Osteoarthritis, KneeADB_01NCT07517159
Adductor Canal Block Combined With Local Infiltration Analgesia vs Local Infiltration Analgesia Alone for Postoperative Pain in Total Knee Arthroplasty
A study testing Adductor Canal block and Local Infiltration Analgesia in people with Osteoarthritis, Knee, run by Ankara University at 1 site in Turkey (Türkiye).
Trial summary
Total knee arthroplasty (TKA) is commonly associated with significant postoperative pain, which may impair early mobilization and functional recovery. Multimodal analgesia techniques are widely used to improve postoperative pain control while minimizing opioid consumption. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Osteoarthritis, Knee
- What is being tested?
- Adductor Canal block and Local Infiltration Analgesia
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 61 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 31 May 2025to 15 Nov 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients aged 18 years and older
- Patients scheduled for elective total knee arthroplasty
- American Society of Anesthesiologists (ASA) physical status I-III
- Patients who provided written informed consent
Who cannot join
- Known allergy to local anesthetics
- Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia
- Infection at the injection site
- Severe hepatic or renal dysfunction
- Neurological disorders affecting lower extremities
- Cognitive impairment preventing pain assessment
- Refusal to participate
- Body mass index (BMI) greater than 30 kg/m²
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Ankara University Faculty of Medicine, Ibni Sina Hospital
Ankara, Ankara, 06100
About this study
Official title: Comparison of the Effect of Adductor Canal Block Combined With Local Infiltration Analgesia Versus Local Infiltration Analgesia Alone on Postoperative Pain Scores in Total Knee Arthroplasty
Total knee arthroplasty (TKA) is commonly associated with significant postoperative pain, which may impair early mobilization and functional recovery. Multimodal analgesia techniques are widely used to improve postoperative pain control while minimizing opioid consumption. Local infiltration analgesia (LIA) is a commonly used method; however, its effectiveness may be limited when used alone. The adductor canal block (ACB) provides effective analgesia while preserving quadriceps muscle strength.
This prospective randomized controlled study aims to compare the effectiveness of adductor canal block combined with local infiltration analgesia versus local infiltration analgesia alone on postoperative pain scores in patients undergoing total knee arthroplasty. The primary outcome is postoperative pain assessed using the NRS at multiple time points within the first 48 hours. Secondary outcomes include opioid consumption, functional recovery parameters and hemodynamic parameters.
The results of this study are expected to contribute to optimizing postoperative analgesia strategies in total knee arthroplasty.
Read the detailed description
Total knee arthroplasty (TKA) is frequently associated with moderate to severe postoperative pain, which can negatively affect early mobilization, rehabilitation, and patient satisfaction. Effective pain management strategies are essential for enhanced recovery protocols. Multimodal analgesia has become the standard approach, combining different techniques to improve analgesic efficacy while reducing opioid-related side effects.
Local infiltration analgesia (LIA) is widely used as part of multimodal analgesia; however, it may not always provide sufficient analgesia when used alone. The adductor canal block (ACB) has gained popularity due to its ability to provide sensory blockade of the saphenous nerve while preserving quadriceps muscle strength, thus facilitating early mobilization.
This prospective randomized controlled trial was conducted to evaluate the effect of combining ACB with LIA compared to LIA alone in patients undergoing total knee arthroplasty. Patients were randomly assigned into two groups: one group received ACB combined with LIA, while the control group received LIA alone.
Postoperative pain was assessed using the Visual Analog Scale (VAS) at 2, 6, 12, 24 and 48 hours postoperatively. Secondary outcomes included total opioid consumption and functional recovery parameters. Demographic data, operative variables, and perioperative characteristics were also recorded and analyzed.
The findings of this study aim to provide evidence regarding the efficacy of combining regional anesthesia techniques with local infiltration analgesia in improving postoperative pain control following total knee arthroplasty.
