EndometriosisTRACK-ENDONCT07882498
Postoperative Pain Trajectories After Endometriosis Surgery
An observational study of Endometriosis and Postoperative Pain, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
Trial summary
The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors. Although surgery is an integral part of treatment, a significant proportion of patients experience persistent pain several months after the procedure. Read more about this study
- Who is it for?
- Ages 18 years and older, women only
- Conditions the study is for
- Endometriosis, Postoperative Pain, Pain Trajectories
- What is being tested?
- Perioperative quantitative sensory testing and questionnaire
- How many people
- 150 participants
- Where
- 1 siteFrance
- Study dates
- 7 Jul 2026to Jan 2029
- How long will I take part?
- 6 Months
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Women only
- No healthy volunteers
- Adult, Older adult
Study population: Patients operated for endometriosis in CHRU Amiens
Who may be able to join
- Age ≥ 18 years
- Imaging-confirmed endometriosis
- Scheduled surgical treatment for endometriosis
- Affiliation to the French Social Security system
- Written informed consent obtained
Who cannot join
- Patients under legal protection (guardians or curators)
- History of psychiatric disorders
- Neurodegenerative diseases
- Inability to self-assess pain using a numerical rating scale
- Non-French-speaking patients
- Pregnancy or breastfeeding
- Refusal to participate
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
CHU Amiens-Picardie
Amiens, 80054
Paul TARPIN, MD, 0322087980, Tarpin.Paul@chu-amiens.fr
About this study
Official title: Pain Trajectories After Surgery for Endometriosis: A 6-Month Prospective Monocentric Study
The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors. Although surgery is an integral part of treatment, a significant proportion of patients experience persistent pain several months after the procedure. To date, postoperative pain trajectories after endometriosis surgery remain poorly characterised, and there are no reliable predictors of chronic postoperative pain (CPP). This prospective, single-centre, longitudinal study aims to identify distinct postoperative pain trajectories and to assess whether perioperative quantitative sensory testing can predict the development of chronic postoperative pain at 3 and 6 months. Patients will undergo perioperative mechanical and pressure tests, including assessment of temporal summation and pressure pain thresholds, combined with validated measures of patient- reported outcomes. Follow-up assessments will be conducted on day 2, day 14, 1 month, 3 months, and 6 months after surgery to capture the dynamic evolution of pain, quality of life, fatigue, sexual function, and central sensitisation symptoms.
- Conditions
- Endometriosis, Postoperative Pain, Pain Trajectories, Chronic Postsurgical Pain, Quantitative Sensory Testing, Central Sensitization
- Being tested
- Perioperative quantitative sensory testing, questionnaire
- Keywords
- Endometriosis, Postoperative pain, Pain trajectories, Chronic postsurgical pain, Quantitative sensory testing, Central sensitization
- Medical subject headings
- Endometriosis, Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Perioperative quantitative sensory testingOther
Perioperative quantitative sensory testing (mechanical temporal summation and pressure pain thresholds)
questionnaireOther
Repeated administration of validated patient-reported outcome questionnaires
What is being measured
The primary outcome is the main question the study is designed to answer.
