Facial AgingNCT07737639
Evaluating Facial Skin Quality Changes Post-Lipofilling
An observational study of Facial Aging, run by L'Oreal at 1 site in France.
Trial summary
The goal of this prospective observational study is to evaluate changes in facial skin quality and identify predictive biological markers in donor adipose tissue in healthy women undergoing autologous facial fat transfer. Read more about this study
- Who is it for?
- Ages 30 years and older, women onlyHealthy volunteers can take part
- Conditions the study is for
- Facial Aging
- How many people
- 15 participants
- Where
- 1 siteFrance
- Study dates
- 10 Jan 2021to 10 Sep 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 years and older
- Women only
- Healthy volunteers accepted
- Adult, Older adult
Study population: The study population consists of individuals seeking aesthetic facial rejuvenation at the Hospices Civils de Lyon (HCL) in Lyon, France. Participants are recruited directly from the standard clinical practice of the principal investigator. A defining characteristic of this cohort is that all individuals have independently elected, and are already scheduled, to undergo an autologous facial fat transfer (lipofilling) procedure for anti-aging purposes prior to and independent of study enrollment. The study observes the outcomes of this pre-planned surgical intervention, with subsequent clinical and instrumental follow-up evaluations.
Who may be able to join
- Female patient volunteers
- Over the age of 30
- Who had decided to have adipose tissue injections and declared eligible to this intervention
- Nonsmoker or less than 5 cigarettes per day
- Informed about the study objectives and procedures, and able to understand them
- Willing and able to fulfil the study requirements and schedule
- Able to give their written informed consent
- French subjects recruited must be affiliated to the French social security system.
Who cannot join
- Having participated within the 30 days before inclusion or currently participating in another clinical study.
- Females in pregnancy or nursing
- Dermatological disorder affecting the investigational areas (like severe acne, rosacea eczema, atopy, psoriasis, seborrheic dermatitis) that may interfere with the study conduct or the study results in the opinion of the Investigator,
- History of skin cancer or auto-immune disease,
- History of allergy, hypersensitivity, or any serious reaction to any medicinal or cosmetic product,
- Any concomitant medical condition that may interfere with the study conduct in the opinion of the investigator (diabetes, HIV+, hepatitis B and C…)
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- Surgical procedure to the face (face lift)
- Cosmetic procedures: filler injection, botulinum toxin injection, laser to the face within the past 4 months
- Actual or past use of systemic or topic drugs, that would interfere with assessment and/or investigational treatments and affect study results in the opinion of the investigator
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A MONOCENTER, OPEN STUDY TO ASSESS THE CHANGES INDUCED BY A LIPOFILLING PROCEDURE ON FACIAL SKIN QUALITY AND AGEING SIGNS IN WOMEN
The goal of this prospective observational study is to evaluate changes in facial skin quality and identify predictive biological markers in donor adipose tissue in healthy women undergoing autologous facial fat transfer. The main questions it aims to answer are:
How does full-face lipofilling alter clinical signs of aging, such as wrinkles, sagging, and skin texture, over a 6-month period? Which baseline biological characteristics (e.g., cellular stemness, extracellular matrix remodeling, angiogenesis) within the donor fat graft predict these clinical skin quality outcomes?
Read more
Participants will:
Undergo a standard full-face autologous fat transfer (lipofilling) procedure. Attend follow-up evaluation visits at 1.5, 3, and 6 months post-procedure. Undergo non-invasive clinical and instrumental skin assessments (e.g., standardized photography, 3D topography, echography, and cutometry).
Complete self-assessment questionnaires regarding perceived skin changes and overall satisfaction with the procedure.
