Mental FatigueNCT07746557
The Effect of Brain Endurance Training on Motor Skill Learning in Adolescents With Mild Mental Fatigue
A study testing Motor Skill Learning in people with Mental Fatigue and Motor Skill Learning, run by Yunliang Zhang.
Trial summary
Objective: To investigate the effects of brain endurance training on improving motor skill learning in adolescents with mild mental fatigue. Methods: Fifty-eight adolescents experiencing mild mental fatigue were recruited. Read more about this study
- Who is it for?
- Ages 18 to 19 years, women only
- Conditions the study is for
- Mental Fatigue, Motor Skill Learning
- What is being tested?
- Motor Skill Learning
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 58 participants
- Where
- No sites listed yet
- Study dates
- 2 Aug 2026to 19 Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 19 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Participants assessed as having mild mental fatigue using the Mental Fatigue VAS scale
- No prior experience in learning specific motor skills
- In good physical health, with no history of central nervous system disorders, musculoskeletal injuries, or mental health conditions
Who cannot join
- Individuals with moderate to severe mental fatigue or no mental fatigue
- Individuals with moderate to severe mental fatigue or no mental fatigue
- Individuals with a history of traumatic brain injury, epilepsy, chronic headaches, ADHD, anxiety, or depression - Individuals who have sustained a musculoskeletal injury within the past month and are unable to complete standardized exercise routines
- Individuals taking medications that affect central nervous system function on a long-term basis, or who have consumed caffeine, energy drinks, or alcohol within 24 hours prior to the experiment - Individuals with persistent sleep disorders
- Individuals unable to cooperate in completing cognitive endurance training and motor skill tests.Individuals with a history of traumatic brain injury, epilepsy, chronic headaches, ADHD, anxiety, or depression
- Individuals who have sustained a musculoskeletal injury within the past month and are unable to complete standardized exercise routines
- Individuals taking medications that affect central nervous system function on a long-term basis, or who have consumed caffeine, energy drinks, or alcohol within 24 hours prior to the experiment
- Individuals with persistent sleep disorders - Individuals unable to cooperate in completing cognitive endurance training and motor skill tests.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Objective: To investigate the effects of brain endurance training on improving motor skill learning in adolescents with mild mental fatigue. Methods: Fifty-eight adolescents experiencing mild mental fatigue were recruited. A 6-week training program was conducted using a 2 (BET group, control group) × 2 (pre- and post-Stroop task) × 3 (0, 3, 6 weeks) mixed-design experimental design. Assessments included basketball free throws, the Visual Analog Scale (VAS-MF), the 3-minute Psychomotor Vigilance Test (PVT-B), the Borg Rating of Perceived Exertion (RPE) to assess performance before and after a 30-minute Stroop task.
- Conditions
- Mental Fatigue, Motor Skill Learning
- Being tested
- Motor Skill Learning
- Medical subject headings
- Mental Fatigue
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Motor Skill LearningBehavioural
During training, the BET group completed a 20-minute 2-back task [28], followed by a 5-minute break, after which they performed free-throw-related physical and technical training. The presentation timing and intervals of the 2-back task stimuli were adjusted every two weeks [18]. During testing, the BET group completed 20 free-throw trials and a 1-minute free-throw test [29] before and after the 30-minute Stroop task, and underwent PVT-B, VAS-MF, and RPE assessments.
Motor Skill LearningBehavioural
The BET group and the control group underwent physical and technical training related to free throws; the training content, intensity, and workload were identical for both groups. While the BET group performed cognitive tasks, the control group rested in place. During testing, the control group completed a 20-free-throw test and a 1-minute free-throw test [29] before and after the 30-minute Stroop task, and underwent PVT-B, VAS-MF, and RPE assessments.
