HypnosisHYPREANCT07518498
Hypnosis During Mechanical Ventilation Weaning
A study testing Hypnosis in people with Hypnosis and Weaning Mechanical Ventilation, run by Central Hospital, Nancy, France at 1 site in France.
Trial summary
Hypnosis is defined as an altered state of consciousness characterized by an increased susceptibility to suggestion. It is a technique commonly used in the medical field, primarily for the management of pain and anxiety. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Hypnosis, Weaning Mechanical Ventilation, Hypnosis During Weaning From Invasive Mechanical Ventilation
- What is being tested?
- Hypnosis
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteFrance
- Study dates
- 1 Jul 2026to 1 Jul 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients aged 18 and older
- Patients hospitalized in the intensive care unit and requiring invasive mechanical ventilation for at least 48 hours
- Presence of the prerequisite criteria for ventilator weaning: effective cough, minimal bronchial congestion, patient awake and not agitated, hemodynamic stability (heart rate less than 140 beats per minute, systolic blood pressure between 90 and 160 mmHg without vasopressors), pressure support ventilation, FiO2 < 40% and PEEP ≤ 8 cmH2O, PaO2/FiO2 > 150, pH > 7.35, respiratory rate < 35 per minute
- Patients enrolled in a social security program or eligible for such a program
- Patients who has received complete information about the clinical research protocol and has signed an informed consent form
- Patients who has undergone a preliminary clinical examination appropriate for the clinical research
Who cannot join
- Contraindication to hypnosis (particularly severe psychotic disorders)
- Non-French-speaking individuals
- Deaf or hard-of-hearing individuals
- State of agitation or acute delirium
- Individuals who have already undergone a spontaneous ventilation test or an attempt at orotracheal extubation during their hospitalization
- Individuals receiving a new anxiolytic or sedative treatment within 2 hours prior to the weaning test
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- Individuals with a tracheostomy
- Women of childbearing age who do not have access to effective contraception
- Individuals covered by Articles L. 1121-5, L. 1121-7, and L. 1121-8 of the Public Health Code (pregnant women, women in labor, or breastfeeding women, minors not emancipated, adult subject to a legal protection measure, adult unable to give consent)
- Person deprived of liberty by a judicial or administrative decision, or a person receiving psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site
Central Hospital
Nancy, 54000
Sébastien Gibot, MD, + 33 383851495, s.gibot@chru-nancy.fr
About this study
Official title: Hypnosis During Mechanical Ventilation Weaning : Feasibility and Physiological Impact
Hypnosis is defined as an altered state of consciousness characterized by an increased susceptibility to suggestion. It is a technique commonly used in the medical field, primarily for the management of pain and anxiety.
The literature demonstrates that better pain management is correlated with a shorter length of stay in the ICU and a shorter duration of mechanical ventilation.
Read more
In patients hospitalized in the ICU requiring invasive mechanical ventilation, the emotional component plays a significant role in dyspnea, which can become an obstacle to weaning from ventilation. The analgesic and anxiolytic treatments used carry numerous side effects and contraindications, limiting their use in ICU patients. Furthermore, pulmonary edema is a common cause of failure to wean from invasive mechanical ventilation. By reducing the occurrence of hypertension and tachycardia, hypnosis could be used as a therapeutic strategy to limit its incidence. Thus, hypnosis could be a valuable therapeutic tool for improving tolerance and the success of ventilator weaning.
Although hypnosis is already commonly used in intensive care units, its use is still limited by a lack of evidence for more specific indications. It is in this context that this study was conducted, to assess the feasibility of conducting a hypnosis session during weaning from invasive mechanical ventilation in the intensive care unit.
- Conditions
- Hypnosis, Weaning Mechanical Ventilation, Hypnosis During Weaning From Invasive Mechanical Ventilation
- Being tested
- Hypnosis
- Keywords
- Hypnosis, Weaning Mechanical Ventilation, Intensive care unit
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
HypnosisBehavioural
The intervention consists of a standardized hypnosis session delivered by a trained practitioner during the weaning phase from invasive mechanical ventilation in an intensive care unit.
| Study group | Role | What they receive |
|---|---|---|
| Patients on invasive mechanical ventilation | Experimental | Not described Receives: Behavioral: Hypnosis |
What is being measured
The primary outcome is the main question the study is designed to answer.
Feasibility of a hypnosis session during weaning from invasive mechanical ventilation.
Number of hypnosis sessions conducted, relative to the number of eligible patients.
Measured: At the end of the recruitment period
Secondary outcomes (7)
Progression of pain and anxiety during weaning from invasive mechanical ventilation using hypnosis.
Assessment of pain and anxiety using visual analog scales before and after the hypnosis session.
Measured: During the hypnosis session (Day 1)
Frequency of failed weaning from invasive mechanical ventilation among patients who underwent a hypnosis session.
Ventilator weaning failure rate.
Measured: During ICU stay
Complications associated with weaning from mechanical ventilation using hypnosis.
Number and types of complications.
Measured: During the ICU stay
Length of stay in the intensive care unit following weaning from mechanical ventilation using hypnosis.
Length of stay in the intensive care unit.
Measured: ICU stay
Mortality following weaning from mechanical ventilation using hypnosis.
Death rate
Measured: At day 28
Patients' experiences
Form for patients who received hypnosis during weaning from mechanical ventilation.
Measured: On the day of discharge from the ICU, and no later than Day 28
Professionals' perceptions of hypnosis
Form for healthcare professionals who have conducted at least one hypnosis session.
