Patello Femoral Pain SyndromeAI- PFPSNCT07405034
AI Driven EX Versus Conventional in PFPS
A study testing conventional exercises therapy program and Ai driven EX in people with Patello Femoral Pain Syndrome, run by Cairo University at 2 sites in Egypt.
Trial summary
This study aims to investigate and compare the effect of AI driven exercises program versus the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome.This study is randomized controlled trial and includes 40 participants .These participants… Read more about this study
- Who is it for?
- Ages 18 to 40 years
- Conditions the study is for
- Patello Femoral Pain Syndrome
- What is being tested?
- conventional exercises therapy program and Ai driven EX
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 2 sitesEgypt
- Study dates
- 26 Feb 2026to 1 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Their ages range from 18- 40 years old, including both genders (male \& female).
- Their BMI will be ≤ 29 kg/m2.
- A traumatic knee pain persisting for at least three months.
Who cannot join
- Any congenital deformity of the lower limb,
- Any recent injuries and surgeries
- severe foot deformities such as hallux valgus and claw toe
- Neuromuscular and neurological disorders.- history of patellofemoral dislocation, subluxation .
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
DINA SAYED ABD ALLAH, Lecturer of Physical Therapy contact
Egypt2 sites
the out-patient clinic faculty of physical therapy, Cairo University,
Cairo, The Capital
the out-patient clinic faculty of physical therapy, Cairo University,
Cairo
Alaa hamdi rizk, master degree, +201023429731, alaa.potter35@gmail.com
DINA SAYED ABD ALLAH, lecturer of PT, +2012 82742057 ext. +2012 82742057, drdinasayed_pt@yahoo.com
About this study
Official title: Artificial Intelligence Driven Exercises Versus Conventional Exercises Therapy for Patellofemoral
This study aims to investigate and compare the effect of AI driven exercises program versus the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome.This study is randomized controlled trial and includes 40 participants .These participants divided into 2 groups (A, B), each group will be assessed with 3 measurments (vas ,dynamic knee valgus, Kujala Anterior Knee Pain Scale) and each group will receive difeerent treatments.
The individuals in group A(study group) will preceive AI driven exercises program while the individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant .
Read the detailed description
PURPOSE : This study aims to investigate and compare the effect of AI driven exercises program versus the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome.
BACKGROUND:
Patellofemoral pain syndrome (PFPS) is one of the most common knee problems that disturb function and daily activities (Menek et al .,2025). Symptoms of PFPS can develop either slowly or abruptly, and pain tends to worsen with activities such as squatting, prolonged sitting, stair climbing, jumping, or running (Menek et al .,2025). PFPS affects approximately 25% of physically active individuals (Smith et al .,2018).
Core training significantly improves pain and functional limitations in patients with PFP and improves lower extremity motor performance to some extent (Y. Wang et al., 2024). These results draw more attention to the importance of the core muscle performance for both prevention and rehabilitation of the knee injuries
HYPOTHESES:
A-Primary Hypotheses:
This study will hypothesize that:
- There will be no significant effect of AI driven exercises program on pain in treatment of patients PFPS .
- There will be no significant effect of AI driven exercises program on function in treatment of patients PFPS .
- There will be no significant differences of AI driven exercises program and on dynamic knee valgus in treatment of patients PFPS.
- There will be no significant differences of conventional exercises therapy on pain in treatment of patients PFPS.
- There will be no significant differences of conventional exercises therapy on function in treatment of patients PFPS.
- There will be no significant differences of conventional exercises therapy dynamic knee valgus in treatment of patients PFPS.
RESEARCH QUESTION:
This study will try to answer the following questions:
This study will try to answer:What are the effects of of AI driven exercises program and the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome ?
- Conditions
- Patello Femoral Pain Syndrome
- Being tested
- conventional exercises therapy program, Ai driven EX
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
conventional exercises therapy programOther
The individual in group B will receive conventional exercises therapy program. Participants are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant
Ai driven EXOther
The individuals in group A(study group) will preceive AI driven exercises program . Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant
| Study group | Role | What they receive |
|---|---|---|
| ( AI driven EX for study group ) | Active comparator | The individuals in group A(study group) will preceive AI driven exercises program while the individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant Receives: Other: Ai driven EX |
| conventional ex group | Other | The individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant . Receives: Other: conventional exercises therapy program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Kujala Anterior Knee Pain Scale
a 13-item scale assessing knee functionality. The total Kujala score ranges from 0 to 100, with higher values indicating better performance. Additionally, The Kujala score is known for its reliability and validity in assessing patients with frozen PFPS
Measured: up to 6 weeks
Secondary outcomes (1)
visual analog scale
Pain intensity is assessed using the visual analog scale. Participants are instructed to indicate their pain level on a line ranging from 0 to 10, with 0 representing no pain and 10 indicating unbearable pain
Measured: up to 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Feb 2026
- Study start26 Feb 2026 (estimated)
- Primary completion30 Oct 2026 (estimated)
- Study completion1 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Patello Femoral Pain SyndromeStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This study is randomized controlled trial and includes 40 participants .These participants divided into 2 groups (A, B), each group will be assessed with 3 measurments (vas ,dynamic knee valgus, Kujala Anterior Knee Pain Scale) and each group will receive difeerent treatments. The individuals in group A(study group) will preceive AI driven exercises program while the individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant .
