Bone Stress FractureNCT07902401
Bone Stress Injury Recovery and Return to Sport: A Natural History Study
An observational study of Bone Stress Fracture, run by HealthPartners Institute at 4 sites in 2 countries.
Trial summary
Lower extremity bone stress injury (BSI) is a common overuse injury in athletes and typically requires 4-12 weeks rehabilitation time, provided the injury does not require surgery. Read more about this study
- Who is it for?
- Ages 16 to 35 years
- Conditions the study is for
- Bone Stress Fracture
- How many people
- 105 participants
- Where
- 4 sitesin 2 countries
- Study dates
- 12 Aug 2025to 12 Aug 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 to 35 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: Participants enrolling at TRIA will be identified by sports medicine clinicians who are participating in this study, and others in the HealthPartners system and on our study team. Clinicians will provide a brief description of the study to potential participants and give them information about who to contact to get additional information about the study or gain permission to share patient contact information with project coordinators for enrollment screening. Patients may also be recruited through clinicians in the greater Minneapolis medical community, through fliers, through targeted social media ads, newsletter, or word of mouth. The investigators may also contact athletic trainers and coaches at colleges in the area to identify potentially eligible athletes.
Who may be able to join
- Diagnosed BSI of the tibia, metatarsal two, three, or four, femoral neck or femoral shaft by MRI, grade two or higher on the Fredericson grading scale7
- Age 16-35 years
- Body Mass Index 17.5-30 kg/m2
- Self-reported minimum of three hours per week of endurance exercise that includes running at least fifteen miles per week during three months prior to injury
- Study enrollment within three weeks of MRI
Who cannot join
- Self-reported history of endocrine disorder that impacts bone health (e.g., diabetes, hyperthyroidism, or primary hyperparathyroidism)
- Self-reported history of bone disease or other bone disorder (e.g., osteopetrosis, osteogenesis imperfecta, osteomalacia, rickets, Paget's disease, or multiple myeloma)
- Use of thyroid hormone replacement at suppressive doses for a history of thyroid cancer
- History of chemotherapy or radiation treatment for cancer in the past 5 years
- Currently taking or have taken oral glucocorticoids for greater than three months (e.g., prednisone or hydrocortisone)
- Current or prior use of osteoporosis medications (e.g., bisphosphonates, teriparatide)
Show all 13Show fewer
- Current use of anti-seizure medications (e.g. Phenytoin (Dilantin), Carbamazepine (Tegretol), Phenobarbitol)
- Currently pregnant
- Currently lactating
- Contraindications to MRI
- BSI is planned to be managed operatively
- Tibial BSI on the anterior aspect of the bone
- Participants that are non-English speaking
Trial locations and contacts
4 sites in 2 countries. Contact the study team or a site near you to ask about taking part.
4 sites in 2 countries
United States3 sites, 3 recruiting
- Recruiting
TRIA Orthopedic Center
Bloomington, Minnesota, 55431
Kristy Popp, PhD, 952-806-5603, kristin.l.popp@healtpartners.com
Elizabeth Whitcomb, 952-806-5603, triaresearch@tria.com
- Recruiting
University of Oregon
Eugene, Oregon, 97403
Mike Hahn, PhD, 541-870-0862, Mhahn@uoregon.edu
Zak Kindl, 541-346-2408, Zkindl@uoregon.edu
- Recruiting
Stanford University
Stanford, California, 94304
Emily Kraus, MD, 308-991-8055, Ekraus@stanford.edu
Gauri Desai, 513-546-9612, gdesai@stanford.edu
Canada1 site, 1 recruiting
- Recruiting
Canadian Institute of Sport Pacific
Victoria, British Columbia, V9E 2C5
Trent Stellingwerf, PhD, 250.208.6674, Tstellingwerff@csipacific.ca
Gayatri Raghavan, 778.288.2137, Graghavan@csipacific.ca
About this study
Lower extremity bone stress injury (BSI) is a common overuse injury in athletes and typically requires 4-12 weeks rehabilitation time, provided the injury does not require surgery. Current BSI treatment strategies include cessation of load-bearing sporting activities, consideration for crutches and/or immobilization, pain management, and a gradual return to activities until symptoms resolve. Premature return to sport can result in risk of complications and reinjury of the healing BSI. Moreover, our prior work reported that 1/3 of women with a tibial BSI will sustain at least one additional BSI within one year, indicating that current return to sport guidelines may be inadequate. However, there are no gold standard or validated clinical, functional or imaging outcomes that are consistently used to assess BSI healing and guide return to sport. In this prospective observational study, the investigators will enroll male and female athletes with a diagnosed BSI. The investigators will utilize diagnostic imaging, blood samples, and questionnaires to identify primary and secondary outcomes for assessing BSI healing in runners. Our long-term goal is to identify whether biomarkers, health and lifestyle factors, and training patterns associated with future BSI have the potential to inform and improve BSI treatment.