| Study group | Role | What they receive |
|---|---|---|
| BET | Experimental | During training, the BET group completed a 20-minute 2-back task [28]; after a 5-minute break, they performed free-throw-related physical and technical training. The training content, intensity, and workload were identical for both groups, and the presentation timing and intervals of the 2-back task stimuli were adjusted every two weeks [18]. During testing, both the BET group and the control group completed 20 free-throw attempts and a 1-minute free-throw test [29] before and after the 30-minute Stroop task, and underwent PVT-B, VAS-MF, and RPE assessments. Receives: Behavioral: Motor Skill Learning |
| Control | Experimental | The BET group and the control group underwent the same physical and technical training related to free throws; the training content, intensity, and workload were identical for both groups. While the BET group performed cognitive tasks, the control group rested in place. The presentation timing and intervals of the 2-back task stimuli were adjusted every two weeks [18]. During testing, both the BET group and the control group completed 20 free-throw trials and a 1-minute free-throw test [29] before and after the 30-minute Stroop task, and underwent PVT-B, VAS-MF, and RPE assessments. Receives: Behavioral: Motor Skill Learning |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of Free Throws Made in Basketball
Measured: From enrollment through Week 3 and then Week 6
Number of Free Throws in 1 Minute
Measured: From enrollment through Week 3 and then Week 6
Free throws made in 1 minute
Measured: From enrollment through Week 3 and then Week 6
Secondary outcomes (3)
VAS-MF
The 10cm VAS-MF was used to assess the degree of mental fatigue. The scale consists of an unmarked horizontal line, with the left end (0 = not at all fatigued) and the right end (10 = completely fatigued) representing the lowest and highest states of this dimension, respectively. Participants are instructed by the examiner to draw a vertical line on the scale that reflects their immediate feelings. A quantitative score is derived by measuring the physical distance (0-10 cm) from the left end of the scale to the marked point.
Measured: From enrollment through Week 3 and then Week 6
RPE
The Borg Rate of Perceived Exertion (RPE) scale assesses perceived exertion (0-10); participants indicate their perceived exertion level using their fingers.
Measured: From enrollment through Week 3 and then Week 6
At the time of the reaction
All cognitive tasks were conducted using E-Prime 3.0 software. During the 3-minute PVT-B reaction time test, a visual stimulus lasting 1-8 seconds was first presented in the center of the computer screen; participants were instructed to press the "space" key as quickly as possible to respond, after which the screen went blank for 500 ms before proceeding to the next cycle.
Measured: From enrollment through Week 3 and then Week 6
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Aug 2026
- Study start2 Aug 2026 (estimated)
- Primary completion13 Sep 2026 (estimated)
- Study completion19 Sep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Mental FatigueStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 58 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Yunliang Zhang
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Yunliang Zhang, Tianjin University of Sport
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07746557
- Sponsor's protocol ID
- TJUS2025-134
- Status last verified
- Jul 2026
- First submitted
- 25 Jul 2026
- Last updated
- 5 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 5 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Brain Endurance Training on Motor Skill Learning in Adolescents With Mild Mental Fatigue
- ClinicalTrials.gov ID
- NCT07746557
- Acronym / sponsor ID
- TJUS2025-134
- Conditions
- Mental Fatigue, Motor Skill Learning
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 58 participants (estimated)
- Lead sponsor
- Yunliang ZhangUniversity, hospital or other
- Study start
- 2 Aug 2026 (estimated)
- Primary completion
- 13 Sep 2026 (estimated)
- Study completion
- 19 Sep 2026 (estimated)
- First posted
