Burn Any Degree Involving 20-29 Percent of Body SurfaceNCT07526610

Predictive Mortality Scales in the Burn Patient Admitted to the Intensive Care Unit

An observational study of Burn Any Degree Involving 20-29 Percent of Body Surface and Burn Any Degree Involving 30-39 Percent of Body Surface, run by Universidad Rey Juan Carlos at 1 site in Spain.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

The data for this retrospective study were collected from the records of patients admitted to the intensive care unit (ICU) for burns at Hospital La Paz from January 1, 2019 to May 31, 2023. Read more about this study

Who is it for?: Ages 18 years and older
Conditions the study is for: Burn Any Degree Involving 20-29 Percent of Body Surface, Burn Any Degree Involving 30-39 Percent of Body Surface, Burn Any Degree Involving 40-49 Percent of Body Surface
How many people: 465 participants
Where: 1 siteSpain
Study dates: 1 Jan 2019to 1 Jan 2026
Phase: Observational
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 years and older
All sexes
No healthy volunteers
Adult, Older adult

Study population: Patients admitted to this burn ICU

Who may be able to join

Patients older than 18 years
Regardless of burned body surface area (BBS (%))
Met the criteria for admission to the ICU for burns according to the American Burn Association

Who cannot join

None listed.

Trial locations and contacts

1 site in 1 country.

Spain1 site

Faculty of Health Sciences
Alcorcón, Madrid, 28922

Other trials in Spain

About this study

The data for this retrospective study were collected from the records of patients admitted to the intensive care unit (ICU) for burns at Hospital La Paz from January 1, 2019 to May 31, 2023.

Read the detailed description

The complete medical records of 710 patients admitted to this burn ICU were reviewed. Patients older than 18 years were included, regardless of burned body surface area (BBS (%)), who met the criteria for admission to the ICU for burns according to the American Burn Association [17]. Therefore, a total sample size of 465 participants was recruited. A sample were recruited by a consecutive sampling method using a successive and non-aleatorized simple method. Subjects were enlisted from the Intensive Care Unit (ICU) for burns at the La Paz Hospital (Madrid- Spain).

Conditions: Burn Any Degree Involving 20-29 Percent of Body Surface, Burn Any Degree Involving 30-39 Percent of Body Surface, Burn Any Degree Involving 40-49 Percent of Body Surface, Burn Any Degree Involving 50-59 Percent of Body Surface, Burn Any Degree Involving 60-65 Percent of Body Surface, Burn Degree Second
Keywords: Burn unit, mortality indicators, burn mortality, burn survival

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT07526610
Study group	Role	What they receive
Burn patients		hospitalized burn patients

What is being measured

The primary outcome is the main question the study is designed to answer.

In-hospital Mortality
In-hospital Mortality
Measured: 2 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1 Jan 20191 Jan 2026

First posted13 Apr 2026
Study start1 Jan 2019
Primary completion31 May 2023
Study completion1 Jan 2026

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (29)Papers the sponsor has linked to this study.
Other trials for Burn Any Degree Involving 20-29 Percent of Body SurfaceStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Observational
Observational model: Cohort
Time perspective: Retrospective
Enrolment: 465 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07526610
Sponsor's protocol ID: 2023.59
Status last verified: Apr 2026
First submitted: 6 Apr 2026
Last updated: 13 Apr 2026
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No: In order to comply with current data protection laws, the study data will not be shared

