Clinical trials: Contracture
Joint Contracture, Contracture
Recurrence of Extremity Joint Contracture After Z-Plasty Versus Full-Thickness Skin Graft
The purpose of this study is to compare how often joint contractures in the arms and legs come back after two common types of reconstructive surgery: Z-plasty and full-thickness skin graft (FTSG).
- Conditions
- Joint Contracture, Contracture, Cicatrix, Burn Scar Contractures
- Trial name
- NCT07885046
- Testing
- Z-Plasty, Full-Thickness Skin Graft
- Volunteers
- 300 people
- Sponsor
- Universitas Sebelas Maret
Management of Postburn Neck Contracture
Pre-expanded Flap Versus Free Flap for Postburn Neck Contracture
This prospective, randomized, parallel-group trial was conducted at two tertiary care centers in Egypt between April 2022 and October 2024.
- Trial name
- SCAIP (NCT07865689)
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines
- Where
- Egypt
- Volunteers
- 2 people
- Sponsor
- South Valley University
CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay
Aprepitant for the Treatment of CLIFAHDD
There are no drug treatments for individuals with Congenital Contractures of the Limb and Face, Hypotonia, and Developmental Delay (CLIFAHDD), an ultra-rare and severe neurodevelopmental disease.
- Conditions
- CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay, NALCN Channelopathy, Ataxia - Other
- Trial name
- NCT07845825
- Testing
- Aprepitant Powder for Oral Suspension
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Burn Joints, Joint Contractures
Effect of Paraffin Wax on Joint Contractures
Limited studies have objectively evaluated the benefit on skin pliability, and relieving itch and pain of paraffin wax, nor has paraffin wax treatment been compared to mineral oil, which is an ingredient in therapeutic paraffin…
- Trial name
- NCT07837687
- Testing
- Paraffin wax, Mineral oil
- Volunteers
- 12 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Facial Scarring, Facial Trauma
Tools for Return of Facial Function
This study will evaluate novel intraoral (inside-the-mouth) splints designed to gently stretch facial tissues that have become tight or scarred following facial trauma, including burn injuries and gunshot wounds.
- Conditions
- Facial Scarring, Facial Trauma, Burn, Orofacial Contracture
- Trial name
- NCT07825844
- Testing
- Intraoral Stretching Splints
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Cerebral Palsy, Spastic, Achilles Tendon Contracture
Myofascial Release Plus Physiotherapy for Children With Cerebral Palsy Post Achilles Tendon Surgery in Gaza (MFR-CP25)
"This study aims to evaluate the effectiveness of adding Myofascial Release (MFR) technique to a conventional physiotherapy program for children with cerebral palsy after Achilles tendon surgery.
- Trial name
- MFR-CP25 (NCT07148856)
- Testing
- Conventional Physiotherapy, Myofascial Release Technique
- Where
- Palestinian Territories
- Volunteers
- 40 people
- Sponsor
- Ismail K. Al-Qudra
Burn Contracture of Skin
Serial Casting for Upper Extremity Burn Contractures
The use of a splint, serial casting and passive stretching have been described in the literature as conservative interventions to manage joint contractures after burn injury.
- Trial name
- NCT05425433
- Testing
- Tailored serial casting intercention
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Dupuytren Disease
Ultrasound Features of Dupuytren's Disease
Dupuytren's disease (DD) is a benign and progressive condition that affects the palmar aponeurosis with a very high global incidence.
- Trial name
- Micro in DD (NCT06956027)
- Testing
- Ultrasound assesment, ROM measurement
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Capsular Contracture Associated With Implant
Prevention of Capsular Contracture in Postmastectomy Patients Undergoing Implant-based Reconstructions
The study plans to evaluate capsular contracture at 1-year follow-up in postmastectomy patients receiving immediate implant-based reconstruction and Capsulase® supplementation in the postoperative period.
- Trial name
- NCT06785610
- Testing
- Capsulase®
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- European Institute of Oncology
Shoulder Injuries, Patient Satisfaction
Conjoint Tendon Resection During Reverse Total Shoulder Arthroplasty
Reverse total shoulder arthroplasty (RTSA) can reliably restore active forward elevation, abduction, and external rotation, which are often lost in patients with massive rotator cuff tears.
- Conditions
- Shoulder Injuries, Patient Satisfaction, Internal Rotation Contracture-shoulder
- Trial name
- NCT05753904
- Testing
- Conjoint Tendon Resection
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Bladder Cancer, Triple Negative Breast Cancer
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This clinical trial is evaluating a drug called HMBD-001 (an anti-HER3 monoclonal antibody) in participants with advanced HER3 positive solid tumours.
