FatigueNCT07892911
A Study to Evaluate the Effects of a Beef Liver Supplement on Energy, Mood, and Mental Clarity
A study testing Intervention in people with Fatigue and Low Mood, run by Ancestral Supplements, LLC at 1 site in United States.
Trial summary
This is a randomized, triple-blind, placebo-controlled clinical trial evaluating the effects of the Ancestral Supplements Grass Fed Beef Liver oral supplement on energy, mood, and mental clarity over 12 weeks. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Fatigue, Low Mood, Mental Clarity
- What is being tested?
- Intervention
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 100 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Sep 2026to 1 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Be male or female
- Be aged 18-50
- Anyone experiencing issues regarding all of the following over the past four weeks: energy levels, mood, and mental clarity
- Anyone who is generally healthy - does not live with any uncontrolled chronic disease
- Anyone who is willing to maintain their current diet, sleep schedule, and activity level for the duration of the study
- Resides in the United States
Who cannot join
- Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
- Currently taking iron supplements or being treated for anemia
- Anyone currently taking oral contraceptives that contain iron
- Anyone currently taking vitamin A supplements, or supplements that contain vitamin A
- Anyone with any allergies or sensitivities to any of the study product ingredients
- Any women who are pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period)
Show all 13Show fewer
- Anyone with hemochromatosis
- Anyone unwilling to follow the study protocol
- Has stopped using hormonal birth control in the past month
- Anyone who is vegan and/or does not consume animal products for any reason
- Anyone who is considered to be a heavy drinker (i.e. 8 or more alcoholic drinks per week for women or 15 or more alcoholic drinks per week for men)
- Planning on introducing any products or any new forms of prescription medication or supplements that target energy levels, mood, or mental clarity, during the study duration
- Currently partaking in another research study or will be partaking in any other research study at any point during this study's duration
Trial locations and contacts
1 site in 1 country.
About this study
This is a randomized, triple-blind, placebo-controlled clinical trial evaluating the effects of the Ancestral Supplements Grass Fed Beef Liver oral supplement on energy, mood, and mental clarity over 12 weeks. One hundred male and female participants aged 18-50 who report concerns regarding energy levels, mood, and mental clarity will be enrolled and randomized equally into an intervention arm (beef liver supplement) or a placebo arm.
Participants will take their assigned product once daily and complete self-reported questionnaires at Baseline, Week 4, Week 8, and Week 12. Blood testing (iron panel) will be conducted at Baseline and Week 12 at a local Quest Diagnostics Clinic. The primary objective is to evaluate the product's effects on energy and mood; the secondary objective is to assess participants' perceptions of the product's effects on energy, mood, and mental clarity, including happiness, anxiety, well-being, brain fog, and concentration.
- Conditions
- Fatigue, Low Mood, Mental Clarity, Iron Deficiency, Brain Fog
- Being tested
- Intervention, Placebo
- Medical subject headings
- Fatigue, Consciousness Disorders, Iron Deficiencies, Mental Fatigue
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
InterventionDietary supplement
Participants receive the Ancestral Supplements Grass Fed Beef Liver supplement (Grass Fed Liver [Bovine], 3000 mg per serving of 6 capsules) taken once daily, with a graduated dose escalation from 1 capsule/day over the first 18 days up to the full serving of 6 capsules/day, for 12 weeks.
PlaceboDietary supplement
Participants receive a matched placebo product (microcrystalline cellulose and natural food color) taken once daily using the same dosing regimen as the intervention arm, for 12 weeks. The taste and appearance of the placebo are matched to the test product.
