Clinical trials: Cardiovascular Mortality
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Hypertension (HTN), Diarrhea
Mortality Control Program for Economically Productive Age Group in Tribal Area of Melghat.
Background: Age specific mortality rate (ASMR) of 16-60 years is very high in Indian tribal areas due to communicable and non-communicable diseases.
- Conditions
- Hypertension (HTN), Diarrhea, Pneumonia, Malaria Fever
- Trial name
- MCPEPAG (NCT07436104)
- Testing
- Trained village health workers (VHWs) , provided treatment of HTN, diarrhoea, malaria, pneumonia, asthma and COPD by Amlodipine, ORS, Norfloxacin, Chloroquine, Azithromycin, salbutamol rotacaps, Appropriate referral
- Where
- India
- Volunteers
- 72,564 people, healthy volunteers welcome
- Sponsor
- MAHAN Trust
Body Weight, Obesity
Meta-analysis of the Nordic Dietary Pattern on Cardiometabolic Risk and Cardiovascular Outcomes
The Nordic Diet is a dietary pattern rich in traditional Nordic foods, including berries, grains, and fatty fish common in northern Europe.
- Conditions
- Body Weight, Obesity, Overweight and Obesity, Obesity, Abdominal
- Trial name
- NCT04094194
- Testing
- Nordic diet
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Unexpected Hospital Mortality, Death, Sudden, Cardiac
Prevention of Serious Adverse Events in Acute Care Hospitals by Afferent Limb and Response Method Intervention - the ALARM Intervention Study.
1. Summary Growing evidence suggests that a significant proportion of in-hospital patient deaths occur after serious adverse events (SAE's).
- Conditions
- Unexpected Hospital Mortality, Death, Sudden, Cardiac, Unplanned Intensive Care Unit Admission
- Trial name
- ALARM (NCT01949025)
- Testing
- ALARM intervention
- Where
- Belgium
- Volunteers
- 69,656 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Pre-eclampsia, Hypertension, Pregnancy Induced
Community Level Interventions for Pre-eclampsia
This project is being undertaken to test the hypothesis that implementing a community based package of care for women with hypertensive disorders of pregnancy will result in overall improvement in maternal and neonatal outcomes.
- Trial name
- CLIP (NCT01911494)
- Testing
- Community Engagement, PIERS on the Move mHealth decision aid, Magnesium Sulfate
- Where
- 4 sites in India, Mozambique and 2 more
- Volunteers
- 87,500 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cardiovascular Diseases, Coronary Heart Disease
Meta-analysis of Vegetarian Diets and Incident Cardiovascular Outcomes
Vegetarian and vegan diets have been shown to reduce cardiometabolic risk factors for chronic diseases, such as cardiovascular disease and diabetes, and have been associated with decreased risk of these chronic diseases.
- Conditions
- Cardiovascular Diseases, Coronary Heart Disease, Stroke, Mortality
- Trial name
- NCT03610828
- Testing
- Vegetarian or Vegan Diets
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Infant, Newborn, Infant, Small for Gestational Age
Vitamin E for Extremely Preterm Infants
The purpose of this pilot trial is to test the safety and efficacy of administering one dose of vitamin E, via a tube into the stomach, to extremely preterm infants (less than 27 weeks gestation and less than 1000 grams birth…
- Conditions
- Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature
- Trial name
- NCT01193270
- Testing
- Vitamin E
- Where
- 16 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Maternal Death, Neonatal Death
Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana
Introduction Maternal and neonatal mortality continue to be to be prominent public health issues in sub Saharan Africa including Ghana, with slow progress made towards attainment of Millennium Development Goals (MDG) 4 \& 5.
- Conditions
- Maternal Death, Neonatal Death, Postpartum Haemorrhage, Pre-eclampsia
- Trial name
- Accelerate (NCT02468310)
- Testing
- Maternal and neonatal emergency protocols
- Where
- Ghana
- Volunteers
- 65,831 people, healthy volunteers welcome
- Sponsor
- Hannah Brown Amoakoh
Diet, Food, and Nutrition, Exercise
The NutriNet-Santé Study
The NutriNet-Santé study was set up to investigate nutrition and health relationships. Specifically, it was the first web-based cohort worldwide on such a large scale (n=171 000 as of 2021) focused on the complex link between…
- Conditions
- Diet, Food, and Nutrition, Exercise, Diseases Category, Cohort Studies
- Trial name
- NCT03335644
- Where
- France
- Volunteers
- 170,000 people, healthy volunteers welcome
- Sponsor
- University of Paris 13
Preg Complications: Hemorrhagic, Infant, Premature, Diseases
Maternal & Infant Morbidity and Mortality
The purpose of this project is to evaluate maternal and infant outcomes based on race at UVA hospital. Health inequities are influenced by a combination of Social, Political, and Clinical determinants of health.
