MyopiaNCT07647146
Corneal Epithelial Thickness Mapping by Anterior Segment Optical Coherence Tomography in Patients With Refractive Errors
An observational study of Myopia and Hyperopia, run by Sohag University at 1 site in Egypt.
Trial summary
This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. It aims to assess the relationship between epithelial thickness patterns and different types of refractive errors. Read more about this study
- Who is it for?
- Ages 18 to 99 yearsHealthy volunteers can take part
- Conditions the study is for
- Myopia, Hyperopia, Astigmatism
- How many people
- 360 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jul 2026to 1 May 2027
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 99 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Adult participants (≥18 years) with refractive errors, including myopia, hyperopia, and astigmatism, as well as emmetropic subjects, recruited from the Ophthalmology Department and undergoing anterior segment optical coherence tomography (AS-OCT) examination.
Who may be able to join
- Age ≥ 18 years-
- Patients diagnosed with myopia or hyperopia by refraction
- Clear cornea with no evidence of corneal pathology
- Ability to undergo reliable anterior segment imaging
Who cannot join
- Inability to fixate or follow instructions
- Family history of keratoconus
- Glaucoma,Cataract
- Previous ocular surgery including refractive surgery
- Keratoconus or suspected corneal ectasia
- Corneal opacities or scars
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- Contact lens wear within the last two weeks
- Ocular trauma
- systemic disease affecting the cornea ( Such as diabetes)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site
Sohag University Hospital
Sohag, Sohag Governorate, 82524
Engy Mohamed Mostafa, Professor, 01005643587, Engymostafa@yahoo.com
Amin Abu-Ali Hassan, Assistant Professor, 01015437008
About this study
This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. It aims to assess the relationship between epithelial thickness patterns and different types of refractive errors.
Read the detailed description
Refractive errors are among the most common ocular conditions affecting visual acuity. Corneal epithelial thickness has been suggested to play a role in the optical properties of the eye and may vary among different refractive states. This observational study aims to evaluate corneal epithelial thickness mapping using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. Patients will be assessed and categorized according to their refractive status, and epithelial thickness measurements will be obtained and analyzed. The study seeks to investigate potential correlations between epithelial thickness distribution and different types of refractive errors to enhance understanding of corneal biomechanics in refractive conditions.
- Conditions
- Myopia, Hyperopia, Astigmatism, Emmetropia
- Keywords
- Corneal epithelial thickness, AS-OCT, anterior segment optical coherence tomography, refractive errors, myopia, hyperopia, astigmatism, cornea
- Medical subject headings
- Myopia, Hyperopia, Astigmatism, Refractive Errors, Corneal Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| All Participants | All participants diagnosed with refractive errors (myopia, hyperopia, astigmatism) and emmetropia will be included in the study. All subjects will undergo anterior segment optical coherence tomography (AS-OCT) for corneal epithelial thickness mapping. Participants will then be analyzed according to their refractive status. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Measurement of corneal epithelial thickness using AS-OCT
Corneal epithelial thickness will be measured using anterior segment optical coherence tomography (AS-OCT). Measurements will include central and regional epithelial thickness values in microns in patients with different refractive errors.
Measured: At baseline during a single study visit when participants undergo AS-OCT examination.
Secondary outcomes (4)
Comparison of epithelial thickness between myopic and hyperopic eyes
Corneal epithelial thickness will be compared between myopic and hyperopic eyes using AS-OCT measurements.
Measured: At baseline (single visit)
Comparison of epithelial thickness in eyes with and without astigmatism
Corneal epithelial thickness will be evaluated and compared between eyes with astigmatism and those without astigmatism using AS-OCT.
Measured: At baseline (single visit)
Corneal epithelial thickness asymmetry across corneal regions and inter-eye comparison
Epithelial thickness will be assessed across different corneal regions and compared between both eyes to evaluate inter-eye asymmetry.
Measured: At baseline (single visit)
Comparison of epithelial thickness in low and high refractive errors
Corneal epithelial thickness profiles will be compared between low and high degrees of myopia and hyperopia using AS-OCT measurements.
Measured: At baseline (single visit)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jun 2026
- Study start1 Jul 2026 (estimated)
- Primary completion1 May 2027 (estimated)
- Study completion1 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MyopiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 360 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Merna Romany Kamel, Sohag University
- Investigators
- Engy Mohamed Mostafa, Professor, Principal investigator, Department of Ophthalmology, Faculty of Medicine, Sohag UniversityAmin Abu-Ali Hassan, Assistant Professor, Study director, Department of Ophthalmology, Faculty of Medicine, Sohag UniversityYasmeen Gamal Abd-El latif, Lecturer, Study director, Department of Ophthalmology, Faculty of Medicine, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07647146
- Sponsor's protocol ID
- Soh-Med-26-5-7MS
- Status last verified
- Jun 2026
- First submitted
- 9 Jun 2026
- Last updated
- 15 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared.