Clinical trials: Burn Scar
Joint Contracture, Contracture
Recurrence of Extremity Joint Contracture After Z-Plasty Versus Full-Thickness Skin Graft
The purpose of this study is to compare how often joint contractures in the arms and legs come back after two common types of reconstructive surgery: Z-plasty and full-thickness skin graft (FTSG).
- Conditions
- Joint Contracture, Contracture, Cicatrix, Burn Scar Contractures
- Trial name
- NCT07885046
- Testing
- Z-Plasty, Full-Thickness Skin Graft
- Volunteers
- 300 people
- Sponsor
- Universitas Sebelas Maret
Burn Scar, Burn Wound
Post-Operative Use of FS2 to Mitigate Scarring in Burn Patients
The goal of this study is to see how an ingredient called kynurenic acid (which we named "FS2") affects scar formation in people with burn injuries that need skin graft surgery.
- Trial name
- NCT06807021
- Testing
- IP1 control cream (Vehicle base), IP2 - 0.5% w/w FS2
- Where
- 2 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Birch BioMed Inc
Burn Scar
Scar Mobilization Improves Scars and Quality of Life in Burned Children.
This quasi-experimental study evaluates the effect of scar tissue mobilization on scar thickness, pliability, and quality of life in children with upper extremity burns.
- Trial name
- NCT07578883
- Testing
- Scar tissue mobilization
- Where
- Pakistan
- Volunteers
- 15 people
- Sponsor
- Riphah International University
Facial Scarring, Facial Trauma
Tools for Return of Facial Function
This study will evaluate novel intraoral (inside-the-mouth) splints designed to gently stretch facial tissues that have become tight or scarred following facial trauma, including burn injuries and gunshot wounds.
- Conditions
- Facial Scarring, Facial Trauma, Burn, Orofacial Contracture
- Trial name
- NCT07825844
- Testing
- Intraoral Stretching Splints
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Burn Scar
Nonsilicone Gel Sheet for Burn Hypertrophic Scars
Overview: The application of gel sheets holds promise for both the prevention and treatment of hypertrophic scar after deep dermal injuries.
- Trial name
- NCT05429411
- Testing
- Silicone gel
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Burn Scar
Scar Management Through Serial Casting
Scar management remains one of the major clinical challenges for burn survivors with hypertrophic scars. Beyond their visible appearance, hypertrophic scars can significantly impair physical function, reduce life satisfaction…
- Trial name
- NCT07645664
- Testing
- Serial casted scar
- Volunteers
- 38 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Burn Scar
Microneedling for Burn Hypertrophic Scars
Approximately 33 to 91% of severe burn victims will develop hypertrophic scars. Hypertrophic scars are defined as erythematous (red), raised and rigid scars that can cause pain and itching, among other things.
- Trial name
- NCT05423613
- Testing
- Microneedling
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Skin Scars, Post-burn Scars
Exploratory Study to Evaluate the Efficacy of the Cosmetic Product RV3895A on Re-epidermised Scars Following Burns and Surgical Stitches in Adults, Adolescents and Children Over a 6-month Follow-up Period
This study is exploratory, non-comparative and open-label, conducted in France. It aims to provide insights into the effectiveness and safety of RV3895A - RY1774, potentially benefiting participants by improving scar appearance…
- Conditions
- Skin Scars, Post-burn Scars, Post-surgical-stitches Scars
- Trial name
- NCT07020507
- Testing
- Product gel RV3895A
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Pierre Fabre Dermo Cosmetique
Burn Scar
Endermotherapy With Burn Hypertrophic Scars
Mechanical massage or endermotherapyTM is applied to scar tissue with the intended therapeutic value being the promotion of structural or physiological changes.
- Trial name
- NCT03697447
- Testing
- Endermotherapy
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Burns, Tele-rehabilitation
Effect of a Tele-rehabilitation Programme in Children With Burns: a Randomized Controlled Trial
The goal of this clinical trial is to compare tele-rehabilitation and routine post-discharge rehabilitation in children with burn injuries.