- Conditions
- Preg Complications: Hemorrhagic, Infant, Premature, Diseases, Preg Complications: Hemorrhagic Intervillous of Placenta, Preg Complications: Bleeding From Female Genital Tract
- Trial name
- NCT06145568
- Testing
- Pregnant Women
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Adiposity, Metabolic Syndrome
Meta-analysis of Low-calorie Sweetened Beverages and Cardiometabolic Outcomes
We propose to conduct a systematic literature review and meta-analysis to assess the association of low-calorie sweetened beverages (LCSBs) on cardiometabolic outcomes in prospective cohort studies.
- Conditions
- Adiposity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Diseases
- Trial name
- NCT04245826
- Testing
- Change in LCSBs Intake, Substitute LCSBs for SSBs or Water
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Pre-Eclampsia, Hypertension, Pregnancy-Induced
Low Dose Calcium to Prevent Preeclampsia
The purpose of this study is to assess, in pregnant women with calcium-poor diets, what is the effectiveness of low-dose (500 mg/day) calcium supplements associated with an educational intervention, compared to the educational…
- Conditions
- Pre-Eclampsia, Hypertension, Pregnancy-Induced, Dietary Calcium Deficiency
- Trial name
- AMCAL (NCT02338687)
- Testing
- calcium, Educational sessions
- Where
- Brazil
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Cardiovascular Disease, Diabetes
Meta-Analyses of Low-risk Lifestyle Behaviours and Patient Important Outcomes
Public health policy is universal in recommending the adoption of low risk low-risk lifestyle behaviors for health promotion and prevention of chronic or non-communicable diseases (NCDs).These behaviors generally include…
- Conditions
- Cardiovascular Disease, Diabetes, Cancer, Mortality
- Trial name
- NCT03234101
- Testing
- Low-risk lifestyle behaviours
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Asphyxia Neonatorum, Neonatal Mortality
Neonatal Resuscitation in Zambia
Asphyxia is a leading cause of neonatal death in Zambia. This study will be conducted in two cities in Zambia to determine if the combined Neonatal Resuscitation Program/Essential Newborn Care Program compared to the new World…
- Conditions
- Asphyxia Neonatorum, Neonatal Mortality, Hypoxic Ischemic Encephalopathy
- Trial name
- NCT00097097
- Testing
- Neonatal Resuscitation
- Where
- Zambia
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Lupus
Disease Progression and Activity in Patients With Systemic Lupus Erythematosus
This study is a continuing follow-up of patients with systemic lupus erythematosus (SLE) and control subjects enrolled in the Carolina Lupus Study and the University of North Carolina (UNC) Lupus Nephritis Study.
- Trial name
- NCT00339261
- Where
- United States
- Volunteers
- 716 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Death, Stroke
Postoperative Atrial Fibrillation and Long-term Survival
The aim of the investigators trial was to evaluate association between new onset postoperative atrial fibrillation (POAF) and late cardiovascular morbidity and mortality.
- Conditions
- Death, Stroke, Myocardial Infarction
- Trial name
- POAF (NCT02349269)
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Pregnancy, Neonatal Mortality
Scalable Public Health Empowerment, Research, and Education Sites (SPHERES)
SPHERES is a health service research trial in the Indonesian primary care system designed to improve health system performance using a structured data-driven action model.
- Conditions
- Pregnancy, Neonatal Mortality, Tuberculosis, Hepatitis B
- Trial name
- SPHERES (NCT07126041)
- Testing
- Prescription for Action (SPHERES Model)
- Where
- 2 sites in Indonesia
- Volunteers
- 1,750,000 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit Indonesia
Screening, Aortic Aneurysm and Dissection
A Study to Evaluate the Feasibility of Screening Relatives of Patients Affected by Non-Syndromic Thoracic Aortic Diseases
The primary hypothesis is that a tailored programme of genetic and imaging screening of first- and second-degree relatives of patients affected by non-syndromic forms of thoracic aortic diseases will identify individuals at risk…
- Conditions
- Screening, Aortic Aneurysm and Dissection, Genetic Disease
- Trial name
- ReST (NCT03861741)
- Testing
- WES, MRI, TTE
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Leicester
oPAP Should be > 25mmHg in Right Heart Catheterization at Rest, There Should be Patients Who Will Undergo Non-cardiac and Non-obstetric Surgery
Postoperative Morbidity / Mortality Rates of Patients With Pulmonary Hypertension
Pulmonary hypertension (PHT) is an oPAP ≥25 mmHg as assessed by right heart catheterization at rest. It is divided into 5 groups according to its etiology and mechanism.
- Trial name
- PulmonaryHT (NCT05565911)
- Testing
- no intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Baskent University
Stroke, Acute Coronary Syndrome
Factors Associated With Perioperative Outcomes in Non-emergency Surgery
This epidemiological study investigates the association of recent stroke, acute coronary syndrome or pneumonia and adverse perioperative outcomes following elective non-cardiac and cardiac surgery using routinely collected UK…
- Conditions
- Stroke, Acute Coronary Syndrome, Pneumonia
- Trial name
- NCT02455492
- Testing
- stroke or myocardial infarction or pneumonia
- Volunteers
- 266,436 people, healthy volunteers welcome
- Sponsor
- University of Nottingham