Anterior Cruciate Ligament InjuriesACL-AnalgesiaNCT07702552
Postoperative Analgesic Efficacy of ACB+iPACK vs FTB+Selective Tibial+Obturator Blocks in ACL Reconstruction
A study testing Ultrasound-guided Adductor Canal Block (ACB), Ultrasound-guided iPACK block and Ultrasound-guided Femoral Triangle Block (FTB) in people with Anterior Cruciate Ligament Injuries and Postoperative Pain, run by Da Nang Hospital.
Trial summary
This prospective, comparative study aims to evaluate the postoperative analgesic efficacy of ultrasound-guided Adductor Canal Block (ACB) combined with iPACK block versus Femoral Triangle Block (FTB) combined with selective tibial nerve block and obturator nerve block in patients undergoing arthroscopic anterior… Read more about this study
- Who is it for?
- Ages 16 years and older
- Conditions the study is for
- Anterior Cruciate Ligament Injuries, Postoperative Pain
- What is being tested?
- Ultrasound-guided Adductor Canal Block (ACB), Ultrasound-guided iPACK block and Ultrasound-guided Femoral Triangle Block (FTB)
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- No sites listed yet
- Study dates
- Jul 2026to Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Age 16 years and older
- Patients undergoing elective arthroscopic anterior cruciate ligament (ACL) reconstruction
- ASA physical status I-II
- Indicated for spinal anesthesia
- Provided informed consent
Who cannot join
- Infection at the injection site
- Spinal cord or lower limb nerve injury
- Contraindications to regional anesthesia (Levobupivacaine)
- Known allergy to Paracetamol or Diclofenac
- Coagulopathy
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
Trong Nhan Phan contact
About this study
Official title: Evaluation of Postoperative Analgesic Efficacy in Anterior Cruciate Ligament Reconstruction: Ultrasound-Guided Adductor Canal Block Combined With iPACK Block Versus Femoral Triangle Block Combined With Selective Tibial and Obturator Nerve Blocks at Da Nang Hospital
This prospective, comparative study aims to evaluate the postoperative analgesic efficacy of ultrasound-guided Adductor Canal Block (ACB) combined with iPACK block versus Femoral Triangle Block (FTB) combined with selective tibial nerve block and obturator nerve block in patients undergoing arthroscopic anterior cruciate ligament (ACL) reconstruction. The primary objective is to determine which regional anesthesia regimen provides superior pain relief at rest and during movement. The secondary objectives include assessing morphine consumption, motor blockade using the Bromage score, patient satisfaction, and potential adverse effects of these anesthesia techniques.
- Being tested
- Ultrasound-guided Adductor Canal Block (ACB), Ultrasound-guided iPACK block, Ultrasound-guided Femoral Triangle Block (FTB), Ultrasound-guided Selective Tibial Nerve Block, Ultrasound-guided Obturator Nerve Block
- Keywords
- Adductor Canal Block, iPACK Block, Femoral Triangle Block, Knee Arthroscopy
- Medical subject headings
- Anterior Cruciate Ligament Injuries, Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ultrasound-guided Adductor Canal Block (ACB)Procedure or surgery
Ultrasound-guided administration of 10 mL levobupivacaine 0.2% into the adductor canal space to provide postoperative analgesia
Ultrasound-guided iPACK blockProcedure or surgery
Ultrasound-guided administration of 15 mL levobupivacaine 0.2% into the space between the popliteal artery and the posterior capsule of the knee to provide posterior knee analgesia.
Ultrasound-guided Femoral Triangle Block (FTB)Procedure or surgery
Ultrasound-guided administration of 10 mL levobupivacaine 0.2% at the distal apex of the femoral triangle to provide anterior and medial knee analgesia
Ultrasound-guided Selective Tibial Nerve BlockProcedure or surgery
Ultrasound-guided administration of 5 mL levobupivacaine 0.2% around the tibial nerve in the popliteal fossa
Ultrasound-guided Obturator Nerve BlockProcedure or surgery
Ultrasound-guided administration of 10 mL levobupivacaine 0.2% targeting the anterior and posterior branches of the obturator nerve within the fascial planes between the adductor muscles.
