Chronic Ankle Instability, CAINCT07581535
Effects of Cervical and Oculomotor Exercises on Functional Status, Balance, and Proprioception in Chronic Ankle Instability
A study testing Exercise in people with Chronic Ankle Instability, CAI, run by Izmir Katip Celebi University at 1 site in Turkey (Türkiye).
Trial summary
Effects of Cervical and Oculomotor Exercises on Functional Status, Balance, and Proprioception in Chronic Ankle Instability Read more about this study
- Who is it for?
- Ages 18 to 45 years
- Conditions the study is for
- Chronic Ankle Instability, CAI
- What is being tested?
- Exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 38 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 7 Jun 2026to 7 Jun 2027
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Diagnosed with unilateral chronic ankle instability (CAI) in accordance with the International Ankle Consortium recommendations
- A history of at least one significant lateral ankle sprain that occurred at least 12 months prior to participation, resulting in inflammatory symptoms such as pain and swelling and causing at least one day of interruption in physical activity
- A history of "giving way" and/or recurrent ankle sprains and/or a feeling of instability in the affected ankle within the past 6 months
- A Cumberland Ankle Instability Tool (CAIT) score of ≤ 25
Who cannot join
- History of surgery or fracture in the lower extremities or spine
- Acute musculoskeletal injury affecting other joints of the lower extremity within the past 3 months (e.g., sprains, fractures) that impaired joint integrity and function and caused at least one day of interruption in physical activity
- History of injection in the affected ankle
- History of ankle sprain in the affected extremity within the past 4 weeks
- Presence of systemic musculoskeletal disorders, neurological disorders, vestibular disorders, or any other condition that may affect balance or sensory function
- Previous participation in any rehabilitation program for the ankle or cervical region
- History of head or neck trauma or diagnosed pathology within the past 12 months
- History of neck pain greater than 3/10 in severity within the past 12 months
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Izmir Katip Celebi University Physiotherapy and Rehabilitation Department
Izmir, Çiğli, 35650
Damla Karabay, +902323293535, damla.gulpinar@ikcu.edu.tr
About this study
Official title: Effects of Cervical and Oculomotor Exercises Added to Conventional Treatment on Ankle Functional Status, Balance, and Proprioception in Individuals With Chronic Ankle Instability: A Randomized Controlled Trial
Effects of Cervical and Oculomotor Exercises on Functional Status, Balance, and Proprioception in Chronic Ankle Instability
Read the detailed description
Effects of Cervical and Oculomotor Exercises Added to Conventional Treatment on Ankle Functional Status, Balance, and Proprioception in Individuals with Chronic Ankle Instability: A Randomized Controlled Trial
- Conditions
- Chronic Ankle Instability, CAI
- Being tested
- Exercise
- Keywords
- Postural Balance, Proprioception, Rehabilitation, Ankle Instability
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ExerciseOther
Participants in the experimental group will receive a conventional rehabilitation program including mobility, strengthening, balance, and proprioceptive exercises targeting the ankle joint. In addition, they will perform cervical stabilization and oculomotor exercises.
ExerciseOther
Participants in the control group will receive a conventional rehabilitation program including mobility, strengthening, balance, and proprioceptive exercises targeting the ankle joint.
| Study group | Role | What they receive |
|---|---|---|
| Conventional Treatment + Cervical and Oculomotor Exercises | Experimental | Participants in the experimental group will receive a conventional rehabilitation program including mobility, strengthening, balance, and proprioceptive exercises targeting the ankle joint. In addition, they will perform cervical stabilization and oculomotor exercises. The intervention will be conducted for 4 weeks, with 3 sessions per week. Participants will follow a home exercise program that includes ankle mobility, strengthening, balance, and oculomotor exercises on days when they do not attend the clinic. Receives: Other: Exercise |
| Conventional Treatment | Active comparator | Participants in the control group will receive a conventional rehabilitation program consisting of mobility, strengthening, balance, and proprioceptive exercises targeting the ankle joint. The intervention will be conducted for 4 weeks, with 3 sessions per week. Participants will follow a home exercise program that includes ankle mobility, strengthening and balance exercises on days when they do not attend the clinic. Receives: Other: Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Y-Balance Test
Dynamic balance performance assessed using balance tests (Y-Balance Test)
Measured: Baseline and post-intervention (after 4 weeks)
Foot and Ankle Ability Measure (FAAM)
Functional status assessed using the Foot and Ankle Ability Measure (FAAM) The daily living activities subscale contains 21 items; the minimum score is 0 and the maximum score is 84. The sports subscale consists of 8 items; the minimum score is 0 and the maximum score is 32. A higher score represents a higher level of physical function.
Measured: Baseline and post-intervention (after 4 weeks)
Secondary outcomes (6)
Ankle Joint Position Error Test
Ankle proprioception assessed using laser beam device joint position error (JPE) tests
Measured: Baseline and post-intervention (after 4 weeks)
Weight Bearing Lunge Test
Ankle dorsiflexion range of motion will be assessed with the weight bearing lunge test
Measured: Baseline and post-intervention (after 4 weeks)
Computerized balance assessment
Postural stability will be assessed using the Prokin Tecnobody balance assessment system.
Measured: Baseline and post-intervention (after 4 weeks)
Side Hop Test
Side hop test will be used to assess the dynamic postural control capacity around the ankle.
Measured: Baseline and post-intervention (after 4 weeks)
Ankle Pain
Ankle pain will be assessed using a visual analog scale (VAS). The VAS is a scale ranging from 0 (no pain) to 10 (most severe pain), with higher scores indicating greater pain.
Measured: Baseline and post-intervention (after 4 weeks)
Cervical Joint Position Error Test
Cervical proprioception will be assessed using the Cervical Joint Position Error Test.
Measured: Baseline and post-intervention (after 4 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 May 2026
- Study start7 Jun 2026 (estimated)
- Primary completion7 Jun 2027 (estimated)
- Study completion7 Jun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Ankle Instability, CAIStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 38 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Izmir Katip Celebi University
- Sponsor type
- University, hospital or other
- Collaborators
- Izmir Bakircay University
- Responsible party
- Principal investigator, Simge Nur UNGAN, Izmir Katip Celebi University
- Investigators
- Damla KARABAY, Assistant Professor, Study chair, Izmir Katip Çelebi UniversitySimge N UNGAN, Physiotherapist (Bachelor), Principal investigator, Izmir Katip Çelebi UniversitySercan Çapkın, Associate Professor, Study director, Izmir Bakırçay University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07581535
- Sponsor's protocol ID
- 2586
- Status last verified
- Jun 2026
- First submitted
- 29 Apr 2026
- Last updated
- 8 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: A final decision regarding the sharing of individual participant data has not yet been made due to considerations related to data protection regulations. If a decision to share is made in the future, only de-identified data relevant to the published results may be shared upon reasonable request and in accordance with applicable regulations.