Read the detailed description
Bone stress injuries (BSIs) result from the accumulation of repetitive skeletal loading that exceeds the bone's capacity for repair. Although magnetic resonance imaging (MRI) is commonly used to diagnose and grade BSIs, there is no accepted standard for determining when an injury has healed sufficiently for an athlete to resume running or unrestricted sport. Previous studies have used measures such as pain-free hopping, pain-free running, completion of a return-to-run program, medical clearance, clinical examination findings, and changes on MRI. However, these measures have not been applied consistently, and their relative time courses and relationships with subsequent injury are not well understood.
This multisite, prospective observational cohort study follows athletes for one year after an MRI-confirmed lower-extremity BSI. The study does not assign an investigational treatment. Participants continue to receive clinical care for their injury and are provided with a standardized, progressive return-to-run framework developed with clinicians and physical therapists experienced in treating runners with BSIs. The primary purpose of the study is to characterize the time course and variability of candidate clinical, functional, and imaging indicators of BSI recovery. Using the date of the diagnostic MRI as a common reference point will allow recovery milestones to be evaluated consistently across participants and injury locations.
Participants complete an initial study visit shortly after diagnosis and return for follow-up assessments during the early recovery period. The timing of follow-up visits differs for femoral-neck injuries because these injuries generally require a longer period of recovery. Study assessments include serial symptom and functional surveys, standardized clinical severity assessments, and repeat MRI of the injured site. Participants report their progression through the return-to-run program in a training diary and complete brief electronic surveys during recovery. After completion of the return-to-run program, participants are contacted monthly through the one-year follow-up to identify any clinically diagnosed subsequent BSI.
Additional assessments are used to explore biological, behavioral, and mechanical factors that may be associated with recovery or subsequent injury. A fasting blood sample collected at baseline is used to measure clinical markers related to bone health and bone metabolism and to conduct exploratory serum protein analyses. Validated questionnaires assess eating attitudes, risk factors for low energy availability, sleep, symptoms of depression and anxiety, and body appreciation. After recovery, a single-leg hopping assessment is used to estimate lower-extremity movement characteristics and loading of the injured and uninjured limbs. Participants who already use a compatible Garmin smartwatch may optionally authorize collection of activity, running, heart-rate, and sleep data.
Analyses will first describe the distribution, timing, and variability of the candidate recovery indicators for the overall cohort and by injury location and sex. Exploratory analyses will evaluate whether recovery indicators, baseline biomarkers, questionnaire measures, training patterns, or movement characteristics are associated with a clinically diagnosed subsequent BSI during the one-year follow-up. Return-to-run adherence will also be described, and sensitivity analyses will examine whether results differ after accounting for adherence. Because the study is intended to characterize recovery and generate estimates for future research rather than test the efficacy of an intervention, enrollment is based on recruitment feasibility rather than a formal hypothesis-testing power calculation.
- Conditions
- Bone Stress Fracture
- Keywords
- Athlete, Runner, Bone Stress Injury, Return to Sport, Bone Healing
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| BSI | Male and female runners with a recent diagnosis of a bone stress injury. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Single leg hopping
Number of days from diagnostic MRI to pain free single leg hopping
Measured: Days from diagnostic MRI to achievement of pain free hopping (up to 12 months)
One mile jog
Number of days from MRI diagnosis to pain free one mile jogging
Measured: Number of days from MRI diagnosis to pain free one mile jogging (up to 12 months)
Thirty minutes jogging
Number of days from diagnostic MRI to pain free thirty minutes jogging
Measured: Number of days from diagnostic MRI to pain free thirty minutes jogging (up to 12 months)
Completion of return to run protocol
Number of days from diagnostic MRI to completion of return to run protocol
Measured: Number of days from diagnostic MRI to completion of return to run protocol (up to 12 months)
Medical clearance
Number of days from diagnostic MRI to medical clearance for unrestricted physical activity
Measured: Number of days from diagnostic MRI to medical clearance for unrestricted physical activity (up to 12 months)
MRI Grade_1
Change in MRI grade from diagnosis to time point 1
Measured: Change in MRI grade from diagnosis to time point 1 (up to 8 weeks)
MRI Grade_2
Change in MRI grade from diagnosis to time point 1
Measured: Change in MRI grade from diagnosis to time point 1 (up to 8 weeks)
Clinical Severity Score_1
Clinical severity score at time point 1
Measured: Clinical severity score at time point 1 (up to 8 weeks)
Clinical Severity Score_2
Clinical severity score at time point 2
Measured: Clinical severity score at time point 2 (up to 12 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Oct 2026
- Study start12 Aug 2025
- Primary completion12 Aug 2028 (estimated)
- Study completion12 Aug 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Bone Stress FractureStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 105 participants (estimated)
Sponsor and investigators
- Lead sponsor
- HealthPartners Institute
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07902401
- Sponsor's protocol ID
- A25-047
- Status last verified
- Oct 2026
- First submitted
- 9 Sep 2026
- Last updated
- 28 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: This trial is observational it doesn't meet ICMJE criteria for requiring an IPD-sharing plan.