| Study group | Role | What they receive |
|---|---|---|
| ACB and iPACK Block Group | Experimental | Ultrasound-guided Adductor Canal Block (10ml levobupivacaine 0.2%) and iPACK block (15ml levobupivacaine 0.2%) combined with standard multimodal analgesia (Paracetamol + Diclofenac). Receives: Procedure: Ultrasound-guided Adductor Canal Block (ACB); Procedure: Ultrasound-guided iPACK block |
| FTB, Tibial and Obturator Blocks Group | Active comparator | Ultrasound-guided Femoral Triangle Block (10ml levobupivacaine 0.2%), selective Tibial Nerve Block (5ml levobupivacaine 0.2%), and Obturator Nerve Block (10ml levobupivacaine 0.2%) combined with standard multimodal analgesia Receives: Procedure: Ultrasound-guided Femoral Triangle Block (FTB); Procedure: Ultrasound-guided Selective Tibial Nerve Block; Procedure: Ultrasound-guided Obturator Nerve Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visual Analog Scale (VAS) for Pain at Rest and Movement
Evaluating pain scores using the Visual Analog Scale (VAS) at rest and during knee flexion at 0, 1, 3, 6, 9, 12, 18, and 24 hours postoperatively
Measured: Within the first 24 hours postoperatively
Secondary outcomes (3)
Total Rescue Morphine Consumption
Measured: Within the first 24 hours postoperatively
Motor Blockade Assessment using Bromage Score
Measured: Within the first 24 hours postoperatively
Patient Satisfaction Score
Measured: 24 hours postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2026
- Study startJul 2026 (estimated)
- Primary completionMar 2027 (estimated)
- Study completionMar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Anterior Cruciate Ligament InjuriesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Investigator
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Da Nang Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Nhan T Phan, MD. MSc, Principal investigator, Da Nang Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07702552
- Sponsor's protocol ID
- 2026.15.171
- Acronym
- ACL-Analgesia
- Status last verified
- Jul 2026
- First submitted
- 8 Jul 2026
- Last updated
- 14 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Bai S, Hu A, Li W, Chen Y, Li X, Song X, Liu D, Ba Y, Chen Q, Liu X, Li Y, Zhang H, Xie Y, Wang X. Comparing the analgesic effects of femoral triangle block and adductor canal block following total knee arthroplasty: a systematic review and meta-analysis. BMC Anesthesiol. 2025 Apr 23;25(1):202. doi: 10.1186/s12871-025-03073-3.
PubMed 40269716Jaeger P, Nielsen ZJ, Henningsen MH, Hilsted KL, Mathiesen O, Dahl JB. Adductor canal block versus femoral nerve block and quadriceps strength: a randomized, double-blind, placebo-controlled, crossover study in healthy volunteers. Anesthesiology. 2013 Feb;118(2):409-15. doi: 10.1097/ALN.0b013e318279fa0b.
PubMed 23241723Ghodki PS, Shalu PS, Sardesai SP. Ultrasound-guided adductor canal block versus femoral nerve block for arthroscopic anterior cruciate ligament repair under general anesthesia. J Anaesthesiol Clin Pharmacol. 2018 Apr-Jun;34(2):242-246. doi: 10.4103/joacp.JOACP_172_17.
PubMed 30104837
Study at a glance
From the registry record, last updated by the sponsor on 14 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Postoperative Analgesic Efficacy in Anterior Cruciate Ligament Reconstruction: Ultrasound-Guided Adductor Canal Block Combined With iPACK Block Versus Femoral Triangle Block Combined With Selective Tibial and Obturator Nerve Blocks at Da Nang Hospital
- ClinicalTrials.gov ID
- NCT07702552
- Acronym / sponsor ID
- ACL-Analgesia / 2026.15.171
- Keywords
- Adductor Canal Block, iPACK Block, Femoral Triangle Block, Knee Arthroscopy
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Da Nang HospitalUniversity, hospital or other
- Study start
- Jul 2026 (estimated)
- Primary completion
- Mar 2027 (estimated)
- Study completion
- Mar 2027 (estimated)
- First posted
- 14 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective, comparative study aims to evaluate the postoperative analgesic efficacy of ultrasound-guided Adductor Canal Block (ACB) combined with iPACK block versus Femoral Triangle Block (FTB) combined with selective tibial nerve block and obturator nerve block in patients undergoing arthroscopic anterior cruciate ligament (ACL) reconstruction. The primary objective is to determine which regional anesthesia regimen provides superior pain relief at rest and during movement. The secondary objectives include assessing morphine consumption, motor blockade using the Bromage score, patient satisfaction, and potential adverse effects of these anesthesia techniques.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ACB and iPACK Block Group | Experimental | Procedure: Ultrasound-guided Adductor Canal Block (ACB), Procedure: Ultrasound-guided iPACK blockUltrasound-guided Adductor Canal Block (10ml levobupivacaine 0.2%) and iPACK block (15ml levobupivacaine 0.2%) combined with standard multimodal analgesia (Paracetamol + Diclofenac). |
