Rotator Cuff TendinopathyNCT07895810
Comparative Effects of Cyriax Approach With and Without Mobilization With Movement in Shoulder Restriction With Rotator Cuff Tendinopathy
A study testing Cyriax Approach with Mobilization with movement and Cyriax Approach without Mobilization with Movement in people with Rotator Cuff Tendinopathy, run by University of Management and Technology Lahore at 1 site in Pakistan.
Trial summary
This randomized clinical trial compares the effects of the Cyriax approach (deep transverse friction massage) with and without Mulligan Mobilization with Movement (MWM) on pain, range of motion and disability in patients with shoulder restriction due to rotator cuff tendinopathy. Read more about this study
- Who is it for?
- Ages 30 to 65 years
- Conditions the study is for
- Rotator Cuff Tendinopathy
- What is being tested?
- Cyriax Approach with Mobilization with movement and Cyriax Approach without Mobilization with Movement
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 38 participants
- Where
- 1 sitePakistan
- Study dates
- 19 Oct 2026to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 30 to 65 years.
- Both male and female genders.
- Symptoms in acute (up to 4 weeks) or sub-acute stage (4-6 weeks).
- Shoulder pain related to the rotator cuff or clinically documented rotator cuff tendinopathy.
- Pain intensity of 4-6 on the Numeric Pain Rating Scale (NPRS).
- Limited range of motion of the shoulder, either passive or active.
- Positive in any two or three impingement/tendinopathy tests: Neer's test, Hawkins-Kennedy test, painful arc test, empty can test and external rotation resistance test.
- Unilateral involvement of the shoulder
Who cannot join
- Previous cervical spine or shoulder surgery.
- Referred pain from the cervical spine or cervical radiculopathy.
- Other conditions affecting the shoulder joint complex: fractures or dislocations, severe osteoarthritis of the glenohumeral or acromioclavicular joint, adhesive capsulitis, shoulder stiffness and glenohumeral instability.
- Full-thickness rotator cuff tear or signs that surgery is necessary.
- Musculoskeletal or systemic inflammatory conditions such as severe osteoarthritis or rheumatoid arthritis.
- Corticosteroid injections within the last six weeks to three months.
- Involvement of both shoulders.
- Concurrent manual therapy or physiotherapy.
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
University of Management & Technology
Lahore, Punjab Province, 54000
About this study
Official title: Comparative Effects of Cyriax Approach With and Without Mobilization With Movement on Pain, Range of Motion and Disability in Shoulder Restriction With Rotator Cuff Tendinopathy
This randomized clinical trial compares the effects of the Cyriax approach (deep transverse friction massage) with and without Mulligan Mobilization with Movement (MWM) on pain, range of motion and disability in patients with shoulder restriction due to rotator cuff tendinopathy. Thirty-eight patients (19 per group) will be recruited by non-probability convenience sampling and randomly allocated to two groups. Both groups will receive laser therapy and conventional physiotherapy; 12 sessions over 4 weeks (3 sessions per week). Outcomes (NPRS, SPADI, Angulus Pro smartphone application) will be measured at baseline and at the 4th week and analyzed using SPSS version 24.
- Conditions
- Rotator Cuff Tendinopathy
- Being tested
- Cyriax Approach with Mobilization with movement, Cyriax Approach without Mobilization with Movement
- Keywords
- Cyriax approach, Mobilization with Movement, Shoulder pain, Shoulder disability, Shoulder restriction, range of motion
- Medical subject headings
- Shoulder Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cyriax Approach with Mobilization with movementOther
Cyriax approach (deep transverse friction massage, 10-12 minutes per session) plus Mulligan Mobilization with Movement (sustained posterolateral glide of the humeral head during pain-free active shoulder movement; 3 sets of 10 repetitions with 30-second rest), together with laser therapy and conventional treatment, 3 sessions per week for 4 weeks.
