No ConditionNCT07349342
Stable Versus Unstable Resistance Training Effects on Physical Fitness and Physiological Biomarkers of Untrained Male University Students
A study testing resistance training in people with No Condition and Health Young Males, run by Addis Ababa University at 1 site in Ethiopia.
Trial summary
The goal of this clinical trial is to learn the effects of stable and unstable resistance training on physical fitness, kidney function and blood lipid tests in healthy young male volunteers. Read more about this study
- Who is it for?
- Ages 20 to 24 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- No Condition, Health Young Males
- What is being tested?
- resistance training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 54 participants
- Where
- 1 siteEthiopia
- Study dates
- 12 Nov 2025to Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 24 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- No resistance training within the previous six months
- Completing a written informed consent document
- Responding to the physical activity readiness questionnaire (PAR-Q) and becoming convenient
Who cannot join
- A history of musculoskeletal injury
- Chronic diseases, including known kidney disease
- A habit of alcohol or drug abuse
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Effects of Stable Versus Unstable Resistance Training on Lipid Profile Selected Physical Fitness and Renal Biomarkers of Untrained Male University Students
The goal of this clinical trial is to learn the effects of stable and unstable resistance training on physical fitness, kidney function and blood lipid tests in healthy young male volunteers. The main questions it aims to answer are:
- Do both stable and unstable resistance training increase the level of urinary protein clearance greater than the control group?
- What is the difference in improvement of lipid profiles among the groups?
- Does unstable resistance training mode rise muscular endurance greater than stable resistance training?
Read more
Researchers will compare stable and unstable resistance training to see if there are differences on physical fitness measures, blood lipid and urinary protein tests.
Participants, in their respective group will receive ten weeks of:
- Stable resistance training
- Unstable resistance training or
- No exercise training intervention
Read the detailed description
This study included volunteer male untrained students living at Kotebe University of Education. Priori statistical power analysis (G*Power version 3.1.9.2, Stuttgart, Germany) was used to estimate the sample size. Based on earlier research, a moderate to high effect size (0.295) was assumed, and considering a dropout probability of 10%, a sample of 54 participants was enough to meet adequate statistical power. All participants provided written informed consent to participate in this study. The training protocol will include ten resistance exercises for each intervention, performed three times a week for 10 weeks. Each session lasts 60 minutes, including a 10 to 15-minute warm-up, a 40-minute main exercise targeting core, upper, and lower limb muscles, and a 5 to 10-minute cool-down and stretching. The protocol will adhere to basic training principles like overload, progression, and specificity. The training will take place in the university gymnasium. The study will be conducted in accordance with local legislation and institutional requirements. It will be strictly governed by the ethical principles of the Declaration of Helsinki.
- Conditions
- No Condition, Health Young Males
- Being tested
- resistance training
- Keywords
- eGFR, urinary albumin to creatinine ratio, lipid profile, muscular strength, body composition, muscle, TRX
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
resistance trainingOther
stable resistance training is represented by traditional resistance training using equipment like medicine ball, resistance machine and own body mass
resistance trainingOther
TRX based resistance training for the upper, lower and abdominal region muscles
| Study group | Role | What they receive |
|---|---|---|
| Unstable resistance training group | Experimental | Receiving total body resistance exercise (TRX) training intervention Receives: Other: resistance training |
| Control group | No intervention | no any structured exercise training intervention |
| stable resistance training group | Experimental | receiving traditional resistance training intervention Receives: Other: resistance training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Urinary Albumin
- It will be measured using random urine samples in milligrams per liter
- The minimum value is 0, the maximum is 20
- A higher score means a worse outcome
Measured: At baseline and after 10 weeks of resistance training interventions
Urinary Creatinine
- It will be measured using random urine samples in millimoles per liter
- The minimum value is 3, the maximum is 25.
