Shoulder TendinopathyNCT07588477
Functional Effects of Tendon Neuroplastic Training in Wrestlers
A study testing Tendon Neuroplastic Training in people with Shoulder Tendinopathy, run by Hacettepe University at 1 site in Turkey (Türkiye).
Trial summary
ABSTRACT AIM: The term tendinopathy describes multifaceted pathologies occurring in the tendon, characterized by pain, functional impairment, and decreased exercise tolerance. The aim of this study is to use Tendon Neuroplastic Training (TNT) in Wrestlers with shoulder tendinopathy between the ages of 14-25; To… Read more about this study
- Who is it for?
- Any age, men only
- Conditions the study is for
- Shoulder Tendinopathy
- What is being tested?
- Tendon Neuroplastic Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 26 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Mar 2024to 22 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Men only
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Being a licensed athlete for at least one year
- Having a diagnosis of tendinopathy based on clinical and radiological examination
- To positive least three of the following diagnostic tests: Neer Test, Hawkins-Kennedy Test, Jobe-Supraspinatus Test, Painful arc at 60-120 degrees of shoulder abduction
- Pain level is below 2 out of 10 at rest and below 3 out of 10 during active movement according to the visual pain scale,
- No limitation in joint range of motion (at least 85% of the healthy side).
Who cannot join
- • Having any vision or hearing problems
- Previous surgery at last 6 month
- Having diagnose complete tendon rupture
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Kayseri Youth and Sports Provincial Directorate
Kayseri, Kayseri, 38100
About this study
Official title: Functional Effects of Tendon Neuroplastic Training in Wrestlers With Shoulder Tendinopathy: a Randomized Controlled Trial
ABSTRACT AIM: The term tendinopathy describes multifaceted pathologies occurring in the tendon, characterized by pain, functional impairment, and decreased exercise tolerance. The aim of this study is to use Tendon Neuroplastic Training (TNT) in Wrestlers with shoulder tendinopathy between the ages of 14-25; To investigate its effects on balance, coordination, mental performance and shoulder functionality.
METHOD: After determining the sample size of the study with the G Power (Software 3.1.9.2) program, 26 athletes were randomly divided into two groups; the study group received a 4-week TNT training protocol, while the control group received 4 weeks of standard eccentric training. Both groups were given exercises for the Supraspinatus, Infraspinatus, Subscapularis and Biceps muscles. The athletes' balance with "Upper Quarter Y Balance", coordination with "Alternate Hand Wall Toss", and mental performance with Stroop Color-Word tests were evaluated. "Kerlan-Jobe" and "Western Ontario Rotator Cuff" scales were used to evaluate shoulder functionality and pain. All assessments were administered before and after exercise training. The data were analyzed statistically with the "IBM SPSS 25" package program.
Key Words: Athlete, Mental Test, Shoulder, Tendinopathy
- Conditions
- Shoulder Tendinopathy
- Being tested
- Tendon Neuroplastic Training
- Keywords
- Athlete, Mental Test, Tendinopathy, Shoulder
- Medical subject headings
- Tendinopathy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Tendon Neuroplastic TrainingOther
Also called External Paced Training
Tendon Neuroplastic Training can be adapted to isometric and isotonic exercises with a digital metronome program. Tendon Neuroplastic Training has been reported to improve functionality and strength, reduce pain and cortical inhibition in athletes by generating 'adaptation' in central nervous system. Resistance training planned with visual or auditory stimuli (externally paced), can induce changes on motor control. the exercises paced to an external audio/visual cue on the participant's smartphone
| Study group | Role | What they receive |
|---|---|---|
| Tendon Neuroplastic Training Group | Experimental | The Group that Perceived Tendon Neuroplastic Training Receives: Other: Tendon Neuroplastic Training |
| Control Group | Other | The Group that Perceived Standard Eccentric Training Receives: Other: Tendon Neuroplastic Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cognitive function
Cognitive function was assessed with the Stroop Test TBAG (Temel Bilimler Araştırma Grubu) Form. The Stroop Test also referred to as the Color- Word Task, was used to assess executive abilities, selective attention, and the ability to inhibit a habitual response. In sports psychology research, the Stroop test and its derivations are commonly used to investigate the benefits of exercise on cognitive function. Stroop Test TBAG Form consists of five cards. For each section, the time taken by participants during the application was measured using a 0.01-second precision smartphone chronometer. The completion time of reading the card, the number of errors and the number of corrections (if any) for each section were recorded on an evaluation form for each participant. There are no minimum or maximum score values for this test. A lower score means a better result.
Measured: "Baseline" and "week 4"
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 May 2026
- Study start15 Mar 2024
- Primary completion8 Mar 2025
- Study completion22 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Shoulder TendinopathyStudies of the same condition, open and under way.