- Conditions
- Osteoarthritis, Knee
- Being tested
- Adductor Canal block, Local Infiltration Analgesia
- Keywords
- Adductor Canal Block, Local Infiltration Analgesia, Total Knee Arthroplasty, Postoperative Pain, Multimodal Analgesia, NRS, Hemodynamic
- Medical subject headings
- Osteoarthritis, Knee, Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Adductor Canal blockProcedure or surgery
Ultrasound-guided adductor canal block was performed using local anesthetic to provide postoperative analgesia.
Local Infiltration AnalgesiaProcedure or surgery
Local infiltration analgesia was administered intraoperatively using local anesthetic agents around the surgical site.
| Study group | Role | What they receive |
|---|---|---|
| ACB+LIA | Experimental | Patients in this group received an adductor canal block combined with local infiltration analgesia for postoperative pain management following total knee arthroplasty. Receives: Procedure: Adductor Canal block; Procedure: Local Infiltration Analgesia |
| LIA | Active comparator | Patients in this group received local infiltration analgesia alone for postoperative pain management following total knee arthroplasty. Receives: Procedure: Local Infiltration Analgesia |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative pain at rest (Numerating Rating Scale, NRS)
Postoperative pain was assessed using the NRS at rest at predefined time points. Postoperative pain was assessed using the Numeric Rating Scale (NRS), ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Pain scores were recorded at rest at predefined time points.
Measured: 2,6,12,24,48
Secondary outcomes (4)
Opioid Consumption
Total opioid consumption within the first 48 hours postoperatively.
Measured: 0-48 hours postoperatively
Knee flexion range of motion (degrees) measured with a goniometer
Functional recovery will be assessed by measuring knee flexion range of motion (degrees) using a standard goniometer at predefined postoperative time points.
Measured: 24 and 48 hours postoperatively
Heart rate (beats per minute)
Heart rate (beats per minute) will be recorded at baseline and at 15-minute intervals from induction of anesthesia to extubation.
Measured: Baseline (preoperative) and every 15 minutes from induction of anesthesia to extubation
Mean arterial pressure (mmHg)
Mean arterial pressure (mmHg) will be recorded at baseline (preoperative) and at 15-minute intervals during the intraoperative period.
Measured: Baseline (before induction of anesthesia) and every 15 minutes from induction of anesthesia to extubation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Apr 2026
- Study start31 May 2025
- Primary completion15 Nov 2025
- Study completion15 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Osteoarthritis, KneeStudies of the same condition, open and under way.
- More trials run by Ankara UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 61 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ankara University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Cagla Beyza Colakoglu, Ankara University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07517159
- Sponsor's protocol ID
- 08-349-25
- Acronym
- ADB_01
- Status last verified
- Mar 2026
- First submitted
- 24 Mar 2026
- Last updated
- 8 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Effect of Adductor Canal Block Combined With Local Infiltration Analgesia Versus Local Infiltration Analgesia Alone on Postoperative Pain Scores in Total Knee Arthroplasty
- ClinicalTrials.gov ID
- NCT07517159
- Acronym / sponsor ID
- ADB_01 / 08-349-25
- Conditions
- Osteoarthritis, Knee
- Keywords
- Adductor Canal Block, Local Infiltration Analgesia, Total Knee Arthroplasty, Postoperative Pain, Multimodal Analgesia, NRS, Hemodynamic
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 61 participants (actual)
- Lead sponsor
- Ankara UniversityUniversity, hospital or other
- Study start
- 31 May 2025 (actual)
- Primary completion
- 15 Nov 2025 (actual)
- Study completion
- 15 Nov 2025 (actual)
- First posted
- 8 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Total knee arthroplasty (TKA) is commonly associated with significant postoperative pain, which may impair early mobilization and functional recovery. Multimodal analgesia techniques are widely used to improve postoperative pain control while minimizing opioid consumption. Local infiltration analgesia (LIA) is a commonly used method; however, its effectiveness may be limited when used alone. The adductor canal block (ACB) provides effective analgesia while preserving quadriceps muscle strength.
