Facial PhotoagingNCT07874113
Regenmedic Cream 2.0 12-week Long-term Clinical Test
A study testing Test facial cream (topical skin care product) in people with Facial Photoaging and Deepening of Facial Wrinkles, run by ChinaNorm at 1 site in China.
Trial summary
The goal of this study is to evaluate the anti-wrinkle, firming, moisturizing and repairing efficacy of a test facial cream after single use and 12 weeks of continuous use via clinical evaluation, instrumental measurement, image analysis and participant self-assessment. Read more about this study
- Who is it for?
- Ages 25 to 50 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Facial Photoaging, Deepening of Facial Wrinkles, Skin Laxity
- What is being tested?
- Test facial cream (topical skin care product)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 70 participants
- Where
- 1 siteChina
- Study dates
- 13 Apr 2026to 7 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 50 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- 1) Chinese female aged from 25 to 50. 2) All skin types, 50% self-declared sensitive skin. 3) Skin type II to IV according to Fitzpatrick classification. 4) Presenting with dull skin, lack of radiance, brightness, transparency on face evaluated by dermatologist.
- 5) Presenting with sagging, elasticity, plumpness, softness, fine line and wrinkles on face evaluated by dermatologist.
- 6) Presenting with corresponding severity for the attribute on face evaluated by dermatologist.
- Cheek Sebaceous Pores: Atlas scale, 2≤grade≤5
- Skin Radiance: Griffiths 10-point scale, 3≤grade≤6
- Skin Redness: Griffiths 10-point scale, 2≤grade≤6
Show all 17Show fewer
- Skin Smoothness: Griffiths 10-point scale, 3≤grade≤6
- Skin Firmness (tactile): Griffiths 10-point scale, 2≤grade≤6
- Global Appearance of Fine Line: Griffiths 10-point scale, 3≤grade≤6
- Nasolabial Fold: Atlas scale, 1≤grade≤5
- Forehead Wrinkles: Atlas scale, 1≤grade≤5
- Crow's Feet Wrinkles: Atlas scale, 1<grade≤6
- Wrinkles of the Corner of the Lips: Atlas scale, 1≤grade≤5
- Underneath Eye Wrinkles: Atlas scale, 2≤grade≤6
- Horizontal Neck Folds: Atlas scale, 1≤grade≤6 7) Did not participate in any clinical test or cosmetic product test on skin within 3 months.
- 8) No disagreement of dermatologist because of other reasons that exclude the participation of the volunteer. 9) In general, good health at the time of the study. 10) Willing and able to participate as evidenced by signing of informed consent \& photo release form.
- 11) Must be willing to comply with all study protocol requirements.
Who cannot join
- 1) Pregnant or breast-feeding woman or woman planning pregnancy during the study.
- 2) Subject deprived of rights by a court or administrative order. 3) Major subject to a guardianship order. 4) Subject residing in a health or social care establishment. 5) Subject in an emergency setting. 6) Subject with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema).
- 7) Subject presenting a stable or progressive serious disease (per investigator's assessment). 8) Immuno-compromised subject. 9) Subject with history of allergy to cosmetic or personal care products or ingredients.
- 10) Subject with history of allergy to metal. 11) Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).
- 12) Subject with history of sunlight sensitivity or allergies. 13) Subjects regularly practicing aquatic or nautical sports. 14) Subjects regularly attending a sauna. 15) Subject with physical highly sensitive constitution. 16) Subject with cardiovascular or circulatory history. 17) Subject with a history of skin cancer or malignant melanoma. 18) Subject with history of medical beauty treatment and taking part in anti-aging studies in the last 3 months before study.
- 19) Intake of antihistamines, antibiotics, corticosteroids, non-steroidal anti-inflammatories or immune-suppressants in the last 6 months before study.
Trial locations and contacts
1 site in 1 country.
China1 site
Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072, Shanghai,
Shanghai, Shanghai Municipality
About this study
The goal of this study is to evaluate the anti-wrinkle, firming, moisturizing and repairing efficacy of a test facial cream after single use and 12 weeks of continuous use via clinical evaluation, instrumental measurement, image analysis and participant self-assessment.
The main questions it aims to answer are:
Read more
Does the test cream produce immediate anti-wrinkle, firming, moisturizing and repairing effects on facial skin after single use? Can 12-week continuous use of the test cream sustainably improve facial skin condition in terms of wrinkles, laxity, hydration and skin repair? This is a single-center clinical study with a self-controlled before-and-after design. Around 70 healthy Chinese women aged 25-50 will be randomly divided into an instrumental group and a questionnaire group, with no fewer than 40 valid clinical test samples and 60 valid questionnaire samples. The study uses four products, including one test cream and three auxiliary skincare products.
