Chronic Lateral Ankle InstabilityCAPSNCT07886463
Functional Biomechanical Analysis in Patients Who Underwent Lateral Ankle Ligament Repair With Augmentation
A study testing Biomechanical motion analysis in people with Chronic Lateral Ankle Instability, run by Clinique du Sport, Bordeaux Mérignac at 1 site in France.
Trial summary
Chronic lateral ankle instability is a common condition in athletic populations and may lead to persistent biomechanical alterations despite appropriate management. This condition typically develops following one or more ankle sprains and is characterized by a sensation of instability, episodes of the ankle giving… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Chronic Lateral Ankle Instability
- What is being tested?
- Biomechanical motion analysis
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 39 participants
- Where
- 1 siteFrance
- Study dates
- 20 Oct 2026to 30 Jun 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Standard indications for lateral ankle ligament repair surgery for chronic lateral ankle instability refractory to conservative treatment.
- Participation in physical activity and/or sports at least once weekly before the onset of symptoms leading to the surgical indication.
Who cannot join
- Concomitant surgical procedures likely to alter postoperative recovery.
- History of major lower-limb fractures.
- Associated injuries involving the lower limbs or lumbar spine.
- Any other surgery performed within 6 months prior to the index procedure.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
Clinique du Sport
Mérignac, 33700
Marion Mandon, PhD, +33 6 78 27 76 72, mmandon@vivalto-sante.com
Guillaume Cordier, MD
About this study
Chronic lateral ankle instability is a common condition in athletic populations and may lead to persistent biomechanical alterations despite appropriate management. This condition typically develops following one or more ankle sprains and is characterized by a sensation of instability, episodes of the ankle giving way, pain, or discomfort during physical or sporting activities. When conventional treatments such as rehabilitation, physiotherapy, and activity modification do not provide sufficient improvement, surgical ligament repair may be recommended.
Although this surgery generally restores ankle stability, there is currently limited evidence regarding how lower-limb function evolves following the procedure. In particular, there is no established objective reference measure to assess functional recovery and support healthcare professionals in making decisions regarding rehabilitation or return to sport.
The prospective interventional comparative analysis proposed in this study aims to evaluate surgery-induced changes in ankle and lower-limb movement and function that can be objectively quantified through biomechanical motion analysis.
- Conditions
- Chronic Lateral Ankle Instability
- Being tested
- Biomechanical motion analysis
- Keywords
- Arthroscopic ligament repair, Biomechanics, Kinematics, Movement analysis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Biomechanical motion analysisOther
Also called three-dimensional biomedical motion analysis, Functional biomechanical analysis
The studied parameters will be categorized as follows:
Kinematics
- Ankle dorsiflexion/plantarflexion, inversion/eversion, and foot internal/external rotation angles
- Knee flexion and valgus/varus angles
- Hip flexion, adduction/abduction, and internal/external rotation angles
- Trunk flexion/extension
- Pelvic frontal plane tilt Kinetics and Inverse Dynamics
- Ankle, knee, and hip extensor joint moments
- Knee adduction moment
- Positive and negative joint power at the knee and ankle
- Vertical ground reaction force (vGRF)
- Anterior-posterior braking and propulsion forces Spatiotemporal Parameters
- Ground contact time
- Stance and flight phase durations
- Jump height (countermovement jump [CMJ] and drop jump) The three-dimensional biomechanical analysis will be performed using a 12-camera Qualisys MIQUS M3 motion capture system synchronized with two floor-embedded AMTI force platforms to quantify lower-limb kinematics, kinetics, and spatiotemporal parameters
| Study group | Role | What they receive |
|---|---|---|
| Motion analysis participants | Experimental | Participants with chronic lateral ankle instability who regularly engage in physical activity and/or sports and are scheduled to undergo lateral ankle ligament repair. Biomechanical motion analysis will be performed preoperatively and at 3 and 6 months postoperatively. Receives: Other: Biomechanical motion analysis |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in biomechanical parameters derived from three-dimensional motion analysis
Change in Kinematic parameters derived from three-dimensional motion analysis between the preoperative assessment (T0), the 3-month postoperative assessment (T1), and the 6-month postoperative assessment (T2). Kinematic variables include ankle, knee, hip, trunk, and pelvic joint angles (°). Data will be collected using a 12-camera Qualisys MIQUS M3 optoelectronic motion capture system (Qualisys AB, Gothenburg, Sweden).