- More trials run by Hacettepe UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hacettepe University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Recep Baloglu, Hacettepe University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07588477
- Sponsor's protocol ID
- 2022/10123
- Status last verified
- May 2026
- First submitted
- 28 Apr 2026
- Last updated
- 14 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: We respect the privacy of participants' data.
Publications
1. Singh A, Sharan L, Shankhapal VR, Shenoy S. From shoulder to ankle: A cross-sectional study of tendinopathy prevalence across the athletic population. J Sport Rehabil Sci. 2026;3(1):1-10. 2. McCausland C, Sawyer E, Eovaldi BJ, Varacallo MA. Anatomy, Shoulder and Upper Limb, Shoulder Muscles. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 8, 2023. 3. Maunder DJ, Nelson BC, Murthi AM, Hoffman RA. The Burden of Shoulder and Elbow Injuries in Wrestling: A Systematic Review of Incidence, Injury Types, and Competition-Level Comparisons. Sports Health: A Multidisciplinary Approach. 2025;0(0). 4. Goodman AD, Twomey-Kozak J, DeFroda SF, Owens BD. Epidemiology of shoulder and elbow injuries in National Collegiate Athletic Association wrestlers, 2009-2010 through 2013-2014. The Physician and Sportsmedicine. 2018;46 (3):361-366. 5. Noh, Ji-Woong & Park, Byoung-Sun & Kim, Meeyoung & Lee, Lim-Kyu & Yang, Seung-Min & Lee, Won-Deok & Shin, Yong-Sub & Kim, Ju-Hyun & Lee, Jeong-Uk & Kwak, Taek-Yong & Lee, Tae-Hyun & Kim, Ju-Young & Park, Jaehong & Kim, Junghwan. (2015). Analysis of combat sports players' injuries according to playing style for sports physiotherapy research. Journal of physical therapy science. 27. 2425-30 6. Thomas RE, Zamanpour K. Injuries in wrestling: systematic review. The Physician and Sportsmedicine. 2018;46(2):168-196 7. Millar N, Silbernagel K, Thorborg K et al. Tendinopathy. Nature Reviews Disease Primers. 2021;7(1):1 8. Reinking M. Tendinopathy in athletes. Phys Ther Sport. 2012; 13: 3-10 9. Taik, F. Z., Karkouri, S., Tahiri, L., Aachari, I., Moulay Berkchi, J., Hmamouchi, I., Abouqal, R., Rkain, H., & Allali, F. (2022). Effects of kinesiotaping on disability and pain in patients with rotator cuff tendinopathy: double-blind randomized clinical trial. BMC musculoskeletal disorders, 23(1), 90 10. Aydeniz B, Ersoy S, Çinicioğlu M, Vural M. Evaluation of Kinesiophobia, Pain and Functional Status in Adhesive Capsulitis and Rotator Cu
Study at a glance
From the registry record, last updated by the sponsor on 14 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Functional Effects of Tendon Neuroplastic Training in Wrestlers With Shoulder Tendinopathy: a Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07588477
- Acronym / sponsor ID
- 2022/10123
- Conditions
- Shoulder Tendinopathy
- Keywords
- Athlete, Mental Test, Tendinopathy, Shoulder
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- Hacettepe UniversityUniversity, hospital or other
- Study start
- 15 Mar 2024 (actual)
- Primary completion
- 8 Mar 2025 (actual)
- Study completion
- 22 Oct 2025 (actual)
- First posted
- 14 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
ABSTRACT AIM: The term tendinopathy describes multifaceted pathologies occurring in the tendon, characterized by pain, functional impairment, and decreased exercise tolerance. The aim of this study is to use Tendon Neuroplastic Training (TNT) in Wrestlers with shoulder tendinopathy between the ages of 14-25; To investigate its effects on balance, coordination, mental performance and shoulder functionality.
METHOD: After determining the sample size of the study with the G Power (Software 3.1.9.2) program, 26 athletes were randomly divided into two groups; the study group received a 4-week TNT training protocol, while the control group received 4 weeks of standard eccentric training. Both groups were given exercises for the Supraspinatus, Infraspinatus, Subscapularis and Biceps muscles. The athletes' balance with "Upper Quarter Y Balance", coordination with "Alternate Hand Wall Toss", and mental performance with Stroop Color-Word tests were evaluated. "Kerlan-Jobe" and "Western Ontario Rotator Cuff" scales were used to evaluate shoulder functionality and pain. All assessments were administered before and after exercise training. The data were analyzed statistically with the "IBM SPSS 25" package program.