Cyriax Approach without Mobilization with MovementOther
Cyriax approach (deep transverse friction massage, 10-12 minutes per session) together with laser therapy and conventional treatment, 3 sessions per week for 4 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Cyriax approach with Mulligan Mobilization | Experimental | Cyriax approach (deep transverse friction massage, 10-12 minutes per session) plus Mulligan Mobilization with Movement (sustained posterolateral glide of the humeral head during pain-free active shoulder movement; 3 sets of 10 repetitions with 30-second rest), together with laser therapy and conventional treatment, 3 sessions per week for 4 weeks Receives: Other: Cyriax Approach with Mobilization with movement |
| Cyriax approach without Mulligan Mobilization | Active comparator | Cyriax approach (deep transverse friction massage, 10-12 minutes per session) together with laser therapy and conventional treatment, 3 sessions per week for 4 weeks. Receives: Other: Cyriax Approach without Mobilization with Movement |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numeric Pain Rating Scale
11-point self-reported scale: 0 representing no pain and 10 the most severe pain (1-3 mild, 4-6 moderate, 7-10 severe pain). Pain is rated at rest and during activity. Reported ICC 0.74-0.92; MCID about 2-2.5 points
Measured: Baseline and after 4 weeks
Shoulder Pain and Disability Index
13-item self-administered questionnaire with a pain subscale (5 items) and a disability subscale (8 items); each item scored 0-10 and total converted to a percentage, higher scores indicating greater disability. Cronbach's alpha about 0.94, test-retest ICC 0.89-0.91; MCID 8-25 points
Measured: Baseline and after 4 weeks
Smartphone Application
Used to measure shoulder range of motion (flexion, extension, abduction, adduction, internal and external rotation) from images or video frames; reported test-retest reliability 0.852-0.856
Measured: Baseline and after 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Oct 2026
- Study start19 Oct 2026
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Rotator Cuff TendinopathyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This randomized clinical trial compares the effects of the Cyriax approach (deep transverse friction massage) with and without Mulligan Mobilization with Movement (MWM) on pain, range of motion and disability in patients with shoulder restriction due to rotator cuff tendinopathy. Thirty-eight patients (19 per group) will be recruited by non-probability convenience sampling and randomly allocated to two groups. Both groups will receive laser therapy and conventional physiotherapy; 12 sessions over 4 weeks (3 sessions per week). Outcomes (NPRS, SPADI, Angulus Pro smartphone application) will be measured at baseline and at the 4th week and analyzed using SPSS version 24.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 38 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Management and Technology Lahore
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ayesha Karim, University of Management and Technology Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07895810
- Sponsor's protocol ID
- RE-192-2026
- Status last verified
- Oct 2026
- First submitted
- 19 Oct 2026
- Last updated
- 29 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The results data collected, de-identified individual participant data will be shared.
Study at a glance
From the registry record, last updated by the sponsor on 29 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Effects of Cyriax Approach With and Without Mobilization With Movement on Pain, Range of Motion and Disability in Shoulder Restriction With Rotator Cuff Tendinopathy
- ClinicalTrials.gov ID
- NCT07895810
- Acronym / sponsor ID
- RE-192-2026
- Conditions
- Rotator Cuff Tendinopathy
- Keywords
- Cyriax approach, Mobilization with Movement, Shoulder pain, Shoulder disability, Shoulder restriction, range of motion
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 38 participants (estimated)
- Lead sponsor
- University of Management and Technology LahoreUniversity, hospital or other
- Study start
- 19 Oct 2026 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 26 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized clinical trial compares the effects of the Cyriax approach (deep transverse friction massage) with and without Mulligan Mobilization with Movement (MWM) on pain, range of motion and disability in patients with shoulder restriction due to rotator cuff tendinopathy. Thirty-eight patients (19 per group) will be recruited by non-probability convenience sampling and randomly allocated to two groups. Both groups will receive laser therapy and conventional physiotherapy; 12 sessions over 4 weeks (3 sessions per week). Outcomes (NPRS, SPADI, Angulus Pro smartphone application) will be measured at baseline and at the 4th week and analyzed using SPSS version 24.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- This randomized clinical trial compares the effects of the Cyriax approach (deep transverse friction massage) with and without Mulligan Mobilization with Movement (MWM) on pain, range of motion and disability in patients with shoulder restriction due to rotator cuff tendinopathy. Thirty-eight patients (19 per group) will be recruited by non-probability convenience sampling and randomly allocated to two groups. Both groups will receive laser therapy and conventional physiotherapy; 12 sessions over 4 weeks (3 sessions per week). Outcomes (NPRS, SPADI, Angulus Pro smartphone application) will be measured at baseline and at the 4th week and analyzed using SPSS version 24.