Measured: From enrollement to 6 months after surgery
Secondary outcomes (9)
Changes in Kinetic Moments Measurements
Kinetic and inverse dynamics measures at T0, T1, and T2 include :
- Ankle, knee, and hip extensor joint moments (N·m/kg)
- Knee adduction moment (N·m/kg)
Measured: From enrollement to 6 months after surgery
Changes in Spatiotemporal Parameters
Spatiotemporal parameters measured at T0, T1, and T2 include:
- Ground contact time (s)
- Stance phase duration (s)
- Flight phase duration (s)
Measured: From enrollement to 6 months after surgery
Limb Symmetry Index (LSI) for selected biomechanical parameters
Inter-limb symmetry will be expressed as a Limb Symmetry Index (LSI), calculated as:
LSI = (Operated limb value / Contralateral limb value) × 100 Values will be expressed as percentages (%). Separate analyses will be performed for each predefined biomechanical parameter.
Measured: From enrollement to 6 months after surgery
Change in Limb Symmetry Index over time
Evolution of the Limb Symmetry Index (LSI) between baseline (T0), 3 months (T1), and 6 months (T2) following surgery.
Measured: From inclusion to 6 months post-surgery
Countermovement Jump (CMJ) Height
Vertical jump height measured during the Countermovement Jump (CMJ), expressed in centimeters.
Measured: From Inclusion to 6 months post-surgery
Drop Jump Height
Vertical jump height measured during the Drop Jump task, expressed in centimeters.
Measured: From enrollement to 6 months after surgery
Changes in Kinetic Joint Power Measurements
Kinetic and inverse dynamics measures at T0, T1, and T2 include :
Positive and negative joint power at the knee and ankle (W/kg)
Measured: From enrollement to 6 months after surgery
Changes in Kinetic Vertical ground reaction force Measurements
Kinetic and inverse dynamics measures at T0, T1, and T2 include :
Vertical ground reaction force (vGRF) (N)
Measured: From enrollement to 6 months after surgery
Changes in Kinetic Reaction Forces Measurements
Kinetic and inverse dynamics measures at T0, T1, and T2 include :
Anterior-posterior braking and propulsive ground reaction forces (N/kg)
Measured: From enrollement to 6 months after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Oct 2026
- Study start20 Oct 2026 (estimated)
- Primary completion30 Jun 2028 (estimated)
- Study completion30 Jun 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Lateral Ankle InstabilityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 39 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Clinique du Sport, Bordeaux Mérignac
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Guillaume Cordier, MD, Principal investigator, Clinique du sport
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07886463
- Sponsor's protocol ID
- 2026-52-SBM
- Other IDs
- 2026-A01650-51
- Acronym
- CAPS
- Status last verified
- Oct 2026
- First submitted
- 25 Sep 2026
- Last updated
- 21 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Functional Biomechanical Analysis in Patients Who Underwent Lateral Ankle Ligament Repair With Augmentation
- ClinicalTrials.gov ID
- NCT07886463
- Acronym / sponsor ID
- CAPS / 2026-52-SBM
- Conditions
- Chronic Lateral Ankle Instability
- Keywords
- Arthroscopic ligament repair, Biomechanics, Kinematics, Movement analysis
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 39 participants (estimated)
- Lead sponsor
- Clinique du Sport, Bordeaux MérignacUniversity, hospital or other
- Study start
- 20 Oct 2026 (estimated)
- Primary completion
- 30 Jun 2028 (estimated)
- Study completion
- 30 Jun 2028 (estimated)
- First posted
- 21 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Chronic lateral ankle instability is a common condition in athletic populations and may lead to persistent biomechanical alterations despite appropriate management. This condition typically develops following one or more ankle sprains and is characterized by a sensation of instability, episodes of the ankle giving way, pain, or discomfort during physical or sporting activities. When conventional treatments such as rehabilitation, physiotherapy, and activity modification do not provide sufficient improvement, surgical ligament repair may be recommended.
Although this surgery generally restores ankle stability, there is currently limited evidence regarding how lower-limb function evolves following the procedure. In particular, there is no established objective reference measure to assess functional recovery and support healthcare professionals in making decisions regarding rehabilitation or return to sport.
The prospective interventional comparative analysis proposed in this study aims to evaluate surgery-induced changes in ankle and lower-limb movement and function that can be objectively quantified through biomechanical motion analysis.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Motion analysis participants | Experimental | Other: Biomechanical motion analysisParticipants with chronic lateral ankle instability who regularly engage in physical activity and/or sports and are scheduled to undergo lateral ankle ligament repair. Biomechanical motion analysis will be performed preoperatively and at 3 and 6 months postoperatively. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Standard indications for lateral ankle ligament repair surgery for chronic lateral ankle instability refractory to conservative treatment.