Publications
Robertson GA, Wood AM. Return to sports after stress fractures of the tibial diaphysis: a systematic review. Br Med Bull. 2015 Jun;114(1):95-111. doi: 10.1093/bmb/ldv006. Epub 2015 Feb 21.
PubMed 25712999Popp KL, Ackerman KE, Rudolph SE, Johannesdottir F, Hughes JM, Tenforde AS, Bredella MA, Xu C, Unnikrishnan G, Reifman J, Bouxsein ML. Changes in Volumetric Bone Mineral Density Over 12 Months After a Tibial Bone Stress Injury Diagnosis: Implications for Return to Sports and Military Duty. Am J Sports Med. 2021 Jan;49(1):226-235. doi: 10.1177/0363546520971782. Epub 2020 Dec 1.
PubMed 33259223Nattiv A, Kennedy G, Barrack MT, Abdelkerim A, Goolsby MA, Arends JC, Seeger LL. Correlation of MRI grading of bone stress injuries with clinical risk factors and return to play: a 5-year prospective study in collegiate track and field athletes. Am J Sports Med. 2013 Aug;41(8):1930-41. doi: 10.1177/0363546513490645. Epub 2013 Jul 3.
PubMed 23825184Fredericson M, Bergman AG, Hoffman KL, Dillingham MS. Tibial stress reaction in runners. Correlation of clinical symptoms and scintigraphy with a new magnetic resonance imaging grading system. Am J Sports Med. 1995 Jul-Aug;23(4):472-81. doi: 10.1177/036354659502300418.
PubMed 7573660Rizzone KH, Ackerman KE, Roos KG, Dompier TP, Kerr ZY. The Epidemiology of Stress Fractures in Collegiate Student-Athletes, 2004-2005 Through 2013-2014 Academic Years. J Athl Train. 2017 Oct;52(10):966-975. doi: 10.4085/1062-6050-52.8.01. Epub 2017 Sep 22.
PubMed 28937802Hoenig T, Ackerman KE, Beck BR, Bouxsein ML, Burr DB, Hollander K, Popp KL, Rolvien T, Tenforde AS, Warden SJ. Bone stress injuries. Nat Rev Dis Primers. 2022 Apr 28;8(1):26. doi: 10.1038/s41572-022-00352-y.
PubMed 35484131
Study at a glance
From the registry record, last updated by the sponsor on 28 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Bone Stress Injury Recovery and Return to Sport: A Natural History Study
- ClinicalTrials.gov ID
- NCT07902401
- Acronym / sponsor ID
- A25-047
- Conditions
- Bone Stress Fracture
- Keywords
- Athlete, Runner, Bone Stress Injury, Return to Sport, Bone Healing
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 105 participants (estimated)
- Lead sponsor
- HealthPartners InstituteUniversity, hospital or other
- Study start
- 12 Aug 2025 (actual)
- Primary completion
- 12 Aug 2028 (estimated)
- Study completion
- 12 Aug 2028 (estimated)
- First posted
- 28 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Lower extremity bone stress injury (BSI) is a common overuse injury in athletes and typically requires 4-12 weeks rehabilitation time, provided the injury does not require surgery. Current BSI treatment strategies include cessation of load-bearing sporting activities, consideration for crutches and/or immobilization, pain management, and a gradual return to activities until symptoms resolve. Premature return to sport can result in risk of complications and reinjury of the healing BSI. Moreover, our prior work reported that 1/3 of women with a tibial BSI will sustain at least one additional BSI within one year, indicating that current return to sport guidelines may be inadequate. However, there are no gold standard or validated clinical, functional or imaging outcomes that are consistently used to assess BSI healing and guide return to sport. In this prospective observational study, the investigators will enroll male and female athletes with a diagnosed BSI. The investigators will utilize diagnostic imaging, blood samples, and questionnaires to identify primary and secondary outcomes for assessing BSI healing in runners. Our long-term goal is to identify whether biomarkers, health and lifestyle factors, and training patterns associated with future BSI have the potential to inform and improve BSI treatment.
