Anterior Cruciate Ligament InjuriesNCT07333092
Investigation of the Effects of Proprioceptive Exercises After Anterior Cruciate Ligament Surgery
A study testing exercise in people with Anterior Cruciate Ligament Injuries and Anterior Cruciate Ligament Rupture, run by Uskudar University at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study is to investigate the effects of proprioceptive exercises on balance, kinesiophobia, and functionality after anterior cruciate ligament surgery. Read more about this study
- Who is it for?
- Ages 20 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
- What is being tested?
- exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Jan 2026to 20 Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Being between 20-40 years of age
- Having undergone anterior cruciate ligament (ACL) surgery
- Being in the 2nd week of rehabilitation after ACL surgery
Who cannot join
- Having a concomitant meniscus injury
- Having a concomitant medial collateral ligament injury
- Being in the 1st week of rehabilitation after ACL surgery
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Şanlıurfa Mehmet Akif İnan Health Application and Research Center
Sanliurfa
Ayşe ŞAN, +905553098565
About this study
Official title: Investigation of the Effects of Proprioceptive Exercises on Balance, Kinesiophobia, and Functionality After Anterior Cruciate Ligament Surgery: A Randomized Controlled Trial
The aim of this study is to investigate the effects of proprioceptive exercises on balance, kinesiophobia, and functionality after anterior cruciate ligament surgery.
Read the detailed description
A sociodemographic form will be used to obtain sociodemographic information, the y-balance test will be used to assess balance at the beginning and end of the study, the Tampa Kinesiophobia Scale will be used to assess kinesiophobia, and the Lysholm Knee Score Scale will be used to assess functionality. Both groups will perform balance exercises currently offered at the hospital. The experimental group will also receive proprioceptive exercises in addition to the balance exercises currently offered at the hospital. The exercises will be performed three days a week for 12 weeks for both groups. In this study, the independent variables are the addition or non-addition of proprioceptive exercises, while balance, kinesiophobia, and functionality are the dependent variables. The significance levels of the obtained data will be statistically analyzed.
- Being tested
- control, exercise
- Medical subject headings
- Anterior Cruciate Ligament Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
controlOther
Patients will only be given balance exercises that are currently available at the hospital.
exerciseOther
In addition to balance exercises, proprioceptive exercises will be performed.
| Study group | Role | What they receive |
|---|---|---|
| control group | Active comparator | balance exercises Receives: Other: control |
| exercise group | Experimental | balance exercises + proprioceptive exercises Receives: Other: control; Other: exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Lysholm Knee Scoring Scale
The Lysholm scale was developed for use by physicians and has been verified in patients with Anterior Cruciate Ligament and meniscal injuries. It's also been approved as a patient-administered tool for assessing symptoms and function in people who have had a variety of knee injuries. The Lysholm scale assesses the domains of symptoms and complaints, as well as functioning in daily activities, however, it doesn't assess the area of sports and recreational activities. There are 8 items on this questionnaire and graded on a scale of 0 to 100, with higher scores suggesting fewer symptoms and better function
Measured: 14 weeks
Tampa Kinesiophobia Questionnaire
Tampa Kinesiophobia Questionnaire is a 17-question questionnaire that assesses avoidance of injury and fear of movement. The scale is scored using a Likert scale (1 = Strongly disagree, 4 = Strongly agree). Items 4, 8, 12 and 16 are reversed to calculate the total score of the scale. The total score is between 17 and 68. As the score of the person increases, it is understood that their kinesiophobia is high. A total score higher than 37 is considered as high kinesiophobia. However, since not every item of the questionnaire addresses patients with headache in this study, some questions were removed, some questions were edited and some questions were added to create a kinesiophobia questionnaire for headache. The newly created questionnaire consists of 23 items. Again, it is scored using a Likert scale with "1 = Strongly disagree, 4 = Strongly agree". As the score increases, it is understood that the level of kinesiophobia is high
Measured: 14 weeks
Y Balance Test
The Y Balance Test will be used to assess dynamic balance by measuring reach distances in three directions (anterior, posteromedial, and posterolateral) while standing on one leg. Each direction will be tested three times, and the average reach distance will be normalized to leg length. A composite score will be calculated and expressed as a percentage to evaluate overall dynamic balance capacity. Higher scores indicate better balance performance.
Measured: 14 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Jan 2026
- Study start15 Jan 2026
- Primary completion20 Jun 2026 (estimated)
- Study completion20 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Anterior Cruciate Ligament InjuriesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Uskudar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Doç.Dr.Ömer Şevgin, Uskudar University
- Investigators
- Ayşe ŞAN, Study chair, Uskudar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07333092
- Sponsor's protocol ID
- Uskudar80
- Status last verified
- Jan 2026
- First submitted
- 30 Dec 2025
- Last updated
- 20 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Zult T, Gokeler A, van Raay JJAM, Brouwer RW, Zijdewind I, Farthing JP, Hortobagyi T. Cross-education does not accelerate the rehabilitation of neuromuscular functions after ACL reconstruction: a randomized controlled clinical trial. Eur J Appl Physiol. 2018 Aug;118(8):1609-1623. doi: 10.1007/s00421-018-3892-1. Epub 2018 May 23.
PubMed 29796857Erayata BN, Menek B. Investigating the effects of percussion massage therapy on pain, functionality, muscle diameter, and proprioception in individuals with ACL reconstruction: a randomized controlled trial. PLoS One. 2025 Mar 26;20(3):e0319731. doi: 10.1371/journal.pone.0319731. eCollection 2025.
