Anterior Cruciate Ligament InjuriesNCT07681193
Effects of Whole Body Vibration on Quadriceps Function, Landing Biomechanics, and Performance in Individuals With ACL Reconstruction
A study testing Whole body vibration (WBV) in people with Anterior Cruciate Ligament Injuries and Anterior Cruciate Ligament Tear, run by University of North Carolina, Chapel Hill at 1 site in United States.
Trial summary
Individuals who undergo anterior cruciate ligament reconstruction (ACLR) are at heightened risk of secondary anterior cruciate ligament (ACL) injury (e.g. additional injury to the ACL in either knee). One of the primary physiological consequences of ACLR is the presence of quadriceps dysfunction (i.e. Read more about this study
- Who is it for?
- Ages 18 to 35 years
- Conditions the study is for
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear, ACL Injury
- What is being tested?
- Whole body vibration (WBV)
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 36 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Sep 2021to 10 May 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Between the ages of 18-35
- History of primary, unilateral ACLR
- Medically cleared for unrestricted physical activity
Who cannot join
- More than 5 years removed from ACLR
- Currently pregnant
- History of other lower extremity surgery
- History of lower extremity injury in previous 6 months
- History of neurological disorder
- Maximal isometric quadriceps torque > 3.0 Nm/kg in the ACLR limb
Trial locations and contacts
1 site in 1 country.
United States1 site
Univesrity of North Carolina at Chapel HIll MOTION Science Institute
Chapel Hill, North Carolina, 27599
About this study
Official title: Use of Whole-body Vibration to Acutely Improve Landing Biomechanics In Individuals With Anterior Cruciate Ligament Reconstruction (ACLR)
Individuals who undergo anterior cruciate ligament reconstruction (ACLR) are at heightened risk of secondary anterior cruciate ligament (ACL) injury (e.g. additional injury to the ACL in either knee). One of the primary physiological consequences of ACLR is the presence of quadriceps dysfunction (i.e. reduced activation and strength) which has been linked to altered gait and landing biomechanics. Aberrant landing biomechanics have been associated with an increased risk of both primary and secondary ACL injury, thus additional research is needed to evaluate the efficacy of treatments aimed to reduce quadriceps dysfunction and restore adequate landing biomechanics in attempts to reduce secondary ACL injury. Whole-body Vibration (WBV) has demonstrated success in improving quadriceps function and gait biomechanics in individuals with ACLR, however its effectiveness on landing biomechanics is unknown. To evaluate the acute effects of WBV on landing biomechanics in those with ACLR, a non-randomized crossover-controlled trial was conducted to determine if a single bout of WBV improved landing biomechanics greater than a control condition. Participants completed two separate testing sessions (separated by at least one week) in which measures of quadriceps function and landing biomechanics were assessed before and after either a control (no WBV) or WBV intervention. Separate linear mixed-effects models of post-test values for each dependent outcome were conducted with condition (control vs WBV) and limb (ACLR vs Uninvolved) as an interaction term, and each condition pre-test values and time post-ACLR as fixed effect covariates and a random effect of subject. The investigators expect to observe a significant improvement in landing biomechanics following WBV compared to the control condition.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear, ACL Injury, ACL Tear, Biomechanical Phenomena
- Being tested
- Whole body vibration (WBV), Sham Whole body vibration
- Keywords
- vibration, quadriceps, secondary injury, ACL reconstruction, Landing biomechanics
- Medical subject headings
- Anterior Cruciate Ligament Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Whole body vibration (WBV)Other
Participants will stand on a WBV platform in a mini-squat position while vibration is applied during six 60-second bouts with 2 minutes of rest between each bout. WBV will be delivered at an acceleration of 2g and a frequency of 30 Hz.