Detailed description
Bone stress injuries (BSIs) result from the accumulation of repetitive skeletal loading that exceeds the bone's capacity for repair. Although magnetic resonance imaging (MRI) is commonly used to diagnose and grade BSIs, there is no accepted standard for determining when an injury has healed sufficiently for an athlete to resume running or unrestricted sport. Previous studies have used measures such as pain-free hopping, pain-free running, completion of a return-to-run program, medical clearance, clinical examination findings, and changes on MRI. However, these measures have not been applied consistently, and their relative time courses and relationships with subsequent injury are not well understood.
This multisite, prospective observational cohort study follows athletes for one year after an MRI-confirmed lower-extremity BSI. The study does not assign an investigational treatment. Participants continue to receive clinical care for their injury and are provided with a standardized, progressive return-to-run framework developed with clinicians and physical therapists experienced in treating runners with BSIs. The primary purpose of the study is to characterize the time course and variability of candidate clinical, functional, and imaging indicators of BSI recovery. Using the date of the diagnostic MRI as a common reference point will allow recovery milestones to be evaluated consistently across participants and injury locations.
Participants complete an initial study visit shortly after diagnosis and return for follow-up assessments during the early recovery period. The timing of follow-up visits differs for femoral-neck injuries because these injuries generally require a longer period of recovery. Study assessments include serial symptom and functional surveys, standardized clinical severity assessments, and repeat MRI of the injured site. Participants report their progression through the return-to-run program in a training diary and complete brief electronic surveys during recovery. After completion of the return-to-run program, participants are contacted monthly through the one-year follow-up to identify any clinically diagnosed subsequent BSI.
Additional assessments are used to explore biological, behavioral, and mechanical factors that may be associated with recovery or subsequent injury. A fasting blood sample collected at baseline is used to measure clinical markers related to bone health and bone metabolism and to conduct exploratory serum protein analyses. Validated questionnaires assess eating attitudes, risk factors for low energy availability, sleep, symptoms of depression and anxiety, and body appreciation. After recovery, a single-leg hopping assessment is used to estimate lower-extremity movement characteristics and loading of the injured and uninjured limbs. Participants who already use a compatible Garmin smartwatch may optionally authorize collection of activity, running, heart-rate, and sleep data.
Analyses will first describe the distribution, timing, and variability of the candidate recovery indicators for the overall cohort and by injury location and sex. Exploratory analyses will evaluate whether recovery indicators, baseline biomarkers, questionnaire measures, training patterns, or movement characteristics are associated with a clinically diagnosed subsequent BSI during the one-year follow-up. Return-to-run adherence will also be described, and sensitivity analyses will examine whether results differ after accounting for adherence. Because the study is intended to characterize recovery and generate estimates for future research rather than test the efficacy of an intervention, enrollment is based on recruitment feasibility rather than a formal hypothesis-testing power calculation.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| BSI | – | –Male and female runners with a recent diagnosis of a bone stress injury. |
Who may qualify
- Ages
- 16 to 35 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
- Study population
- Participants enrolling at TRIA will be identified by sports medicine clinicians who are participating in this study, and others in the HealthPartners system and on our study team. Clinicians will provide a brief description of the study to potential participants and give them information about who to contact to get additional information about the study or gain permission to share patient contact information with project coordinators for enrollment screening. Patients may also be recruited through clinicians in the greater Minneapolis medical community, through fliers, through targeted social media ads, newsletter, or word of mouth. The investigators may also contact athletic trainers and coaches at colleges in the area to identify potentially eligible athletes.
