StrokeNCT07879807
Post-Stroke Apraxia, Motor Function, Balance, and Gait
An observational study of Stroke and Ideomotor Apraxia, run by Izmir City Hospital at 1 site in Turkey (Türkiye).
Trial summary
The goal of this observational study is to examine whether ideomotor apraxia is associated with motor function, balance, walking performance, and independence in daily activities in adults with hemiplegia after stroke. Read more about this study
- Who is it for?
- Ages 18 to 90 years
- Conditions the study is for
- Stroke, Ideomotor Apraxia, Hemiplegia
- What is being tested?
- Standardized clinical assessment
- How many people
- 54 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Oct 2026to 15 Oct 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 90 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adults aged 18 to 90 years with hemiplegia following ischemic or hemorrhagic stroke who attend the Physical Medicine and Rehabilitation Clinic at Izmir City Hospital, Türkiye. Patients meeting the eligibility criteria will be recruited consecutively during routine clinical visits. All study assessments will be completed during a single session.
Who may be able to join
- Age 18 to 90 years.
- Diagnosis of ischemic or hemorrhagic stroke with hemiplegia.
- At least one month since stroke onset.
- Provision of written informed consent.
Who cannot join
- Severe aphasia preventing comprehension or performance of assessment instructions.
- Mini-Mental State Examination score below 18 or severe cognitive impairment.
- Severe unilateral spatial neglect.
- Cerebellar stroke.
- Another neurological disorder that may affect motor performance, including Parkinson disease, atypical parkinsonism, multiple sclerosis, or dementia.
- Visual or hearing impairment preventing completion of the assessments.
Show all 11Show fewer
- Orthopedic disease, contracture, amputation, or recent surgery preventing upper or lower limb assessment.
- Severe plantar flexor spasticity, defined as a Modified Ashworth Scale score of 3 or higher.
- Fugl-Meyer upper extremity motor score below 20.
- Inability to walk at least 10 meters with or without an assistive device.
- Acute systemic illness or another medical condition preventing participation.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site
Izmir City Hospital
Izmir, İzmir, 35540
Aylin Dikici, MD, +90 506 484 34 42, aylinkaraman401@hotmail.com
Aylin Dikici, MD
About this study
Official title: Evaluation of the Relationship Between the Presence of Post-Stroke Ideomotor Apraxia and Motor Function, Balance, and Gait Parameters
The goal of this observational study is to examine whether ideomotor apraxia is associated with motor function, balance, walking performance, and independence in daily activities in adults with hemiplegia after stroke. Ideomotor apraxia is a condition in which a person has difficulty planning and correctly performing learned movements, despite understanding the instructions. It is common after stroke, particularly when the left side of the brain is affected.
The main questions this study aims to answer are:
Read more
- Do participants with ideomotor apraxia have lower independence in daily activities, as measured by the motor subscale of the Functional Independence Measure (Motor FIM), than participants without apraxia?
- Is the severity of ideomotor apraxia associated with upper limb motor function, balance, and walking performance?
Participants will attend one assessment session during routine follow-up at the Physical Medicine and Rehabilitation Clinic. They will undergo standardized clinical assessments of apraxia, upper limb motor function, balance, walking performance, and independence in daily activities. No treatment, medication, blood sampling, or imaging will be performed as part of this study.
Read the detailed description
This single-center, observational, cross-sectional study will investigate the association between ideomotor apraxia and functional outcomes in adults with post-stroke hemiplegia.
Ideomotor apraxia may interfere with the performance of purposeful movements and everyday tasks. Evaluating its relationship with motor impairment and functional performance may help clarify its relevance to rehabilitation assessment after stroke.
Participants will be evaluated during a single session at the Physical Medicine and Rehabilitation Clinic. Ideomotor apraxia will be assessed using the Test for Upper Limb Apraxia (TULIA). Upper limb motor impairment will be evaluated using the upper extremity section of the Fugl-Meyer Assessment. Additional standardized assessments will evaluate balance, walking performance, and independence in daily activities.
