Chronic Ankle Instability, CAINCT07584746
Lower Extremity Mobility for CAI
A study testing traditional rehabilitation for Chronic Ankle Instability, Ankle mobility exercises and Hip mobility exercises in people with Chronic Ankle Instability, CAI, run by Cairo University.
Trial summary
This study will be conducted to determine the effect of addition of ankle mobility versus hip mobility exercises to traditional rehabilitation to patients with chronic ankle instability. Read more about this study
- Who is it for?
- Ages 18 to 30 years
- Conditions the study is for
- Chronic Ankle Instability, CAI
- What is being tested?
- traditional rehabilitation for Chronic Ankle Instability, Ankle mobility exercises and Hip mobility exercises
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- No sites listed yet
- Study dates
- Jun 2026to Oct 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Adults (18-30 years old) with chronic ankle instability
- Patient's Body mass index (BMI) will range from 18.5- 29.9 kg/m2
- A history of at least one ankle sprain with the initial sprain occurring 12 months prior to study
- Most recent injury 3 months prior to start of treatment with at least one day of interrupted desired physical activity and associated inflammatory symptoms (pain, swelling, etc.).
- A history of previous giving way and/or recurrent sprain, and/or feeling of instability to injured ankle.
- Cumberland Ankle Instability Tool: score of ≤ 24.
Who cannot join
- Other lower extremity injury surgery 6 months before testing
- Patient suffered an acute sprain in the previous 6 weeks to the start of the study.
- History of neuromuscular disorders.
- Systemic diseases that affect balance.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effects of Targeted Mobility Interventions at the Ankle Versus Hip on Clinical and Functional Outcomes in Chronic Ankle Instability
This study will be conducted to determine the effect of addition of ankle mobility versus hip mobility exercises to traditional rehabilitation to patients with chronic ankle instability. the main purpose is to answer the following question:
- out of these interventions which would better improve lower limb flexibility, range of motion, severity of functional instability and dynamic postural control?
Read more
Researcher will compare between ankle mobility versus hip mobility exercises
Participants will be allocated in 2 experimental groups:
- group A will include 20 patients receiving conventional physiotherapy in addition to ankle mobility exercises
- group B will include 20 patients receiving conventional physiotherapy in addition to hip mobility exercises
Patients will receive 3 sessions per week for 6 weeks in a physiotherapy outpatient facility for both groups
- Conditions
- Chronic Ankle Instability, CAI
- Being tested
- traditional rehabilitation for Chronic Ankle Instability, Ankle mobility exercises, Hip mobility exercises
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
traditional rehabilitation for Chronic Ankle InstabilityOther
- Ankle muscles strengthening exercises
- balance training
Ankle mobility exercisesOther
9 ankle mobility exercises including: ankle pumps, ankle circles, forward lunges, plantarflexion stretch, calf stretch, squat with overhead reach, heel drops on step, ankle flexion with band and scoops
Hip mobility exercisesOther
8 hip mobility exercises including: 90/90 hip stretch, frog stretch, world's greatest stretch, banded hamstring stretch, backward lunges, butterfly, pigeon stretch and banded hip stretch.
| Study group | Role | What they receive |
|---|---|---|
| Group A | Experimental | 20 patients (10 males and 10 females) will receive ankle mobility exercises and traditional physiotherapy program Receives: Other: traditional rehabilitation for Chronic Ankle Instability; Other: Ankle mobility exercises |
| Group B | Experimental | 20 patients (10 males and 10 females) will receive hip mobility exercises and traditional physiotherapy program Receives: Other: traditional rehabilitation for Chronic Ankle Instability; Other: Hip mobility exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
lower limb flexibility
measure the lower trunk and lower extremity flexibility with modified sit and reach test, sideways split and single legged knee bend test
Measured: 6 weeks
Range of motion
Hip flexion and extension range of motion Ankle dorsiflexion and plantarflexion range of motion
Measured: 6 weeks
severity of chronic ankle instability
using the Arabic version of the Cumberland Ankle Instability Tool, a tool used to describe the severity of chronic ankle instability, with the highest possible score is: 30 and the lowest possible score is: 0 Higher scores indicate better ankle stability, while lower scores indicate higher severity of functional instability
Measured: 6 weeks
Dynamic postural control
using the modified star excursion balance test
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 May 2026
- Study startJun 2026 (estimated)
- Primary completionSep 2026 (estimated)
- Study completionOct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Ankle Instability, CAIStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Amal Mounir Mohamed, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07584746
- Sponsor's protocol ID
- Mobility training for CAI
- Status last verified
- May 2026
- First submitted
- 7 May 2026
- Last updated
- 18 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 18 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Targeted Mobility Interventions at the Ankle Versus Hip on Clinical and Functional Outcomes in Chronic Ankle Instability
- ClinicalTrials.gov ID
- NCT07584746
- Acronym / sponsor ID
- Mobility training for CAI
- Conditions
- Chronic Ankle Instability, CAI
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- Jun 2026 (estimated)
- Primary completion
- Sep 2026 (estimated)
- Study completion
- Oct 2026 (estimated)
- First posted
- 13 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will be conducted to determine the effect of addition of ankle mobility versus hip mobility exercises to traditional rehabilitation to patients with chronic ankle instability. the main purpose is to answer the following question:
- out of these interventions which would better improve lower limb flexibility, range of motion, severity of functional instability and dynamic postural control?