- A higher score means a better outcome
Measured: At baseline and after 10 weeks of training intervention
Urinary albumin to creatinine ratio
- Urinary albumin to creatinine ratio is computed by dividing the obtained urinary albumin by urinary creatinine
- It is measured in milligrams per millimole
- The minimum value is 0, the maximum is 3
- A high score means a worse outcome
Measured: At baseline and after 10 weeks of resistance training interventions
Serum Creatinine
- It is measured using a fasting blood sample in micromoles per liter
- The minimum value is 50, the maximum is 110
- A higher score means a worse outcome
Measured: At baseline and after 10 weeks of resistance training intervention
Estimated Glomerular Filtration Rate
- Estimated glomerular filtration rate is computed using a serum creatinine-based equation
- The scores are reported in milliliters per minute per 1.73 square meters
- The minimum value is 90, the maximum is 130
- A higher score means a better renal function
Measured: At baseline and after 10 weeks of resistance training interventions
High-Density Lipoprotein Cholesterol
- It is measured using a fasting blood sample tests in millimoles per liter
- The minimum value is 1, the maximum is greater than or equal to 2
- A higher score means a protective and better outcome
Measured: At baseline and after 10 weeks of resistance training
Low-Density Llipoprotein Cholesterol
- It is measured using a fasting blood sample in millimoles per liter
- The minimum value is 0, the maximum is 2.6
- A higher score means a worse outcome
Measured: At baseline and after 10 weeks of resistance training
Total Cholesterol
- It is measured using a fasting blood sample test in millimoles per liter
- The minimum score is 0, the maximum is 5.2
- A higher score means a worse outcome
Measured: At baseline and after 10 weeks of resistance training
Triglycerides
- Triglycerides are measured using a fasting blood sample test in millimoles per liter
- The minimum value is 0, the maximum is 1.7
- A higher score means a worse outcome
Measured: At baseline and after 10 weeks of resistance training
Hand Grip Strength
- Hand grip strength test will be used to measure muscular strength
- It is measured in kilograms
- The minimum value is 27, the maximum is 56
- A higher score means a better outcome
Measured: At baseline and after 10 weeks of training intervention
Muscular Endurance
- Push-up and sit-up tests will be used to measure muscular endurance
- The number of repetitions is a unit for both tests
- The minimum score for push-up is 20, the maximum is 40
- The minimum value for sit-up is 25, the maximum is 45
- A higher score means a better outcome
Measured: At baseline and after 10 weeks of training intervention
Core Endurance
- The McGill core endurance test will be conducted and reported in seconds
- The minimum value is 45, the maximum is 120
- A higher score means a better outcome
Measured: At baseline and after 10 weeks of training intervention
Flexibility
- Sit and reach test will be conducted and reported in centimeters
- The minimum value is 20, and the maximum is 35
- A higher score means a better outcome
Measured: At baseline and after 10 weeks of training intervention
Body Fat Percentage
- It will be estimated using 3 site skin fold measures in millimeters
- Body density will be calculated by the Jackson \& Pollock equation
- The obtained density is converted into body fat percentage using the Sir equation
- The minimum value is 10, the maximum is 22
- A higher score means aworse outcome
Measured: At baseline and after 10 weeks of training intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jan 2026
- Study start12 Nov 2025
- Primary completionFeb 2026 (estimated)
- Study completionFeb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for No ConditionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This study employs a randomized pre-post-test experimental design with three groups. It involves a stable and unstable resistance training intervention for two training groups and a control group without training intervention but, advised to continue their regular daily routine.