- Conditions
- Facial Aging
- Keywords
- autologous fat grafting, lipofilling, facial rejuvenation, adipose-derived stem cells, skin quality
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Autologous Facial Fat Grafting | This cohort consists of healthy female volunteers, aged 30 and older, who have independently elected and scheduled to undergo a full-face autologous fat transfer (lipofilling) procedure for facial rejuvenation. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Wrinkles and Fine Lines Severity
Assessed by a trained expert using dynamic scales and photonumeric atlas books. This category evaluates the severity of crow's feet (grade 0-6), underneath eye wrinkles (grade 0-5), forehead wrinkles (grade 0-5), upper lip wrinkles (grade 0-6), nasolabial folds (grade 0-5), and cheek folds (grade 0-8). For all scales, a lower grade indicates less severe wrinkles (clinical improvement).
Measured: Baseline up to 6 months post-procedure
Change in Skin Pigmentation and Color Uniformity
This category includes assessments of lateral and malar pigmentation (6-point scale), dark circles (grade 0-8), full face dyschromia/skin tone heterogeneity (6-point scale), and cheek erythrosis/redness (6-point scale). Lower grades indicate reduced pigmentation and more uniform skin tone (clinical improvement).
Measured: Baseline up to 6 months post-procedure
Change in Skin Elasticity, Sagging, and Structural Aging Signs
Assessed clinically and via standardized photographs to evaluate structural skin changes. This includes grading of sagging/lower facial ptosis (grade 0-5), eye bags (grade 0-7), clinical skin elasticity on the cheek (6-point scale), and full face elastosis (6-point scale). Lower grades indicate less sagging and elastosis (clinical improvement).
Measured: Baseline up to 6 months post-procedure
Change in Skin Texture and Surface Quality
This comprehensive category encompasses full face brightness (6-point scale, where higher is better), pore visibility (grade 0-7), water mobility (grade 0-10), papyraceus/papery aspect of the cheek (6-point scale), and skin surface parameters including oiliness, shininess, dryness, and roughness (4-point scales). With the exception of brightness, lower grades generally indicate smoother, improved skin texture.
Measured: Baseline up to 6 months post-procedure
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Jul 2026
- Study start10 Jan 2021
- Primary completion10 Nov 2023
- Study completion10 Sep 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Facial AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 15 participants (actual)
Sponsor and investigators
- Lead sponsor
- L'Oreal
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Hospices Civils de Lyon
- Responsible party
- Sponsor
- Investigators
- Stephanie Nouveau, Study director, L'Oreal
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07737639
- Sponsor's protocol ID
- ACR_MORE_17-06664
- Status last verified
- Jul 2026
- First submitted
- 27 Jul 2026
- Last updated
- 30 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 30 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A MONOCENTER, OPEN STUDY TO ASSESS THE CHANGES INDUCED BY A LIPOFILLING PROCEDURE ON FACIAL SKIN QUALITY AND AGEING SIGNS IN WOMEN
- ClinicalTrials.gov ID
- NCT07737639
- Acronym / sponsor ID
- ACR_MORE_17-06664
- Conditions
- Facial Aging
- Keywords
- autologous fat grafting, lipofilling, facial rejuvenation, adipose-derived stem cells, skin quality
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 15 participants (actual)
- Lead sponsor
- L'OrealIndustry (pharma, biotech, devices)
- Collaborators
- Hospices Civils de Lyon
- Study start
- 10 Jan 2021 (actual)
- Primary completion
- 10 Nov 2023 (actual)
- Study completion
- 10 Sep 2024 (actual)
- First posted
- 30 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this prospective observational study is to evaluate changes in facial skin quality and identify predictive biological markers in donor adipose tissue in healthy women undergoing autologous facial fat transfer. The main questions it aims to answer are:
How does full-face lipofilling alter clinical signs of aging, such as wrinkles, sagging, and skin texture, over a 6-month period? Which baseline biological characteristics (e.g., cellular stemness, extracellular matrix remodeling, angiogenesis) within the donor fat graft predict these clinical skin quality outcomes?