Researcher will compare between ankle mobility versus hip mobility exercises
Participants will be allocated in 2 experimental groups:
- group A will include 20 patients receiving conventional physiotherapy in addition to ankle mobility exercises
- group B will include 20 patients receiving conventional physiotherapy in addition to hip mobility exercises
Patients will receive 3 sessions per week for 6 weeks in a physiotherapy outpatient facility for both groups
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A | Experimental | Other: traditional rehabilitation for Chronic Ankle Instability, Other: Ankle mobility exercises20 patients (10 males and 10 females) will receive ankle mobility exercises and traditional physiotherapy program |
| Group B | Experimental | Other: traditional rehabilitation for Chronic Ankle Instability, Other: Hip mobility exercises20 patients (10 males and 10 females) will receive hip mobility exercises and traditional physiotherapy program |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Adults (18-30 years old) with chronic ankle instability
- Patient's Body mass index (BMI) will range from 18.5- 29.9 kg/m2
- A history of at least one ankle sprain with the initial sprain occurring 12 months prior to study
- Most recent injury 3 months prior to start of treatment with at least one day of interrupted desired physical activity and associated inflammatory symptoms (pain, swelling, etc.).
- A history of previous giving way and/or recurrent sprain, and/or feeling of instability to injured ankle.
Key exclusion criteria (4 listed)
- Other lower extremity injury surgery 6 months before testing
- Patient suffered an acute sprain in the previous 6 weeks to the start of the study.
- History of neuromuscular disorders.
- Systemic diseases that affect balance.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| traditional rehabilitation for Chronic Ankle Instability* Ankle muscles strengthening exercises * balance training | Other | Group A, Group B |
| Ankle mobility exercises9 ankle mobility exercises including: ankle pumps, ankle circles, forward lunges, plantarflexion stretch, calf stretch, squat with overhead reach, heel drops on step, ankle flexion with band and scoops | Other | Group A |
| Hip mobility exercises8 hip mobility exercises including: 90/90 hip stretch, frog stretch, world's greatest stretch, banded hamstring stretch, backward lunges, butterfly, pigeon stretch and banded hip stretch. | Other | Group B |
Primary outcome
lower limb flexibility
Time frame: 6 weeks
measure the lower trunk and lower extremity flexibility with modified sit and reach test, sideways split and single legged knee bend test
Range of motion
Time frame: 6 weeks
Hip flexion and extension range of motion Ankle dorsiflexion and plantarflexion range of motion
severity of chronic ankle instability
Time frame: 6 weeks
using the Arabic version of the Cumberland Ankle Instability Tool, a tool used to describe the severity of chronic ankle instability, with the highest possible score is: 30 and the lowest possible score is: 0 Higher scores indicate better ankle stability, while lower scores indicate higher severity of functional instability
Dynamic postural control
Time frame: 6 weeks
using the modified star excursion balance test
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 May 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing traditional rehabilitation for Chronic Ankle Instability, Ankle mobility exercises and Hip mobility exercises in people with Chronic Ankle Instability, CAI, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 18 May 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Amal Mounir Mohamed (+201141099494, amalmunir26@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
lower limb flexibility (time frame: 6 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 May 2026.