- Masking
- None (open label)
- Enrolment
- 54 participants (actual)
Sponsor and investigators
- Lead sponsor
- Addis Ababa University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Cherinet Zewdie Zemela, Addis Ababa University
- Investigators
- Aschenaki T Tessema, Ph.D., Study chair, Addis Ababa UniversityCherinet Z Zemela, MSc, Principal investigator, Kotebe University of EducationZeru B Tola, Ph.D., Study chair, Addis Ababa University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07349342
- Sponsor's protocol ID
- CNS-IRB/05/2015/2023
- Status last verified
- Dec 2025
- First submitted
- 30 Dec 2025
- Last updated
- 16 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: After publication on journals, I will share all individual participant data that underlie results in a publication
Study at a glance
From the registry record, last updated by the sponsor on 16 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Effects of Stable Versus Unstable Resistance Training on Lipid Profile Selected Physical Fitness and Renal Biomarkers of Untrained Male University Students
- ClinicalTrials.gov ID
- NCT07349342
- Acronym / sponsor ID
- CNS-IRB/05/2015/2023
- Conditions
- No Condition, Health Young Males
- Keywords
- eGFR, urinary albumin to creatinine ratio, lipid profile, muscular strength, body composition, muscle, TRX
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 54 participants (actual)
- Lead sponsor
- Addis Ababa UniversityUniversity, hospital or other
- Study start
- 12 Nov 2025 (actual)
- Primary completion
- Feb 2026 (estimated)
- Study completion
- Feb 2026 (estimated)
- First posted
- 16 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn the effects of stable and unstable resistance training on physical fitness, kidney function and blood lipid tests in healthy young male volunteers. The main questions it aims to answer are:
- Do both stable and unstable resistance training increase the level of urinary protein clearance greater than the control group?
- What is the difference in improvement of lipid profiles among the groups?
- Does unstable resistance training mode rise muscular endurance greater than stable resistance training?
Researchers will compare stable and unstable resistance training to see if there are differences on physical fitness measures, blood lipid and urinary protein tests.
Participants, in their respective group will receive ten weeks of:
- Stable resistance training
- Unstable resistance training or
- No exercise training intervention
Detailed description
This study included volunteer male untrained students living at Kotebe University of Education. Priori statistical power analysis (G*Power version 3.1.9.2, Stuttgart, Germany) was used to estimate the sample size. Based on earlier research, a moderate to high effect size (0.295) was assumed, and considering a dropout probability of 10%, a sample of 54 participants was enough to meet adequate statistical power. All participants provided written informed consent to participate in this study. The training protocol will include ten resistance exercises for each intervention, performed three times a week for 10 weeks. Each session lasts 60 minutes, including a 10 to 15-minute warm-up, a 40-minute main exercise targeting core, upper, and lower limb muscles, and a 5 to 10-minute cool-down and stretching. The protocol will adhere to basic training principles like overload, progression, and specificity. The training will take place in the university gymnasium. The study will be conducted in accordance with local legislation and institutional requirements. It will be strictly governed by the ethical principles of the Declaration of Helsinki.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- This study employs a randomized pre-post-test experimental design with three groups. It involves a stable and unstable resistance training intervention for two training groups and a control group without training intervention but, advised to continue their regular daily routine.
| Arm | Type | Receives |
|---|---|---|
| Unstable resistance training group | Experimental | Other: resistance trainingReceiving total body resistance exercise (TRX) training intervention |
| Control group | No intervention | –no any structured exercise training intervention |
| stable resistance training group | Experimental | Other: resistance trainingreceiving traditional resistance training intervention |
Who may qualify
- Ages
- 20 to 24 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- No resistance training within the previous six months
- Completing a written informed consent document
- Responding to the physical activity readiness questionnaire (PAR-Q) and becoming convenient
Key exclusion criteria (3 listed)
- A history of musculoskeletal injury
- Chronic diseases, including known kidney disease
- A habit of alcohol or drug abuse
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| resistance trainingstable resistance training is represented by traditional resistance training using equipment like medicine ball, resistance machine and own body mass | Other | stable resistance training group |
