Clinical trials: Diabetes Prevention
Diabetes Mellitus, Type 1
Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus
Type 1 diabetes (T1D) is an autoimmune disease. This means that the immune system (the part of the body which helps fight infections) mistakenly attacks and destroys the cells that produce insulin (islet cells found in the…
- Trial name
- TN07 (NCT00419562)
- Testing
- Oral Insulin
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 560 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Diabetes
Family Weight Management Study
The purpose of this study is to address the Healthy People 2010 obesity prevention objective. This study will test the effects of a comprehensive family weight management program on the BMI z-score of 7-12 year-old children with…
- Trial name
- NCT00851201
- Testing
- Intensive lifestyle, Standard intervention
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiovascular Diseases, Diabetes Mellitus, Type 2
Healthy Lifestyle Promotion Program in Communities From the Yaqui Valley
The aim is to evaluate the change in indicators of lifestyle and its effect on cardiometabolic biomarkers as a response to an integrative mother-child intervention to promote healthy lifestyles and prevent food insecurity and…
- Trial name
- NUTRIGANDO (NCT05945862)
- Testing
- NUTRIGANDO
- Where
- Mexico
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Instituto Tecnologico de Sonora
Type 1 Diabetes
MDRS for Prevention of Nocturnal Hypoglycemia
The investigators have developed a unique Remote \& Safety diabetes management system (MDRS) that offers real-time remote monitoring and control of glucose levels.
- Trial name
- MDRS (NCT01509157)
- Testing
- MDRS System (Remote & Safety diabetes management system), Continuous Glucose Monitoring
- Where
- Israel
- Volunteers
- 38 people
- Sponsor
- Rabin Medical Center
Obesity, Type 2 Diabetes
Reducing Obesity and Type 2 Diabetes in High Risk Youth
Compare the effect of the HEALT[e]TEEN program and a HEALTH[e]TEEN plus coping skills training delivered to high school students on BMI, nutrition and physical activity behaviors, and self-efficacy over 6 months.
- Trial name
- HEALTH[e]TEEN (NCT01560676)
- Testing
- HEALTH[e]TEEN, HEALTH[e]TEEN + CST
- Where
- United States
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Yale University
Obesity, Type 2 Diabetes
Video Games for Obesity and Diabetes Prevention-Diab & Nano
With the increasing rates of child obesity and diabetes, innovative programs are needed that capture children's attention and permit behavior change messages to get through.
- Trial name
- G4H-DiabNano (NCT01846377)
- Testing
- G4H-Diab-Nano
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Type 2 Diabetes, Chronic Disease
PRE-STARt Intervention - Trial of an Interactive Family Based Lifestyle Programme
To investigate whether the interactive family based lifestyle programme leads to behaviour change at 6 months with the primary outcome being increased levels of moderate to vigorous physical activity (MVPA).
- Conditions
- Type 2 Diabetes, Chronic Disease, Obesity
- Trial name
- NCT02845791
- Testing
- Interactive Lifestyle programme workshop
- Where
- United Kingdom
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Type 1 Diabetes
Primary Intervention With Mucosal Insulin
A dose with proven drug bioavailability to the immune system for use in a phase II/III primary T1DM (type 1 diabetes) vaccination trial (POINT study) in genetically at risk subjects.
- Trial name
- Pre-POINT (NCT02620553)
- Testing
- Human Insulin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 2, Prediabetic State
Finding the Patient's Voice Diabetes Prevention Programs
This study uses patient engagement to develop a diabetes prevention program focused on adolescents and families.
- Trial name
- NCT02700503
- Testing
- Encourage 2.0
- Where
- 3 sites in United States
- Volunteers
- 146 people
- Sponsor
- Indiana University
Prediabetes, Type 1 Diabetes
TEFA Family Prevention: Glutenfree Diet to Preserve Beta-cell Function
To evaluate the effect of Gluten Free Diet (GFD) on beta-cell function and glucose metabolism in subjects with one or several islet autoantibodies without and with dysglycemia at baseline.
