Clinical trials: Antihypertensive Agents
Anemia, Sickle Cell, Sickle Cell Disease
Preventing Sickle Cell Kidney Disease
Untreated hypertension and renal injury are risk factors for increased morbidity and mortality in sickle cell disease, yet early markers of progressive disease have not been identified and therapies to prevent the development of…
- Conditions
- Anemia, Sickle Cell, Sickle Cell Disease, Kidney Disease, Hypertension
- Trial name
- NCT02373241
- Testing
- Losartan
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Neonatal Abstinence Syndrome
Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain
The long term goals of our research are to establish the best pharmacological treatment for NAS and determine how pharmacologic treatment of NAS affects long-term developmental outcomes.
- Trial name
- No-POPPY (NCT03396588)
- Testing
- Clonidine, Morphine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Henrietta Bada
Arterial Hypertension
Once-daily Fixed Combination of Three Antihypertensive Drugs
Randomized comparison of once-daily fixed combiNation versus free-drug combination of three antihypertensive agents in arterial hypertension
- Trial name
- ONE&ONLY (NCT02710539)
- Testing
- perindopril, indapamide , amlodipine, Tripliam (perindopril, indapamide, amlodipine)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Hypertension
Bisoprolol in Hypertension: Effect on Concomitant Elevated Heart Rate
The b.p.m study will be performed to gain the insight in the courses of illness and therapy in subjects, suffering from hypertension and that have elevated heart rate.
- Trial name
- NCT01109043
- Testing
- Bisoprolol or bisoprolol + HCTZ
- Where
- Austria
- Volunteers
- 351 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Prader-Willi Syndrome, Aggression
Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome
This is a placebo-controlled clinical trial to assess whether Guanfacine Extended Release (GXR) reduces aggression and self injurious behavior in individuals with Prader Willi Syndrome (PWS).
- Conditions
- Prader-Willi Syndrome, Aggression, Self-Injurious Behavior, Pathologic Processes
- Trial name
- PWS-GXR (NCT05657860)
- Testing
- Guanfacine Extended Release
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Maimonides Medical Center
Preeclampsia, Gestational Hypertension
The ACHIEVE Trial: Achieving Longer Gestation in Preeclampsia Via Antihypertensive Therapy.
The Achieve Trial is a randomized clinical trial to test whether lowering blood pressure to less than 140/90 mmHg in women with hypertensive disorders of pregnancy will prolong pregnancy.
- Conditions
- Preeclampsia, Gestational Hypertension, Hypertensive Disorder of Pregnancy
- Trial name
- Achieve (NCT05676476)
- Testing
- Antihypertensive treatment
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- University of Alabama at Birmingham
Hypertension
Evidence Synthesis: Hypertension Medication Adherence & Intensification
Hypertension affects nearly 50 million Americans [1] and is the most common chronic condition among veterans. Unfortunately, many patients with established hypertension have poorly controlled blood pressure (BP); control rates in…
- Trial name
- NCT00682968
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Cardiovascular Diseases, Hypertension
Adherence to Antihypertensive Therapy--Data Analyses
To assess factors that may influence adherence to antihypertensive drug therapy.
- Trial name
- NCT00006552
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension
Chronic Hypertension and Pregnancy (CHAP) Project
The purpose of this study is to evaluate whether a blood pressure treatment strategy during pregnancy to achieve targets that are recommended for non-pregnant reproductive-age adults (<140/90 mmHg) compared ACOG- recommended…
- Trial name
- CHAP (NCT02299414)
- Testing
- Anti-hypertensive therapy, No anti-hypertensive therapy (unless BP is severe)
- Where
- 72 sites in United States
- Volunteers
- 2,408 people
- Sponsor
- University of Alabama at Birmingham
Cardiovascular Diseases, Heart Diseases
White Coat Hypertension and Antihypertensive Treatment Effect - SCOR in Hypertension
To investigate the mechanisms of white coat hypertension and study it further as a risk factor for heart damage.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005316
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension
Pharmacogenomic Evaluation of Antihypertensive Responses
There are many medications available for the treatment of high blood pressure (hypertension), but finding the right one for a specific patient can be challenging.