| resistance trainingTRX based resistance training for the upper, lower and abdominal region muscles | Other | Unstable resistance training group |
Primary outcome
Urinary Albumin
Time frame: At baseline and after 10 weeks of resistance training interventions
* It will be measured using random urine samples in milligrams per liter * The minimum value is 0, the maximum is 20 * A higher score means a worse outcome
Urinary Creatinine
Time frame: At baseline and after 10 weeks of training intervention
* It will be measured using random urine samples in millimoles per liter * The minimum value is 3, the maximum is 25. * A higher score means a better outcome
Urinary albumin to creatinine ratio
Time frame: At baseline and after 10 weeks of resistance training interventions
* Urinary albumin to creatinine ratio is computed by dividing the obtained urinary albumin by urinary creatinine * It is measured in milligrams per millimole * The minimum value is 0, the maximum is 3 * A high score means a worse outcome
Serum Creatinine
Time frame: At baseline and after 10 weeks of resistance training intervention
* It is measured using a fasting blood sample in micromoles per liter * The minimum value is 50, the maximum is 110 * A higher score means a worse outcome
Estimated Glomerular Filtration Rate
Time frame: At baseline and after 10 weeks of resistance training interventions
* Estimated glomerular filtration rate is computed using a serum creatinine-based equation * The scores are reported in milliliters per minute per 1.73 square meters * The minimum value is 90, the maximum is 130 * A higher score means a better renal function
High-Density Lipoprotein Cholesterol
Time frame: At baseline and after 10 weeks of resistance training
* It is measured using a fasting blood sample tests in millimoles per liter * The minimum value is 1, the maximum is greater than or equal to 2 * A higher score means a protective and better outcome
Low-Density Llipoprotein Cholesterol
Time frame: At baseline and after 10 weeks of resistance training
* It is measured using a fasting blood sample in millimoles per liter * The minimum value is 0, the maximum is 2.6 * A higher score means a worse outcome
Total Cholesterol
Time frame: At baseline and after 10 weeks of resistance training
* It is measured using a fasting blood sample test in millimoles per liter * The minimum score is 0, the maximum is 5.2 * A higher score means a worse outcome
Triglycerides
Time frame: At baseline and after 10 weeks of resistance training
* Triglycerides are measured using a fasting blood sample test in millimoles per liter * The minimum value is 0, the maximum is 1.7 * A higher score means a worse outcome
Hand Grip Strength
Time frame: At baseline and after 10 weeks of training intervention
* Hand grip strength test will be used to measure muscular strength * It is measured in kilograms * The minimum value is 27, the maximum is 56 * A higher score means a better outcome
Muscular Endurance
Time frame: At baseline and after 10 weeks of training intervention
* Push-up and sit-up tests will be used to measure muscular endurance * The number of repetitions is a unit for both tests * The minimum score for push-up is 20, the maximum is 40 * The minimum value for sit-up is 25, the maximum is 45 * A higher score means a better outcome
Core Endurance
Time frame: At baseline and after 10 weeks of training intervention
* The McGill core endurance test will be conducted and reported in seconds * The minimum value is 45, the maximum is 120 * A higher score means a better outcome
Flexibility
Time frame: At baseline and after 10 weeks of training intervention
* Sit and reach test will be conducted and reported in centimeters * The minimum value is 20, and the maximum is 35 * A higher score means a better outcome
Body Fat Percentage
Time frame: At baseline and after 10 weeks of training intervention
* It will be estimated using 3 site skin fold measures in millimeters * Body density will be calculated by the Jackson \& Pollock equation * The obtained density is converted into body fat percentage using the Sir equation * The minimum value is 10, the maximum is 22 * A higher score means aworse outcome
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jan 2026.
- Individual participant dataSharing planned: Yes. After publication on journals, I will share all individual participant data that underlie results in a publication
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Aschenaki T Tessema, Ph.D. study chair
Addis Ababa University
Cherinet Z Zemela, MSc principal investigator
Kotebe University of Education
Zeru B Tola, Ph.D. study chair
Addis Ababa University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing resistance training in people with No Condition and Health Young Males, run by Addis Ababa University at 1 site in Ethiopia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 16 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Ethiopia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Urinary Albumin (time frame: At baseline and after 10 weeks of resistance training interventions). The study lists 14 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jan 2026.