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alaa hamdi elsaid rizk, Cairo University
- Investigators
- SALWA FADL abdelmegeed, Professor of Physical Therapy, Study director, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07405034
- Sponsor's protocol ID
- P.T.REC/012/006096
- Acronym
- AI- PFPS
- Status last verified
- Jan 2026
- First submitted
- 26 Jan 2026
- Last updated
- 12 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Data is available with correspondig offer on reasonable request
Study at a glance
From the registry record, last updated by the sponsor on 12 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Artificial Intelligence Driven Exercises Versus Conventional Exercises Therapy for Patellofemoral
- ClinicalTrials.gov ID
- NCT07405034
- Acronym / sponsor ID
- AI- PFPS / P.T.REC/012/006096
- Conditions
- Patello Femoral Pain Syndrome
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 26 Feb 2026 (estimated)
- Primary completion
- 30 Oct 2026 (estimated)
- Study completion
- 1 Jan 2027 (estimated)
- First posted
- 12 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate and compare the effect of AI driven exercises program versus the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome.This study is randomized controlled trial and includes 40 participants .These participants divided into 2 groups (A, B), each group will be assessed with 3 measurments (vas ,dynamic knee valgus, Kujala Anterior Knee Pain Scale) and each group will receive difeerent treatments.
The individuals in group A(study group) will preceive AI driven exercises program while the individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant .
Detailed description
PURPOSE : This study aims to investigate and compare the effect of AI driven exercises program versus the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome.
BACKGROUND:
Patellofemoral pain syndrome (PFPS) is one of the most common knee problems that disturb function and daily activities (Menek et al .,2025). Symptoms of PFPS can develop either slowly or abruptly, and pain tends to worsen with activities such as squatting, prolonged sitting, stair climbing, jumping, or running (Menek et al .,2025). PFPS affects approximately 25% of physically active individuals (Smith et al .,2018).
Core training significantly improves pain and functional limitations in patients with PFP and improves lower extremity motor performance to some extent (Y. Wang et al., 2024). These results draw more attention to the importance of the core muscle performance for both prevention and rehabilitation of the knee injuries
HYPOTHESES:
A-Primary Hypotheses:
This study will hypothesize that:
- There will be no significant effect of AI driven exercises program on pain in treatment of patients PFPS .
- There will be no significant effect of AI driven exercises program on function in treatment of patients PFPS .
- There will be no significant differences of AI driven exercises program and on dynamic knee valgus in treatment of patients PFPS.
- There will be no significant differences of conventional exercises therapy on pain in treatment of patients PFPS.
- There will be no significant differences of conventional exercises therapy on function in treatment of patients PFPS.
- There will be no significant differences of conventional exercises therapy dynamic knee valgus in treatment of patients PFPS.
RESEARCH QUESTION:
This study will try to answer the following questions:
This study will try to answer:What are the effects of of AI driven exercises program and the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome ?
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- This study is randomized controlled trial and includes 40 participants .These participants divided into 2 groups (A, B), each group will be assessed with 3 measurments (vas ,dynamic knee valgus, Kujala Anterior Knee Pain Scale) and each group will receive difeerent treatments. The individuals in group A(study group) will preceive AI driven exercises program while the individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant .
| Arm | Type | Receives |
|---|---|---|
| ( AI driven EX for study group ) | Active comparator | Other: Ai driven EXThe individuals in group A(study group) will preceive AI driven exercises program while the individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant |
| conventional ex group | Other | Other: conventional exercises therapy programThe individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant . |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Their ages range from 18- 40 years old, including both genders (male \& female).
- Their BMI will be ≤ 29 kg/m2.
- A traumatic knee pain persisting for at least three months.
Key exclusion criteria (4 listed)
- Any congenital deformity of the lower limb,
- Any recent injuries and surgeries
- severe foot deformities such as hallux valgus and claw toe
- Neuromuscular and neurological disorders.- history of patellofemoral dislocation, subluxation .
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| conventional exercises therapy programThe individual in group B will receive conventional exercises therapy program. Participants are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant | Other | conventional ex group |
| Ai driven EXThe individuals in group A(study group) will preceive AI driven exercises program . Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant | Other | ( AI driven EX for study group ) |
Primary outcome
Kujala Anterior Knee Pain Scale
Time frame: up to 6 weeks
a 13-item scale assessing knee functionality. The total Kujala score ranges from 0 to 100, with higher values indicating better performance. Additionally, The Kujala score is known for its reliability and validity in assessing patients with frozen PFPS
1 secondary outcome
visual analog scale
Time frame: up to 6 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Feb 2026.
- Individual participant dataSharing planned: No. Data is available with correspondig offer on reasonable request
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
DINA SAYED ABD ALLAH, Lecturer of Physical Therapy contact
SALWA FADL abdelmegeed, Professor of Physical Therapy study director
Cairo University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing conventional exercises therapy program and Ai driven EX in people with Patello Femoral Pain Syndrome, run by Cairo University at 2 sites in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 12 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Alaa Hamdi Rizk, master degree (+201023429731 ext. +201023429731, alaa.potter35@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Kujala Anterior Knee Pain Scale (time frame: up to 6 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Feb 2026.