Sham Whole body vibrationOther
Participants will stand on a WBV platform in a mini-squat position during six 60-second bouts with 2 minutes of rest between each bout. No vibration will be applied.
| Study group | Role | What they receive |
|---|---|---|
| Whole body vibration followed by No Intervention (Control) | Experimental | Participants in this arm will receive Whole Body Vibration followed by a washout period of 1 week, then receive the Sham Whole body vibration (Control). Each condition will be evaluated in a single session (i.e. acute effects). Receives: Other: Whole body vibration (WBV); Other: Sham Whole body vibration |
| Sham Whole body vibration (Control) followed by Whole Body Vibration | Experimental | Participants in this arm will receive Sham Whole body vibration (Control) followed by a washout period of 1 week, then receive Whole Body Vibration. Each condition will be evaluated in a single session (i.e. acute effects). Receives: Other: Whole body vibration (WBV); Other: Sham Whole body vibration |
What is being measured
The primary outcome is the main question the study is designed to answer.
Internal Knee Adduction Moment (KAM)
Peak value during landing in both single-leg and double-leg tasks averaged over 3 trials and normalized to the product of body weight and height
Measured: Separate values prior to and immediately following the intervention (within 5 minutes).
Internal Knee Extension Moment (KEM)
Peak value during landing in both single-leg and double-leg tasks averaged over 3 trials and normalized to a product of body weight*height
Measured: Separate values prior to and immediately following the intervention (within 5 minutes).
Knee Flexion Angle (KFA)
Peak value during landing in both single-leg and double-leg tasks averaged over 3 trials
Measured: Separate values prior to and immediately following the intervention (within 5 minutes).
Secondary outcomes (3)
Dynamic Postural Control
Time-to-stabilization during single-leg landing
Measured: Separate values prior to and immediately following the intervention (within 5 minutes).
Vertical Ground Reaction Force
Peak value during landing in both single-leg and double-leg tasks
Measured: Separate values prior to and immediately following the intervention (within 5 minutes).
Frontal Plane Kinematics
Peak value during landing in both single-leg and double-leg tasks
Measured: Separate values prior to and immediately following the intervention (within 5 minutes).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Jul 2026
- Study start1 Sep 2021
- Primary completion22 Apr 2022
- Study completion10 May 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Anterior Cruciate Ligament InjuriesStudies of the same condition, open and under way.
- More trials run by University of North Carolina, Chapel HillThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of North Carolina, Chapel Hill
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Derek Dewig, Principal investigator, University of North Carolina, Chapel Hill
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07681193
- Sponsor's protocol ID
- 21-0305
- Status last verified
- Jun 2026
- First submitted
- 10 Jun 2026
- Last updated
- 2 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Deidentified individual data that supports the results will be shared beginning 9 and continuing for 36 months following publication provided the investigator who proposes to use the data has approval from an Institutional Review Board (IRB), Independent Ethics Committee (IEC), or Research Ethics Board (REB), as applicable, and executes a data use/sharing agreement with UNC.
Study at a glance
From the registry record, last updated by the sponsor on 2 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Use of Whole-body Vibration to Acutely Improve Landing Biomechanics In Individuals With Anterior Cruciate Ligament Reconstruction (ACLR)
- ClinicalTrials.gov ID
- NCT07681193
- Acronym / sponsor ID
- 21-0305
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear, ACL Injury, ACL Tear, Biomechanical Phenomena
- Keywords
- vibration, quadriceps, secondary injury, ACL reconstruction, Landing biomechanics
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- University of North Carolina, Chapel HillUniversity, hospital or other
- Study start
- 1 Sep 2021 (actual)
- Primary completion
- 22 Apr 2022 (actual)
- Study completion
- 10 May 2022 (actual)
- First posted
- 2 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Individuals who undergo anterior cruciate ligament reconstruction (ACLR) are at heightened risk of secondary anterior cruciate ligament (ACL) injury (e.g. additional injury to the ACL in either knee). One of the primary physiological consequences of ACLR is the presence of quadriceps dysfunction (i.e. reduced activation and strength) which has been linked to altered gait and landing biomechanics. Aberrant landing biomechanics have been associated with an increased risk of both primary and secondary ACL injury, thus additional research is needed to evaluate the efficacy of treatments aimed to reduce quadriceps dysfunction and restore adequate landing biomechanics in attempts to reduce secondary ACL injury. Whole-body Vibration (WBV) has demonstrated success in improving quadriceps function and gait biomechanics