- 5 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Objective: To investigate the effects of brain endurance training on improving motor skill learning in adolescents with mild mental fatigue. Methods: Fifty-eight adolescents experiencing mild mental fatigue were recruited. A 6-week training program was conducted using a 2 (BET group, control group) × 2 (pre- and post-Stroop task) × 3 (0, 3, 6 weeks) mixed-design experimental design. Assessments included basketball free throws, the Visual Analog Scale (VAS-MF), the 3-minute Psychomotor Vigilance Test (PVT-B), the Borg Rating of Perceived Exertion (RPE) to assess performance before and after a 30-minute Stroop task.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| BET | Experimental | Behavioral: Motor Skill LearningDuring training, the BET group completed a 20-minute 2-back task [28]; after a 5-minute break, they performed free-throw-related physical and technical training. The training content, intensity, and workload were identical for both groups, and the presentation timing and intervals of the 2-back task stimuli were adjusted every two weeks [18]. During testing, both the BET group and the control group completed 20 free-throw attempts and a 1-minute free-throw test [29] before and after the 30-minute Stroop task, and underwent PVT-B, VAS-MF, and RPE assessments. |
| Control | Experimental | Behavioral: Motor Skill LearningThe BET group and the control group underwent the same physical and technical training related to free throws; the training content, intensity, and workload were identical for both groups. While the BET group performed cognitive tasks, the control group rested in place. The presentation timing and intervals of the 2-back task stimuli were adjusted every two weeks [18]. During testing, both the BET group and the control group completed 20 free-throw trials and a 1-minute free-throw test [29] before and after the 30-minute Stroop task, and underwent PVT-B, VAS-MF, and RPE assessments. |
Who may qualify
- Ages
- 18 to 19 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Participants assessed as having mild mental fatigue using the Mental Fatigue VAS scale
- No prior experience in learning specific motor skills
- In good physical health, with no history of central nervous system disorders, musculoskeletal injuries, or mental health conditions
Key exclusion criteria (8 listed)
- Individuals with moderate to severe mental fatigue or no mental fatigue
- Individuals with moderate to severe mental fatigue or no mental fatigue
- Individuals with a history of traumatic brain injury, epilepsy, chronic headaches, ADHD, anxiety, or depression - Individuals who have sustained a musculoskeletal injury within the past month and are unable to complete standardized exercise routines
- Individuals taking medications that affect central nervous system function on a long-term basis, or who have consumed caffeine, energy drinks, or alcohol within 24 hours prior to the experiment - Individuals with persistent sleep disorders
- Individuals unable to cooperate in completing cognitive endurance training and motor skill tests.Individuals with a history of traumatic brain injury, epilepsy, chronic headaches, ADHD, anxiety, or depression
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Motor Skill LearningDuring training, the BET group completed a 20-minute 2-back task [28], followed by a 5-minute break, after which they performed free-throw-related physical and technical training. The presentation timing and intervals of the 2-back task stimuli were adjusted every two weeks [18]. During testing, the BET group completed 20 free-throw trials and a 1-minute free-throw test [29] before and after the 30-minute Stroop task, and underwent PVT-B, VAS-MF, and RPE assessments. | Behavioural | BET |
| Motor Skill LearningThe BET group and the control group underwent physical and technical training related to free throws; the training content, intensity, and workload were identical for both groups. While the BET group performed cognitive tasks, the control group rested in place. During testing, the control group completed a 20-free-throw test and a 1-minute free-throw test [29] before and after the 30-minute Stroop task, and underwent PVT-B, VAS-MF, and RPE assessments. | Behavioural | Control |
Primary outcome
Number of Free Throws Made in Basketball
Time frame: From enrollment through Week 3 and then Week 6
Number of Free Throws in 1 Minute
Time frame: From enrollment through Week 3 and then Week 6
Free throws made in 1 minute
Time frame: From enrollment through Week 3 and then Week 6
3 secondary outcomes
VAS-MF
Time frame: From enrollment through Week 3 and then Week 6
RPE
Time frame: From enrollment through Week 3 and then Week 6
At the time of the reaction
Time frame: From enrollment through Week 3 and then Week 6
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Aug 2026.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Motor Skill Learning in people with Mental Fatigue and Motor Skill Learning, run by Yunliang Zhang.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 5 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yunliang ZHANG (+8613920900801, yunliangzhang@126.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of Free Throws Made in Basketball (time frame: From enrollment through Week 3 and then Week 6). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Aug 2026; AzTrials last refreshed its copy on 6 Nov 2026.