AphasiaNCT07347327
The Effect of Dual-target tACS Combined With Speech Training on Repetition Disorder After Stroke
A study testing speech training and real tACS in people with Aphasia, run by Ke Dong, MD at 1 site in China.
Trial summary
This clinical trial aims to study whether dual-target transcranial alternating current stimulation (tACS) applied to the auditory and motor brain region can improve repetition disorder in people with stroke, and to evaluate the safety of tACS. The main goals are to answer the following questions: 1. Read more about this study
- Who is it for?
- Ages 30 to 80 years
- Conditions the study is for
- Aphasia
- What is being tested?
- speech training and real tACS
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 28 participants
- Where
- 1 siteChina
- Study dates
- 1 Jan 2023to 29 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Meeting the diagnostic criteria for hemorrhagic or ischemic stroke in the Chinese Guidelines for the Prevention and Treatment of Cerebrovascular Diseases(2nd edition), with the first onset, single hemisphere stroke, and confirmed by CT or MRI,course of diease 1-6 months;
- Age ranging from 30 to 80 years old;
- Native language is Mandarin or Cantonese;
- Right-handed;
- Diagnosed with aphasia by the Western Aphasia Battery (WAB) scale;
- Able to cooperate in completing the speech repetition test;
- Normal hearing.
Who cannot join
- Currently receiving non-invasive brain stimulation treatment;
- Lesions involving the Broca or STG brain regions;
- History of epilepsy, mental illness,or other neurological or mental disorders;
- Any contraindications for transcranial electrical stimulation.
Trial locations and contacts
1 site in 1 country.
China1 site
Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong
About this study
This clinical trial aims to study whether dual-target transcranial alternating current stimulation (tACS) applied to the auditory and motor brain region can improve repetition disorder in people with stroke, and to evaluate the safety of tACS. The main goals are to answer the following questions:
- Can dual-tACS stimulation of the auditory and motor brain area improve repetition functions in people with aphasia after stroke?
- Can it improve the integration of auditory information and speech motor control during communication?
Read more
Researchers will compare the effects of real tACS versus sham (placebo) stimulation to see if real stimulation leads to better outcomes in aphasia patients.
Participants will:
- Receive one extra 20-minute session of either real or sham tACS each day for 10 days
- Attend clinic visits before and after 10-days stimulation for clinical assessments(WAB) and fNIRS recording related brain activity
- Conditions
- Aphasia
- Being tested
- speech training, real tACS, sham tACS
- Medical subject headings
- Aphasia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
speech trainingBehavioural
speech training(especially repetition training) synchronized with tACS stimulation
real tACSOther
dual-target tACS on auditory and motor brain area at a frequency of 8 Hz,with individualized current intensity, delivered for 20 minutes.
sham tACSOther
except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in real group.
| Study group | Role | What they receive |
|---|---|---|
| real group | Experimental | dual-target tACS on auditory and motor brain area at a frequency of 8 Hz,with individualized current intensity, delivered for 20 minutes. Receives: Behavioral: speech training; Other: real tACS |
| sham group | Sham comparator | sham tACS except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in real group. Receives: Behavioral: speech training; Other: sham tACS |
What is being measured
The primary outcome is the main question the study is designed to answer.
Western Aphasia Battery (WAB) score
Western Aphasia Battery (WAB) score：0-100，higher score means better language function
Measured: Baseline and 10-days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jan 2026
- Study start1 Jan 2023
- Primary completion26 Dec 2025
- Study completion29 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AphasiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ke Dong, MD
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Ke Dong, MD, First Affiliated Hospital, Sun Yat-Sen University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07347327
- Sponsor's protocol ID
- Nos.82102648
- Status last verified
- Jan 2026
- First submitted
- 9 Jan 2026
- Last updated
- 22 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Dual-target tACS Combined With Speech Training on Repetition Disorder After Stroke
- ClinicalTrials.gov ID
- NCT07347327
- Acronym / sponsor ID
- Nos.82102648
- Conditions
- Aphasia
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- Ke Dong, MDUniversity, hospital or other
- Study start
- 1 Jan 2023 (actual)
- Primary completion
- 26 Dec 2025 (actual)
- Study completion
- 29 Dec 2025 (actual)
- First posted
- 16 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical trial aims to study whether dual-target transcranial alternating current stimulation (tACS) applied to the auditory and motor brain region can improve repetition disorder in people with stroke, and to evaluate the safety of tACS. The main goals are to answer the following questions:
- Can dual-tACS stimulation of the auditory and motor brain area improve repetition functions in people with aphasia after stroke?
- Can it improve the integration of auditory information and speech motor control during communication?
Researchers will compare the effects of real tACS versus sham (placebo) stimulation to see if real stimulation leads to better outcomes in aphasia patients.
Participants will:
- Receive one extra 20-minute session of either real or sham tACS each day for 10 days
- Attend clinic visits before and after 10-days stimulation for clinical assessments(WAB) and fNIRS recording related brain activity
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| real group | Experimental | Behavioral: speech training, Other: real tACSdual-target tACS on auditory and motor brain area at a frequency of 8 Hz,with individualized current intensity, delivered for 20 minutes. |
| sham group | Sham comparator | Behavioral: speech training, Other: sham tACSsham tACS except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in real group. |
Who may qualify
- Ages
- 30 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Meeting the diagnostic criteria for hemorrhagic or ischemic stroke in the Chinese Guidelines for the Prevention and Treatment of Cerebrovascular Diseases(2nd edition), with the first onset, single hemisphere stroke, and confirmed by CT or MRI,course of diease 1-6 months;
- Age ranging from 30 to 80 years old;
- Native language is Mandarin or Cantonese;
- Right-handed;
- Diagnosed with aphasia by the Western Aphasia Battery (WAB) scale;
Key exclusion criteria (4 listed)
- Currently receiving non-invasive brain stimulation treatment;
- Lesions involving the Broca or STG brain regions;
- History of epilepsy, mental illness,or other neurological or mental disorders;
- Any contraindications for transcranial electrical stimulation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| speech trainingspeech training(especially repetition training) synchronized with tACS stimulation | Behavioural | real group, sham group |
| real tACSdual-target tACS on auditory and motor brain area at a frequency of 8 Hz,with individualized current intensity, delivered for 20 minutes. | Other | real group |
| sham tACSexcept for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in real group. | Other | sham group |
Primary outcome
Western Aphasia Battery (WAB) score
Time frame: Baseline and 10-days
Western Aphasia Battery (WAB) score：0-100，higher score means better language function
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jan 2026.
Related trials for Aphasia
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Effect of Anomia Rehabilitation Combined With Metacognitive Training in Patients With Chronic Vascular Aphasia
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Aphasia, ALS
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Cerebellar Brain Stimulation Plus Language Therapy for People at Risk of Poor Aphasia Recovery After Stroke
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Not yet recruitingObservational study
Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive Screen
Stroke, Ischemic Stroke
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing speech training and real tACS in people with Aphasia, run by Ke Dong, MD at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Western Aphasia Battery (WAB) score (time frame: Baseline and 10-days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jan 2026.