Patellofemoral Pain SyndromeNCT07812519
Pain and Movement Responses to Resistance Training to Muscular Failure in Patients With Patellofemoral Pain
An observational study of Patellofemoral Pain Syndrome, run by Ted Gunhamn.
Trial summary
This study aims to investigate the effect of training to muscular failure in patients with patellofemoral pain (PFP). In a cross-sectional observational design, participants with PFP will be be performing a knee exercise to voluntarily muscular failure. Read more about this study
- Who is it for?
- Ages 15 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Patellofemoral Pain Syndrome
- What is being tested?
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- How many people
- 30 participants
- Where
- No sites listed yet
- Study dates
- Dec 2026to May 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 to 35 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Study population: This project will include patients diagnosed with PFP (ICD-10: M22.2).
Who may be able to join
- Patients diagnosed with PFP in only one knee by a licensed healthcare professional.
- Aged 15-35 years.
- A physical activity level of 3/10 or higher on the Tegner Activity Scale before the injury.
Who cannot join
- Any prior injury or condition with residual symptoms that may affect the results.
- Current injury or condition affecting the performance of the test.
- Resting pain greater than 0-1/10 on the Numeric Pain Rating Scale (NRS) and pain greater than 1-2/10 during light daily activities such as walking, sitting, standing, or climbing stairs.
About this study
This study aims to investigate the effect of training to muscular failure in patients with patellofemoral pain (PFP). In a cross-sectional observational design, participants with PFP will be be performing a knee exercise to voluntarily muscular failure. The participants will throughout the exercise trial report pain levels and continue until 1) not being able to perform the exercise as instructed or 2) reaching a pain level of 5/10 (which is a common threshold for acceptable pain within rehabilitation). During this trial, the participants will be filmed and a biomechanical analysis will be performed to see if/how compensatory movements occur.
- Conditions
- Patellofemoral Pain Syndrome
- Being tested
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Keywords
- Patellofemoral Pain, Biomechanichs, Single leg squat
- Medical subject headings
- Patellofemoral Pain Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EXERCISE TRAINING WITH OR WITHOUT MEDICATIONOther
Resistance training to muscular failure in patients with patellofemoral pain.
| Study group | Role | What they receive |
|---|---|---|
| Patellofemoral Pain | Patients diagnosed with patellofemoral pain syndrome by health care provider. Receives: Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATION | |
| Control | Healthy adults without injuries/diseases preventing the participants from performing the trial to voluntary muscular failure Receives: Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATION |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Response
Numeric pain rating scale 0-10. Participants will rate their perceived pain at baseline before the trial, during the trial and the day after the trial.
Measured: Approximately 24 hours, from baseline before the trial and the day after the trial.
Knee extensor moment (Nm)
Will be measured using force plates and a 3d camera biomechanic analysis system (qualisys)
Measured: Changes in knee extensor moment between the first and final repetition during the trial, approximately 2 minutes.
Hip extensor moment (Nm)
Will be measured using force plates and a 3d camera biomechanic analysis system (qualisys)
Measured: Changes in hip extensor moment between the first and final repetition during the trial, approximately 2 minutes.
Knee flexion angle (degrees)
Knee flexion angle will be measured using a 3d camera biomechanical analysis system (qualisys)
Measured: Changes between in knee flexion angle between the first and final repetition during the trial, approximately 2 minutes.
Hip flexion angle (degress)
Hip flexion angle will be measured using a 3d camera biomechanical analysis system (qualisys)
Measured: Changes between in hip flexion angle between the first and final repetition during the trial, approximately 2 minutes.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Sep 2026
- Study startDec 2026 (estimated)
- Primary completionDec 2027 (estimated)
- Study completionMay 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Patellofemoral Pain SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ted Gunhamn
- Sponsor type
- University, hospital or other
- Collaborators
- Västra Götalandsregionen, Molndal Hospital
- Responsible party
- Sponsor-investigator, Ted Gunhamn, Linnaeus University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07812519
- Sponsor's protocol ID
- 2024-01422-01-02
- Status last verified
- Sep 2026
- First submitted
- 1 Sep 2026
- Last updated
- 28 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Pain and Movement Responses to Resistance Training to Muscular Failure in Patients With Patellofemoral Pain
- ClinicalTrials.gov ID
- NCT07812519
- Acronym / sponsor ID
- 2024-01422-01-02
- Conditions
- Patellofemoral Pain Syndrome
- Keywords
- Patellofemoral Pain, Biomechanichs, Single leg squat
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Ted GunhamnUniversity, hospital or other
- Collaborators
- Västra Götalandsregionen, Molndal Hospital
- Study start
- Dec 2026 (estimated)
- Primary completion
- Dec 2027 (estimated)
- Study completion
- May 2028 (estimated)
- First posted
- 10 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate the effect of training to muscular failure in patients with patellofemoral pain (PFP). In a cross-sectional observational design, participants with PFP will be be performing a knee exercise to voluntarily muscular failure. The participants will throughout the exercise trial report pain levels and continue until 1) not being able to perform the exercise as instructed or 2) reaching a pain level of 5/10 (which is a common threshold for acceptable pain within rehabilitation). During this trial, the participants will be filmed and a biomechanical analysis will be performed to see if/how compensatory movements occur.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Patellofemoral Pain | – | Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATIONPatients diagnosed with patellofemoral pain syndrome by health care provider. |
| Control | – | Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATIONHealthy adults without injuries/diseases preventing the participants from performing the trial to voluntary muscular failure |
Who may qualify
- Ages
- 15 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
- Study population
- This project will include patients diagnosed with PFP (ICD-10: M22.2).
Key inclusion criteria (3 listed)
- Patients diagnosed with PFP in only one knee by a licensed healthcare professional.
- Aged 15-35 years.
- A physical activity level of 3/10 or higher on the Tegner Activity Scale before the injury.
Key exclusion criteria (3 listed)
- Any prior injury or condition with residual symptoms that may affect the results.
- Current injury or condition affecting the performance of the test.
- Resting pain greater than 0-1/10 on the Numeric Pain Rating Scale (NRS) and pain greater than 1-2/10 during light daily activities such as walking, sitting, standing, or climbing stairs.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EXERCISE TRAINING WITH OR WITHOUT MEDICATIONResistance training to muscular failure in patients with patellofemoral pain. | Other | Control, Patellofemoral Pain |
Primary outcome
Pain Response
Time frame: Approximately 24 hours, from baseline before the trial and the day after the trial.
Numeric pain rating scale 0-10. Participants will rate their perceived pain at baseline before the trial, during the trial and the day after the trial.
Knee extensor moment (Nm)
Time frame: Changes in knee extensor moment between the first and final repetition during the trial, approximately 2 minutes.
Will be measured using force plates and a 3d camera biomechanic analysis system (qualisys)
Hip extensor moment (Nm)
Time frame: Changes in hip extensor moment between the first and final repetition during the trial, approximately 2 minutes.
Will be measured using force plates and a 3d camera biomechanic analysis system (qualisys)
Knee flexion angle (degrees)
Time frame: Changes between in knee flexion angle between the first and final repetition during the trial, approximately 2 minutes.
Knee flexion angle will be measured using a 3d camera biomechanical analysis system (qualisys)
Hip flexion angle (degress)
Time frame: Changes between in hip flexion angle between the first and final repetition during the trial, approximately 2 minutes.
Hip flexion angle will be measured using a 3d camera biomechanical analysis system (qualisys)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Patellofemoral Pain Syndrome, run by Ted Gunhamn.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 28 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Response (time frame: Approximately 24 hours, from baseline before the trial and the day after the trial.). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Sep 2026.