- Trial name
- TEFA (NCT02605148)
- Testing
- Gluten free diet, Omega 3 fatty acid, Vitamin D
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Lund University
Obesity, Overweight
Pediatric Preventative Health Screenings - Obesity and Family-Centered Outcomes
In 2012, an Expert Panel of the National Heart Lung and Blood Institute published guidelines on cardiovascular health and risk reduction in children; among these guidelines were screening recommendations for obesity and…
- Conditions
- Obesity, Overweight, Blood Pressure, Hypercholesteremia
- Trial name
- NCT02850224
- Testing
- Motivational interviewing to elicit PCO in pediatrics
- Where
- United States
- Volunteers
- 703 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Overweight, Glucose Intolerance
Diabetes Prevention In Estrie
This study compared the efficacy at one year of an interdisciplinary approach including individual counseling and group seminars versus group seminars alone to induce weight loss in subjects at high risk of developing type 2…
- Trial name
- NCT00991549
- Testing
- interdisciplinary intervention or meeting-seminars
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- Université de Sherbrooke
Diabetes Mellitus, Type 2
A Comprehensive Community Approach for Diabetes Prevention and Care for a Vulnerable Population in Galveston
To improve diabetes self-management outcomes, patients with type 2 diabetes (n=150 - aged 13-84) recruited from St. Vincent Clinic (SVC) and Teen Health Center Inc., Clinics will be randomized using block randomization to receive…
- Trial name
- NCT05097534
- Testing
- iDSMES, Standard of Care
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Obesity, Type 2 Diabetes
REACH-OUT: Chicago Children's Diabetes Prevention Program
The purpose of this research study is to evaluate two nutrition and exercise programs in children ages 9-12 who are at risk for developing type 2 diabetes.
- Trial name
- REACH-OUT (NCT00723853)
- Testing
- Reach-Out Program, nutritional and exercise program, Reach-In Program, standard of care
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Chicago
Diabetes Mellitus, Type 2, Obesity
Lifestyle Modification for Type 2 Diabetes Prevention in Overweight Youth
The number of youth with Type 2 diabetes (T2D) is rising in the population, which is a concerning public health trend. There has been little research testing ways to prevent the development of this disease in children who are at…
- Trial name
- NCT01610219
- Testing
- Lifestyle Modification for Type 2 Diabetes Prevention, Nutrition and Physical Activity
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pre Diabetes
Diabetes Prevention Program in Youth
The purpose of this study is to test the effectiveness of an out-of-school diabetes prevention program for youth (ages 7-15) with a family history of pre-diabetes or type 2 diabetes.
- Trial name
- NCT03042936
- Testing
- Insulin Superheroes Club Curriculum
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Type 2 Diabetes
Computer Based Intervention for Type 2 Diabetes in Youth
Interactive multimedia programs have been demonstrated to produce substantial change in children's dietary behaviors. This SBIR-Phase 2 protocol will evaluate the two video game interventions designed to change diabetes related…
- Trial name
- NCT00570466
- Testing
- Video Games, Web and DVD knowledge
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes
Beta Cell Function in (Pre)Type 1 Diabetes
Increased glycemic variability has been proposed as an independent predictor of hypoglycemia in diabetic patients. Likewise, episodes of dysglycemia have been found to be predictive of diabetes in antibodypositive nondiabetic…
- Trial name
- NCT01402037
- Testing
- Glucose, Continuous glucose monitoring
- Where
- 3 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Diabetes, Alzheimer Disease
The Diabetes Prevention Program Outcomes Study AD/ADRD Project
The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for…
- Conditions
- Diabetes, Alzheimer Disease, Dementia, Vascular, Dementia
- Trial name
- DPPOS-4 (NCT05704309)
- Where
- 27 sites in United States
- Volunteers
- 1,976 people, healthy volunteers welcome
- Sponsor
- Marinella Temprosa
Type 1 Diabetes Mellitus
Hypoglycemia Prevention After Exercise in Adolescent T1DM Patients Using a Control to Range System
In this protocol the investigators plan to demonstrate management of glucose using a modular insulin management system based on continuous glucose monitoring and targeted towards the avoidance of hypoglycemic and prolonged…
- Trial name
- MDB005 (NCT01390259)
- Testing
- Open-Loop, Closed-Loop
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Virginia