Measured: Throughout the study's enrollment period.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Apr 2026
- Study start1 Jul 2026 (estimated)
- Primary completion1 Jun 2027 (estimated)
- Study completion1 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HypnosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Central Hospital, Nancy, France
- Sponsor type
- University, hospital or other
- Collaborators
- Centre Hospitalier Régional Metz-Thionville
- Responsible party
- Principal investigator, Gibot Sébastien, Central Hospital, Nancy, France
- Investigators
- Viviane MARTIN, PhD, Study director, The Regional and University Hospital Center of Nancy
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07518498
- Sponsor's protocol ID
- 2025PI107
- Acronym
- HYPREA
- Status last verified
- Apr 2026
- First submitted
- 30 Mar 2026
- Last updated
- 8 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 8 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Hypnosis During Mechanical Ventilation Weaning : Feasibility and Physiological Impact
- ClinicalTrials.gov ID
- NCT07518498
- Acronym / sponsor ID
- HYPREA / 2025PI107
- Conditions
- Hypnosis, Weaning Mechanical Ventilation, Hypnosis During Weaning From Invasive Mechanical Ventilation
- Keywords
- Hypnosis, Weaning Mechanical Ventilation, Intensive care unit
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Central Hospital, Nancy, FranceUniversity, hospital or other
- Collaborators
- Centre Hospitalier Régional Metz-Thionville
- Study start
- 1 Jul 2026 (estimated)
- Primary completion
- 1 Jun 2027 (estimated)
- Study completion
- 1 Jul 2027 (estimated)
- First posted
- 8 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Hypnosis is defined as an altered state of consciousness characterized by an increased susceptibility to suggestion. It is a technique commonly used in the medical field, primarily for the management of pain and anxiety.
The literature demonstrates that better pain management is correlated with a shorter length of stay in the ICU and a shorter duration of mechanical ventilation.
In patients hospitalized in the ICU requiring invasive mechanical ventilation, the emotional component plays a significant role in dyspnea, which can become an obstacle to weaning from ventilation. The analgesic and anxiolytic treatments used carry numerous side effects and contraindications, limiting their use in ICU patients. Furthermore, pulmonary edema is a common cause of failure to wean from invasive mechanical ventilation. By reducing the occurrence of hypertension and tachycardia, hypnosis could be used as a therapeutic strategy to limit its incidence. Thus, hypnosis could be a valuable therapeutic tool for improving tolerance and the success of ventilator weaning.
Although hypnosis is already commonly used in intensive care units, its use is still limited by a lack of evidence for more specific indications. It is in this context that this study was conducted, to assess the feasibility of conducting a hypnosis session during weaning from invasive mechanical ventilation in the intensive care unit.
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients on invasive mechanical ventilation | Experimental | Behavioral: Hypnosis |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Patients aged 18 and older
- Patients hospitalized in the intensive care unit and requiring invasive mechanical ventilation for at least 48 hours
- Presence of the prerequisite criteria for ventilator weaning: effective cough, minimal bronchial congestion, patient awake and not agitated, hemodynamic stability (heart rate less than 140 beats per minute, systolic blood pressure between 90 and 160 mmHg without vasopressors), pressure support ventilation, FiO2 < 40% and PEEP ≤ 8 cmH2O, PaO2/FiO2 > 150, pH > 7.35, respiratory rate < 35 per minute
- Patients enrolled in a social security program or eligible for such a program
- Patients who has received complete information about the clinical research protocol and has signed an informed consent form
Key exclusion criteria (10 listed)
- Contraindication to hypnosis (particularly severe psychotic disorders)
- Non-French-speaking individuals
- Deaf or hard-of-hearing individuals
- State of agitation or acute delirium
- Individuals who have already undergone a spontaneous ventilation test or an attempt at orotracheal extubation during their hospitalization
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| HypnosisThe intervention consists of a standardized hypnosis session delivered by a trained practitioner during the weaning phase from invasive mechanical ventilation in an intensive care unit. | Behavioural | Patients on invasive mechanical ventilation |
Primary outcome
Feasibility of a hypnosis session during weaning from invasive mechanical ventilation.
Time frame: At the end of the recruitment period
Number of hypnosis sessions conducted, relative to the number of eligible patients.
7 secondary outcomes
Progression of pain and anxiety during weaning from invasive mechanical ventilation using hypnosis.
Time frame: During the hypnosis session (Day 1)
Frequency of failed weaning from invasive mechanical ventilation among patients who underwent a hypnosis session.
Time frame: During ICU stay
Complications associated with weaning from mechanical ventilation using hypnosis.
Time frame: During the ICU stay
Length of stay in the intensive care unit following weaning from mechanical ventilation using hypnosis.
Time frame: ICU stay
Mortality following weaning from mechanical ventilation using hypnosis.
Time frame: At day 28
Patients' experiences
Time frame: On the day of discharge from the ICU, and no later than Day 28
Professionals' perceptions of hypnosis
Time frame: Throughout the study's enrollment period.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Apr 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Viviane MARTIN, PhD study director
The Regional and University Hospital Center of Nancy
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Hypnosis in people with Hypnosis and Weaning Mechanical Ventilation, run by Central Hospital, Nancy, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 8 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Sébastien Gibot, MD (+ 33 383851495, s.gibot@chru-nancy.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Feasibility of a hypnosis session during weaning from invasive mechanical ventilation. (time frame: At the end of the recruitment period). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Apr 2026; AzTrials last refreshed its copy on 27 Oct 2026.