| FTB, Tibial and Obturator Blocks Group | Active comparator | Procedure: Ultrasound-guided Femoral Triangle Block (FTB), Procedure: Ultrasound-guided Selective Tibial Nerve Block, Procedure: Ultrasound-guided Obturator Nerve BlockUltrasound-guided Femoral Triangle Block (10ml levobupivacaine 0.2%), selective Tibial Nerve Block (5ml levobupivacaine 0.2%), and Obturator Nerve Block (10ml levobupivacaine 0.2%) combined with standard multimodal analgesia |
Who may qualify
- Ages
- 16 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (5 listed)
- Age 16 years and older
- Patients undergoing elective arthroscopic anterior cruciate ligament (ACL) reconstruction
- ASA physical status I-II
- Indicated for spinal anesthesia
- Provided informed consent
Key exclusion criteria (5 listed)
- Infection at the injection site
- Spinal cord or lower limb nerve injury
- Contraindications to regional anesthesia (Levobupivacaine)
- Known allergy to Paracetamol or Diclofenac
- Coagulopathy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ultrasound-guided Adductor Canal Block (ACB)Ultrasound-guided administration of 10 mL levobupivacaine 0.2% into the adductor canal space to provide postoperative analgesia | Procedure or surgery | ACB and iPACK Block Group |
| Ultrasound-guided iPACK blockUltrasound-guided administration of 15 mL levobupivacaine 0.2% into the space between the popliteal artery and the posterior capsule of the knee to provide posterior knee analgesia. | Procedure or surgery | ACB and iPACK Block Group |
| Ultrasound-guided Femoral Triangle Block (FTB)Ultrasound-guided administration of 10 mL levobupivacaine 0.2% at the distal apex of the femoral triangle to provide anterior and medial knee analgesia | Procedure or surgery | FTB, Tibial and Obturator Blocks Group |
| Ultrasound-guided Selective Tibial Nerve BlockUltrasound-guided administration of 5 mL levobupivacaine 0.2% around the tibial nerve in the popliteal fossa | Procedure or surgery | FTB, Tibial and Obturator Blocks Group |
| Ultrasound-guided Obturator Nerve BlockUltrasound-guided administration of 10 mL levobupivacaine 0.2% targeting the anterior and posterior branches of the obturator nerve within the fascial planes between the adductor muscles. | Procedure or surgery | FTB, Tibial and Obturator Blocks Group |
Primary outcome
Visual Analog Scale (VAS) for Pain at Rest and Movement
Time frame: Within the first 24 hours postoperatively
Evaluating pain scores using the Visual Analog Scale (VAS) at rest and during knee flexion at 0, 1, 3, 6, 9, 12, 18, and 24 hours postoperatively
3 secondary outcomes
Total Rescue Morphine Consumption
Time frame: Within the first 24 hours postoperatively
Motor Blockade Assessment using Bromage Score
Time frame: Within the first 24 hours postoperatively
Patient Satisfaction Score
Time frame: 24 hours postoperatively
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jul 2026.
- Results publication: PubMed 40269716Bai S, Hu A, Li W, Chen Y, Li X, Song X, Liu D, Ba Y, Chen Q, Liu X, Li Y, Zhang H, Xie Y, Wang X. Comparing the analgesic effects of femoral triangle block and adductor canal block following total knee arthroplasty: a systematic review and meta-analysis. BMC Anesthesiol. 2025 Apr 23;25(1):202. doi: 10.1186/s12871-025-03073-3.
- Results publication: PubMed 23241723Jaeger P, Nielsen ZJ, Henningsen MH, Hilsted KL, Mathiesen O, Dahl JB. Adductor canal block versus femoral nerve block and quadriceps strength: a randomized, double-blind, placebo-controlled, crossover study in healthy volunteers. Anesthesiology. 2013 Feb;118(2):409-15. doi: 10.1097/ALN.0b013e318279fa0b.
- Results publication: PubMed 30104837Ghodki PS, Shalu PS, Sardesai SP. Ultrasound-guided adductor canal block versus femoral nerve block for arthroscopic anterior cruciate ligament repair under general anesthesia. J Anaesthesiol Clin Pharmacol. 2018 Apr-Jun;34(2):242-246. doi: 10.4103/joacp.JOACP_172_17.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Trong Nhan Phan contact
Nhan T Phan, MD. MSc principal investigator
Da Nang Hospital
Questions about this trial
What is this clinical trial studying?
A study testing Ultrasound-guided Adductor Canal Block (ACB), Ultrasound-guided iPACK block and Ultrasound-guided Femoral Triangle Block (FTB) in people with Anterior Cruciate Ligament Injuries and Postoperative Pain, run by Da Nang Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 14 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Nhan Trong Phan, MD. MSc (+84856271294, dr.phantrongnhan@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visual Analog Scale (VAS) for Pain at Rest and Movement (time frame: Within the first 24 hours postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07702552, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jul 2026.