This prospective randomized controlled study aims to compare the effectiveness of adductor canal block combined with local infiltration analgesia versus local infiltration analgesia alone on postoperative pain scores in patients undergoing total knee arthroplasty. The primary outcome is postoperative pain assessed using the NRS at multiple time points within the first 48 hours. Secondary outcomes include opioid consumption, functional recovery parameters and hemodynamic parameters.
The results of this study are expected to contribute to optimizing postoperative analgesia strategies in total knee arthroplasty.
Detailed description
Total knee arthroplasty (TKA) is frequently associated with moderate to severe postoperative pain, which can negatively affect early mobilization, rehabilitation, and patient satisfaction. Effective pain management strategies are essential for enhanced recovery protocols. Multimodal analgesia has become the standard approach, combining different techniques to improve analgesic efficacy while reducing opioid-related side effects.
Local infiltration analgesia (LIA) is widely used as part of multimodal analgesia; however, it may not always provide sufficient analgesia when used alone. The adductor canal block (ACB) has gained popularity due to its ability to provide sensory blockade of the saphenous nerve while preserving quadriceps muscle strength, thus facilitating early mobilization.
This prospective randomized controlled trial was conducted to evaluate the effect of combining ACB with LIA compared to LIA alone in patients undergoing total knee arthroplasty. Patients were randomly assigned into two groups: one group received ACB combined with LIA, while the control group received LIA alone.
Postoperative pain was assessed using the Visual Analog Scale (VAS) at 2, 6, 12, 24 and 48 hours postoperatively. Secondary outcomes included total opioid consumption and functional recovery parameters. Demographic data, operative variables, and perioperative characteristics were also recorded and analyzed.
The findings of this study aim to provide evidence regarding the efficacy of combining regional anesthesia techniques with local infiltration analgesia in improving postoperative pain control following total knee arthroplasty.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ACB+LIA | Experimental | Procedure: Adductor Canal block, Procedure: Local Infiltration AnalgesiaPatients in this group received an adductor canal block combined with local infiltration analgesia for postoperative pain management following total knee arthroplasty. |
| LIA | Active comparator | Procedure: Local Infiltration AnalgesiaPatients in this group received local infiltration analgesia alone for postoperative pain management following total knee arthroplasty. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patients aged 18 years and older
- Patients scheduled for elective total knee arthroplasty
- American Society of Anesthesiologists (ASA) physical status I-III
- Patients who provided written informed consent
Key exclusion criteria (8 listed)
- Known allergy to local anesthetics
- Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia
- Infection at the injection site
- Severe hepatic or renal dysfunction
- Neurological disorders affecting lower extremities
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Adductor Canal blockUltrasound-guided adductor canal block was performed using local anesthetic to provide postoperative analgesia. | Procedure or surgery | ACB+LIA |
| Local Infiltration AnalgesiaLocal infiltration analgesia was administered intraoperatively using local anesthetic agents around the surgical site. | Procedure or surgery | ACB+LIA, LIA |
Primary outcome
Postoperative pain at rest (Numerating Rating Scale, NRS)
Time frame: 2,6,12,24,48
Postoperative pain was assessed using the NRS at rest at predefined time points. Postoperative pain was assessed using the Numeric Rating Scale (NRS), ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Pain scores were recorded at rest at predefined time points.
4 secondary outcomes
Opioid Consumption
Time frame: 0-48 hours postoperatively
Knee flexion range of motion (degrees) measured with a goniometer
Time frame: 24 and 48 hours postoperatively
Heart rate (beats per minute)
Time frame: Baseline (preoperative) and every 15 minutes from induction of anesthesia to extubation
Mean arterial pressure (mmHg)
Time frame: Baseline (before induction of anesthesia) and every 15 minutes from induction of anesthesia to extubation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Adductor Canal block and Local Infiltration Analgesia in people with Osteoarthritis, Knee, run by Ankara University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative pain at rest (Numerating Rating Scale, NRS) (time frame: 2,6,12,24,48). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Apr 2026.