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AzTrials

Psoriasis (PsO)PsOUND-PSONCT07390487

The Effects of Audio-Based Therapy on Anxiety in Psoriasis

A study testing Music Therapy and Pink Noise in people with Psoriasis (PsO) and Anxiety, run by University of California, San Francisco at 1 site in United States.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

Anxiety in psoriasis is associated with impaired quality of life, and the prevalence of anxiety symptoms in psoriatic populations is approximately 34% and anxiety disorders up to 16%. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Psoriasis (PsO), Anxiety
What is being tested?
Music Therapy and Pink Noise
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
120 participants
Where
1 siteUnited States
Study dates
1 Feb 2026to Dec 2027
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Age ≥18 years
  • Self-reported dermatologist-diagnosed psoriasis
  • GAD 2-Item Score ≥1 at screening
  • Ability to consent and complete pre- and post-intervention surveys.
  • Internet access and the ability to use a computer/smartphone with headphones for a single 23-30 minute session at home.

Who cannot join

  • Severe hearing impairment precluding headphone listening
  • Any condition requiring strict sound avoidance (such as seizure/epilepsy, major head trauma, severe sound-triggered migraine) that would make participation unsafe.
  • Other diagnoses that in the investigator's judgment preclude safe participation or interfere with anxiety or psoriasis evaluation.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Amélie Spangenberg, Psoriasis Clinical Research Fellow, MBBS contact

415-944-7618

amelie.spangenberg@ucsf.edu

United States1 site, 1 recruiting

  • Liao Lab at UCSF

    San Francisco, California, 94115

    Amélie Spangenberg, Psoriasis Clinical Research Fellow, MBBS, 415-944-7618, amelie.spangenberg@ucsf.edu

    Wilson Liao, MD

    Recruiting

Other trials in United States

About this study

Anxiety in psoriasis is associated with impaired quality of life, and the prevalence of anxiety symptoms in psoriatic populations is approximately 34% and anxiety disorders up to 16%. Many experts recommend routine screening, referral, and interventions for anxiety in psoriasis; however, many barriers inhibit access to mental health resources and proper management. To our knowledge, there is a lack of easily accessible interventions that manage anxiety. Audio-based therapy offers convenient and effective interventions that show reduced anxiety in published, randomized studies and is a promising management for psoriasis patients. This study will evaluate the effects of audio therapy in patients with psoriasis and measure changes in overall symptoms.

Being tested
Music Therapy, Pink Noise
Keywords
Surveys and Questionnaires, Acoustic Stimulation, Complementary Therapies
Medical subject headings
Psoriasis, Anxiety Disorders

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Music TherapyBehavioural

    Also called Music therapy and auditory beat stimulation (ABS), Music, Complementary Therapy, Complementary Therapies

    Participants listen to the iso-principle music with added auditory beat stimulation playlist for 23-30 minutes.

  • Pink NoiseBehavioural

    Participants listen to the pink noise playlist for 23-30 minutes.

Study groups in NCT07390487
Study groupRoleWhat they receive
Music TherapyExperimentalParticipants listen to the iso-principle music with added auditory beat stimulation playlist for 23-30 minutes.
Receives: Behavioral: Music Therapy
Pink NoiseSham comparatorParticipants listen to the pink noise playlist for 23-30 minutes.
Receives: Behavioral: Pink Noise

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Anxiety: State Trait Inventory for Cognitive and Somatic Anxiety (STICSA)

    The STICSA has good reliability and validity as a measure of state and trait cognitive and somatic anxiety. In this study, the post-intervention anxiety score is subtracted from the pre-intervention anxiety score, giving a measure of anxiety reduction. Greater anxiety reduction scores would indicate a better anxiety outcome.

    Measured: From the pre-intervention survey to the post-intervention survey, approximately 30 minutes.

Secondary outcomes (2)

  1. Mood: Positive and Negative Affect Scale (PANAS)

    The PANAS has demonstrated good reliability and validity, and has been widely used in numerous studies to assess mood. In this study, the post-intervention PANAS scores are subtracted from the pre-intervention PANAS scores, giving a measure of positive and negative mood changes. The scale generates two scores: 1) Positive affect (higher score indicates better mood outcome) and 2) Negative affect (higher score indicates worse mood outcome).

    Measured: From the pre-intervention survey to the post-intervention survey, approximately 30 minutes.

