Periodontal DiseaseNCT07446127
Adjunctive Diode Laser Therapy in Non-Surgical Periodontal Therapy
A study testing LASER assisted SRP and RsD in people with Periodontal Disease and Periodontal Pockets, run by Tel Aviv University at 1 site in Israel.
Trial summary
The goal of this clinical trial is to evaluate the efficacy of adjunctive application of diode laser to mechanical, non-surgical root surface debridement in patients attending periodontal office. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Periodontal Disease, Periodontal Pockets, Periodontal Attachment Loss
- What is being tested?
- LASER assisted SRP and RsD
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteIsrael
- Study dates
- 1 Jan 2026to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Systemically healthy patients
- Each patient should have more than 20 teeth remaining, and at least 5 teeth per quadrant
- Each patient presented ≥ 30% of sites involved
- At least 2 teeth with a probing depth of ≥ 5 mm in each quadrant, with evident radiographic bone loss.
Who cannot join
- History of systemic diseases affecting the periodontium
- Smokers and alcoholic patients
- Use of medication within the last 6 months, which might affect the periodontal status
- Pregnant and lactating women
- Patients who had any periodontal treatment ≤ 12 months before the examination.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Israel1 site, 1 recruiting
- Recruiting
Dr Younis Mahmoud
Afula, North, 1839203
Mahmoud Dt Younis, DMD, +972544934823, younisma@hotmail.com
Michael Dr Saminsky, DMD, +972545508436, sachermiki@gmail.com
About this study
Official title: Evaluation of the Effect of Adjunctive Diode Laser Therapy in Mechanical Scaling and Root Surface Debridement in Non-Surgical Periodontal Therapy
The goal of this clinical trial is to evaluate the efficacy of adjunctive application of diode laser to mechanical, non-surgical root surface debridement in patients attending periodontal office. The main question it aims to answer is:
To compare the clinical effectiveness of adjunctive application of a 940-nm diode laser with root surface debridement to the effectiveness of root surface debridement alone.
Read more
This study is a split-mouth design, where each quadrant will be randomly allocated to one of the following groups:
Control group (root surface debridement - RsD): scaling and root planing alone. Laser group (RsD + laser): scaling and root planing with adjunctive diode laser therapy Quadrants will be randomly allocated to the treatment groups
- Being tested
- LASER assisted SRP, RsD
- Keywords
- diode laser, non surgical periodontal treatment
- Medical subject headings
- Periodontal Diseases, Periodontal Pocket, Periodontal Attachment Loss
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
LASER assisted SRPDevice
Two quadrants will be treated mechanically (ScR) with adjunctive diode laser and another two quadrants mechanically (ScR) only
RsDDevice
mechanical root surface debridement with periodontal curettes
| Study group | Role | What they receive |
|---|---|---|
| test quadrants | Experimental | two contralateral jaw quadrants in each patient mouth will undergo RsD and Laser Diode assisted SRP treatment Receives: Device: LASER assisted SRP |
| control quadrants | Active comparator | two contralateral jaw quadrants in each patient mouth (same patient cohort) will undergo RsD treatment only Receives: Device: RsD |
What is being measured
The primary outcome is the main question the study is designed to answer.
PPD
periodontal pocket depth
Measured: prior to treatment and 12 weeks and 6 months after treatment
Secondary outcomes (2)
CAL
clinical attachment level
Measured: prior to treatment and 12 weeks and 6 months after the treatment
BOP
bleeding on probing
Measured: prior to treatment and 12 weeks and 6 months after the treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Mar 2026
- Study start1 Jan 2026
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (14)Papers the sponsor has linked to this study.
- Other trials for Periodontal DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Model description
- split mouth
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Tel Aviv University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Michael Saminsky, Tel Aviv University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07446127
- Sponsor's protocol ID
- 0011601-1
- Status last verified
- Feb 2026
- First submitted
- 18 Feb 2026
- Last updated
- 3 Mar 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No: no personal data will be shared and/or disclosed. only periodontal parameters collected from the medical registries will be statistically analyzed and further published in the scientific literature
Publications
Schwarz F, Aoki A, Becker J, Sculean A. Laser application in non-surgical periodontal therapy: a systematic review. J Clin Periodontol. 2008 Sep;35(8 Suppl):29-44. doi: 10.1111/j.1600-051X.2008.01259.x.
