HIV Infections
Pediatric Impact: Promoting Adherence to Medications Among HIV-infected Children
The purpose of the study is to develop and evaluate an intervention to promote adherence to HIV medications among children 5-12 years of age.
- Trial name
- NCT00134602
- Testing
- Needs assessment followed by tailored intervention
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Centers for Disease Control and Prevention
HIV
Incentives to Promote Medication Adherence Among HIV-Infected Youth
Medication adherence is one of the most salient predictors of patient outcomes in the era following development of effective treatment for HIV infection.
- Trial name
- NCT02206906
- Testing
- Incentive intervention model
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- St. Jude Children's Research Hospital
HIV Disease Progression
Acceptability, Feasibility and Effectiveness of Online Peer Support Group for ART Adherence Among Youth
In Uganda, Youth living with HIV/AIDS (YLHIVA) enrolled in HIV treatment experience suboptimal treatment adherence and have lower viral load suppression (VLS) rates compared to younger children or adults.
- Trial name
- NCT05688709
- Testing
- WhatsApp peer support group
- Where
- 3 sites in Uganda
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Infectious Diseases Research Collaboration, Uganda
HIV
Evaluating a Youth-Focused Economic Empowerment Approach to HIV Treatment Adherence
The goal of Suubi+Adherence is to examine the impact and cost associated with an innovative intervention to increase adherence to HIV treatment for HIV-infected adolescents.
- Trial name
- NCT01790373
- Testing
- Suubi+Adherence, Bolstered Standard of Care
- Where
- 2 sites in United States, Uganda
- Volunteers
- 702 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Antiretroviral Therapy (ART) Adherence Among Adolescents Living With HIV
Adaptive Text Messaging and Non-Monetary Incentives to Sustain ART Adherence Among Adolescents Living With HIV in Ethiopia
Many adolescents living with HIV have difficulty taking their medicine on time, which can make it less effective and affect their health.
- Trial name
- NCT07377760
- Testing
- Non-adaptive reminder text messaging, Adaptive interventions, The control arm
- Where
- Ethiopia
- Volunteers
- 327 people
- Sponsor
- Arba Minch University
Human Immunodeficiency Virus, Mental Disorder
Integrated Mental Health Care for Pregnant Women With HIV in Kenya: The Tunawiri Study
This study seeks to improve mental health, pregnancy, and HIV outcomes among pregnant and postpartum women living with HIV with common mental health disorders in Kenya.
- Trial name
- NCT06117163
- Testing
- Collaborative Care Model
- Where
- Kenya
- Volunteers
- 900 people
- Sponsor
- University of Colorado, Denver
HIV Infections
The Effectiveness of SMS in Improving Antiretroviral Medication Adherence Among Adolescents Living With HIV in Nigeria
The non-maintenance of ART adherence is a major barrier to the achievement of optimal treatment outcomes among adolescents living with HIV.
- Trial name
- STARTA (NCT03394391)
- Testing
- Daily ART-adherence SMS reminder, Standard Adherence Counselling/Patient experience group chat
- Where
- 5 sites in Nigeria
- Volunteers
- 212 people
- Sponsor
- Dr. Olumide ABIODUN
Medication Adherence, Adjustment Reaction With Anxiety and Depression
Mindfulness and Acceptance Based Therapy for Adolescents Living With HIV
Adolescents represent a growing share of people living with HIV in sub-Saharan Africa (SSA), yet show poor adherence to medication and viral suppression (VS) compared to adults.
- Conditions
- Medication Adherence, Adjustment Reaction With Anxiety and Depression, Mental Health Issue
- Trial name
- NCT05010317
- Testing
- Mindfulness and acceptance based therapy, Standard of care
- Where
- 2 sites in Uganda
- Volunteers
- 122 people
- Sponsor
- Infectious Diseases Research Collaboration, Uganda
HIV, HIV Infections
Measurement of Adherence to ART in HIV-Infected Children in Uganda (The CHARTA Study)
This study will compare methods of determining whether HIV-infected children take their medications.
- Trial name
- NCT00868257
- Where
- Uganda
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
HIV
Emtricitabine/Tenofovir Alafenamide as Salvage ART
Background: HIV attacks the immune system. Antiretroviral therapy (ART) is a combination of drugs used for treating HIV infection. For some people, ART drugs stop working against their HIV.
- Trial name
- NCT02556333
- Testing
- FTC/TAF
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)