- Trial name
- NCT00246519
- Testing
- Hydrochlorothiazide, Atenolol
- Where
- 3 sites in United States
- Volunteers
- 1,701 people
- Sponsor
- University of Florida
Arterial Hypertension
Low-dose Combination of Three Antihypertensive Drugs
The aim of the study is to compare the efficacy and safety of low-dose combination of three antihypertensive drugs versus fixed high-dose combination of two antihypertensive drugs in arterial hypertension
- Trial name
- 3D (NCT02710552)
- Testing
- Tripliam (perindopril, indapamide, amlodipine), Reaptan (perindopril, amlodipine)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Coronary Artery Spasm, Hypertension
The Prevalence of Coronary Spasm in Hypertensive Patients Treated With Antihypertensive Medication
Autonomic nerve function is involved in both blood pressure (BP) regulation and the pathogenesis of coronary artery spasm(CAS), but few studies have been published about the relationship between CAS and effect of BP lowering…
- Trial name
- NCT01882790
- Where
- 3 sites in South Korea
- Volunteers
- 1,933 people
- Sponsor
- Korea University
Pulmonary Arterial Hypertension
Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)
COMPASS-2 is a Phase 4, prospective, randomized, double-blind, placebo-controlled, event-driven study evaluating the effect of bosentan on the time to first confirmed morbidity/mortality event in patients with symptomatic PAH…
- Trial name
- Compass-2 (NCT00303459)
- Testing
- bosentan
- Volunteers
- 334 people
- Sponsor
- Actelion
Hypertension
A Study of Losartan Compared to Losartan/HCTZ in Pediatric Patients With Hypertension (0954A-327)
The purpose of this study is to test the safety and effectiveness of Losartan as compared to Losartan/HCTZ in pediatric patients (6 to 17 years) with high blood pressure.
- Trial name
- NCT00447603
- Testing
- hydrochlorothiazide (+) losartan potassium, losartan potassium
- Volunteers
- 40 people
- Sponsor
- Organon and Co
Different Classes of the Antihypertensive Treatment
Egypt Hypertension Study
This study is an epidemiological non-interventional trial that aims to evaluate standard daily practice in managing patients with arterial hypertension.
- Trial name
- NCT02604771
- Where
- Egypt
- Volunteers
- 1,500 people
- Sponsor
- AstraZeneca
Renal Cancer
Mechanisms of Anti-VEGF Induced Hypertension
Background: High blood pressure is a common complication observed in cancer patients prescribed anti-VEGF drugs. Increased blood pressure increases the risk of heart attacks and strokes, thus adversely affecting survival and…
- Trial name
- NCT02156310
- Where
- Australia
- Volunteers
- 2,000 people
- Sponsor
- Arduino Mangoni
Hypertension
Antihypertensive and Cardioprotective Evaluation of a Functional Olive Oil
The general objective of this study is to evaluate the effect of a nutritional intervention with an extra virgin olive oil (EVOO) rich in bioactive compounds (polyphenols) and a functional oil of adequate organoleptic quality…
- Trial name
- NCT05460221
- Testing
- Optimized oil group, Functional oil group, Control group
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Granada
Hypertension, Dementia
BedMed-Frail: Does the Potential Benefit of Bedtime Antihypertensive Prescribing Extend to Frail Populations?
High blood pressure (present in 1 of 5 Canadian adults) increases the risk of heart attack and stroke. Blood pressure lowering pills reduce this risk - but perhaps not optimally.
- Trial name
- NCT04054648
- Testing
- Bedtime administration of the participant's pre-existing antihypertensive medications
- Where
- Canada
- Volunteers
- 776 people
- Sponsor
- University of Alberta
Essential Hypertension
Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension
Children are increasingly being diagnosed with essential hypertension and the absence of comparative effectiveness research in antihypertensive therapies has contributed to considerable differences in prescribing practices among…
- Trial name
- NCT02412761
- Testing
- Lisinopril, Amlodipine, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- The University of Texas Health Science Center, Houston