PubMed 18724840Jia L, Jia J, Xie M, Zhang X, Li T, Shi L, Shi H, Zhang X. Clinical attachment level gain of lasers in scaling and root planing of chronic periodontitis: a network meta-analysis of randomized controlled clinical trials. Lasers Med Sci. 2020 Mar;35(2):473-485. doi: 10.1007/s10103-019-02875-5. Epub 2019 Nov 5.
PubMed 31691054Moritz A, Gutknecht N, Doertbudak O, Goharkhay K, Schoop U, Schauer P, Sperr W. Bacterial reduction in periodontal pockets through irradiation with a diode laser: a pilot study. J Clin Laser Med Surg. 1997 Feb;15(1):33-7. doi: 10.1089/clm.1997.15.33.
PubMed 9467340Aoki A, Sasaki KM, Watanabe H, Ishikawa I. Lasers in nonsurgical periodontal therapy. Periodontol 2000. 2004;36:59-97. doi: 10.1111/j.1600-0757.2004.03679.x. No abstract available.
PubMed 15330944Gojkov-Vukelic M, Hadzic S, Dedic A, Konjhodzic R, Beslagic E. Application of a diode laser in the reduction of targeted periodontal pathogens. Acta Inform Med. 2013 Dec;21(4):237-40. doi: 10.5455/aim.2013.21.237-240. Epub 2013 Dec 4.
PubMed 24554796Matarese G, Ramaglia L, Cicciu M, Cordasco G, Isola G. The Effects of Diode Laser Therapy as an Adjunct to Scaling and Root Planing in the Treatment of Aggressive Periodontitis: A 1-Year Randomized Controlled Clinical Trial. Photomed Laser Surg. 2017 Dec;35(12):702-709. doi: 10.1089/pho.2017.4288. Epub 2017 Sep 14.
PubMed 28945145Dukic W, Bago I, Aurer A, Roguljic M. Clinical effectiveness of diode laser therapy as an adjunct to non-surgical periodontal treatment: a randomized clinical study. J Periodontol. 2013 Aug;84(8):1111-7. doi: 10.1902/jop.2012.110708. Epub 2012 Oct 17.
PubMed 23075433De Micheli G, de Andrade AK, Alves VT, Seto M, Pannuti CM, Cai S. Efficacy of high intensity diode laser as an adjunct to non-surgical periodontal treatment: a randomized controlled trial. Lasers Med Sci. 2011 Jan;26(1):43-8. doi: 10.1007/s10103-009-0753-5. Epub 2010 Feb 4.
PubMed 20131073Pawelczyk-Madalinska M, Benedicenti S, Salagean T, Bordea IR, Hanna R. Impact of Adjunctive Diode Laser Application to Non-Surgical Periodontal Therapy on Clinical, Microbiological and Immunological Outcomes in Management of Chronic Periodontitis: A Systematic Review of Human Randomized Controlled Clinical Trials. J Inflamm Res. 2021 Jun 15;14:2515-2545. doi: 10.2147/JIR.S304946. eCollection 2021.
PubMed 34163210Jia L, Jia J, Wu M, Li T, Zhao C, Shi H, Zhang X. Probing depth reduction of laser application in periodontal therapy: a network meta-analysis. Lasers Med Sci. 2022 Mar;37(2):1217-1226. doi: 10.1007/s10103-021-03376-0. Epub 2021 Jul 29.
PubMed 34327566Gur AT, Guncu GN, Akman AC, Pinar A, Karabulut E, Nohutcu RM. Evaluation of GCF IL-17, IL-10, TWEAK, and sclerostin levels after scaling and root planing and adjunctive use of diode laser application in patients with periodontitis. J Periodontol. 2022 Aug;93(8):1161-1172. doi: 10.1002/JPER.21-0494. Epub 2022 Jan 25.
PubMed 34962665Mokhtari MR, Ahrari F, Dokouhaki S, Fallahrastegar A, Ghasemzadeh A. Effectiveness of an 810-nm Diode Laser in Addition to Non-surgical Periodontal Therapy in Patients With Chronic Periodontitis: A Randomized Single-Blind Clinical Trial. J Lasers Med Sci. 2021 Jul 19;12:e37. doi: 10.34172/jlms.2021.37. eCollection 2021.
