Clinical trials: Basal Cell Carcinoma
Basal Cell Carcinoma, Locally Advanced Basal Cell Carcinoma
Oral Hedgehog Inhibitors in the Treatment of Basal Cell Carcinoma in the Netherlands: a Prospective Registration Study
Background: Oral hedgehog inhibitors vismodegib and sonidegib have been used for the treatment of locally advanced (laBCC), metastatic basal cell carcinoma (mBCC) and in basal cell nevus syndrome (BCNS) patients.
- Conditions
- Basal Cell Carcinoma, Locally Advanced Basal Cell Carcinoma, Metastatic Basal Cell Carcinoma, Gorlin Syndrome
- Trial name
- NCT05463757
- Testing
- Vismodegib, Sonidegib
- Where
- 8 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- Maastricht University Medical Center
Eyelid Tumor
Mohs Surgery Combind With Cryotherapy for Eyelid Malignant Tumors.
This study aim to investigate whether the prognosis of eyelid malignant tumor is better treated with Mohs surgery combind with cryotherapy than Mohs surgery only.
- Trial name
- NCT05072327
- Testing
- Mohs surgery, cryotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Benign Skin Tumor, Basal Cell Carcinoma
Study to Examine Lesions of the Skin Using Confocal Laser Microscopy
Using ex-vivo confocal laser scanning microscopy, a reliable statement can be made about the extent, histological structure and possible significance of a skin change without having to send tissue samples for demanding and…
- Conditions
- Benign Skin Tumor, Basal Cell Carcinoma, Melanoma, Squamous Cell Cancer
- Trial name
- NCT06598137
- Testing
- Ex vivo confocal laser microscopy
- Where
- Germany
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- LMU Klinikum
Melanoma (Skin), Non-melanomatous Skin Cancer
Isotretinoin in Preventing Skin Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Isotretinoin may be effective in preventing the development or recurrence of skin cancer.
- Trial name
- NCT00025012
- Testing
- isotretinoin
- Where
- United States
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Basal Cell Carcinoma
Microarray Analysis of microRNA Expression in Basal Cell Carcinoma
Perturbations in microRNA (miRNA) expression profiles has been reported for a variety of cancers. This study will be an exploratory analysis of miRNA expression in basal cell carcinoma by miRNA expression profiling using…
- Trial name
- NCT01498250
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Ruhr University of Bochum
Head and Neck Cancer, Pain
Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer
RATIONALE: Acupuncture may help relieve pain and dysfunction caused by cancer surgery. It is not yet known whether acupuncture is more effective than standard therapy in treating pain and dysfunction in patients who have…
- Trial name
- NCT00090337
- Testing
- acupuncture therapy, standard follow-up care
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma (Skin)
Machine Learning Analysis of Two-photon Fluorescence Microscopy of Dermatologic Biopsies
The goal of this study is to investigate the ability of a machine learning model to evaluate two-photon fluorescence microscopy images of dermatologic biopsies at point of care.
- Trial name
- NCT07682831
- Testing
- Two photon microscopy imaging
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Rochester
Non-melanomatous Skin Cancer
Topical Imiquimod Compared With Surgery in Treating Patients With Basal Cell Skin Cancer
RATIONALE: Biological therapies such as imiquimod use different ways to stimulate the immune system and stop cancer cells from growing.
- Trial name
- NCT00066872
- Testing
- imiquimod, conventional surgery
- Where
- 3 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Queen's Medical Center
Carcinoma, Basal Cell
Recurrence Rate and Esthetic Outcome After Excision of Basal Cell Carcinomas Excluded From Trial NCT00515970
Currently, we conduct a prospective, randomized trial comparing the outcome of surgical excision with the outcome of curettage in nodular and superficial BCCs.
- Trial name
- NCT00639652
- Testing
- 3D-histology, Shave excision
- Where
- Germany
- Volunteers
- 800 people
- Sponsor
- University Hospital Tuebingen
Skin Basal Cell Carcinoma
Effectiveness of Narrow Margins in Patients With Low-Risk Basal Cell Carcinoma Undergoing Surgery
This clinical trial studies the effectiveness of narrow margins in patients with low-risk basal cell carcinoma undergoing surgery to remove skin lesions on the face.