- Conditions
- Bladder Cancer, Triple Negative Breast Cancer, Castration-resistant Prostate Cancer, Cervical Cancer
- Trial name
- NCT05057013
- Testing
- HMBD-001, HMBD-001 and enzalutamide
- Where
- 4 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- Cancer Research UK
Cerebral Palsy, Contracture
Repurposing 5-Azacytidine for the Treatment of Muscle Contractures in Children With Cerebral Palsy
In this controlled dose-escalation study, we will study the initial safety, biological properties, and potential efficacy of 5-azacytidine (AZA).
- Trial name
- NCT06377085
- Testing
- 5-Azacytidine 10mg/m^2
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Shirley Ryan AbilityLab
Equinus Contracture
A Needle Technique for Achilles Tendon Lengthening in Pediatric Patients: A Prospective Study on Efficacy, Safety, and Feasibility
For years, we have used a minimally invasive and biological variant of Achilles tendon lengthening using a needle inserted into the Achilles tendon so that it is weakened and can be gradually stretched to the desired length.
- Trial name
- NCT06912061
- Testing
- Needle tendon lengthening technique
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Vestre Viken Hospital Trust
H Syndrome
Histiocytosis and Inflammatory Manifestations in Patients with H Syndrome
H syndrome is a rare genetic disorder predisposing to histiocytosis. Our knowledge of the clinical spectrum of these patients is based on case reports and small patient series.
- Trial name
- NCT06742073
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Rabin Medical Center
Contracture, Hand
Effects of Paraffin Wax Therapy vs METs in Post Burn Hand Contractures
The degree of the burn and the rate of scar development during healing are the main determinants of loss of hand function following thermal injury.
- Trial name
- NCT06198062
- Testing
- Paraffin wax bath therapy, Paraffin Wax Bath Therapy and Muscle Energy Techniques
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Cerebral Palsy
Early Intervention in Infants With Cerebral Palsy
Contractures are a frequent cause of reduced mobility in children with Cerebral palsy (CP) already at the age of 2-3 years. Reduced muscle use and muscle growth have been suggested as key factors in the development of…
- Trial name
- CONTRACT (NCT04250454)
- Testing
- CONTRACT
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- University of Copenhagen
Breast Implant; Complications, Breast Implant Infection
Comparative Analysis of Two Animal-derived ADMs in Irradiated Implant-based Reconstruction
The goal of this retrospective observational trial is to compare two different devices, used in implant-based breast reconstruction, called acellular dermal matrices, which are a sort of collagen patch that integrates with the…
- Conditions
- Breast Implant; Complications, Breast Implant Infection, Implant Capsular Contracture, Breast Seroma
- Trial name
- RTADM (NCT06139588)
- Testing
- acellular dermal matrix implant for breast reconstruction
- Where
- Italy
- Volunteers
- 146 people
- Sponsor
- European Institute of Oncology
Dupuytren Disease of Palm and Finger, With Contracture
Hand Therapy or Not Following Collagenase Treatment for Dupuytren's Contracture?
This study evaluates if hand therapy have an impact on the patients' preformance of and satisfaction with everyday activities or not following collagenase injection treatment for Dupuytren's contracture.
- Trial name
- NCT03580213
- Testing
- Hand therapy MCPJ affected, Hand therapy PIPJ affected
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- Haukeland University Hospital
Hamstring Contractures
Neurodynamics vs. Stretching in Soccer Players With Short Hamstring Syndrome
Comparison of the effects of passive stretching vs. sciatic nerve gliding in soccer players presenting with short hamstring syndrome.
- Trial name
- NCT05866913
- Testing
- Sciatic nerve slippage., Passive stretching of the hamstring muscles., passive shoulder mobilization.
- Where
- Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Breast Implant-Associated Anaplastic Large Cell Lymphoma, Capsular Contracture, Implant
Breast-implant ASsocIated anaplastIc Large Cell Lymphoma and CApsular Contracture
BASILICA is a UK NIHR Biomedical Research Centre funded study recruiting patients at The Royal Marsden NHS Foundation Trust. The study aims to obtain blood and tissue samples from patients with breast implant-associated…
- Conditions
- Breast Implant-Associated Anaplastic Large Cell Lymphoma, Capsular Contracture, Implant, Breast Implant; Complications
- Trial name
- BASILICA (NCT05017337)
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust