AzTrials
AzTrials

Joint ContractureNCT07885046

Recurrence of Extremity Joint Contracture After Z-Plasty Versus Full-Thickness Skin Graft

An observational study of Joint Contracture and Contracture, run by Universitas Sebelas Maret.

Not yet recruiting

Opening soon. The study is approved but enrolment has not started yet. Sites may already take enquiries.

Sites and contacts
Official record

Search all trials

Trial summary

The purpose of this study is to compare how often joint contractures in the arms and legs come back after two common types of reconstructive surgery: Z-plasty and full-thickness skin graft (FTSG). A joint contracture is a tightening of scar tissue, most often after a deep burn, that limits how far a joint can move. Read more about this study

Who is it for?
Any age
Conditions the study is for
Joint Contracture, Contracture, Cicatrix
What is being tested?
Z-Plasty and Full-Thickness Skin Graft
Type of treatment
Surgery or procedure
How many people
300 participants
Where
No sites listed yet
Study dates
13 Oct 2026to 31 Jan 2027
Phase
Observational

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages Any age
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Study population: Patients of all ages with extremity joint contracture, predominantly post-burn scar contracture, who underwent surgical contracture release with either Z-plasty or full-thickness skin graft at the Department of Plastic, Reconstructive and Aesthetic Surgery, Dr. Moewardi General Hospital, a tertiary referral hospital in Surakarta, Indonesia, between 2016 and 2026. Participants are identified retrospectively from hospital medical records.

Who may be able to join

  • Patients diagnosed with joint contracture of the extremities (shoulder, elbow, wrist/hand, hip, knee, or ankle)
  • Underwent surgical excision/release of the contracture using either Z-plasty or full-thickness skin graft (FTSG) as the sole closure technique at Dr. Moewardi General Hospital between 2016 and 2026
  • Complete medical records, including preoperative data, operative report, and postoperative follow-up records of at least 6 months

Who cannot join

  • Contracture of non-burn etiology not comparable to post-burn contracture (e.g., congenital or purely neurogenic contracture)
  • Combined surgical techniques in a single procedure (e.g., Z-plasty combined with skin graft) that prevent clear group allocation
  • Incomplete or missing medical records, or loss to follow-up before the minimum recurrence-assessment period

Trial locations and contacts

No sites are listed yet. Contact the study team or a site near you to ask about taking part.

Naufal Helmi Musyaffa, MD contact

+6282236363445

naufalhelmimusyaffa@gmail.com

About this study

Official title: Comparative Analysis of Joint Contracture Recurrence in the Extremities After Excision With Z-Plasty Versus Full-Thickness Skin Graft (FTSG) : A Retrospective Cohort Study

The purpose of this study is to compare how often joint contractures in the arms and legs come back after two common types of reconstructive surgery: Z-plasty and full-thickness skin graft (FTSG).

A joint contracture is a tightening of scar tissue, most often after a deep burn, that limits how far a joint can move. Surgery can release the tight scar, but the contracture may return over time. Z-plasty rearranges nearby skin to lengthen the scar, while FTSG covers the released area with full-thickness skin taken from another part of the body. Previous studies have shown conflicting results about which technique has a lower risk of the contracture returning.

Read more

This study will review the medical records of patients who had contracture release surgery of the shoulder, elbow, wrist/hand, hip, knee, or ankle at Dr. Moewardi General Hospital, Surakarta, Indonesia, between 2016 and 2026. No new treatment or procedure will be given to patients, and all patient information will be kept anonymous.

The study hypothesis is that the rate of contracture recurrence differs between patients treated with Z-plasty and those treated with FTSG. The results may help surgeons choose the most suitable technique to reduce the risk of recurrence and improve patients' movement and quality of life.

Read the detailed description

Background Deep (full-thickness) burns over joints frequently lead to scar contractures that restrict range of motion (ROM), impair function and independence in daily activities, and reduce quality of life. Approximately one-third of burn patients have at least one contracture at hospital discharge. Despite surgical release, recurrence remains a clinical problem, with a pooled recurrence rate of about 10% reported for hand burn contractures. Z-plasty (local transposition flaps that lengthen the scar axis without donor tissue) and full-thickness skin graft (FTSG; coverage of the post-release defect with full-thickness skin from a donor site) are the two most commonly used techniques for releasing extremity contractures. Comparative evidence on recurrence is inconsistent: some studies report lower recurrence after Z-plasty and others report no significant difference. This variation may reflect differences in anatomical site, contracture morphology (linear band versus broad planar defect), burn severity, operative technique, rehabilitation adherence, and length of follow-up. Evidence specific to extremity joint contractures remains limited.

Objectives The primary objective is to compare the recurrence rate of extremity joint contracture after surgical excision/release with Z-plasty versus FTSG. Secondary objectives are to describe the demographic and clinical characteristics of patients in each group, to determine the recurrence rate within each group, and to identify factors associated with contracture recurrence.

Study Design This is a single-center, observational, analytic, retrospective cohort study based on review of existing medical records. Patients are grouped according to the closure technique documented in the operative report (Z-plasty alone or FTSG alone). Treatment allocation was determined by routine clinical care; no intervention is assigned or administered as part of this study.

