Depigmentation TreatmentEffect of CoeNCT07677826
Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation
A study testing surgical depigmentation, Coenzyme Q10 and Vitamin C in people with Depigmentation Treatment and Depigmentation, run by Al-Azhar University at 1 site in Egypt.
Trial summary
This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Depigmentation Treatment, Depigmentation
- What is being tested?
- surgical depigmentation, Coenzyme Q10 and Vitamin C
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteEgypt
- Study dates
- 2 Mar 2026to 20 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Systemically healthy patient of both genders aged from 18-45 years.
- Presence of bilateral physiologic gingival pigmentation in the anterior maxillary or mandibular region DOPI grades III-IV only.
- Good oral hygiene.
- Thick gingival phenotype.
Who cannot join
- Patient clinically diagnosed with periodontitis.
- Pregnant or lactating females.
- Patient with previous treatment of gingival hyperpigmentation.
- History of hypersensitivity to any study material.
- Patients who are active or previous smokers.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
nora abdelgawad abdelgawad, phd contact
Egypt1 site, 1 recruiting
- Recruiting
Faculty of dental medicine for girls? ALAZHAR University, Cairo, egypt
Nāşir
Nora Abdelgawad Associate professor, Phd, +×01019407891, Noramohamed.26@azhar.edu.eg
About this study
Official title: Ffect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation a Randomized Clinical Study
This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation.
- Conditions
- Depigmentation Treatment, Depigmentation
- Being tested
- surgical depigmentation, Coenzyme Q10, Vitamin C, Surgical Gingival Depigmentation Coenzyme Q10 Vitamin C
- Medical subject headings
- Vitiligo
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
surgical depigmentationProcedure or surgery
Surgical gingival depigmentation performed using the conventional scalpel technique. The pigmented gingival epithelium is surgically removed under local anesthesia to eliminate melanin pigmentation and improve gingival esthetics.
Coenzyme Q10Dietary supplement
Coenzyme Q10 administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation.
Vitamin CDietary supplement
Vitamin C administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation.
Surgical Gingival Depigmentation Coenzyme Q10 Vitamin CDietary supplement
Coenzyme Q10 and vitamin c administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival repigmentation.
| Study group | Role | What they receive |
|---|---|---|
| control | Active comparator | Surgical Depigmentation Alone Receives: Procedure: surgical depigmentation |
| test I | Experimental | Surgical Depigmentation + CoQ10 Receives: Procedure: surgical depigmentation; Dietary Supplement: Coenzyme Q10 |
| Test II | Experimental | Surgical Depigmentation + Vitamin C Receives: Procedure: surgical depigmentation; Dietary Supplement: Vitamin C |
| Test III | Experimental | Surgical Depigmentation + CoQ10 + Vitamin C Receives: Procedure: surgical depigmentation; Dietary Supplement: Surgical Gingival Depigmentation Coenzyme Q10 Vitamin C |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in gingival pigmentation intensity using the Dummett Oral Pigmentation Index (DOPI). The DOPI scale from 0 to 3, where:0 = No clinical pigmentation ,1 = Mild pigmentation , 2 = Moderate pigmentation 3 = Heavy pigmentation
Change in gingival pigmentation intensity that measured by using a standardized gingival pigmentation index (DOPI)
Measured: 1 week, 1 month and 3 months. ,6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2026
- Study start2 Mar 2026
- Primary completion1 Dec 2026 (estimated)
- Study completion20 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Depigmentation TreatmentStudies of the same condition, open and under way.
