Acute Kidney Injury (AKI)NCT07602465
The Impact of Blood Pressure Variability During the Induction and Surgical Periods on Postoperative Acute Kidney Injury
An observational study of Acute Kidney Injury (AKI), run by Zhongda Hospital at 1 site in China.
Trial summary
The goal of this multicenter retrospective cohort study aimed to explore the effect of BPV during anesthesia induction and surgery on the occurrence of postoperative AKI in non-cardiac surgery patients. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Kidney Injury (AKI)
- How many people
- 5,000 participants
- Where
- 1 siteChina
- Study dates
- 1 Jun 2026to 1 Dec 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Adult, Older adult
Study population: Southeast University Zhongda Hospital (2013-2024), Nanjing First Hospital (2016-2024), and the First Affiliated Hospital of Anhui Medical University (2013-2023)
Who may be able to join
- Undergoing non-cardiac surgery；
- Adult；
Who cannot join
- Undergoing urological surgeries that partially directly affect kidney function (including relief of urinary tract obstruction, nephrectomy, or kidney transplantation);
- Surgery duration less than 60 minutes;
- Weight < 30 kg or BMI > 35 kg/m2;
- Patients who underwent reoperation within 7 days after surgery;
- Surgeries not performed under general anesthesia;
- ASA > IV;
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- No serum creatinine measurement available within 6 months before surgery (baseline value) or within 7 days after surgery;
- Preexisting renal dysfunction or a diagnosis of chronic kidney disease before surgery (creatinine > 443 μmol/L);
- No invasive blood pressure monitoring during the anesthesia induction period, or missing more than 25% of intraoperative invasive blood pressure data collection.
Trial locations and contacts
1 site in 1 country.
China1 site
Zhongda Hospital Southeast University
Nanjing, Jiangsu Provincce, 210000
About this study
The goal of this multicenter retrospective cohort study aimed to explore the effect of BPV during anesthesia induction and surgery on the occurrence of postoperative AKI in non-cardiac surgery patients.
- Conditions
- Acute Kidney Injury (AKI)
- Keywords
- Acute kidney injury, Blood pressure variability, Anesthesia induction period, Non-cardiac surgery
- Medical subject headings
- Acute Kidney Injury
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| HH | High induction blood pressure variability + High surgery blood pressure variability | |
| HL | High induction blood pressure variability + Low surgery blood pressure variability | |
| LH | Low induction blood pressure variability + High surgery blood pressure variability | |
| LL | Low induction blood pressure variability + Low surgery blood pressure variability |
What is being measured
The primary outcome is the main question the study is designed to answer.
AKI
AKI diagnosed according to KDIGO criteria within 7 days after surgery was the primary outcome event.
Measured: Within 7 days after surgery.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 May 2026
- Study start1 Jun 2026
- Primary completion1 Dec 2026 (estimated)
- Study completion1 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Kidney Injury (AKI)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 5,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Zhongda Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Nanjing First Hospital, Nanjing Medical University, The First Affiliated Hospital of Anhui Medical University
- Responsible party
- Principal investigator, Lanyue Zhu, Zhongda Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07602465
- Sponsor's protocol ID
- 2025ZDSYLL420
- Status last verified
- Sep 2026
- First submitted
- 15 May 2026
- Last updated
- 10 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact of Blood Pressure Variability During the Induction and Surgical Periods on Postoperative Acute Kidney Injury
- ClinicalTrials.gov ID
- NCT07602465
- Acronym / sponsor ID
- 2025ZDSYLL420
- Conditions
- Acute Kidney Injury (AKI)
- Keywords
- Acute kidney injury, Blood pressure variability, Anesthesia induction period, Non-cardiac surgery
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 5,000 participants (estimated)
- Lead sponsor
- Zhongda HospitalUniversity, hospital or other
- Collaborators
- Nanjing First Hospital, Nanjing Medical University, The First Affiliated Hospital of Anhui Medical University
- Study start
- 1 Jun 2026 (actual)
- Primary completion
- 1 Dec 2026 (estimated)
- Study completion
- 1 Dec 2026 (estimated)
- First posted
- 22 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this multicenter retrospective cohort study aimed to explore the effect of BPV during anesthesia induction and surgery on the occurrence of postoperative AKI in non-cardiac surgery patients.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| HH | – | –High induction blood pressure variability + High surgery blood pressure variability |
| HL | – | –High induction blood pressure variability + Low surgery blood pressure variability |
| LH | – | –Low induction blood pressure variability + High surgery blood pressure variability |
| LL | – | –Low induction blood pressure variability + Low surgery blood pressure variability |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- Southeast University Zhongda Hospital (2013-2024), Nanjing First Hospital (2016-2024), and the First Affiliated Hospital of Anhui Medical University (2013-2023)
Key inclusion criteria (2 listed)
- Undergoing non-cardiac surgery；
- Adult；
Key exclusion criteria (9 listed)
- Undergoing urological surgeries that partially directly affect kidney function (including relief of urinary tract obstruction, nephrectomy, or kidney transplantation);
- Surgery duration less than 60 minutes;
- Weight < 30 kg or BMI > 35 kg/m2;
- Patients who underwent reoperation within 7 days after surgery;
- Surgeries not performed under general anesthesia;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
AKI
Time frame: Within 7 days after surgery.
AKI diagnosed according to KDIGO criteria within 7 days after surgery was the primary outcome event.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Kidney Injury (AKI), run by Zhongda Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 10 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
AKI (time frame: Within 7 days after surgery.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Sep 2026.