DepressionNCT07741422
Investigating a Mediation Model of Emotion Regulation and Psychological Resilience in Relationship Between Mindfulness and Negative Emotions Among College Students in Guangzhou
A study testing Mindfulness-Based Intervention and Health Education in people with Depression and Anxiety, run by Universiti Sains Malaysia at 1 site in China.
Trial summary
This study examines whether a four-week mindfulness-based intervention can reduce depression, anxiety, and stress among college students in Guangzhou, China. It also investigates whether changes in mindfulness, emotion regulation, and psychological resilience may help explain the effects of the intervention. Read more about this study
- Who is it for?
- Ages 18 to 30 years
- Conditions the study is for
- Depression, Anxiety, Stress
- What is being tested?
- Mindfulness-Based Intervention and Health Education
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 135 participants
- Where
- 1 siteChina
- Study dates
- 1 Apr 2026to 20 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- - Full-time college students enrolled at a participating institution in Guangzhou, China.
- Aged 18 to 30 years.
- Able to read and understand Chinese.
- Willing to provide informed consent.
- Completed the initial questionnaire assessment.
- Reported at least mild symptoms of depression, anxiety, or stress on at least one subscale of the Depression Anxiety Stress Scales-21.
- Willing and able to participate in the four-week intervention and complete the required assessm
Who cannot join
- - Currently receiving psychiatric or psychological treatment.
- Diagnosed with a severe mental disorder or other severe psychopathology that could interfere with participation.
- At acute risk of suicide or self-harm.
- Currently participating in another psychological or mental health intervention.
- Currently engaging in regular mindfulness meditation or enrolled in another mindfulness-based program.
- Pregnant.
- Having a physical or medical condition that prevents participation in the intervention activities.
- Unable to complete the intervention or study assessments.
Trial locations and contacts
1 site in 1 country.
About this study
This study examines whether a four-week mindfulness-based intervention can reduce depression, anxiety, and stress among college students in Guangzhou, China. It also investigates whether changes in mindfulness, emotion regulation, and psychological resilience may help explain the effects of the intervention.
Eligible participants will be randomly assigned to either a mindfulness intervention group or a health education control group. The intervention group will receive weekly mindfulness-based training and complete brief daily mindfulness practice, while the control group will receive health education sessions. Participants will complete questionnaires assessing mindfulness, cognitive reappraisal, expressive suppression, psychological resilience, depression, anxiety, and stress before and after the intervention and at follow-up.
- Conditions
- Depression, Anxiety, Stress
- Being tested
- Mindfulness-Based Intervention, Health Education
- Keywords
- Mindfulness, Mindfulness-Based Intervention, Emotion Regulation, Cognitive Reappraisal, Expressive Suppression, Psychological Resilience, College Students, Negative Emotions
- Medical subject headings
- Depression, Anxiety Disorders, Emotional Regulation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mindfulness-Based InterventionBehavioural
Participants received a four-week mindfulness-based intervention consisting of one 90-minute group session per week and approximately 10 minutes of daily home practice. The program included mindful breathing, body scan practice, mindful movement, awareness of thoughts and emotions, and exercises for responding to stress. The intervention was adapted from mindfulness-based stress reduction principles for college students.
Health EducationBehavioural
Participants received a four-week health education program consisting of one group session per week. The sessions addressed general stress management, emotional well-being, healthy lifestyle practices, and other health-related topics. The program did not include mindfulness meditation or formal mindfulness practice.
| Study group | Role | What they receive |
|---|---|---|
| Mindfulness-Based Intervention | Experimental | Participants in this arm will receive a four-week mindfulness-based intervention. The program includes weekly group sessions and brief daily home practice focusing on mindful breathing, body awareness, mindful movement, and awareness of thoughts and emotions. Receives: Behavioral: Mindfulness-Based Intervention |
| Health Education Control Group | Active comparator | Participants in this arm will receive health education sessions of comparable frequency and duration, focusing on stress management, emotional well-being, and healthy lifestyle practices. Receives: Behavioral: Health Education |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Depression, Anxiety, and Stress Symptoms Assessed by the Depression Anxiety Stress Scales-21
Depression, anxiety, and stress symptoms will be assessed using the 21-item Depression Anxiety Stress Scales (DASS-21). The scale contains three 7-item subscales measuring depression, anxiety, and stress. Each item is rated from 0 to 3. Subscale scores are summed and multiplied by two, with higher scores indicating greater symptom severity.
Measured: Baseline and immediately after the 4-week intervention
Secondary outcomes (4)
Change in Mindfulness Assessed by the 15-Item Five Facet Mindfulness Questionnaire
Mindfulness will be assessed using the 15-item Five Facet Mindfulness Questionnaire (FFMQ-15). Items are rated on a Likert-type scale and summed to produce a total score, with higher scores indicating a higher level of mindfulness.
Measured: Baseline and immediately after the 4-week intervention
Change in Cognitive Reappraisal Assessed by the Emotion Regulation Questionnaire
Cognitive reappraisal will be assessed using the 6-item cognitive reappraisal subscale of the Emotion Regulation Questionnaire. Items are rated from 1 to 7 and summed, with higher scores indicating greater use of cognitive reappraisal.
Measured: Baseline and immediately after the 4-week intervention
Change in Expressive Suppression Assessed by the Emotion Regulation Questionnaire
Expressive suppression will be assessed using the 4-item expressive suppression subscale of the Emotion Regulation Questionnaire. Items are rated from 1 to 7 and summed, with higher scores indicating greater use of expressive suppression.