- More trials run by Al-Azhar UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Surgical gingival depigmentation performed using the conventional scalpel technique under local anesthesia. The pigmented gingival epithelium is surgically removed to eliminate physiologic melanin pigmentation and improve gingival esthetics. The procedure is performed as the standard treatment for gingival hyperpigmentation in all study participants.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nora Abdelgawad Mohamed, Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07677826
- Sponsor's protocol ID
- P-ME-26-1
- Acronym
- Effect of Coe
- Status last verified
- Jun 2026
- First submitted
- 24 Jun 2026
- Last updated
- 1 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Ffect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation a Randomized Clinical Study
- ClinicalTrials.gov ID
- NCT07677826
- Acronym / sponsor ID
- Effect of Coe / P-ME-26-1
- Conditions
- Depigmentation Treatment, Depigmentation
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Al-Azhar UniversityUniversity, hospital or other
- Study start
- 2 Mar 2026 (actual)
- Primary completion
- 1 Dec 2026 (estimated)
- Study completion
- 20 Dec 2026 (estimated)
- First posted
- 1 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 4
- Model description
- Surgical gingival depigmentation performed using the conventional scalpel technique under local anesthesia. The pigmented gingival epithelium is surgically removed to eliminate physiologic melanin pigmentation and improve gingival esthetics. The procedure is performed as the standard treatment for gingival hyperpigmentation in all study participants.
| Arm | Type | Receives |
|---|---|---|
| control | Active comparator | Procedure: surgical depigmentationSurgical Depigmentation Alone |
| test I | Experimental | Procedure: surgical depigmentation, Dietary Supplement: Coenzyme Q10Surgical Depigmentation + CoQ10 |
| Test II | Experimental | Procedure: surgical depigmentation, Dietary Supplement: Vitamin CSurgical Depigmentation + Vitamin C |
| Test III | Experimental | Procedure: surgical depigmentation, Dietary Supplement: Surgical Gingival Depigmentation Coenzyme Q10 Vitamin CSurgical Depigmentation + CoQ10 + Vitamin C |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Systemically healthy patient of both genders aged from 18-45 years.
- Presence of bilateral physiologic gingival pigmentation in the anterior maxillary or mandibular region DOPI grades III-IV only.
- Good oral hygiene.
- Thick gingival phenotype.
Key exclusion criteria (5 listed)
- Patient clinically diagnosed with periodontitis.
- Pregnant or lactating females.
- Patient with previous treatment of gingival hyperpigmentation.
- History of hypersensitivity to any study material.
- Patients who are active or previous smokers.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| surgical depigmentationSurgical gingival depigmentation performed using the conventional scalpel technique. The pigmented gingival epithelium is surgically removed under local anesthesia to eliminate melanin pigmentation and improve gingival esthetics. | Procedure or surgery | Test II, Test III, control, test I |
| Coenzyme Q10Coenzyme Q10 administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation. | Dietary supplement | test I |
| Vitamin CVitamin C administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation. | Dietary supplement | Test II |
| Surgical Gingival Depigmentation Coenzyme Q10 Vitamin CCoenzyme Q10 and vitamin c administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival repigmentation. | Dietary supplement | Test III |
Primary outcome
Change in gingival pigmentation intensity using the Dummett Oral Pigmentation Index (DOPI). The DOPI scale from 0 to 3, where:0 = No clinical pigmentation ,1 = Mild pigmentation , 2 = Moderate pigmentation 3 = Heavy pigmentation
Time frame: 1 week, 1 month and 3 months. ,6 months
Change in gingival pigmentation intensity that measured by using a standardized gingival pigmentation index (DOPI)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
nora abdelgawad abdelgawad, phd contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing surgical depigmentation, Coenzyme Q10 and Vitamin C in people with Depigmentation Treatment and Depigmentation, run by Al-Azhar University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 1 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact nora abdelgawad associate professor, phd (+201019407891, noramohamed.26@azhar.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in gingival pigmentation intensity using the Dummett Oral Pigmentation Index (DOPI). The DOPI scale from 0 to 3, where:0 = No clinical pigmentation ,1 = Mild pigmentation , 2 = Moderate pigmentation 3 = Heavy pigmentation (time frame: 1 week, 1 month and 3 months. ,6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Jul 2026.