in individuals with ACLR, however its effectiveness on landing biomechanics is unknown. To evaluate the acute effects of WBV on landing biomechanics in those with ACLR, a non-randomized crossover-controlled trial was conducted to determine if a single bout of WBV improved landing biomechanics greater than a control condition. Participants completed two separate testing sessions (separated by at least one week) in which measures of quadriceps function and landing biomechanics were assessed before and after either a control (no WBV) or WBV intervention. Separate linear mixed-effects models of post-test values for each dependent outcome were conducted with condition (control vs WBV) and limb (ACLR vs Uninvolved) as an interaction term, and each condition pre-test values and time post-ACLR as fixed effect covariates and a random effect of subject. The investigators expect to observe a significant improvement in landing biomechanics following WBV compared to the control condition.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Whole body vibration followed by No Intervention (Control) | Experimental | Other: Whole body vibration (WBV), Other: Sham Whole body vibrationParticipants in this arm will receive Whole Body Vibration followed by a washout period of 1 week, then receive the Sham Whole body vibration (Control). Each condition will be evaluated in a single session (i.e. acute effects). |
| Sham Whole body vibration (Control) followed by Whole Body Vibration | Experimental | Other: Whole body vibration (WBV), Other: Sham Whole body vibrationParticipants in this arm will receive Sham Whole body vibration (Control) followed by a washout period of 1 week, then receive Whole Body Vibration. Each condition will be evaluated in a single session (i.e. acute effects). |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Between the ages of 18-35
- History of primary, unilateral ACLR
- Medically cleared for unrestricted physical activity
Key exclusion criteria (6 listed)
- More than 5 years removed from ACLR
- Currently pregnant
- History of other lower extremity surgery
- History of lower extremity injury in previous 6 months
- History of neurological disorder
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Whole body vibration (WBV)Participants will stand on a WBV platform in a mini-squat position while vibration is applied during six 60-second bouts with 2 minutes of rest between each bout. WBV will be delivered at an acceleration of 2g and a frequency of 30 Hz. | Other | Sham Whole body vibration (Control) followed by Whole Body Vibration, Whole body vibration followed by No Intervention (Control) |
| Sham Whole body vibrationParticipants will stand on a WBV platform in a mini-squat position during six 60-second bouts with 2 minutes of rest between each bout. No vibration will be applied. | Other | Sham Whole body vibration (Control) followed by Whole Body Vibration, Whole body vibration followed by No Intervention (Control) |
Primary outcome
Internal Knee Adduction Moment (KAM)
Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).
Peak value during landing in both single-leg and double-leg tasks averaged over 3 trials and normalized to the product of body weight and height
Internal Knee Extension Moment (KEM)
Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).
Peak value during landing in both single-leg and double-leg tasks averaged over 3 trials and normalized to a product of body weight*height
Knee Flexion Angle (KFA)
Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).
Peak value during landing in both single-leg and double-leg tasks averaged over 3 trials
3 secondary outcomes
Dynamic Postural Control
Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).
Vertical Ground Reaction Force
Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).
Frontal Plane Kinematics
Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jul 2026.
- Individual participant dataSharing planned: Yes. Deidentified individual data that supports the results will be shared beginning 9 and continuing for 36 months following publication provided the investigator who proposes to use the data has approval from an Institutional Review Board (IRB), Independent Ethics Committee (IEC), or Research Ethics Board (REB), as applicable, and executes a data use/sharing agreement with UNC.
Related trials for Anterior Cruciate Ligament Injuries
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Stair Biomechanics and Vibration Study After ACLR
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Supporting Athletes' Return to Sports After ACL Reconstruction: A Study of a Psychological Readiness Program
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Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Derek Dewig principal investigator
University of North Carolina, Chapel Hill
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Whole body vibration (WBV) in people with Anterior Cruciate Ligament Injuries and Anterior Cruciate Ligament Tear, run by University of North Carolina, Chapel Hill at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Internal Knee Adduction Moment (KAM) (time frame: Separate values prior to and immediately following the intervention (within 5 minutes).). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jul 2026.