The primary analysis will compare Motor Functional Independence Measure (Motor FIM) scores between participants with and without ideomotor apraxia. Secondary analyses will examine associations between TULIA scores and measures of upper limb motor function, balance, and walking performance. Potential confounding factors, including demographic and stroke-related characteristics, will be considered in the analyses. Based on a previously reported effect size (Cohen's d = 1.06), with alpha = 0.05 and 90% power, a total of 54 participants will be enrolled, allowing for 10% data loss.
All study procedures are limited to clinical assessments and collection of relevant clinical information. Participation will not alter routine clinical care.
- Conditions
- Stroke, Ideomotor Apraxia, Hemiplegia
- Being tested
- Standardized clinical assessment
- Keywords
- Post-stroke rehabilitation, Upper limb motor function, Balance, Walking performance, Functional independence, Activities of daily living, Test for Upper Limb Apraxia, TULIA, Fugl-Meyer Assessment, Motor FIM
- Medical subject headings
- Stroke, Apraxia, Ideomotor, Hemiplegia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Standardized clinical assessmentOther
Single-session assessment including the Test for Upper Limb Apraxia (TULIA), Fugl-Meyer Assessment-Upper Extremity, Berg Balance Scale, Functional Ambulation Categories, 10-Meter Walk Test, and Functional Independence Measure. No treatment is administered.
| Study group | Role | What they receive |
|---|---|---|
| Stroke patients without ideomotor apraxia | Not described Receives: Other: Standardized clinical assessment | |
| Stroke patients with ideomotor apraxia | Not described Receives: Other: Standardized clinical assessment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Motor Functional Independence Measure (Motor FIM) Score
The Motor FIM comprises 13 items assessing self-care, sphincter control, transfers, and locomotion. Scores range from 13 to 91, with higher scores indicating greater functional independence. Motor FIM scores will be compared between participants with and without ideomotor apraxia (defined by the Test for Upper Limb Apraxia [TULIA] cut-off), and their association with the TULIA total score will be examined.
Measured: At enrollment, during a single assessment session
Secondary outcomes (5)
Fugl-Meyer Assessment Upper Extremity Motor Score
Upper limb motor impairment will be assessed using the upper extremity motor section of the Fugl-Meyer Assessment. Scores range from 0 to 66, with higher scores indicating better motor function. Its association with the TULIA total score will be examined.
Measured: At enrollment, during a single assessment session
Functional Ambulation Categories Score
Walking independence will be assessed using the Functional Ambulation Categories, scored from 0 to 5. Higher scores indicate greater walking independence and less need for assistance from another person. Its association with the TULIA total score will be examined.
Measured: At enrollment, during a single assessment session
Comfortable Walking Speed on the 10-Meter Walk Test
Comfortable walking speed will be assessed using the 10-Meter Walk Test and expressed in meters per second. Higher values indicate faster walking speed. Its association with the TULIA total score will be examined.
Measured: At enrollment, during a single assessment session
Total Functional Independence Measure Score
Overall functional independence will be assessed using the 18-item Functional Independence Measure, covering motor and cognitive domains. Total scores range from 18 to 126, with higher scores indicating greater independence. Its association with the TULIA total score will be examined.
Measured: At enrollment, during a single assessment session
Berg Balance Scale Score
Balance will be assessed using the Berg Balance Scale, comprising 14 items scored from 0 to 4. Total scores range from 0 to 56, with higher scores indicating better balance. Its association with the TULIA total score will be examined.