Participants will:
Undergo a standard full-face autologous fat transfer (lipofilling) procedure. Attend follow-up evaluation visits at 1.5, 3, and 6 months post-procedure. Undergo non-invasive clinical and instrumental skin assessments (e.g., standardized photography, 3D topography, echography, and cutometry).
Complete self-assessment questionnaires regarding perceived skin changes and overall satisfaction with the procedure.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Autologous Facial Fat Grafting | – | –This cohort consists of healthy female volunteers, aged 30 and older, who have independently elected and scheduled to undergo a full-face autologous fat transfer (lipofilling) procedure for facial rejuvenation. |
Who may qualify
- Ages
- 30 years and older
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of individuals seeking aesthetic facial rejuvenation at the Hospices Civils de Lyon (HCL) in Lyon, France. Participants are recruited directly from the standard clinical practice of the principal investigator. A defining characteristic of this cohort is that all individuals have independently elected, and are already scheduled, to undergo an autologous facial fat transfer (lipofilling) procedure for anti-aging purposes prior to and independent of study enrollment. The study observes the outcomes of this pre-planned surgical intervention, with subsequent clinical and instrumental follow-up evaluations.
Key inclusion criteria (8 listed)
- Female patient volunteers
- Over the age of 30
- Who had decided to have adipose tissue injections and declared eligible to this intervention
- Nonsmoker or less than 5 cigarettes per day
- Informed about the study objectives and procedures, and able to understand them
Key exclusion criteria (9 listed)
- Having participated within the 30 days before inclusion or currently participating in another clinical study.
- Females in pregnancy or nursing
- Dermatological disorder affecting the investigational areas (like severe acne, rosacea eczema, atopy, psoriasis, seborrheic dermatitis) that may interfere with the study conduct or the study results in the opinion of the Investigator,
- History of skin cancer or auto-immune disease,
- History of allergy, hypersensitivity, or any serious reaction to any medicinal or cosmetic product,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Change in Wrinkles and Fine Lines Severity
Time frame: Baseline up to 6 months post-procedure
Assessed by a trained expert using dynamic scales and photonumeric atlas books. This category evaluates the severity of crow's feet (grade 0-6), underneath eye wrinkles (grade 0-5), forehead wrinkles (grade 0-5), upper lip wrinkles (grade 0-6), nasolabial folds (grade 0-5), and cheek folds (grade 0-8). For all scales, a lower grade indicates less severe wrinkles (clinical improvement).
Change in Skin Pigmentation and Color Uniformity
Time frame: Baseline up to 6 months post-procedure
This category includes assessments of lateral and malar pigmentation (6-point scale), dark circles (grade 0-8), full face dyschromia/skin tone heterogeneity (6-point scale), and cheek erythrosis/redness (6-point scale). Lower grades indicate reduced pigmentation and more uniform skin tone (clinical improvement).
Change in Skin Elasticity, Sagging, and Structural Aging Signs
Time frame: Baseline up to 6 months post-procedure
Assessed clinically and via standardized photographs to evaluate structural skin changes. This includes grading of sagging/lower facial ptosis (grade 0-5), eye bags (grade 0-7), clinical skin elasticity on the cheek (6-point scale), and full face elastosis (6-point scale). Lower grades indicate less sagging and elastosis (clinical improvement).
Change in Skin Texture and Surface Quality
Time frame: Baseline up to 6 months post-procedure
This comprehensive category encompasses full face brightness (6-point scale, where higher is better), pore visibility (grade 0-7), water mobility (grade 0-10), papyraceus/papery aspect of the cheek (6-point scale), and skin surface parameters including oiliness, shininess, dryness, and roughness (4-point scales). With the exception of brightness, lower grades generally indicate smoother, improved skin texture.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jul 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Stephanie Nouveau study director
L'Oreal
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Facial Aging, run by L'Oreal at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Wrinkles and Fine Lines Severity (time frame: Baseline up to 6 months post-procedure). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jul 2026.