Lumbar Central Canal StenosesNCT07456137
Prospective Evaluation of Upright Versus Supine CT Myelography of the Lumbar Spine
A study testing Upright CT in people with Lumbar Central Canal Stenoses and Neural Foraminal Stenoses, run by University of Kansas Medical Center at 1 site in United States.
Trial summary
The purpose of this prospective study is to compare the diagnostic utility of standing (upright, weight-bearing) CT myelography with standard supine CT myelography for the evaluation of lumbar central canal and neural foraminal stenoses. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Lumbar Central Canal Stenoses, Neural Foraminal Stenoses
- What is being tested?
- Upright CT
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteUnited States
- Study dates
- Jun 2026to Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥ 18 years
- Outpatient status
- Scheduled for routine supine CT myelography
Who cannot join
- Inpatient status
- Presence of metallic lumbar spinal hardware
- History of osseous metastatic disease involving the lumbar spine
- Acute traumatic injury involving the lumbar spine
- Pregnancy
- Participant body habitus exceeding the scanner's safe operational limits (e.g., gantry/bore size clearance, table weight capacity) as defined by the device manufacturer.
- Inability to tolerate CT scanning (e.g., severe pain, unable to stand independently for an extended period)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
The University of Kansas Medical Center
Kansas City, Kansas, 66160
About this study
The purpose of this prospective study is to compare the diagnostic utility of standing (upright, weight-bearing) CT myelography with standard supine CT myelography for the evaluation of lumbar central canal and neural foraminal stenoses. This study aims to determine whether upright positioning provides additional diagnostic information in patients unable to undergo MRI, with the goal of improving assessment and management of degenerative lumbar spine disease.
- Being tested
- Upright CT
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Upright CTRadiation
Also called Upright CT Myelography
Upright CT Myelography
| Study group | Role | What they receive |
|---|---|---|
| Upright and Supine CT Myelography | Other | Upright and Supine CT Myelography Receives: Radiation: Upright CT |
What is being measured
The primary outcome is the main question the study is designed to answer.
Does upright CT imaging change management plans for patients with lumbar spinal stenosis
To determine whether upright CT imaging changes the management plan (yes or no) for patients with lumbar spinal stenosis.
Measured: 1 week
Secondary outcomes (6)
Spine measurements
Objective measurements at different angles (mm) will be taken of the spine.
Measured: 1 day
Severity grading of central canal stenosis
Severity grading (mild, moderate, severe) of central canal stenosis in the spine.
Measured: 1 day
Severity grading of neural foraminal stenosis
Severity grading (mild, moderate, severe) of neural foraminal stenosis in the spine.
Measured: 1 day
Presence or absence of nerve root compression
Presence or absence of nerve root compression in the spine.
Measured: 1 day
Presence or absence of disc bulges
Presence or absence of disc bulges in the spine.
Measured: 1 day
Presence or absence of herniations
Presence or absence of herniations in the spine.
Measured: 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Mar 2026
- Study startJun 2026 (estimated)
- Primary completionDec 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Lumbar Central Canal StenosesStudies of the same condition, open and under way.
- More trials run by University of Kansas Medical CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Kansas Medical Center
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Samuel Hund, University of Kansas Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07456137
- Sponsor's protocol ID
- STUDY00162088
- Status last verified
- Nov 2025
- First submitted
- 13 Nov 2025
- Last updated
- 10 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 10 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prospective Evaluation of Upright Versus Supine CT Myelography of the Lumbar Spine
- ClinicalTrials.gov ID
- NCT07456137
- Acronym / sponsor ID
- STUDY00162088
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- University of Kansas Medical CenterUniversity, hospital or other
- Study start
- Jun 2026 (estimated)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 6 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this prospective study is to compare the diagnostic utility of standing (upright, weight-bearing) CT myelography with standard supine CT myelography for the evaluation of lumbar central canal and neural foraminal stenoses. This study aims to determine whether upright positioning provides additional diagnostic information in patients unable to undergo MRI, with the goal of improving assessment and management of degenerative lumbar spine disease.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Upright and Supine CT Myelography | Other | Radiation: Upright CTUpright and Supine CT Myelography |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age ≥ 18 years
- Outpatient status
- Scheduled for routine supine CT myelography
Key exclusion criteria (7 listed)
- Inpatient status
- Presence of metallic lumbar spinal hardware
- History of osseous metastatic disease involving the lumbar spine
- Acute traumatic injury involving the lumbar spine
- Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Upright CTAlso: Upright CT MyelographyUpright CT Myelography | Radiation | Upright and Supine CT Myelography |
Primary outcome
Does upright CT imaging change management plans for patients with lumbar spinal stenosis
Time frame: 1 week
To determine whether upright CT imaging changes the management plan (yes or no) for patients with lumbar spinal stenosis.
6 secondary outcomes
Spine measurements
Time frame: 1 day
Severity grading of central canal stenosis
Time frame: 1 day
Severity grading of neural foraminal stenosis
Time frame: 1 day
Presence or absence of nerve root compression
Time frame: 1 day
Presence or absence of disc bulges
Time frame: 1 day
Presence or absence of herniations
Time frame: 1 day
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jul 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Upright CT in people with Lumbar Central Canal Stenoses and Neural Foraminal Stenoses, run by University of Kansas Medical Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 10 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Does upright CT imaging change management plans for patients with lumbar spinal stenosis (time frame: 1 week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jul 2026.