Clinical trials: Biomarker Discovery
Wilson's Disease
Cohort Research on Wilson's Disease
Wilson's disease (WD) is an inherited disorder that causes abnormal copper accumulation in the brain and/or liver. Some people develop neurological or psychiatric symptoms whereas other develop liver disease.
- Trial name
- CROWD (NCT04212195)
- Testing
- Next generation sequencing, Imaging and fluid biomarkers
- Where
- 11 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College, London
Breast Cancer
Triple-B Study;Carboplatin-cyclophosphamide Versus Paclitaxel With or Without Atezolizumab as First-line Treatment in Advanced Triple Negative Breast Cancer
Triple negative breast cancer (TNBC) is a difficult to treat molecular subtype with a poor survival. TNBC can be divided into at least two molecular entities; BRCA-like and non-BRCA-like.
- Trial name
- Triple-B (NCT01898117)
- Testing
- Carbo/cyclo, Carbo/cyclo + atezolizumab, Paclitaxel
- Where
- 49 sites in Netherlands
- Volunteers
- 304 people
- Sponsor
- The Netherlands Cancer Institute
ADHD - Attention Deficit Disorder With Hyperactivity, Autism Spectrum Disorder (ASD)
Biomarkers of ASD/ADHD and Factors Affecting Anxiety and Depression in Children and Young Adults
The PUREMIND OS1/OS2 study is a multinational, prospective, longitudinal observational study designed to identify early neurophysiological, biological, environmental, and psychosocial markers associated with neurodevelopmental…
- Conditions
- ADHD - Attention Deficit Disorder With Hyperactivity, Autism Spectrum Disorder (ASD), Developmental Coordination Disorder (DCD)
- Trial name
- PUREMIND-OS (NCT07570381)
- Where
- United Kingdom
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Sepsis, Newborn Sepsis
T6A Biomarker for Detection of Bacterial Infection in Newborn Infants
This bi-center study aims to assess the efficacy of a new biomarker, N6-threonylcarbamoyladenosine (t6A), for the early diagnosis of Early-Onset Sepsis (EOS) in newborns.
- Conditions
- Sepsis, Newborn Sepsis, Biomarker Discovery
- Trial name
- T6ASepsis (NCT07670624)
- Where
- 2 sites in Austria, Poland
- Volunteers
- 210 people
- Sponsor
- Salzburger Landeskliniken
Cancer
Discovery of Microbiome-based Biomarkers for Patients With Cancer Using Metagenomic Approach
Multicentric prospective study with collection of biological samples as part of type II research
- Trial name
- ONCOBIOTICS (NCT04567446)
- Testing
- Stool, Blood sample
- Where
- 9 sites in France
- Volunteers
- 1,100 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Crohn Disease (CD), Ulcerative Colitis (UC)
IBD Biomarker Discovery and Validation Platform
The goal of this observational study is to establish a multicenter prospective clinical and biospecimen platform for biomarker discovery and validation in inflammatory bowel disease, including Crohn's disease and ulcerative…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD)
- Trial name
- IBD-BIOP (NCT07686406)
- Where
- 2 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Kidney Cancer
Biomarkers in Urine Samples From Patients With Wilms Tumor
RATIONALE: Studying samples of urine from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer. PURPOSE: This clinical trial studies biomarkers in urine from patients with Wilms tumor.
- Trial name
- NCT01550393
- Testing
- proteomic profiling, enzyme-linked immunosorbent assay, laboratory biomarker analysis
- Volunteers
- 100 people
- Sponsor
- Children's Oncology Group
Acute Febrile Illness, Bacterial Infections
AI-Guided Proteomic Biomarker Panel for Differentiating Bacterial and Viral Infections in Acute Febrile Illness
This study is a proteomics-based diagnostic biomarker study conducted on the same patient cohort as the transcriptomic biomarker study (NCT065529754).