Participants will:
Use the test cream once on-site and continuously at home for 12 weeks with matched auxiliary products.
Attend six scheduled visits at key time points: 2 weeks before product use for washout and screening (T-2W), baseline detection and immediate assessment after single product use (T0+Timm), 1 week after continuous product use (T1W), 4 weeks after continuous product use (T4W), 8 weeks after continuous product use (T8W), and 12 weeks after continuous product use (T12W) .
Complete group-specific assessments: the instrumental group will undergo instrumental tests, clinical evaluation and image collection; the questionnaire group will finish clinical screening and self-assessment.
Receive skin indicator detection and efficacy evaluation at all designated time points to verify the product's skincare effects.
- Being tested
- Test facial cream (topical skin care product)
- Medical subject headings
- Cutis Laxa
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Test facial cream (topical skin care product)Other
Topical test facial cream for facial skin application. Participants apply the cream once on-site and then use it daily at home for 12 consecutive weeks, together with assigned auxiliary skin care products. The study evaluates anti-aging efficacy including wrinkles, skin laxity and elasticity.
| Study group | Role | What they receive |
|---|---|---|
| Test Facial Cream Intervention Arm | Experimental | All participants apply the same test facial cream. Subjects are randomly assigned to either instrumental assessment subgroup or questionnaire subgroup for different outcome measurements. Skin efficacy indicators are evaluated at baseline, immediately after single use, 1,4,8 and 12 weeks of continuous use. Receives: Other: Test facial cream (topical skin care product) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change from baseline in dermatologist clinical scoring of facial skin attributes
Dermatologist clinical assessment scoring of cheek sebaceous pores, skin dullness, skin redness, skin radiance, skin brightness, skin plumpness, fine lines, skin firmness, skin elasticity, skin softness, skin smoothness, skin translucency, facial sagging, nasolabial fold, forehead wrinkles, glabellar wrinkles, crow's feet wrinkles, lip corner wrinkles, under-eye wrinkles, inter-ocular wrinkles and horizontal neck folds.
Measured: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Secondary outcomes (4)
Change from baseline in facial imaging parameters
Facial and local skin images captured by Visia-CR Gen5, Capture Frame \& Digital Camera, Ultrascan UC22, Primos CR and Two-photon Microscopic Imaging System (SUPERVERSION 780).
Measured: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Change from baseline in skin hydration
Skin hydration measured by Corneometer on facial skin.
Measured: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Change from baseline in transepidermal water loss (TEWL)
Transepidermal water loss (TEWL) measured by Vapometer on facial skin
Measured: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Change from baseline in subject self-assessment questionnaire
Subject self-evaluation of skin condition completed via consumer questionnaire.
Measured: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Oct 2026
- Study start13 Apr 2026
- Primary completion23 Jul 2026
- Study completion7 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Facial PhotoagingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 70 participants (actual)
Sponsor and investigators
- Lead sponsor
- ChinaNorm
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07874113
- Sponsor's protocol ID
- C26005015
- Status last verified
- Oct 2026
- First submitted
- 8 Oct 2026
- Last updated
- 14 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Regenmedic Cream 2.0 12-week Long-term Clinical Test
- ClinicalTrials.gov ID
- NCT07874113
- Acronym / sponsor ID
- C26005015
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 70 participants (actual)
- Lead sponsor
- ChinaNormIndustry (pharma, biotech, devices)
- Study start
- 13 Apr 2026 (actual)
- Primary completion
- 23 Jul 2026 (actual)
- Study completion
- 7 Aug 2026 (actual)
- First posted
- 14 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to evaluate the anti-wrinkle, firming, moisturizing and repairing efficacy of a test facial cream after single use and 12 weeks of continuous use via clinical evaluation, instrumental measurement, image analysis and participant self-assessment.
The main questions it aims to answer are:
Does the test cream produce immediate anti-wrinkle, firming, moisturizing and repairing effects on facial skin after single use? Can 12-week continuous use of the test cream sustainably improve facial skin condition in terms of wrinkles, laxity, hydration and skin repair? This is a single-center clinical study with a self-controlled before-and-after design. Around 70 healthy Chinese women aged 25-50 will be randomly divided into an instrumental group and a questionnaire group, with no fewer than 40 valid clinical test samples and 60 valid questionnaire samples. The study uses four products, including one test cream and three auxiliary skincare products.