  2. Itch: Itch Numeric Rating Score (INRS)

    The INRS has good reliability and validity as a measure of 24-hour itch severity, though validity testing over more acute intervals remains limited. In this study, the post-intervention itch score is subtracted from the pre-intervention itch score, giving a measure of itch reduction. Greater itch reduction scores may indicate a better itch outcome.

    Measured: From the pre-intervention survey to the post-intervention survey, approximately 30 minutes.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted5 Feb 2026
  2. Study start1 Feb 2026
  3. Primary completionDec 2027 (estimated)
  4. Study completionDec 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Supportive care
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
120 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07390487
Sponsor's protocol ID
PsOUND-PSO
Acronym
PsOUND-PSO
Status last verified
Jul 2026
First submitted
29 Jan 2026
Last updated
23 Jul 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Yan D, Blauvelt A, Dey AK, Golpanian RS, Hwang ST, Mehta NN, Myers B, Shi ZR, Yosipovitch G, Bell S, Liao W. New Frontiers in Psoriatic Disease Research, Part II: Comorbidities and Targeted Therapies. J Invest Dermatol. 2021 Oct;141(10):2328-2337. doi: 10.1016/j.jid.2021.02.743. Epub 2021 Apr 19.

    PubMed 33888321

  • Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol. 1988 Jun;54(6):1063-70. doi: 10.1037//0022-3514.54.6.1063.

    PubMed 3397865

  • Riew GJ, Kamal K, Hijaz B, Awh KC, Nambudiri VE. Clinical music interventions and music therapy in dermatology. Arch Dermatol Res. 2023 Nov;315(9):2485-2490. doi: 10.1007/s00403-023-02634-1. Epub 2023 May 19.

    PubMed 37208459

  • Mallik A, Russo FA. The effects of music & auditory beat stimulation on anxiety: A randomized clinical trial. PLoS One. 2022 Mar 9;17(3):e0259312. doi: 10.1371/journal.pone.0259312. eCollection 2022.

    PubMed 35263341

  • Jalenques I, Bourlot F, Martinez E, Pereira B, D'Incan M, Lauron S, Rondepierre F. Prevalence and Odds of Anxiety Disorders and Anxiety Symptoms in Children and Adults with Psoriasis: Systematic Review and Meta-analysis. Acta Derm Venereol. 2022 Aug 26;102:adv00769. doi: 10.2340/actadv.v102.1386.

    PubMed 35604236

  • Hedemann TL, Liu X, Kang CN, Husain MI. Associations between psoriasis and mental illness: an update for clinicians. Gen Hosp Psychiatry. 2022 Mar-Apr;75:30-37. doi: 10.1016/j.genhosppsych.2022.01.006. Epub 2022 Jan 25.

    PubMed 35101785

  • Gros DF, Antony MM, Simms LJ, McCabe RE. Psychometric properties of the State-Trait Inventory for Cognitive and Somatic Anxiety (STICSA): comparison to the State-Trait Anxiety Inventory (STAI). Psychol Assess. 2007 Dec;19(4):369-81. doi: 10.1037/1040-3590.19.4.369.

    PubMed 18085930

  • Phan NQ, Blome C, Fritz F, Gerss J, Reich A, Ebata T, Augustin M, Szepietowski JC, Stander S. Assessment of pruritus intensity: prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus. Acta Derm Venereol. 2012 Sep;92(5):502-7. doi: 10.2340/00015555-1246.

    PubMed 22170091

  • Gray EK, Watson, D. Assessing positive and negative affect via self-report. In: Coan JA, Allen, J.J.B., editor. Handbook of emotion elicitation and assessment. New York, NY: Oxford University Press; 2007.

  • Bados A, Gomez-Benito J, Balaguer G. The state-trait anxiety inventory, trait version: does it really measure anxiety? J Pers Assess. 2010 Nov;92(6):560-7. doi: 10.1080/00223891.2010.513295.

    PubMed 20954057

Questions about this trial

What is this clinical trial studying?

A study testing Music Therapy and Pink Noise in people with Psoriasis (PsO) and Anxiety, run by University of California, San Francisco at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 23 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Amélie Spangenberg, Psoriasis Clinical Research Fellow, MBBS (415-944-7618, amelie.spangenberg@ucsf.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Anxiety: State Trait Inventory for Cognitive and Somatic Anxiety (STICSA) (time frame: From the pre-intervention survey to the post-intervention survey, approximately 30 minutes.). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07390487, which also lists 10 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jul 2026.

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