- Conditions
- Burns, Tele-rehabilitation, Scar, Children
- Trial name
- NCT06386549
- Testing
- tele-rehabilitation
- Where
- China
- Volunteers
- 44 people
- Sponsor
- LIAO Peng
Burns, Burn Scar
Dermal Substitution in Pediatric Burns
The standard treatment of deep dermal to full thickness burns is surgical removal of the burn followed by skin transplantation. Dermal substitutes are increasingly used in the treatment of deep burns to replace lost dermis.
- Trial name
- GlyPeB (NCT05309720)
- Testing
- Glyaderm
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Cryotherapy Effect, Burn Scar
Observation of the Comfort and Efficacy of CO2 Laser Combined With Cryo 6 for Burn or Linear Scars.
To investigate the effect of 10,600 nm CO2 laser combined with Zimmer Cryo 6 forced cold air device on the comfort and efficacy of patients with burn scars or post-operative linear scars, and to provide a safer, more effective…
- Conditions
- Cryotherapy Effect, Burn Scar, Scar; Previous Cesarean Section
- Trial name
- NCT05555602
- Testing
- Cold-air cooling
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kaiyang Lv, MD-PhD
Burns, Scar
Examine the Validity of a Panel of Objective Burn Scar Measurement Tools
Reliable scar assessment is essential not only when designing clinical trials to investigate the efficacy of new and existing scar therapies, but also in everyday, clinical practice, to examine the progress of our patients' care.
- Conditions
- Burns, Scar, Hypertrophic
- Trial name
- BOSS-2 (NCT05126017)
- Volunteers
- 60 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Burn Scar, Scar
Mechanistic Basis of Ablative Carbon Dioxide Laser in Treating Hypertrophic Scars
This is an observational cohort study which will look at the biomarkers from blood and tissue sample for adult patients with hypertrophic scarring due to burns/trauma incident over 12 months from date of recruitment.
- Trial name
- SMOOTH (NCT04736251)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Naiem Moiemen
Burn Injury, Soft Tissue Injury
Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects
The purpose of this study is the evaluation of the safety of autologous tissue-engineered dermal substitutes "denovoDerm" (first arm) and dermo-epidermal skin substitutes "denovoSkin" (second arm) transplanted onto the wound bed…
- Conditions
- Burn Injury, Soft Tissue Injury, Skin Necrosis, Scars
- Trial name
- NCT02145130
- Testing
- denovoDerm, denovoSkin
- Where
- 2 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Burns, Electrical Burn
The Treatment Challenges and Limitation in High-Voltage Pediatric Electrical Burn at Rural Area
A case of high-voltage pediatric electrical burn involving a fully conscious 13-year old boy who was admitted to the emergency room after being electrocuted by high-voltage power cable, with superficial partial thickness burn…
- Conditions
- Burns, Electrical Burn, Burn Degree Second, Burn Scar
- Trial name
- NCT04772573
- Where
- Indonesia
- Volunteers
- 1 people
- Sponsor
- S.K. Lerik General Hospital
Burn Scar
Comparison of Length Gain Between Square Flap and Z-plasty in Post Burn Contracture Release
the purpose of this study is to compare the gain in length after postburn contracture release using two different techniques, the more commonly practised z - plasty and relatively newer technique, square flap
- Trial name
- NCT04690543
- Testing
- z-plasty, square flap
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Burn Scar
Comparative Study Between Fat Injection And Platelet Rich Plasma In Post Burn Facial Scar
Best method in management of facial burn scar
- Trial name
- NCT04557514
- Testing
- platelet rich plasma injection in post burn facial scar, fat injection in post burn facial scar
- Volunteers
- 60 people
- Sponsor
- Assiut University
Burn Scar
CO2 Laser Phototherapy for Management of Mature Burn Scars
Evaluate mature burn scars before and after treatment with CO2 for patients age 3-21 while comparing the treated areas to an untreated control area in the same patient.
- Trial name
- NCT03197649
- Testing
- Laser phototherapy treatment
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
Burn Scars
Fractionated Carbon Dioxide Laser and Burn Scar Contractures: Evaluation of Post-Treatment Scar Function and Appearance
The investigators are studying the appearance and function of burn scars after treatment with fractionated carbon dioxide laser.
- Trial name
- NCT02115646
- Testing
- fractionated carbon dioxide laser
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts General Hospital