PubMed 40138389Keays SL, Bullock-Saxton JE, Newcombe P, Bullock MI. The effectiveness of a pre-operative home-based physiotherapy programme for chronic anterior cruciate ligament deficiency. Physiother Res Int. 2006 Dec;11(4):204-18. doi: 10.1002/pri.341.
PubMed 17236528
Study at a glance
From the registry record, last updated by the sponsor on 20 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of the Effects of Proprioceptive Exercises on Balance, Kinesiophobia, and Functionality After Anterior Cruciate Ligament Surgery: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07333092
- Acronym / sponsor ID
- Uskudar80
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Uskudar UniversityUniversity, hospital or other
- Study start
- 15 Jan 2026 (actual)
- Primary completion
- 20 Jun 2026 (estimated)
- Study completion
- 20 Aug 2026 (estimated)
- First posted
- 12 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to investigate the effects of proprioceptive exercises on balance, kinesiophobia, and functionality after anterior cruciate ligament surgery.
Detailed description
A sociodemographic form will be used to obtain sociodemographic information, the y-balance test will be used to assess balance at the beginning and end of the study, the Tampa Kinesiophobia Scale will be used to assess kinesiophobia, and the Lysholm Knee Score Scale will be used to assess functionality. Both groups will perform balance exercises currently offered at the hospital. The experimental group will also receive proprioceptive exercises in addition to the balance exercises currently offered at the hospital. The exercises will be performed three days a week for 12 weeks for both groups. In this study, the independent variables are the addition or non-addition of proprioceptive exercises, while balance, kinesiophobia, and functionality are the dependent variables. The significance levels of the obtained data will be statistically analyzed.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| control group | Active comparator | Other: controlbalance exercises |
| exercise group | Experimental | Other: control, Other: exercisebalance exercises + proprioceptive exercises |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Being between 20-40 years of age
- Having undergone anterior cruciate ligament (ACL) surgery
- Being in the 2nd week of rehabilitation after ACL surgery
Key exclusion criteria (3 listed)
- Having a concomitant meniscus injury
- Having a concomitant medial collateral ligament injury
- Being in the 1st week of rehabilitation after ACL surgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| controlPatients will only be given balance exercises that are currently available at the hospital. | Other | control group, exercise group |
| exerciseIn addition to balance exercises, proprioceptive exercises will be performed. | Other | exercise group |
Primary outcome
Lysholm Knee Scoring Scale
Time frame: 14 weeks
The Lysholm scale was developed for use by physicians and has been verified in patients with Anterior Cruciate Ligament and meniscal injuries. It's also been approved as a patient-administered tool for assessing symptoms and function in people who have had a variety of knee injuries. The Lysholm scale assesses the domains of symptoms and complaints, as well as functioning in daily activities, however, it doesn't assess the area of sports and recreational activities. There are 8 items on this questionnaire and graded on a scale of 0 to 100, with higher scores suggesting fewer symptoms and better function
Tampa Kinesiophobia Questionnaire
Time frame: 14 weeks
Tampa Kinesiophobia Questionnaire is a 17-question questionnaire that assesses avoidance of injury and fear of movement. The scale is scored using a Likert scale (1 = Strongly disagree, 4 = Strongly agree). Items 4, 8, 12 and 16 are reversed to calculate the total score of the scale. The total score is between 17 and 68. As the score of the person increases, it is understood that their kinesiophobia is high. A total score higher than 37 is considered as high kinesiophobia. However, since not every item of the questionnaire addresses patients with headache in this study, some questions were removed, some questions were edited and some questions were added to create a kinesiophobia questionnaire for headache. The newly created questionnaire consists of 23 items. Again, it is scored using a Likert scale with "1 = Strongly disagree, 4 = Strongly agree". As the score increases, it is understood that the level of kinesiophobia is high
Y Balance Test
Time frame: 14 weeks
The Y Balance Test will be used to assess dynamic balance by measuring reach distances in three directions (anterior, posteromedial, and posterolateral) while standing on one leg. Each direction will be tested three times, and the average reach distance will be normalized to leg length. A composite score will be calculated and expressed as a percentage to evaluate overall dynamic balance capacity. Higher scores indicate better balance performance.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jan 2026.
- Background: PubMed 29796857Zult T, Gokeler A, van Raay JJAM, Brouwer RW, Zijdewind I, Farthing JP, Hortobagyi T. Cross-education does not accelerate the rehabilitation of neuromuscular functions after ACL reconstruction: a randomized controlled clinical trial. Eur J Appl Physiol. 2018 Aug;118(8):1609-1623. doi: 10.1007/s00421-018-3892-1. Epub 2018 May 23.
- Background: PubMed 40138389Erayata BN, Menek B. Investigating the effects of percussion massage therapy on pain, functionality, muscle diameter, and proprioception in individuals with ACL reconstruction: a randomized controlled trial. PLoS One. 2025 Mar 26;20(3):e0319731. doi: 10.1371/journal.pone.0319731. eCollection 2025.
- Background: PubMed 17236528Keays SL, Bullock-Saxton JE, Newcombe P, Bullock MI. The effectiveness of a pre-operative home-based physiotherapy programme for chronic anterior cruciate ligament deficiency. Physiother Res Int. 2006 Dec;11(4):204-18. doi: 10.1002/pri.341.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Ayşe ŞAN study chair
Uskudar University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing exercise in people with Anterior Cruciate Ligament Injuries and Anterior Cruciate Ligament Rupture, run by Uskudar University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ömer ŞEVGİN (+905069787535, omer.sevgin@uskudar.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Lysholm Knee Scoring Scale (time frame: 14 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07333092, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jan 2026.