Participants will:
Use the test cream once on-site and continuously at home for 12 weeks with matched auxiliary products.
Attend six scheduled visits at key time points: 2 weeks before product use for washout and screening (T-2W), baseline detection and immediate assessment after single product use (T0+Timm), 1 week after continuous product use (T1W), 4 weeks after continuous product use (T4W), 8 weeks after continuous product use (T8W), and 12 weeks after continuous product use (T12W) .
Complete group-specific assessments: the instrumental group will undergo instrumental tests, clinical evaluation and image collection; the questionnaire group will finish clinical screening and self-assessment.
Receive skin indicator detection and efficacy evaluation at all designated time points to verify the product's skincare effects.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Test Facial Cream Intervention Arm | Experimental | Other: Test facial cream (topical skin care product)All participants apply the same test facial cream. Subjects are randomly assigned to either instrumental assessment subgroup or questionnaire subgroup for different outcome measurements. Skin efficacy indicators are evaluated at baseline, immediately after single use, 1,4,8 and 12 weeks of continuous use. |
Who may qualify
- Ages
- 25 to 50 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (17 listed)
- 1) Chinese female aged from 25 to 50. 2) All skin types, 50% self-declared sensitive skin. 3) Skin type II to IV according to Fitzpatrick classification. 4) Presenting with dull skin, lack of radiance, brightness, transparency on face evaluated by dermatologist.
- 5) Presenting with sagging, elasticity, plumpness, softness, fine line and wrinkles on face evaluated by dermatologist.
- 6) Presenting with corresponding severity for the attribute on face evaluated by dermatologist.
- 8) No disagreement of dermatologist because of other reasons that exclude the participation of the volunteer. 9) In general, good health at the time of the study. 10) Willing and able to participate as evidenced by signing of informed consent \& photo release form.
- 11) Must be willing to comply with all study protocol requirements.
Key exclusion criteria (6 listed)
- 1) Pregnant or breast-feeding woman or woman planning pregnancy during the study.
- 2) Subject deprived of rights by a court or administrative order. 3) Major subject to a guardianship order. 4) Subject residing in a health or social care establishment. 5) Subject in an emergency setting. 6) Subject with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema).
- 7) Subject presenting a stable or progressive serious disease (per investigator's assessment). 8) Immuno-compromised subject. 9) Subject with history of allergy to cosmetic or personal care products or ingredients.
- 10) Subject with history of allergy to metal. 11) Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).
- 12) Subject with history of sunlight sensitivity or allergies. 13) Subjects regularly practicing aquatic or nautical sports. 14) Subjects regularly attending a sauna. 15) Subject with physical highly sensitive constitution. 16) Subject with cardiovascular or circulatory history. 17) Subject with a history of skin cancer or malignant melanoma. 18) Subject with history of medical beauty treatment and taking part in anti-aging studies in the last 3 months before study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Test facial cream (topical skin care product)Topical test facial cream for facial skin application. Participants apply the cream once on-site and then use it daily at home for 12 consecutive weeks, together with assigned auxiliary skin care products. The study evaluates anti-aging efficacy including wrinkles, skin laxity and elasticity. | Other | Test Facial Cream Intervention Arm |
Primary outcome
Change from baseline in dermatologist clinical scoring of facial skin attributes
Time frame: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Dermatologist clinical assessment scoring of cheek sebaceous pores, skin dullness, skin redness, skin radiance, skin brightness, skin plumpness, fine lines, skin firmness, skin elasticity, skin softness, skin smoothness, skin translucency, facial sagging, nasolabial fold, forehead wrinkles, glabellar wrinkles, crow's feet wrinkles, lip corner wrinkles, under-eye wrinkles, inter-ocular wrinkles and horizontal neck folds.
4 secondary outcomes
Change from baseline in facial imaging parameters
Time frame: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Change from baseline in skin hydration
Time frame: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Change from baseline in transepidermal water loss (TEWL)
Time frame: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Change from baseline in subject self-assessment questionnaire
Time frame: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Test facial cream (topical skin care product) in people with Facial Photoaging and Deepening of Facial Wrinkles, run by ChinaNorm at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 17 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 14 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change from baseline in dermatologist clinical scoring of facial skin attributes (time frame: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Oct 2026; AzTrials last refreshed its copy on 26 Oct 2026.