Brief Pain Inventory values for pain intensity and interference measurement
Postoperative pain trajectories derived from repeated assessments of pain intensity and interference (Brief Pain Inventory) Brief Pain Inventory (BPI) is a questionnaire with 15 questions. For each question 0 is the smallest score and 10 is the highest score
Measured: day 2
EHP-5 values for quality of life measurement
Postoperative pain trajectories derived from quality of life (EHP-5) EHP-5 (Endometriosis health profile 5) is a questionnaire with 10 questions
Measured: day 2
EHP-5 values for quality of life measurement
Postoperative pain trajectories derived from quality of life (EHP-5) EHP-5 (Endometriosis health profile 5) is a questionnaire with 10 questions
Measured: at 6 months
FSFI values for sexual function measurement
Postoperative pain trajectories derived sexual function (FSFI), Female Sexual Function Index (FSFI) is a questionnaire with 4 questions
Measured: day 2
FSFI values for sexual function measurement
Postoperative pain trajectories derived sexual function (FSFI), Female Sexual Function Index (FSFI) is a questionnaire with 4 questions
Measured: at 6 months
Brief Pain Inventory values for pain intensity and interference measurements
Postoperative pain trajectories derived from repeated assessments of pain intensity and interference (Brief Pain Inventory)
Measured: at 6 months
PROMIS Fatigue SF-6a values for fatigue measurement
Postoperative pain trajectories derived from fatigue (PROMIS Fatigue SF-6a) PROMIS Fatigue SF-6a is a questionnaire with 6 questions
Measured: day 2
PROMIS Fatigue SF-6a values for fatigue measurement
Postoperative pain trajectories derived from fatigue (PROMIS Fatigue SF-6a) PROMIS Fatigue SF-6a is a questionnaire with 6 questions
Measured: at 6 months
Convergences PP values for central sensitization symptoms measurement
Postoperative pain trajectories derived from and central sensitization symptoms (Convergences PP) Score Convergence PP is a questionnaire with 4 questions
Measured: day 2
Convergences PP values for central sensitization symptoms measurement
Postoperative pain trajectories derived from and central sensitization symptoms (Convergences PP) Score Convergence PP is a questionnaire with 4 questions
Measured: at 6 months
Secondary outcomes (5)
Prevalence of chronic postsurgical pain
Measured: at 3 months
Prevalence of chronic postsurgical pain
Measured: at 6 months
Correlation between pain trajectories and CPSP
Measured: at 3 months
Predictive value of perioperative QST parameters
Predictive value of perioperative QST parameters (preoperative and postoperative day 2) for CPSP
Measured: at 3 months
Predictive value of perioperative QST parameters
Predictive value of perioperative QST parameters (preoperative and postoperative day 2) for CPSP
Measured: at 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Oct 2026
- Study start7 Jul 2026
- Primary completionJul 2028 (estimated)
- Study completionJan 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for EndometriosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 150 participants (estimated)
- Target duration
- 6 Months
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire, Amiens
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07882498
- Sponsor's protocol ID
- PI2026_843_0027
- Acronym
- TRACK-ENDO
- Status last verified
- Sep 2026
- First submitted
- 29 Sep 2026
- Last updated
- 20 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Pain Trajectories After Surgery for Endometriosis: A 6-Month Prospective Monocentric Study
- ClinicalTrials.gov ID
- NCT07882498
- Acronym / sponsor ID
- TRACK-ENDO / PI2026_843_0027
- Conditions
- Endometriosis, Postoperative Pain, Pain Trajectories, Chronic Postsurgical Pain, Quantitative Sensory Testing, Central Sensitization
- Keywords
- Endometriosis, Postoperative pain, Pain trajectories, Chronic postsurgical pain, Quantitative sensory testing, Central sensitization
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 150 participants (estimated)
- Lead sponsor
- Centre Hospitalier Universitaire, AmiensUniversity, hospital or other
- Study start
- 7 Jul 2026 (actual)
- Primary completion
- Jul 2028 (estimated)
- Study completion
- Jan 2029 (estimated)
- First posted