Publications

Queiroz LF, Anami EH, Zampar EF, Tanita MT, Cardoso LT, Grion CM. Epidemiology and outcome analysis of burn patients admitted to an Intensive Care Unit in a University Hospital. Burns. 2016 May;42(3):655-62. doi: 10.1016/j.burns.2015.08.002. Epub 2016 Jan 4.
PubMed 26762620
Williams FN, Strassle PD, Knowlin L, Napravnik S, van Duin D, Charles A, Nizamani R, Jones SW, Cairns BA. Sex-Based Differences in Inpatient Burn Mortality. World J Surg. 2019 Dec;43(12):3035-3043. doi: 10.1007/s00268-019-05165-x.
PubMed 31511940
Bagheri M, Fuchs PC, Lefering R, Grigutsch D, Busche MN, Niederstatter I, The German Burn Registry, Schiefer JL. Effect of comorbidities on clinical outcome of patients with burn injury - An analysis of the German Burn Registry. Burns. 2021 Aug;47(5):1053-1058. doi: 10.1016/j.burns.2020.04.040. Epub 2020 May 13.
PubMed 34092418
Knowlin L, Reid T, Williams F, Cairns B, Charles A. Burn mortality in patients with preexisting cardiovascular disease. Burns. 2017 Aug;43(5):949-955. doi: 10.1016/j.burns.2017.01.026. Epub 2017 Feb 8.
PubMed 28189352
Abarca L, Guilabert P, Martin N, Usua G, Barret JP, Colomina MJ. Epidemiology and mortality in patients hospitalized for burns in Catalonia, Spain. Sci Rep. 2023 Sep 1;13(1):14364. doi: 10.1038/s41598-023-40198-2.
PubMed 37658072
Woods JF, Quinlan CS, Shelley OP. Predicting Mortality in Severe Burns-What Is the Score?: Evaluation and Comparison of 4 Mortality Prediction Scores in an Irish Population. Plast Reconstr Surg Glob Open. 2016 Feb 5;4(1):e606. doi: 10.1097/GOX.0000000000000584. eCollection 2016 Jan. No abstract available.
PubMed 27104105
Pantet O, Faouzi M, Brusselaers N, Vernay A, Berger MM. Comparison of mortality prediction models and validation of SAPS II in critically ill burns patients. Ann Burns Fire Disasters. 2016 Jun 30;29(2):123-129.
PubMed 28149234
Romanowski KS, Sen S. Wound healing in older adults with severe burns: Clinical treatment considerations and challenges. Burns Open. 2022 Apr;6(2):57-64. doi: 10.1016/j.burnso.2022.01.002. Epub 2022 Feb 1.
PubMed 35571008
Lundgren RS, Kramer CB, Rivara FP, Wang J, Heimbach DM, Gibran NS, Klein MB. Influence of comorbidities and age on outcome following burn injury in older adults. J Burn Care Res. 2009 Mar-Apr;30(2):307-14. doi: 10.1097/BCR.0b013e318198a416.
PubMed 19165104
Obed D, Salim M, Dastagir N, Knoedler S, Dastagir K, Panayi AC, Vogt PM. Comparative Analysis of Composite Mortality Prediction Scores in Intensive Care Burn Patients. Int J Environ Res Public Health. 2022 Sep 28;19(19):12321. doi: 10.3390/ijerph191912321.
PubMed 36231617
Greenhalgh DG, Hill DM, Burmeister DM, Gus EI, Cleland H, Padiglione A, Holden D, Huss F, Chew MS, Kubasiak JC, Burrell A, Manzanares W, Gomez MC, Yoshimura Y, Sjoberg F, Xie WG, Egipto P, Lavrentieva A, Jain A, Miranda-Altamirano A, Raby E, Aramendi I, Sen S, Chung KK, Alvarez RJQ, Han C, Matsushima A, Elmasry M, Liu Y, Donoso CS, Bolgiani A, Johnson LS, Vana LPM, de Romero RVD, Allorto N, Abesamis G, Luna VN, Gragnani A, Gonzalez CB, Basilico H, Wood F, Jeng J, Li A, Singer M, Luo G, Palmieri T, Kahn S, Joe V, Cartotto R. Surviving Sepsis After Burn Campaign. Burns. 2023 Nov;49(7):1487-1524. doi: 10.1016/j.burns.2023.05.003. Epub 2023 May 6.
PubMed 37839919
Hirche C, Kreken Almeland S, Dheansa B, Fuchs P, Governa M, Hoeksema H, Korzeniowski T, Lumenta DB, Marinescu S, Martinez-Mendez JR, Plock JA, Sander F, Ziegler B, Kneser U. Eschar removal by bromelain based enzymatic debridement (Nexobrid(R)) in burns: European consensus guidelines update. Burns. 2020 Jun;46(4):782-796. doi: 10.1016/j.burns.2020.03.002. Epub 2020 Mar 30.
PubMed 32241591
Shoham Y, Gasteratos K, Singer AJ, Krieger Y, Silberstein E, Goverman J. Bromelain-based enzymatic burn debridement: A systematic review of clinical studies on patient safety, efficacy and long-term outcomes. Int Wound J. 2023 Dec;20(10):4364-4383. doi: 10.1111/iwj.14308. Epub 2023 Jul 16.
PubMed 37455553
Bagheri M, Fuchs PC, Lefering R, Daniels M, Schulz A, The German Burn Registry, Schiefer JL. The BUrn Mortality Prediction (BUMP) Score - An improved mortality prediction score based on data of the German burn registry. Burns. 2023 Feb;49(1):110-119. doi: 10.1016/j.burns.2022.02.007. Epub 2022 Feb 9.
PubMed 35210139
Bartels P, Thamm OC, Elrod J, Fuchs P, Reinshagen K, German Burn Registry, Koenigs I. The ABSI is dead, long live the ABSI - reliable prediction of survival in burns with a modified Abbreviated Burn Severity Index. Burns. 2020 Sep;46(6):1272-1279. doi: 10.1016/j.burns.2020.05.003. Epub 2020 May 19.
PubMed 32534892