Key inclusion criteria (5 listed)
- Diagnosed BSI of the tibia, metatarsal two, three, or four, femoral neck or femoral shaft by MRI, grade two or higher on the Fredericson grading scale7
- Age 16-35 years
- Body Mass Index 17.5-30 kg/m2
- Self-reported minimum of three hours per week of endurance exercise that includes running at least fifteen miles per week during three months prior to injury
- Study enrollment within three weeks of MRI
Key exclusion criteria (13 listed)
- Self-reported history of endocrine disorder that impacts bone health (e.g., diabetes, hyperthyroidism, or primary hyperparathyroidism)
- Self-reported history of bone disease or other bone disorder (e.g., osteopetrosis, osteogenesis imperfecta, osteomalacia, rickets, Paget's disease, or multiple myeloma)
- Use of thyroid hormone replacement at suppressive doses for a history of thyroid cancer
- History of chemotherapy or radiation treatment for cancer in the past 5 years
- Currently taking or have taken oral glucocorticoids for greater than three months (e.g., prednisone or hydrocortisone)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Single leg hopping
Time frame: Days from diagnostic MRI to achievement of pain free hopping (up to 12 months)
Number of days from diagnostic MRI to pain free single leg hopping
One mile jog
Time frame: Number of days from MRI diagnosis to pain free one mile jogging (up to 12 months)
Number of days from MRI diagnosis to pain free one mile jogging
Thirty minutes jogging
Time frame: Number of days from diagnostic MRI to pain free thirty minutes jogging (up to 12 months)
Number of days from diagnostic MRI to pain free thirty minutes jogging
Completion of return to run protocol
Time frame: Number of days from diagnostic MRI to completion of return to run protocol (up to 12 months)
Number of days from diagnostic MRI to completion of return to run protocol
Medical clearance
Time frame: Number of days from diagnostic MRI to medical clearance for unrestricted physical activity (up to 12 months)
Number of days from diagnostic MRI to medical clearance for unrestricted physical activity
MRI Grade_1
Time frame: Change in MRI grade from diagnosis to time point 1 (up to 8 weeks)
Change in MRI grade from diagnosis to time point 1
MRI Grade_2
Time frame: Change in MRI grade from diagnosis to time point 1 (up to 8 weeks)
Change in MRI grade from diagnosis to time point 1
Clinical Severity Score_1
Time frame: Clinical severity score at time point 1 (up to 8 weeks)
Clinical severity score at time point 1
Clinical Severity Score_2
Time frame: Clinical severity score at time point 2 (up to 12 weeks)
Clinical severity score at time point 2
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Oct 2026.
- Background: PubMed 25712999Robertson GA, Wood AM. Return to sports after stress fractures of the tibial diaphysis: a systematic review. Br Med Bull. 2015 Jun;114(1):95-111. doi: 10.1093/bmb/ldv006. Epub 2015 Feb 21.
- Background: PubMed 33259223Popp KL, Ackerman KE, Rudolph SE, Johannesdottir F, Hughes JM, Tenforde AS, Bredella MA, Xu C, Unnikrishnan G, Reifman J, Bouxsein ML. Changes in Volumetric Bone Mineral Density Over 12 Months After a Tibial Bone Stress Injury Diagnosis: Implications for Return to Sports and Military Duty. Am J Sports Med. 2021 Jan;49(1):226-235. doi: 10.1177/0363546520971782. Epub 2020 Dec 1.
- Background: PubMed 23825184Nattiv A, Kennedy G, Barrack MT, Abdelkerim A, Goolsby MA, Arends JC, Seeger LL. Correlation of MRI grading of bone stress injuries with clinical risk factors and return to play: a 5-year prospective study in collegiate track and field athletes. Am J Sports Med. 2013 Aug;41(8):1930-41. doi: 10.1177/0363546513490645. Epub 2013 Jul 3.
- Background: PubMed 7573660Fredericson M, Bergman AG, Hoffman KL, Dillingham MS. Tibial stress reaction in runners. Correlation of clinical symptoms and scintigraphy with a new magnetic resonance imaging grading system. Am J Sports Med. 1995 Jul-Aug;23(4):472-81. doi: 10.1177/036354659502300418.
- Background: PubMed 28937802Rizzone KH, Ackerman KE, Roos KG, Dompier TP, Kerr ZY. The Epidemiology of Stress Fractures in Collegiate Student-Athletes, 2004-2005 Through 2013-2014 Academic Years. J Athl Train. 2017 Oct;52(10):966-975. doi: 10.4085/1062-6050-52.8.01. Epub 2017 Sep 22.
- Background: PubMed 35484131Hoenig T, Ackerman KE, Beck BR, Bouxsein ML, Burr DB, Hollander K, Popp KL, Rolvien T, Tenforde AS, Warden SJ. Bone stress injuries. Nat Rev Dis Primers. 2022 Apr 28;8(1):26. doi: 10.1038/s41572-022-00352-y.
- Individual participant dataSharing planned: No. This trial is observational it doesn't meet ICMJE criteria for requiring an IPD-sharing plan.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
4 sites in 2 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Bone Stress Fracture, run by HealthPartners Institute at 4 sites in 2 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 28 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 4 sites in United States, Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Kristy Popp, PhD (952-806-5603, Kristy.L.Popp@HealthPartners.Com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Single leg hopping (time frame: Days from diagnostic MRI to achievement of pain free hopping (up to 12 months)). The study lists 9 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07902401, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Oct 2026.