Measured: At enrollment, during a single assessment session
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Oct 2026
- Study start15 Oct 2026 (estimated)
- Primary completion15 Oct 2027 (estimated)
- Study completion15 Oct 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 54 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Izmir City Hospital
- Sponsor type
- Other government
- Responsible party
- Sponsor
- Investigators
- Aylin Dikici, MD, Principal investigator, University of Health Sciences, Izmir City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07879807
- Sponsor's protocol ID
- 2026/28
- Status last verified
- Oct 2026
- First submitted
- 10 Oct 2026
- Last updated
- 19 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared with other researchers to protect participant privacy and confidentiality. Study findings will be reported in aggregate form through scientific publications and presentations.
Publications
Cosar SNS, Ozen S, Selcuk ST, Yemisci OU. Does the presence of ideomotor apraxia in stroke patients adversely affect rehabilitation outcomes? A prospective study. Neurology Asia. 2020;25(4):459-465.
Vanbellingen T, Kersten B, Van Hemelrijk B, Van de Winckel A, Bertschi M, Muri R, De Weerdt W, Bohlhalter S. Comprehensive assessment of gesture production: a new test of upper limb apraxia (TULIA). Eur J Neurol. 2010 Jan;17(1):59-66. doi: 10.1111/j.1468-1331.2009.02741.x. Epub 2009 Jul 9.
PubMed 19614961
Study at a glance
From the registry record, last updated by the sponsor on 19 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Relationship Between the Presence of Post-Stroke Ideomotor Apraxia and Motor Function, Balance, and Gait Parameters
- ClinicalTrials.gov ID
- NCT07879807
- Acronym / sponsor ID
- 2026/28
- Conditions
- Stroke, Ideomotor Apraxia, Hemiplegia
- Keywords
- Post-stroke rehabilitation, Upper limb motor function, Balance, Walking performance, Functional independence, Activities of daily living, Test for Upper Limb Apraxia, TULIA
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 54 participants (estimated)
- Lead sponsor
- Izmir City HospitalOther government
- Study start
- 15 Oct 2026 (estimated)
- Primary completion
- 15 Oct 2027 (estimated)
- Study completion
- 15 Oct 2027 (estimated)
- First posted
- 19 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to examine whether ideomotor apraxia is associated with motor function, balance, walking performance, and independence in daily activities in adults with hemiplegia after stroke. Ideomotor apraxia is a condition in which a person has difficulty planning and correctly performing learned movements, despite understanding the instructions. It is common after stroke, particularly when the left side of the brain is affected.
The main questions this study aims to answer are:
- Do participants with ideomotor apraxia have lower independence in daily activities, as measured by the motor subscale of the Functional Independence Measure (Motor FIM), than participants without apraxia?
- Is the severity of ideomotor apraxia associated with upper limb motor function, balance, and walking performance?
Participants will attend one assessment session during routine follow-up at the Physical Medicine and Rehabilitation Clinic. They will undergo standardized clinical assessments of apraxia, upper limb motor function, balance, walking performance, and independence in daily activities. No treatment, medication, blood sampling, or imaging will be performed as part of this study.
Detailed description
This single-center, observational, cross-sectional study will investigate the association between ideomotor apraxia and functional outcomes in adults with post-stroke hemiplegia.
Ideomotor apraxia may interfere with the performance of purposeful movements and everyday tasks. Evaluating its relationship with motor impairment and functional performance may help clarify its relevance to rehabilitation assessment after stroke.
Participants will be evaluated during a single session at the Physical Medicine and Rehabilitation Clinic. Ideomotor apraxia will be assessed using the Test for Upper Limb Apraxia (TULIA). Upper limb motor impairment will be evaluated using the upper extremity section of the Fugl-Meyer Assessment. Additional standardized assessments will evaluate balance, walking performance, and independence in daily activities.
The primary analysis will compare Motor Functional Independence Measure (Motor FIM) scores between participants with and without ideomotor apraxia. Secondary analyses will examine associations between TULIA scores and measures of upper limb motor function, balance, and walking performance. Potential confounding factors, including demographic and stroke-related characteristics, will be considered in the analyses. Based on a previously reported effect size (Cohen's d = 1.06), with alpha = 0.05 and 90% power, a total of 54 participants will be enrolled, allowing for 10% data loss.
