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AzTrials

Wound HealingNCT07796269

Post-Extraction Wound Healing in Elderly

An observational study of Wound Healing, run by University of Nebraska at 1 site in United States.

Not yet recruiting

Opening soon. The study is approved but enrolment has not started yet. Sites may already take enquiries.

Sites and contacts
Official record
Search all trials

Trial summary

Patients presenting to the University of Nebraska Medical Center College of Dentistry for a posterior extraction will be offered participation in the study. Prior to extraction, subjects will undergo clinical measurements, xray, gingival crevicular fluid (GCF) and saliva sampling and a blood draw. Read more about this study

Who is it for?
Ages 65 to 80 years
Conditions the study is for
Wound Healing
What is being tested?
tooth extraction
Type of treatment
Surgery or procedure
How many people
72 participants
Where
1 siteUnited States
Study dates
1 Nov 2026to 1 Nov 2030
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 65 to 80 years
  • All sexes
  • No healthy volunteers
  • Older adult

Study population: Study population will be made of patients at the UNMC College of Dentistry requiring posterior extraction, aged 65-80.

Who may be able to join

  • needs posterior tooth extracted
  • no systemic conditions or meds affecting wound healing
  • non-smoker

Who cannot join

  • systemic conditions or meds known to affect wound healing
  • smokers

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Amy Killeen, DDS, MS contact

4024727848

akilleen@unmc.edu

United States1 site

  • University of Nebraska Medical Center College of Dentistry

    Lincoln, Nebraska, 68583

    Amy Killeen, DDS, MS, 4024727848, akilleen@unmc.edu

Other trials in United States

About this study

Patients presenting to the University of Nebraska Medical Center College of Dentistry for a posterior extraction will be offered participation in the study. Prior to extraction, subjects will undergo clinical measurements, xray, gingival crevicular fluid (GCF) and saliva sampling and a blood draw. Following atraumatic tooth extraction, the subjects will be reevaluated for healing at 1, 2-weeks and 3 months. At each appointment, GCF, saliva and wound fluid (WF) will be collected and at 3 months a second xray will be taken.

Conditions
Wound Healing
Being tested
tooth extraction
Keywords
extraction, elderly

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • tooth extractionProcedure or surgery

    posterior tooth extraction

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Amount of Interleukin-1 beta (IL1-B) in gingival crevicular at baseline

    Measurement of IL1B in GCF

    Measured: Baseline

Secondary outcomes (1)

  1. Bone Density

    Change in bone density post-extraction

    Measured: 3 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted1 Sep 2026
  2. Study start1 Nov 2026 (estimated)
  3. Primary completion1 Nov 2028 (estimated)
  4. Study completion1 Nov 2030 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
72 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07796269
Sponsor's protocol ID
0672-26-EP
Status last verified
Aug 2026
First submitted
27 Aug 2026
Last updated
14 Sep 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Dignam P, Elshafey M, Jeganathan A, Foo M, Park JS, Ratnaweera M. Prevalence and Factors Influencing Post-Operative Complications following Tooth Extraction: A Narrative Review. Int J Dent. 2024;2024:7712829. Epub 20240509. doi: 10.1155/2024/7712829. PubMed PMID: 38756385; PMCID: PMC11098612. 2. Khalid KA, Nawi AFM, Zulkifli N, Barkat MA, Hadi H. Aging and Wound Healing of the Skin: A Review of Clinical and Pathophysiological Hallmarks. Life (Basel). 2022;12(12). Epub 20221219. doi: 10.3390/life12122142. PubMed PMID: 36556508; PMCID: PMC9784880. 3. Martin P, Pardo-Pastor C, Jenkins RG, Rosenblatt J. Imperfect wound healing sets the stage for chronic diseases. Science. 2024;386(6726):eadp2974. Epub 20241206. doi: 10.1126/science.adp2974. PubMed PMID: 39636982. 4. Amler MH. Age factor in human alveolar bone repair. J Oral Implantol. 1993;19(2):138-42. PubMed PMID: 8246300. 5. Elani HW, Starr JR, Da Silva JD, Gallucci GO. Trends in Dental Implant Use in the U.S., 1999-2016, and Projections to 2026. J Dent Res. 2018;97(13):1424-30. Epub 20180803. doi: 10.1177/0022034518792567. PubMed PMID: 30075090; PMCID: PMC6854267. 6. Udeabor SE, Heselich A, Al-Maawi S, Alqahtani AF, Sader R, Ghanaati S. Current Knowledge on the Healing of the Extraction Socket: A Narrative Review. Bioengineering (Basel). 2023;10(10). Epub 20230929. doi: 10.3390/bioengineering10101145. PubMed PMID: 37892875; PMCID: PMC10604628. 7. Sims NA. Influences of the IL-6 cytokine family on bone structure and function. Cytokine. 2021;146:155655. Epub 20210728. doi: 10.1016/j.cyto.2021.155655. PubMed PMID: 34332274. 8. Ramadan DE, Hariyani N, Indrawati R, Ridwan RD, Diyatri I. Cytokines and Chemokines in Periodontitis. Eur J Dent. 2020;14(3):483-95. Epub 20200623. doi: 10.1055/s-0040-1712718. PubMed PMID: 32575137; PMCID: PMC7440949. 9. Razavi P, Rezaee SA, Akhondian S, Asgari N, Fatemi K, Mohajertehran F. Matrix Metalloproteinase-3 but Not Matrix Metalloproteinase-9, Implicated in the Manifestation of

Questions about this trial

What is this clinical trial studying?

An observational study of Wound Healing, run by University of Nebraska at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: opening soon, as of the sponsor's last update on 14 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Amy Killeen, DDS, MS (4024727848, akilleen@unmc.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Amount of Interleukin-1 beta (IL1-B) in gingival crevicular at baseline (time frame: Baseline). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07796269, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Sep 2026.

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