Measured: Baseline and immediately after the 4-week intervention
Change in Psychological Resilience Assessed by the Connor-Davidson Resilience Scale
Psychological resilience will be assessed using the Connor-Davidson Resilience Scale. Item scores are summed to produce a total score, with higher scores indicating greater psychological resilience.
Measured: Baseline and immediately after the 4-week intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Aug 2026
- Study start1 Apr 2026
- Primary completion20 Apr 2026
- Study completion20 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for DepressionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 135 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universiti Sains Malaysia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Wang Donglin, Universiti Sains Malaysia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07741422
- Sponsor's protocol ID
- USM/JEPeM/KK/25090763
- Status last verified
- Jan 2026
- First submitted
- 27 Jul 2026
- Last updated
- 3 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared publicly because the consent obtained from participants did not specifically include public or external sharing of individual-level data. Only aggregated and de-identified study findings will be reported in publications and academic presentations.
Study at a glance
From the registry record, last updated by the sponsor on 3 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigating a Mediation Model of Emotion Regulation and Psychological Resilience in Relationship Between Mindfulness and Negative Emotions Among College Students in Guangzhou
- ClinicalTrials.gov ID
- NCT07741422
- Acronym / sponsor ID
- USM/JEPeM/KK/25090763
- Conditions
- Depression, Anxiety, Stress
- Keywords
- Mindfulness, Mindfulness-Based Intervention, Emotion Regulation, Cognitive Reappraisal, Expressive Suppression, Psychological Resilience, College Students, Negative Emotions
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 135 participants (actual)
- Lead sponsor
- Universiti Sains MalaysiaUniversity, hospital or other
- Study start
- 1 Apr 2026 (actual)
- Primary completion
- 20 Apr 2026 (actual)
- Study completion
- 20 May 2026 (actual)
- First posted
- 3 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study examines whether a four-week mindfulness-based intervention can reduce depression, anxiety, and stress among college students in Guangzhou, China. It also investigates whether changes in mindfulness, emotion regulation, and psychological resilience may help explain the effects of the intervention.
Eligible participants will be randomly assigned to either a mindfulness intervention group or a health education control group. The intervention group will receive weekly mindfulness-based training and complete brief daily mindfulness practice, while the control group will receive health education sessions. Participants will complete questionnaires assessing mindfulness, cognitive reappraisal, expressive suppression, psychological resilience, depression, anxiety, and stress before and after the intervention and at follow-up.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Mindfulness-Based Intervention | Experimental | Behavioral: Mindfulness-Based InterventionParticipants in this arm will receive a four-week mindfulness-based intervention. The program includes weekly group sessions and brief daily home practice focusing on mindful breathing, body awareness, mindful movement, and awareness of thoughts and emotions. |
| Health Education Control Group | Active comparator | Behavioral: Health EducationParticipants in this arm will receive health education sessions of comparable frequency and duration, focusing on stress management, emotional well-being, and healthy lifestyle practices. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- - Full-time college students enrolled at a participating institution in Guangzhou, China.
- Aged 18 to 30 years.
- Able to read and understand Chinese.
- Willing to provide informed consent.
- Completed the initial questionnaire assessment.
Key exclusion criteria (8 listed)
- - Currently receiving psychiatric or psychological treatment.
- Diagnosed with a severe mental disorder or other severe psychopathology that could interfere with participation.
- At acute risk of suicide or self-harm.
- Currently participating in another psychological or mental health intervention.
- Currently engaging in regular mindfulness meditation or enrolled in another mindfulness-based program.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mindfulness-Based InterventionParticipants received a four-week mindfulness-based intervention consisting of one 90-minute group session per week and approximately 10 minutes of daily home practice. The program included mindful breathing, body scan practice, mindful movement, awareness of thoughts and emotions, and exercises for responding to stress. The intervention was adapted from mindfulness-based stress reduction principles for college students. | Behavioural | Mindfulness-Based Intervention |
| Health EducationParticipants received a four-week health education program consisting of one group session per week. The sessions addressed general stress management, emotional well-being, healthy lifestyle practices, and other health-related topics. The program did not include mindfulness meditation or formal mindfulness practice. | Behavioural | Health Education Control Group |
Primary outcome
Change in Depression, Anxiety, and Stress Symptoms Assessed by the Depression Anxiety Stress Scales-21
Time frame: Baseline and immediately after the 4-week intervention
Depression, anxiety, and stress symptoms will be assessed using the 21-item Depression Anxiety Stress Scales (DASS-21). The scale contains three 7-item subscales measuring depression, anxiety, and stress. Each item is rated from 0 to 3. Subscale scores are summed and multiplied by two, with higher scores indicating greater symptom severity.
4 secondary outcomes
Change in Mindfulness Assessed by the 15-Item Five Facet Mindfulness Questionnaire
Time frame: Baseline and immediately after the 4-week intervention
Change in Cognitive Reappraisal Assessed by the Emotion Regulation Questionnaire
Time frame: Baseline and immediately after the 4-week intervention
Change in Expressive Suppression Assessed by the Emotion Regulation Questionnaire
Time frame: Baseline and immediately after the 4-week intervention
Change in Psychological Resilience Assessed by the Connor-Davidson Resilience Scale
Time frame: Baseline and immediately after the 4-week intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Aug 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared publicly because the consent obtained from participants did not specifically include public or external sharing of individual-level data. Only aggregated and de-identified study findings will be reported in publications and academic presentations.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mindfulness-Based Intervention and Health Education in people with Depression and Anxiety, run by Universiti Sains Malaysia at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Depression, Anxiety, and Stress Symptoms Assessed by the Depression Anxiety Stress Scales-21 (time frame: Baseline and immediately after the 4-week intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Aug 2026.