All study procedures are limited to clinical assessments and collection of relevant clinical information. Participation will not alter routine clinical care.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Stroke patients without ideomotor apraxia | – | Other: Standardized clinical assessment |
| Stroke patients with ideomotor apraxia | – | Other: Standardized clinical assessment |
Who may qualify
- Ages
- 18 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adults aged 18 to 90 years with hemiplegia following ischemic or hemorrhagic stroke who attend the Physical Medicine and Rehabilitation Clinic at Izmir City Hospital, Türkiye. Patients meeting the eligibility criteria will be recruited consecutively during routine clinical visits. All study assessments will be completed during a single session.
Key inclusion criteria (4 listed)
- Age 18 to 90 years.
- Diagnosis of ischemic or hemorrhagic stroke with hemiplegia.
- At least one month since stroke onset.
- Provision of written informed consent.
Key exclusion criteria (11 listed)
- Severe aphasia preventing comprehension or performance of assessment instructions.
- Mini-Mental State Examination score below 18 or severe cognitive impairment.
- Severe unilateral spatial neglect.
- Cerebellar stroke.
- Another neurological disorder that may affect motor performance, including Parkinson disease, atypical parkinsonism, multiple sclerosis, or dementia.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Standardized clinical assessmentSingle-session assessment including the Test for Upper Limb Apraxia (TULIA), Fugl-Meyer Assessment-Upper Extremity, Berg Balance Scale, Functional Ambulation Categories, 10-Meter Walk Test, and Functional Independence Measure. No treatment is administered. | Other | Stroke patients with ideomotor apraxia, Stroke patients without ideomotor apraxia |
Primary outcome
Motor Functional Independence Measure (Motor FIM) Score
Time frame: At enrollment, during a single assessment session
The Motor FIM comprises 13 items assessing self-care, sphincter control, transfers, and locomotion. Scores range from 13 to 91, with higher scores indicating greater functional independence. Motor FIM scores will be compared between participants with and without ideomotor apraxia (defined by the Test for Upper Limb Apraxia [TULIA] cut-off), and their association with the TULIA total score will be examined.
5 secondary outcomes
Fugl-Meyer Assessment Upper Extremity Motor Score
Time frame: At enrollment, during a single assessment session
Functional Ambulation Categories Score
Time frame: At enrollment, during a single assessment session
Comfortable Walking Speed on the 10-Meter Walk Test
Time frame: At enrollment, during a single assessment session
Total Functional Independence Measure Score
Time frame: At enrollment, during a single assessment session
Berg Balance Scale Score
Time frame: At enrollment, during a single assessment session
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Oct 2026.
- BackgroundCosar SNS, Ozen S, Selcuk ST, Yemisci OU. Does the presence of ideomotor apraxia in stroke patients adversely affect rehabilitation outcomes? A prospective study. Neurology Asia. 2020;25(4):459-465.
- Background: PubMed 19614961Vanbellingen T, Kersten B, Van Hemelrijk B, Van de Winckel A, Bertschi M, Muri R, De Weerdt W, Bohlhalter S. Comprehensive assessment of gesture production: a new test of upper limb apraxia (TULIA). Eur J Neurol. 2010 Jan;17(1):59-66. doi: 10.1111/j.1468-1331.2009.02741.x. Epub 2009 Jul 9.
- Individual participant dataSharing planned: No. Individual participant data will not be shared with other researchers to protect participant privacy and confidentiality. Study findings will be reported in aggregate form through scientific publications and presentations.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Aylin Dikici, MD principal investigator
University of Health Sciences, Izmir City Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Stroke and Ideomotor Apraxia, run by Izmir City Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 19 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Aylin Dikici, MD (+90 506 484 34 42, aylinkaraman401@hotmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Motor Functional Independence Measure (Motor FIM) Score (time frame: At enrollment, during a single assessment session). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07879807, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Oct 2026.