- Conditions
- Acute Febrile Illness, Bacterial Infections, Viral Infections, Sepsis
- Trial name
- NCT07205575
- Testing
- Proteomic Biomarker Panel
- Where
- China
- Volunteers
- 394 people
- Sponsor
- Qilu Hospital of Shandong University
Epilepsy
Microbiome Composition and Biomarker Discovery in Refractory Pediatric Epilepsy
Research study to look for bio markers in epilepsy patients on ketogenic diet
- Trial name
- NCT04311242
- Testing
- Diet
- Where
- United States
- Sponsor
- Senda Biosciences
COVID-19, SARS-CoV 2 Infection, Health Disparities
EMPOWER - BAME vs COVID
The COVID-19 virus pandemic has massively affected us all. Moreover, there is a disproportionately high number of COVID-19 severe infections and deaths in British Black, Asian and minority ethnic (BAME) patients.
- Trial name
- NCT04399733
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Autism, Children
Biomarker of Children With Familial Autoimmune History
The purpose of this study is to identify biomarkers in this subset of autism patients, design a protein based assay system for screening serum for these biomarkers and confirm that these serum antibodies are still present at one…
- Trial name
- NCT01541033
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Le Bonheur Children's Hospital
Eosinophilic Esophagitis
Metabolomics for Biomarker Discovery in Children With EoE
The investigators are seeking to enroll 8 children ages 2-18 already undergoing upper endoscopy. For the purposes of research, a peripheral blood and clean catch urine specimen will be obtained to measure plasma and urine…
- Trial name
- NCT03107819
- Testing
- Plasma and urine metabolomics
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pancreatic Cancer, Head and Neck Cancer
Creation of the BioBank, Early Detection and Discovery Biomarkers
To establish a multidisciplinary research structure for tissue repository that facilitates projects that bridge specialties that normally may or may not interact.
- Conditions
- Pancreatic Cancer, Head and Neck Cancer, Breast Cancer
- Trial name
- NCT00901680
- Where
- United States
- Volunteers
- 3,028 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Osteosarcoma
Genetic Biomarkers in Tissue Samples From Patients With Osteosarcoma
This clinical trial studies genetic biomarkers in tissue samples from patients with osteosarcoma. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA…
- Trial name
- NCT01807143
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Oncology Group
Sarcoma
Biomarkers in Patients With Rhabdomyosarcoma
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01466283
- Testing
- DNA methylation analysis, fluorescence in situ hybridization, gene expression analysis
- Volunteers
- 20 people
- Sponsor
- Children's Oncology Group
Down Syndrome
Phosphoproteomic Profile of Children With Down Syndrome
One of the major causes of cognitive disorders limiting the learning abilities of children with Down's syndrome is excess activity of the DYRK1A protein kinase, whose gene is located on chromosome 21.
- Trial name
- PEPS (NCT06279208)
- Testing
- Blood sample
- Where
- 9 sites in France
- Volunteers
- 60 people
- Sponsor
- Perha Pharmaceuticals
Malaria, Asymptomatic Parasitaemia
Community-Based Cohort Study of Hidden Malaria Infections, Diagnostic Gaps, & Mosquito Vector Dynamics in Odisha, India
The goal of this prospective cohort study is to understand the factors responsible for the persistence of malaria transmission in some areas despite intensive control efforts.
- Trial name
- CSCMi3 (NCT07770048)
- Where
- 2 sites in India
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant
Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study
Idiopathic Nephrotic Syndrome is a rare disease of the kidneys, which typically affects children. For most affected children there is the need of a prolonged treatment with drugs reducing the activity of the immune system, also…
- Conditions
- Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant, Nephrotic Syndrome in Children, Glomerulonephritis
- Trial name
- PRECISE (NCT06792448)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Microbial Keratitis
Microbial Keratitis Sampling for Biomarker Discovery
The goal of this observational study is to identify prognostic and/or diagnostic signatures (biomarkers) related to microbial keratitis outcomes.
- Trial name
- NCT05888883
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Allergy;Food
Biomarkers in Food Allergy Diagnosis
Food allergy is a global burden, affecting patients, society as a whole and the economy. For most common food allergies, patients synthesize specific IgE-antibodies against harmless food proteins.
- Trial name
- APSIS (NCT04604912)
- Where
- 2 sites in Luxembourg
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health