- Participation in physical activity and/or sports at least once weekly before the onset of symptoms leading to the surgical indication.
Key exclusion criteria (4 listed)
- Concomitant surgical procedures likely to alter postoperative recovery.
- History of major lower-limb fractures.
- Associated injuries involving the lower limbs or lumbar spine.
- Any other surgery performed within 6 months prior to the index procedure.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Biomechanical motion analysisAlso: three-dimensional biomedical motion analysis, Functional biomechanical analysisThe studied parameters will be categorized as follows: Kinematics * Ankle dorsiflexion/plantarflexion, inversion/eversion, and foot internal/external rotation angles * Knee flexion and valgus/varus angles * Hip flexion, adduction/abduction, and internal/external rotation angles * Trunk flexion/extension * Pelvic frontal plane tilt Kinetics and Inverse Dynamics * Ankle, knee, and hip extensor joint moments * Knee adduction moment * Positive and negative joint power at the knee and ankle * Vertical ground reaction force (vGRF) * Anterior-posterior braking and propulsion forces Spatiotemporal Parameters * Ground contact time * Stance and flight phase durations * Jump height (countermovement jump [CMJ] and drop jump) The three-dimensional biomechanical analysis will be performed using a 12-camera Qualisys MIQUS M3 motion capture system synchronized with two floor-embedded AMTI force platforms to quantify lower-limb kinematics, kinetics, and spatiotemporal parameters | Other | Motion analysis participants |
Primary outcome
Change in biomechanical parameters derived from three-dimensional motion analysis
Time frame: From enrollement to 6 months after surgery
Change in Kinematic parameters derived from three-dimensional motion analysis between the preoperative assessment (T0), the 3-month postoperative assessment (T1), and the 6-month postoperative assessment (T2). Kinematic variables include ankle, knee, hip, trunk, and pelvic joint angles (°). Data will be collected using a 12-camera Qualisys MIQUS M3 optoelectronic motion capture system (Qualisys AB, Gothenburg, Sweden).
9 secondary outcomes
Changes in Kinetic Moments Measurements
Time frame: From enrollement to 6 months after surgery
Changes in Spatiotemporal Parameters
Time frame: From enrollement to 6 months after surgery
Limb Symmetry Index (LSI) for selected biomechanical parameters
Time frame: From enrollement to 6 months after surgery
Change in Limb Symmetry Index over time
Time frame: From inclusion to 6 months post-surgery
Countermovement Jump (CMJ) Height
Time frame: From Inclusion to 6 months post-surgery
Drop Jump Height
Time frame: From enrollement to 6 months after surgery
Changes in Kinetic Joint Power Measurements
Time frame: From enrollement to 6 months after surgery
Changes in Kinetic Vertical ground reaction force Measurements
Time frame: From enrollement to 6 months after surgery
Changes in Kinetic Reaction Forces Measurements
Time frame: From enrollement to 6 months after surgery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Oct 2026.
- Individual participant dataSharing planned: No
Related trials for Chronic Lateral Ankle Instability
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Brostrom Chronic Lateral Ankle Instability Repairs Augmented With BioBrace®
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Long-term Evaluation of Sports Activity in Patients Whose Ankle Was Treated by Anatomical Reconstruction or Arthroscopic Repair Following Chronic Lateral Instability
Ankle Instability
RecruitingObservational study
Comparison of MBR + Suture Tape and MBR for CLAI : A Prospective Cohort Study
Ankle Sprain, Hypermobility, Joint
Not yet recruiting
Fu's Subcutaneous Needling for Postacute Lateral Ankle Sprain and Prevention of Chronic Ankle Instability
Chronic Ankle Instability, Lateral Ankle Sprain
Not yet recruiting
Neurocognitive Exercises for Ankle Instability
Ankle Sprains
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Guillaume Cordier, MD principal investigator
Clinique du sport
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Biomechanical motion analysis in people with Chronic Lateral Ankle Instability, run by Clinique du Sport, Bordeaux Mérignac at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Marion Mandon, PhD (+33 6 78 27 76 72, DRC@vivalto-sante.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in biomechanical parameters derived from three-dimensional motion analysis (time frame: From enrollement to 6 months after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Oct 2026.