Study at a glance

From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Predictive Mortality Scales in the Burn Patient Admitted to the Intensive Care Unit
ClinicalTrials.gov ID: NCT07526610
Acronym / sponsor ID: 2023.59
Conditions: Burn Any Degree Involving 20-29 Percent of Body Surface, Burn Any Degree Involving 30-39 Percent of Body Surface, Burn Any Degree Involving 40-49 Percent of Body Surface, Burn Any Degree Involving 50-59 Percent of Body Surface, Burn Any Degree Involving 60-65 Percent of Body Surface, Burn Degree Second
Keywords: Burn unit, mortality indicators, burn mortality, burn survival
Study type: Observational
Recruitment status: Completed
Enrolment: 465 participants (actual)
Lead sponsor: Universidad Rey Juan CarlosUniversity, hospital or other
Collaborators: Hospital Universitario La Paz
Study start: 1 Jan 2019 (actual)
Primary completion: 31 May 2023 (actual)
Study completion: 1 Jan 2026 (actual)
First posted: 13 Apr 2026 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

The data for this retrospective study were collected from the records of patients admitted to the intensive care unit (ICU) for burns at Hospital La Paz from January 1, 2019 to May 31, 2023.

Detailed description

Study design

Observational model: Cohort
Time perspective: Retrospective
Number of arms: 1

Arm	Type	Receives
Burn patients	–	–hospitalized burn patients

Who may qualify

Ages: 18 years and older
Sex: All
Healthy volunteers: Not accepted
Age groups: Adult, Older adult
Study population: Patients admitted to this burn ICU

Key inclusion criteria (3 listed)

Patients older than 18 years
Regardless of burned body surface area (BBS (%))
Met the criteria for admission to the ICU for burns according to the American Burn Association

Key exclusion criteria (0 listed)