| Arm | Type | Receives |
|---|---|---|
| Cyriax approach with Mulligan Mobilization | Experimental | Other: Cyriax Approach with Mobilization with movementCyriax approach (deep transverse friction massage, 10-12 minutes per session) plus Mulligan Mobilization with Movement (sustained posterolateral glide of the humeral head during pain-free active shoulder movement; 3 sets of 10 repetitions with 30-second rest), together with laser therapy and conventional treatment, 3 sessions per week for 4 weeks |
| Cyriax approach without Mulligan Mobilization | Active comparator | Other: Cyriax Approach without Mobilization with MovementCyriax approach (deep transverse friction massage, 10-12 minutes per session) together with laser therapy and conventional treatment, 3 sessions per week for 4 weeks. |
Who may qualify
- Ages
- 30 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Age 30 to 65 years.
- Both male and female genders.
- Symptoms in acute (up to 4 weeks) or sub-acute stage (4-6 weeks).
- Shoulder pain related to the rotator cuff or clinically documented rotator cuff tendinopathy.
- Pain intensity of 4-6 on the Numeric Pain Rating Scale (NPRS).
Key exclusion criteria (8 listed)
- Previous cervical spine or shoulder surgery.
- Referred pain from the cervical spine or cervical radiculopathy.
- Other conditions affecting the shoulder joint complex: fractures or dislocations, severe osteoarthritis of the glenohumeral or acromioclavicular joint, adhesive capsulitis, shoulder stiffness and glenohumeral instability.
- Full-thickness rotator cuff tear or signs that surgery is necessary.
- Musculoskeletal or systemic inflammatory conditions such as severe osteoarthritis or rheumatoid arthritis.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cyriax Approach with Mobilization with movementCyriax approach (deep transverse friction massage, 10-12 minutes per session) plus Mulligan Mobilization with Movement (sustained posterolateral glide of the humeral head during pain-free active shoulder movement; 3 sets of 10 repetitions with 30-second rest), together with laser therapy and conventional treatment, 3 sessions per week for 4 weeks. | Other | Cyriax approach with Mulligan Mobilization |
| Cyriax Approach without Mobilization with MovementCyriax approach (deep transverse friction massage, 10-12 minutes per session) together with laser therapy and conventional treatment, 3 sessions per week for 4 weeks. | Other | Cyriax approach without Mulligan Mobilization |
Primary outcome
Numeric Pain Rating Scale
Time frame: Baseline and after 4 weeks
11-point self-reported scale: 0 representing no pain and 10 the most severe pain (1-3 mild, 4-6 moderate, 7-10 severe pain). Pain is rated at rest and during activity. Reported ICC 0.74-0.92; MCID about 2-2.5 points
Shoulder Pain and Disability Index
Time frame: Baseline and after 4 weeks
13-item self-administered questionnaire with a pain subscale (5 items) and a disability subscale (8 items); each item scored 0-10 and total converted to a percentage, higher scores indicating greater disability. Cronbach's alpha about 0.94, test-retest ICC 0.89-0.91; MCID 8-25 points
Smartphone Application
Time frame: Baseline and after 4 weeks
Used to measure shoulder range of motion (flexion, extension, abduction, adduction, internal and external rotation) from images or video frames; reported test-retest reliability 0.852-0.856
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Oct 2026.
- Related InfoLink provided by the sponsor.
- Related InfoLink provided by the sponsor.
- Related InfoLink provided by the sponsor.
- Related InfoLink provided by the sponsor.
- Related InfoLink provided by the sponsor.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. The results data collected, de-identified individual participant data will be shared.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Cyriax Approach with Mobilization with movement and Cyriax Approach without Mobilization with Movement in people with Rotator Cuff Tendinopathy, run by University of Management and Technology Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 29 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numeric Pain Rating Scale (time frame: Baseline and after 4 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Oct 2026.