- 20 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors. Although surgery is an integral part of treatment, a significant proportion of patients experience persistent pain several months after the procedure. To date, postoperative pain trajectories after endometriosis surgery remain poorly characterised, and there are no reliable predictors of chronic postoperative pain (CPP). This prospective, single-centre, longitudinal study aims to identify distinct postoperative pain trajectories and to assess whether perioperative quantitative sensory testing can predict the development of chronic postoperative pain at 3 and 6 months. Patients will undergo perioperative mechanical and pressure tests, including assessment of temporal summation and pressure pain thresholds, combined with validated measures of patient- reported outcomes. Follow-up assessments will be conducted on day 2, day 14, 1 month, 3 months, and 6 months after surgery to capture the dynamic evolution of pain, quality of life, fatigue, sexual function, and central sensitisation symptoms.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
- Target follow-up
- 6 Months
Who may qualify
- Ages
- 18 years and older
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients operated for endometriosis in CHRU Amiens
Key inclusion criteria (5 listed)
- Age ≥ 18 years
- Imaging-confirmed endometriosis
- Scheduled surgical treatment for endometriosis
- Affiliation to the French Social Security system
- Written informed consent obtained
Key exclusion criteria (7 listed)
- Patients under legal protection (guardians or curators)
- History of psychiatric disorders
- Neurodegenerative diseases
- Inability to self-assess pain using a numerical rating scale
- Non-French-speaking patients
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Perioperative quantitative sensory testingPerioperative quantitative sensory testing (mechanical temporal summation and pressure pain thresholds) | Other | – |
| questionnaireRepeated administration of validated patient-reported outcome questionnaires | Other | – |
Primary outcome
Brief Pain Inventory values for pain intensity and interference measurement
Time frame: day 2
Postoperative pain trajectories derived from repeated assessments of pain intensity and interference (Brief Pain Inventory) Brief Pain Inventory (BPI) is a questionnaire with 15 questions. For each question 0 is the smallest score and 10 is the highest score
EHP-5 values for quality of life measurement
Time frame: day 2
Postoperative pain trajectories derived from quality of life (EHP-5) EHP-5 (Endometriosis health profile 5) is a questionnaire with 10 questions
EHP-5 values for quality of life measurement
Time frame: at 6 months
Postoperative pain trajectories derived from quality of life (EHP-5) EHP-5 (Endometriosis health profile 5) is a questionnaire with 10 questions
FSFI values for sexual function measurement
Time frame: day 2
Postoperative pain trajectories derived sexual function (FSFI), Female Sexual Function Index (FSFI) is a questionnaire with 4 questions
FSFI values for sexual function measurement
Time frame: at 6 months
Postoperative pain trajectories derived sexual function (FSFI), Female Sexual Function Index (FSFI) is a questionnaire with 4 questions
Brief Pain Inventory values for pain intensity and interference measurements
Time frame: at 6 months
Postoperative pain trajectories derived from repeated assessments of pain intensity and interference (Brief Pain Inventory)
PROMIS Fatigue SF-6a values for fatigue measurement
Time frame: day 2
Postoperative pain trajectories derived from fatigue (PROMIS Fatigue SF-6a) PROMIS Fatigue SF-6a is a questionnaire with 6 questions
PROMIS Fatigue SF-6a values for fatigue measurement
Time frame: at 6 months
Postoperative pain trajectories derived from fatigue (PROMIS Fatigue SF-6a) PROMIS Fatigue SF-6a is a questionnaire with 6 questions
Convergences PP values for central sensitization symptoms measurement
Time frame: day 2
Postoperative pain trajectories derived from and central sensitization symptoms (Convergences PP) Score Convergence PP is a questionnaire with 4 questions
Convergences PP values for central sensitization symptoms measurement
Time frame: at 6 months
Postoperative pain trajectories derived from and central sensitization symptoms (Convergences PP) Score Convergence PP is a questionnaire with 4 questions
5 secondary outcomes
Prevalence of chronic postsurgical pain
Time frame: at 3 months
Prevalence of chronic postsurgical pain
Time frame: at 6 months
Correlation between pain trajectories and CPSP
Time frame: at 3 months
Predictive value of perioperative QST parameters
Time frame: at 3 months
Predictive value of perioperative QST parameters
Time frame: at 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Endometriosis and Postoperative Pain, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Paul Tarpin (33+3.22.08.79.80, Tarpin.paul@chu-amiens.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Brief Pain Inventory values for pain intensity and interference measurement (time frame: day 2). The study lists 10 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Oct 2026; AzTrials last refreshed its copy on 26 Oct 2026.