PubMed 34733760Lu JW, Huang SH, Lei XX, Deng L, Luo LJ. Clinical outcomes of diode laser as an adjunct to nonsurgical periodontal therapy for residual periodontal pockets in mandibular second molars-a randomized controlled clinical trial. Clin Oral Investig. 2023 Aug;27(8):4493-4501. doi: 10.1007/s00784-023-05071-6. Epub 2023 May 23.
PubMed 37219608Alizadeh Tabari Z, Pournasir L, Mohammadreza S, Anbari F. Clinical Efficacy of the 940-nm Diode Laser in the Treatment of Recurrent Pockets in the Periodontal Maintenance Phase. J Lasers Med Sci. 2021 Nov 6;12:e68. doi: 10.34172/jlms.2021.68. eCollection 2021.
PubMed 35155153
Study at a glance
From the registry record, last updated by the sponsor on 3 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Effect of Adjunctive Diode Laser Therapy in Mechanical Scaling and Root Surface Debridement in Non-Surgical Periodontal Therapy
- ClinicalTrials.gov ID
- NCT07446127
- Acronym / sponsor ID
- 0011601-1
- Keywords
- diode laser, non surgical periodontal treatment
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Tel Aviv UniversityUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 3 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to evaluate the efficacy of adjunctive application of diode laser to mechanical, non-surgical root surface debridement in patients attending periodontal office. The main question it aims to answer is:
To compare the clinical effectiveness of adjunctive application of a 940-nm diode laser with root surface debridement to the effectiveness of root surface debridement alone.
This study is a split-mouth design, where each quadrant will be randomly allocated to one of the following groups:
Control group (root surface debridement - RsD): scaling and root planing alone. Laser group (RsD + laser): scaling and root planing with adjunctive diode laser therapy Quadrants will be randomly allocated to the treatment groups
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- split mouth
| Arm | Type | Receives |
|---|---|---|
| test quadrants | Experimental | Device: LASER assisted SRPtwo contralateral jaw quadrants in each patient mouth will undergo RsD and Laser Diode assisted SRP treatment |
| control quadrants | Active comparator | Device: RsDtwo contralateral jaw quadrants in each patient mouth (same patient cohort) will undergo RsD treatment only |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Systemically healthy patients
- Each patient should have more than 20 teeth remaining, and at least 5 teeth per quadrant
- Each patient presented ≥ 30% of sites involved
- At least 2 teeth with a probing depth of ≥ 5 mm in each quadrant, with evident radiographic bone loss.
Key exclusion criteria (5 listed)
- History of systemic diseases affecting the periodontium
- Smokers and alcoholic patients
- Use of medication within the last 6 months, which might affect the periodontal status
- Pregnant and lactating women
- Patients who had any periodontal treatment ≤ 12 months before the examination.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| LASER assisted SRPTwo quadrants will be treated mechanically (ScR) with adjunctive diode laser and another two quadrants mechanically (ScR) only | Device | test quadrants |
| RsDmechanical root surface debridement with periodontal curettes | Device | control quadrants |
Primary outcome
PPD
Time frame: prior to treatment and 12 weeks and 6 months after treatment
periodontal pocket depth
2 secondary outcomes
CAL
Time frame: prior to treatment and 12 weeks and 6 months after the treatment
BOP
Time frame: prior to treatment and 12 weeks and 6 months after the treatment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Mar 2026.
- Background: PubMed 18724840Schwarz F, Aoki A, Becker J, Sculean A. Laser application in non-surgical periodontal therapy: a systematic review. J Clin Periodontol. 2008 Sep;35(8 Suppl):29-44. doi: 10.1111/j.1600-051X.2008.01259.x.
- Background: PubMed 31691054Jia L, Jia J, Xie M, Zhang X, Li T, Shi L, Shi H, Zhang X. Clinical attachment level gain of lasers in scaling and root planing of chronic periodontitis: a network meta-analysis of randomized controlled clinical trials. Lasers Med Sci. 2020 Mar;35(2):473-485. doi: 10.1007/s10103-019-02875-5. Epub 2019 Nov 5.
- Background: PubMed 9467340Moritz A, Gutknecht N, Doertbudak O, Goharkhay K, Schoop U, Schauer P, Sperr W. Bacterial reduction in periodontal pockets through irradiation with a diode laser: a pilot study. J Clin Laser Med Surg. 1997 Feb;15(1):33-7. doi: 10.1089/clm.1997.15.33.