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Primary outcome

In-hospital Mortality
Time frame: 2 years
In-hospital Mortality

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
Background: PubMed 26762620Queiroz LF, Anami EH, Zampar EF, Tanita MT, Cardoso LT, Grion CM. Epidemiology and outcome analysis of burn patients admitted to an Intensive Care Unit in a University Hospital. Burns. 2016 May;42(3):655-62. doi: 10.1016/j.burns.2015.08.002. Epub 2016 Jan 4.
Background: PubMed 31511940Williams FN, Strassle PD, Knowlin L, Napravnik S, van Duin D, Charles A, Nizamani R, Jones SW, Cairns BA. Sex-Based Differences in Inpatient Burn Mortality. World J Surg. 2019 Dec;43(12):3035-3043. doi: 10.1007/s00268-019-05165-x.
Background: PubMed 34092418Bagheri M, Fuchs PC, Lefering R, Grigutsch D, Busche MN, Niederstatter I, The German Burn Registry, Schiefer JL. Effect of comorbidities on clinical outcome of patients with burn injury - An analysis of the German Burn Registry. Burns. 2021 Aug;47(5):1053-1058. doi: 10.1016/j.burns.2020.04.040. Epub 2020 May 13.
Background: PubMed 28189352Knowlin L, Reid T, Williams F, Cairns B, Charles A. Burn mortality in patients with preexisting cardiovascular disease. Burns. 2017 Aug;43(5):949-955. doi: 10.1016/j.burns.2017.01.026. Epub 2017 Feb 8.
Background: PubMed 37658072Abarca L, Guilabert P, Martin N, Usua G, Barret JP, Colomina MJ. Epidemiology and mortality in patients hospitalized for burns in Catalonia, Spain. Sci Rep. 2023 Sep 1;13(1):14364. doi: 10.1038/s41598-023-40198-2.
Background: PubMed 27104105Woods JF, Quinlan CS, Shelley OP. Predicting Mortality in Severe Burns-What Is the Score?: Evaluation and Comparison of 4 Mortality Prediction Scores in an Irish Population. Plast Reconstr Surg Glob Open. 2016 Feb 5;4(1):e606. doi: 10.1097/GOX.0000000000000584. eCollection 2016 Jan. No abstract available.
Background: PubMed 28149234Pantet O, Faouzi M, Brusselaers N, Vernay A, Berger MM. Comparison of mortality prediction models and validation of SAPS II in critically ill burns patients. Ann Burns Fire Disasters. 2016 Jun 30;29(2):123-129.
Background: PubMed 35571008Romanowski KS, Sen S. Wound healing in older adults with severe burns: Clinical treatment considerations and challenges. Burns Open. 2022 Apr;6(2):57-64. doi: 10.1016/j.burnso.2022.01.002. Epub 2022 Feb 1.
Background: PubMed 19165104Lundgren RS, Kramer CB, Rivara FP, Wang J, Heimbach DM, Gibran NS, Klein MB. Influence of comorbidities and age on outcome following burn injury in older adults. J Burn Care Res. 2009 Mar-Apr;30(2):307-14. doi: 10.1097/BCR.0b013e318198a416.
Background: PubMed 36231617Obed D, Salim M, Dastagir N, Knoedler S, Dastagir K, Panayi AC, Vogt PM. Comparative Analysis of Composite Mortality Prediction Scores in Intensive Care Burn Patients. Int J Environ Res Public Health. 2022 Sep 28;19(19):12321. doi: 10.3390/ijerph191912321.
Background: PubMed 37839919Greenhalgh DG, Hill DM, Burmeister DM, Gus EI, Cleland H, Padiglione A, Holden D, Huss F, Chew MS, Kubasiak JC, Burrell A, Manzanares W, Gomez MC, Yoshimura Y, Sjoberg F, Xie WG, Egipto P, Lavrentieva A, Jain A, Miranda-Altamirano A, Raby E, Aramendi I, Sen S, Chung KK, Alvarez RJQ, Han C, Matsushima A, Elmasry M, Liu Y, Donoso CS, Bolgiani A, Johnson LS, Vana LPM, de Romero RVD, Allorto N, Abesamis G, Luna VN, Gragnani A, Gonzalez CB, Basilico H, Wood F, Jeng J, Li A, Singer M, Luo G, Palmieri T, Kahn S, Joe V, Cartotto R. Surviving Sepsis After Burn Campaign. Burns. 2023 Nov;49(7):1487-1524. doi: 10.1016/j.burns.2023.05.003. Epub 2023 May 6.
Background: PubMed 32241591Hirche C, Kreken Almeland S, Dheansa B, Fuchs P, Governa M, Hoeksema H, Korzeniowski T, Lumenta DB, Marinescu S, Martinez-Mendez JR, Plock JA, Sander F, Ziegler B, Kneser U. Eschar removal by bromelain based enzymatic debridement (Nexobrid(R)) in burns: European consensus guidelines update. Burns. 2020 Jun;46(4):782-796. doi: 10.1016/j.burns.2020.03.002. Epub 2020 Mar 30.
Individual participant dataSharing planned: No. In order to comply with current data protection laws, the study data will not be shared

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

The record lists no contact. Use the official record to reach the sponsor.

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

An observational study of Burn Any Degree Involving 20-29 Percent of Body Surface and Burn Any Degree Involving 30-39 Percent of Body Surface, run by Universidad Rey Juan Carlos at 1 site in Spain.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

In-hospital Mortality (time frame: 2 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07526610, which also lists 29 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.