Key Words: Athlete, Mental Test, Shoulder, Tendinopathy
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Tendon Neuroplastic Training Group | Experimental | Other: Tendon Neuroplastic TrainingThe Group that Perceived Tendon Neuroplastic Training |
| Control Group | Other | Other: Tendon Neuroplastic TrainingThe Group that Perceived Standard Eccentric Training |
Who may qualify
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (5 listed)
- Being a licensed athlete for at least one year
- Having a diagnosis of tendinopathy based on clinical and radiological examination
- To positive least three of the following diagnostic tests: Neer Test, Hawkins-Kennedy Test, Jobe-Supraspinatus Test, Painful arc at 60-120 degrees of shoulder abduction
- Pain level is below 2 out of 10 at rest and below 3 out of 10 during active movement according to the visual pain scale,
- No limitation in joint range of motion (at least 85% of the healthy side).
Key exclusion criteria (3 listed)
- • Having any vision or hearing problems
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Tendon Neuroplastic TrainingAlso: External Paced TrainingTendon Neuroplastic Training can be adapted to isometric and isotonic exercises with a digital metronome program. Tendon Neuroplastic Training has been reported to improve functionality and strength, reduce pain and cortical inhibition in athletes by generating 'adaptation' in central nervous system. Resistance training planned with visual or auditory stimuli (externally paced), can induce changes on motor control. the exercises paced to an external audio/visual cue on the participant's smartphone | Other | Control Group, Tendon Neuroplastic Training Group |
Primary outcome
Cognitive function
Time frame: "Baseline" and "week 4"
Cognitive function was assessed with the Stroop Test TBAG (Temel Bilimler Araştırma Grubu) Form. The Stroop Test also referred to as the Color- Word Task, was used to assess executive abilities, selective attention, and the ability to inhibit a habitual response. In sports psychology research, the Stroop test and its derivations are commonly used to investigate the benefits of exercise on cognitive function. Stroop Test TBAG Form consists of five cards. For each section, the time taken by participants during the application was measured using a 0.01-second precision smartphone chronometer. The completion time of reading the card, the number of errors and the number of corrections (if any) for each section were recorded on an evaluation form for each participant. There are no minimum or maximum score values for this test. A lower score means a better result.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 May 2026.
- Background1. Singh A, Sharan L, Shankhapal VR, Shenoy S. From shoulder to ankle: A cross-sectional study of tendinopathy prevalence across the athletic population. J Sport Rehabil Sci. 2026;3(1):1-10. 2. McCausland C, Sawyer E, Eovaldi BJ, Varacallo MA. Anatomy, Shoulder and Upper Limb, Shoulder Muscles. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 8, 2023. 3. Maunder DJ, Nelson BC, Murthi AM, Hoffman RA. The Burden of Shoulder and Elbow Injuries in Wrestling: A Systematic Review of Incidence, Injury Types, and Competition-Level Comparisons. Sports Health: A Multidisciplinary Approach. 2025;0(0). 4. Goodman AD, Twomey-Kozak J, DeFroda SF, Owens BD. Epidemiology of shoulder and elbow injuries in National Collegiate Athletic Association wrestlers, 2009-2010 through 2013-2014. The Physician and Sportsmedicine. 2018;46 (3):361-366. 5. Noh, Ji-Woong & Park, Byoung-Sun & Kim, Meeyoung & Lee, Lim-Kyu & Yang, Seung-Min & Lee, Won-Deok & Shin, Yong-Sub & Kim, Ju-Hyun & Lee, Jeong-Uk & Kwak, Taek-Yong & Lee, Tae-Hyun & Kim, Ju-Young & Park, Jaehong & Kim, Junghwan. (2015). Analysis of combat sports players' injuries according to playing style for sports physiotherapy research. Journal of physical therapy science. 27. 2425-30 6. Thomas RE, Zamanpour K. Injuries in wrestling: systematic review. The Physician and Sportsmedicine. 2018;46(2):168-196 7. Millar N, Silbernagel K, Thorborg K et al. Tendinopathy. Nature Reviews Disease Primers. 2021;7(1):1 8. Reinking M. Tendinopathy in athletes. Phys Ther Sport. 2012; 13: 3-10 9. Taik, F. Z., Karkouri, S., Tahiri, L., Aachari, I., Moulay Berkchi, J., Hmamouchi, I., Abouqal, R., Rkain, H., & Allali, F. (2022). Effects of kinesiotaping on disability and pain in patients with rotator cuff tendinopathy: double-blind randomized clinical trial. BMC musculoskeletal disorders, 23(1), 90 10. Aydeniz B, Ersoy S, Çinicioğlu M, Vural M. Evaluation of Kinesiophobia, Pain and Functional Status in Adhesive Capsulitis and Rotator Cu
- Individual participant dataSharing planned: No. We respect the privacy of participants' data.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Tendon Neuroplastic Training in people with Shoulder Tendinopathy, run by Hacettepe University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 14 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cognitive function (time frame: "Baseline" and "week 4"). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07588477, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 May 2026.