Tooth ExtractionNCT07396350
IMMEDIATE IMPLANT With Different Types of Membrane
A study testing immediate implant with dentin-derived barrier membrane and immediate implant with eprf membrane in people with Tooth Extraction, run by Mansoura University at 1 site in Egypt.
Trial summary
Forty patients will be selected from the outpatient's clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University for replacement of non-restorable tooth in posterior mandibular area with immediate implants. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Tooth Extraction
- What is being tested?
- immediate implant with dentin-derived barrier membrane and immediate implant with eprf membrane
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jan 2024to 1 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
None listed.
Who cannot join
- Tobacco Smokers.
- Pregnancy.
- Patients with a history of radiation to the head and neck.
- Bruxism and parafunctional habits
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Autogenous Dentine Derived Barrier Membrane Versus Extended Platelet Rich Fibrin Membrane in Immediate Implant Placement in Posterior Mandible: a 2 Year Follow up
Forty patients will be selected from the outpatient's clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University for replacement of non-restorable tooth in posterior mandibular area with immediate implants.
- Conditions
- Tooth Extraction
- Being tested
- immediate implant with dentin-derived barrier membrane, immediate implant with eprf membrane
- Keywords
- dental implant
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
immediate implant with dentin-derived barrier membraneProcedure or surgery
immediate implant with dentin-derived barrier membrane with allograft covering any peri-implant defect and jumping gap.
immediate implant with eprf membraneProcedure or surgery
immediate implant with eprf membrane with allograft covering any peri-implant defect and jumping gap.
| Study group | Role | What they receive |
|---|---|---|
| immediate implant with dentin-derived membrane | Experimental | Not described Receives: Procedure: immediate implant with dentin-derived barrier membrane |
| immediate implant with extended platelet rich fibrin membrane | Experimental | Not described Receives: Procedure: immediate implant with eprf membrane |
What is being measured
The primary outcome is the main question the study is designed to answer.
Implant stability
The implant stability was evaluated immediately postoperatively and after 3, 6, and 12 months. An Osstell Mentor device (Osstell, Savadaled, Sweden; Integration Diagnostics) was utilized to assess implant stability utilizing resonance frequency analysis (RFA). Measurements were made at 90° in four different directions in order to calculate the RFA value. The implant stability quotient (ISQ) was calculated by averaging the results for each implant.
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Feb 2026
- Study start1 Jan 2024
- Primary completion1 Jan 2025
- Study completion1 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Tooth ExtractionStudies of the same condition, open and under way.
- More trials run by Mansoura UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mansoura University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07396350
- Sponsor's protocol ID
- R.26.01.96
- Status last verified
- Feb 2026
- First submitted
- 2 Feb 2026
- Last updated
- 9 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Abdelsameaa SE, Alruwaili AM, El-Gohary N, Elsheikh HA. Dentine-derived barrier membrane versus extended platelet-rich fibrin for guided bone regeneration: a 2-year randomized clinical trial. BMC Oral Health. 2026 May 21;26(1):960. doi: 10.1186/s12903-026-08582-2.
PubMed 42168967
Study at a glance
From the registry record, last updated by the sponsor on 9 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Autogenous Dentine Derived Barrier Membrane Versus Extended Platelet Rich Fibrin Membrane in Immediate Implant Placement in Posterior Mandible: a 2 Year Follow up
- ClinicalTrials.gov ID
- NCT07396350
- Acronym / sponsor ID
- R.26.01.96
- Conditions
- Tooth Extraction
- Keywords
- dental implant
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Mansoura UniversityUniversity, hospital or other
- Study start
- 1 Jan 2024 (actual)
- Primary completion
- 1 Jan 2025 (actual)
- Study completion
- 1 Jan 2026 (actual)
- First posted
- 9 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Forty patients will be selected from the outpatient's clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University for replacement of non-restorable tooth in posterior mandibular area with immediate implants.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| immediate implant with dentin-derived membrane | Experimental | Procedure: immediate implant with dentin-derived barrier membrane |
| immediate implant with extended platelet rich fibrin membrane | Experimental | Procedure: immediate implant with eprf membrane |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (0 listed)
Key exclusion criteria (4 listed)
- Tobacco Smokers.
- Pregnancy.
- Patients with a history of radiation to the head and neck.
- Bruxism and parafunctional habits
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| immediate implant with dentin-derived barrier membraneimmediate implant with dentin-derived barrier membrane with allograft covering any peri-implant defect and jumping gap. | Procedure or surgery | immediate implant with dentin-derived membrane |
| immediate implant with eprf membraneimmediate implant with eprf membrane with allograft covering any peri-implant defect and jumping gap. | Procedure or surgery | immediate implant with extended platelet rich fibrin membrane |
Primary outcome
Implant stability
Time frame: 12 months
The implant stability was evaluated immediately postoperatively and after 3, 6, and 12 months. An Osstell Mentor device (Osstell, Savadaled, Sweden; Integration Diagnostics) was utilized to assess implant stability utilizing resonance frequency analysis (RFA). Measurements were made at 90° in four different directions in order to calculate the RFA value. The implant stability quotient (ISQ) was calculated by averaging the results for each implant.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Feb 2026.
- Derived from this study: PubMed 42168967Abdelsameaa SE, Alruwaili AM, El-Gohary N, Elsheikh HA. Dentine-derived barrier membrane versus extended platelet-rich fibrin for guided bone regeneration: a 2-year randomized clinical trial. BMC Oral Health. 2026 May 21;26(1):960. doi: 10.1186/s12903-026-08582-2.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing immediate implant with dentin-derived barrier membrane and immediate implant with eprf membrane in people with Tooth Extraction, run by Mansoura University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Implant stability (time frame: 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07396350, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Feb 2026.