- Trial name
- NCT02579551
- Testing
- Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Non-Melanomatous Skin Cancer
Low Fat Diet to Prevent Disease Progression in Patients With Skin Cancer
RATIONALE: A low-fat, balanced diet may prevent disease progression in patients with nonmelanomatous skin cancer. PURPOSE: Randomized phase II trial to study the effectiveness of a low-fat, balanced diet to prevent disease…
- Trial name
- NCT00003097
- Testing
- preventative dietary intervention
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Baylor College of Medicine
Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma
Two-photon Fluorescence Microscopy of Dermatologic Biopsies
The goal of this study is to investigate the ability of two-photon fluorescence microscopy to evaluate dermatologic biopsies. The main questions it aims to answer are: How well do two-photon fluorescence images of biopsies taken…
- Conditions
- Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma, Melanocytic Lesion, Adult
- Trial name
- NCT07773688
- Testing
- Two photon microscopy imaging
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- University of Rochester
Squamous Cell Carcinoma, Basal Cell Carcinoma
Comparison of Translocator Protein Expression and Binding Activity in Normal Tissue Versus Non Melanotic Malignancy
Translocator protein (TSPO) is a intracellular protein that is found primarily in the outer membrane of the mitochondria that is encoded by the TSPO gene.
- Trial name
- NCT01265472
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Non-melanoma Skin Cancer
Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma
Vitamin D has a crucial role in cancer control and prevention.vitamin D receptor (VDR) and its heterodimer Retinoid X receptor (RXR) are equally important in the cell.
- Trial name
- NCT05550766
- Volunteers
- 50 people
- Sponsor
- Sohag University
Skin Cancer
An Appearance-Based Intervention to Reduce Teen Skin Cancer Risk
The purpose of this study is to determine whether a skin cancer prevention website is effective at reduce female teenagers' desire to use indoor tanning and ultimately their use of indoor tanning over an 18 month period.
- Trial name
- iSTART (NCT01508013)
- Testing
- Appearance-Focused Website Intervention, Control Website
- Where
- United States
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- East Tennessee State University
Basal Cell Carcinoma, Gorlin Syndrome
Nevoid Basal Cell Carcinomas in Gorlin Syndrome
The overall aim of the project is to gain knowledge about the expected course of nevoid basal cell carcinomas and the usefulness of dermatoscopy in young individuals with Gorlin syndrome.
- Trial name
- NCT05898347
- Testing
- Active surveillance
- Where
- Norway
- Volunteers
- 7 people
- Sponsor
- Oslo University Hospital
Basal Cell Cancer
AI in Histipathological Diagnosis of Bcc
The goal of this study is to evaluate the diagnostic performance of an Artificial Intelligence (AI) algorithm in the histopathological diagnosis of bcc compared to certified dermatopathologists
- Trial name
- AI\bcc (NCT07786376)
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Basal Cell Carcinoma
AI-Based Risk Classification and Histopathological Subtype Prediction of Basal Cell Carcinoma Using Dermoscopic Images
This retrospective observational study aims to develop and evaluate a convolutional neural network (CNN)-based artificial intelligence model for risk classification and histopathological subtype prediction of basal cell carcinoma…
- Trial name
- BCC-AI (NCT07677124)
- Where
- Turkey (Türkiye)
- Volunteers
- 2,500 people
- Sponsor
- Istanbul Training and Research Hospital
Carcinoma, Basal Cell, Carcinoma, Squamous Cell
Determine the Efficacy of Topical Tretinoin Cream for the Prevention of Nonmelanoma Skin Cancer
One-third of all malignancies in the United States (approximately one million cases diagnosed annually) are nonmelanoma skin cancer (NMSC).
- Conditions
- Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Skin Neoplasms
- Trial name
- NCT00007631
- Where
- 7 sites in United States
- Volunteers
- 1,131 people
- Sponsor
- US Department of Veterans Affairs
Non-melanomatous Skin Cancer, Precancerous Condition
Photodynamic Therapy in Treating Patients With Skin Cancer
RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. Photodynamic therapy using aminolevulinic acid may be effective in treating patients with skin cancer.
- Trial name
- NCT00002975
- Testing
- aminolevulinic acid
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Roswell Park Cancer Institute