Setting and Study Period Department of Plastic, Reconstructive and Aesthetic Surgery, Dr. Moewardi General Hospital / Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia. Medical records from 2016 to 2026 will be reviewed. Data collection and analysis are planned for July to November 2026.

Sampling Total (consecutive) sampling will be used: all patients meeting the eligibility criteria during the study period will be included, given the limited number of cases at a single institution. No formal a priori sample size calculation is performed.

Variables The exposure is the surgical technique (Z-plasty or FTSG). The outcome is contracture recurrence, defined as loss of the corrected ROM or development of a tethering scar band requiring revision, assessed by goniometric evaluation at least 6 to 12 months postoperatively. Potential confounders recorded include age, anatomical joint involved, depth of the initial burn, duration of follow-up, adherence to postoperative rehabilitation (physiotherapy, splinting, pressure garments), and comorbidities such as diabetes mellitus.

Data Collection and Management Data will be abstracted from medical records using a standardized, investigator-designed data collection form covering de-identified patient characteristics, clinical characteristics, operative technique, pre- and postoperative ROM, and recurrence status at the last recorded follow-up. Data will be verified and cleaned for completeness and internal consistency before analysis. Patients with incomplete records or loss to follow-up before the minimum recurrence-assessment period will be excluded, so the primary analysis will be a complete-case analysis.

Statistical Analysis Descriptive (univariate) statistics will summarize participant characteristics. Recurrence proportions between the Z-plasty and FTSG groups will be compared using the chi-square test, or Fisher's exact test when any expected cell count is less than 5. If appropriate, multivariable logistic regression will be performed to adjust for potential confounders. Statistical significance is set at p < 0.05.

Ethics The study will be submitted for approval to the Health Research Ethics Committee of Dr. Moewardi General Hospital before data collection. Only secondary data from medical records are used, no direct intervention involves participants, and all data will be anonymized to protect patient confidentiality in accordance with Indonesian medical records regulations.

Being tested
Z-Plasty, Full-Thickness Skin Graft
Keywords
joint contracture, z-plasty, FTSG, Contracture Release, Contracture Recurrence
Medical subject headings
Contracture, Cicatrix

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Z-PlastyProcedure or surgery

    Surgical release of extremity joint contracture using Z-plasty as the sole closure technique. After incision/excision of the contracted scar band, two opposing triangular local flaps are transposed to lengthen the scar axis and reorient the scar along relaxed skin tension lines, without the need for donor-site tissue. Performed as part of routine clinical care; not assigned by the study.

  • Full-Thickness Skin GraftProcedure or surgery

    Surgical release of extremity joint contracture by excision of the contracted scar, followed by coverage of the resulting defect with a full-thickness skin graft (epidermis and entire dermis) harvested from a donor site, used as the sole closure technique without combined local flap transposition. Performed as part of routine clinical care; not assigned by the study.

Study groups in NCT07885046
Study groupRoleWhat they receive
Z-PlastyPatients with extremity joint contracture (shoulder, elbow, wrist/hand, hip, knee, or ankle) who underwent surgical excision/release of the contracture with Z-plasty as the sole closure technique at Dr. Moewardi General Hospital between 2016 and 2026. Z-plasty involves transposition of two opposing triangular local flaps to lengthen the scar axis and reorient the scar without donor tissue. Data are obtained retrospectively from medical records; the procedure was performed as part of routine clinical care and was not assigned by the study.
Receives: Procedure: Z-Plasty
Full-Thickness Skin Graft (FTSG)Patients with extremity joint contracture (shoulder, elbow, wrist/hand, hip, knee, or ankle) who underwent surgical excision/release of the contracture with full-thickness skin graft (FTSG) as the sole closure technique at Dr. Moewardi General Hospital between 2016 and 2026. FTSG involves covering the post-release defect with a graft containing the epidermis and full dermis harvested from a donor site. Data are obtained retrospectively from medical records; the procedure was performed as part of routine clinical care and was not assigned by the study.
Receives: Procedure: Full-Thickness Skin Graft

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Rate of Contracture Recurrence

    Proportion of participants with contracture recurrence in each group, defined as loss of the surgically corrected range of motion (ROM) or the development of a tethering scar band requiring revision surgery, as documented in medical records based on goniometric evaluation. Recurrence is recorded as a binary outcome (recurrence / no recurrence) and compared between the Z-plasty and FTSG groups.

    Measured: At least 6 months after surgery (assessed at last recorded follow-up)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted21 Oct 2026
  2. Study start13 Oct 2026 (estimated)
  3. Primary completion1 Jan 2027 (estimated)
  4. Study completion31 Jan 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Retrospective
Enrolment
300 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07885046
Sponsor's protocol ID
1.308/VII/HREC/2026
Other IDs
308/VII/HREC/2026
Status last verified
Jul 2026
First submitted
13 Oct 2026
Last updated
21 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: Individual participant data will not be shared because the study uses retrospective medical record data from a single hospital, and sharing was not covered by the ethics approval (308/VII/HREC/2026) or by hospital medical record confidentiality regulations. Aggregate results will be reported in publications.

Free account

Keep searching with a free account

You’ve used your 3 free searches for this session. Log in or create a free AzTrials account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in