- Background: PubMed 15330944Aoki A, Sasaki KM, Watanabe H, Ishikawa I. Lasers in nonsurgical periodontal therapy. Periodontol 2000. 2004;36:59-97. doi: 10.1111/j.1600-0757.2004.03679.x. No abstract available.
- Background: PubMed 24554796Gojkov-Vukelic M, Hadzic S, Dedic A, Konjhodzic R, Beslagic E. Application of a diode laser in the reduction of targeted periodontal pathogens. Acta Inform Med. 2013 Dec;21(4):237-40. doi: 10.5455/aim.2013.21.237-240. Epub 2013 Dec 4.
- Background: PubMed 28945145Matarese G, Ramaglia L, Cicciu M, Cordasco G, Isola G. The Effects of Diode Laser Therapy as an Adjunct to Scaling and Root Planing in the Treatment of Aggressive Periodontitis: A 1-Year Randomized Controlled Clinical Trial. Photomed Laser Surg. 2017 Dec;35(12):702-709. doi: 10.1089/pho.2017.4288. Epub 2017 Sep 14.
- Background: PubMed 23075433Dukic W, Bago I, Aurer A, Roguljic M. Clinical effectiveness of diode laser therapy as an adjunct to non-surgical periodontal treatment: a randomized clinical study. J Periodontol. 2013 Aug;84(8):1111-7. doi: 10.1902/jop.2012.110708. Epub 2012 Oct 17.
- Background: PubMed 20131073De Micheli G, de Andrade AK, Alves VT, Seto M, Pannuti CM, Cai S. Efficacy of high intensity diode laser as an adjunct to non-surgical periodontal treatment: a randomized controlled trial. Lasers Med Sci. 2011 Jan;26(1):43-8. doi: 10.1007/s10103-009-0753-5. Epub 2010 Feb 4.
- Background: PubMed 34163210Pawelczyk-Madalinska M, Benedicenti S, Salagean T, Bordea IR, Hanna R. Impact of Adjunctive Diode Laser Application to Non-Surgical Periodontal Therapy on Clinical, Microbiological and Immunological Outcomes in Management of Chronic Periodontitis: A Systematic Review of Human Randomized Controlled Clinical Trials. J Inflamm Res. 2021 Jun 15;14:2515-2545. doi: 10.2147/JIR.S304946. eCollection 2021.
- Background: PubMed 34327566Jia L, Jia J, Wu M, Li T, Zhao C, Shi H, Zhang X. Probing depth reduction of laser application in periodontal therapy: a network meta-analysis. Lasers Med Sci. 2022 Mar;37(2):1217-1226. doi: 10.1007/s10103-021-03376-0. Epub 2021 Jul 29.
- Background: PubMed 34962665Gur AT, Guncu GN, Akman AC, Pinar A, Karabulut E, Nohutcu RM. Evaluation of GCF IL-17, IL-10, TWEAK, and sclerostin levels after scaling and root planing and adjunctive use of diode laser application in patients with periodontitis. J Periodontol. 2022 Aug;93(8):1161-1172. doi: 10.1002/JPER.21-0494. Epub 2022 Jan 25.
- Background: PubMed 34733760Mokhtari MR, Ahrari F, Dokouhaki S, Fallahrastegar A, Ghasemzadeh A. Effectiveness of an 810-nm Diode Laser in Addition to Non-surgical Periodontal Therapy in Patients With Chronic Periodontitis: A Randomized Single-Blind Clinical Trial. J Lasers Med Sci. 2021 Jul 19;12:e37. doi: 10.34172/jlms.2021.37. eCollection 2021.
- Individual participant dataSharing planned: No. no personal data will be shared and/or disclosed. only periodontal parameters collected from the medical registries will be statistically analyzed and further published in the scientific literature
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing LASER assisted SRP and RsD in people with Periodontal Disease and Periodontal Pockets, run by Tel Aviv University at 1 site in Israel.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 3 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Israel. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mahmoud Dr Younis, DMD (+972544934823, younisma@hotmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
PPD (time frame: prior to treatment and 12 weeks and 6 months after treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07446127, which also lists 14 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Mar 2026.