| Study group | Role | What they receive |
|---|---|---|
| Intervention (Beef Liver Supplement) | Experimental | Not described Receives: Dietary Supplement: Intervention |
| Placebo Comparator | Placebo comparator | Not described Receives: Dietary Supplement: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Iron Status
Change in blood iron levels assessed via iron panel blood test (Quest Diagnostics, iron test code 001339)
Measured: Baseline and Week 12
Change in Energy Levels
Change in self-reported energy levels assessed via self-reported questionnaire
Measured: Baseline, Week 4, Week 8, and Week 12
Change in Mood
Change in self-reported mood assessed via self-reported questionnaire
Measured: Baseline, Week 4, Week 8, and Week 12
Secondary outcomes (6)
Change in Self-Reported Vitality
Change in perceived vitality related to energy, mood, focus, and mental clarity assessed via self-reported questionnaire
Measured: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Happiness
Change in perceived happiness assessed via self-reported questionnaire
Measured: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Anxiety
Change in perceived anxiety assessed via self-reported questionnaire
Measured: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Well-being
Change in perceived well-being assessed via self-reported questionnaire
Measured: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Brain Fog
Change in perceived brain fog assessed via self-reported questionnaire
Measured: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Concentration
Change in perceived concentration assessed via self-reported questionnaire
Measured: Baseline, Week 4, Week 8, and Week 12
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Oct 2026
- Study start1 Sep 2026
- Primary completion1 Dec 2026 (estimated)
- Study completion1 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for FatigueStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ancestral Supplements, LLC
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07892911
- Sponsor's protocol ID
- #20806
- Other IDs
- legacy-_20806
- Status last verified
- Oct 2026
- First submitted
- 19 Oct 2026
- Last updated
- 23 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Study to Evaluate the Effects of a Beef Liver Supplement on Energy, Mood, and Mental Clarity
- ClinicalTrials.gov ID
- NCT07892911
- Acronym / sponsor ID
- #20806
- Conditions
- Fatigue, Low Mood, Mental Clarity, Iron Deficiency, Brain Fog
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 100 participants (actual)
- Lead sponsor
- Ancestral Supplements, LLCIndustry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Study start
- 1 Sep 2026 (actual)
- Primary completion
- 1 Dec 2026 (estimated)
- Study completion
- 1 Dec 2026 (estimated)
- First posted
- 23 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a randomized, triple-blind, placebo-controlled clinical trial evaluating the effects of the Ancestral Supplements Grass Fed Beef Liver oral supplement on energy, mood, and mental clarity over 12 weeks. One hundred male and female participants aged 18-50 who report concerns regarding energy levels, mood, and mental clarity will be enrolled and randomized equally into an intervention arm (beef liver supplement) or a placebo arm.
Participants will take their assigned product once daily and complete self-reported questionnaires at Baseline, Week 4, Week 8, and Week 12. Blood testing (iron panel) will be conducted at Baseline and Week 12 at a local Quest Diagnostics Clinic. The primary objective is to evaluate the product's effects on energy and mood; the secondary objective is to assess participants' perceptions of the product's effects on energy, mood, and mental clarity, including happiness, anxiety, well-being, brain fog, and concentration.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Intervention (Beef Liver Supplement) | Experimental | Dietary Supplement: Intervention |
| Placebo Comparator | Placebo comparator | Dietary Supplement: Placebo |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Be male or female
- Be aged 18-50
- Anyone experiencing issues regarding all of the following over the past four weeks: energy levels, mood, and mental clarity
- Anyone who is generally healthy - does not live with any uncontrolled chronic disease
- Anyone who is willing to maintain their current diet, sleep schedule, and activity level for the duration of the study
Key exclusion criteria (13 listed)
- Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
- Currently taking iron supplements or being treated for anemia
- Anyone currently taking oral contraceptives that contain iron
- Anyone currently taking vitamin A supplements, or supplements that contain vitamin A
- Anyone with any allergies or sensitivities to any of the study product ingredients
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| InterventionParticipants receive the Ancestral Supplements Grass Fed Beef Liver supplement (Grass Fed Liver [Bovine], 3000 mg per serving of 6 capsules) taken once daily, with a graduated dose escalation from 1 capsule/day over the first 18 days up to the full serving of 6 capsules/day, for 12 weeks. | Dietary supplement | Intervention (Beef Liver Supplement) |
| PlaceboParticipants receive a matched placebo product (microcrystalline cellulose and natural food color) taken once daily using the same dosing regimen as the intervention arm, for 12 weeks. The taste and appearance of the placebo are matched to the test product. | Dietary supplement | Placebo Comparator |
Primary outcome
Change in Iron Status
Time frame: Baseline and Week 12
Change in blood iron levels assessed via iron panel blood test (Quest Diagnostics, iron test code 001339)
Change in Energy Levels
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in self-reported energy levels assessed via self-reported questionnaire
Change in Mood
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in self-reported mood assessed via self-reported questionnaire
6 secondary outcomes
Change in Self-Reported Vitality
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Happiness
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Anxiety
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Well-being
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Brain Fog
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Concentration
Time frame: Baseline, Week 4, Week 8, and Week 12
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Intervention in people with Fatigue and Low Mood, run by Ancestral Supplements, LLC at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 23 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Iron Status (time frame: Baseline and Week 12). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Oct 2026.