Detrusor UnderactivityNCT07596537
The Effect of Detrusor Underactivity in Determining Outcomes After Transurethral Resection of the Prostate for Treatment of Benign Prostatic Hyperplasia
A study testing transurethral resection of Prostate in people with Detrusor Underactivity and Transurethral Resection of the Prostate (TURP), run by Ain Shams University.
Trial summary
The aim of this clinical trial is to evaluate the effect of detrusor underactivity on the functional and symptomatic outcomes following transurethral resection of the prostate (TURP) in benign prostatic hyperplasia patients presenting with chronic urinary retention. Read more about this study
- Who is it for?
- Ages 50 years and older, men only
- Conditions the study is for
- Detrusor Underactivity, Transurethral Resection of the Prostate (TURP)
- What is being tested?
- transurethral resection of Prostate
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- No sites listed yet
- Study dates
- 1 May 2026to 1 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 years and older
- Men only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age: more than 50-year-old
- Chronic urinary retention secondary to BPH
- Prostate size Above 30 and less than 100gm
Who cannot join
- Prostate size over 100 gm and less than 30 gm
- Prostatic carcinoma
- Urinary bladder carcinoma
- Acute urinary retention
- Urethral stricture.
- Previous bladder, urethral or prostate surgery.
- Acute urinary tract infection.
- Neurogenic bladder
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
The aim of this clinical trial is to evaluate the effect of detrusor underactivity on the functional and symptomatic outcomes following transurethral resection of the prostate (TURP) in benign prostatic hyperplasia patients presenting with chronic urinary retention.
The main questions it aims to answer are:
Will they restore spontaneous voiding?
They will be divided into 2 comparative groups (each group 45 patients) based on detrusor contractility.
- Group (A) consists of patients with normal detrusor (bladder contractility index more than 100).
- Group (B) consists of patients with underactive detrusor (bladder contractility index less than 100).
- Being tested
- transurethral resection of Prostate
- Medical subject headings
- Urinary Bladder, Underactive
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
transurethral resection of ProstateProcedure or surgery
Standard TURP
| Study group | Role | What they receive |
|---|---|---|
| consists of patients with underactive detrusor (bladder contractility index less than 100). | Active comparator | • Group (B) - Underactive Detrusor Receives: Procedure: transurethral resection of Prostate |
| consists of patients with normal detrusor (bladder contractility index more than 100). | Active comparator | • Group (A) - Normal detrusor Receives: Procedure: transurethral resection of Prostate |
What is being measured
The primary outcome is the main question the study is designed to answer.
Restore spontaneous voiding
All the included patients in this study are urethral catheter-dependant pre-operatively and have very bad voiding parameters. we will assess how they will benefit after TURP by regaining spontaneous voiding without the need for urethral catheters any more.
Measured: 3 months
Secondary outcomes (2)
Flow rate improvement
uroflowmetry will be done to all patients 3 months post operative and results will be compared
Measured: 3 months
Post voiding residual urine volume decrease
Post voiding residual urine volume will be calculated using ultrasound and results will be compared
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 May 2026
- Study start1 May 2026 (estimated)
- Primary completion1 Dec 2026 (estimated)
- Study completion1 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Detrusor UnderactivityStudies of the same condition, open and under way.
- More trials run by Ain Shams UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, samir sherif, Ain Shams University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07596537
- Sponsor's protocol ID
- Detrusor Underactivity & TURP
- Status last verified
- May 2026
- First submitted
- 5 May 2026
- Last updated
- 20 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 20 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Detrusor Underactivity in Determining Outcomes After Transurethral Resection of the Prostate for Treatment of Benign Prostatic Hyperplasia
- ClinicalTrials.gov ID
- NCT07596537
- Acronym / sponsor ID
- Detrusor Underactivity & TURP
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 1 May 2026 (estimated)
- Primary completion
- 1 Dec 2026 (estimated)
- Study completion
- 1 Dec 2026 (estimated)
- First posted
- 19 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this clinical trial is to evaluate the effect of detrusor underactivity on the functional and symptomatic outcomes following transurethral resection of the prostate (TURP) in benign prostatic hyperplasia patients presenting with chronic urinary retention.
The main questions it aims to answer are:
Will they restore spontaneous voiding?
They will be divided into 2 comparative groups (each group 45 patients) based on detrusor contractility.
- Group (A) consists of patients with normal detrusor (bladder contractility index more than 100).
- Group (B) consists of patients with underactive detrusor (bladder contractility index less than 100).
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| consists of patients with underactive detrusor (bladder contractility index less than 100). | Active comparator | Procedure: transurethral resection of Prostate• Group (B) - Underactive Detrusor |
| consists of patients with normal detrusor (bladder contractility index more than 100). | Active comparator | Procedure: transurethral resection of Prostate• Group (A) - Normal detrusor |
Who may qualify
- Ages
- 50 years and older
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age: more than 50-year-old
- Chronic urinary retention secondary to BPH
- Prostate size Above 30 and less than 100gm
Key exclusion criteria (8 listed)
- Prostate size over 100 gm and less than 30 gm
- Prostatic carcinoma
- Urinary bladder carcinoma
- Acute urinary retention
- Urethral stricture.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| transurethral resection of ProstateStandard TURP | Procedure or surgery | consists of patients with normal detrusor (bladder contractility index more than 100)., consists of patients with underactive detrusor (bladder contractility index less than 100). |
Primary outcome
Restore spontaneous voiding
Time frame: 3 months
All the included patients in this study are urethral catheter-dependant pre-operatively and have very bad voiding parameters. we will assess how they will benefit after TURP by regaining spontaneous voiding without the need for urethral catheters any more.
2 secondary outcomes
Flow rate improvement
Time frame: 3 months
Post voiding residual urine volume decrease
Time frame: 3 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 May 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing transurethral resection of Prostate in people with Detrusor Underactivity and Transurethral Resection of the Prostate (TURP), run by Ain Shams University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 May 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Samir Sherif Rizkallah, MBBCH (+201226846005, 150278@med.asu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Restore spontaneous voiding (time frame: 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 May 2026.