HİP FRACTURENCT07329829
Perioperative Analgesic Effects of PENG Versus PENG Plus LFCN Block in Hip Surgeries
A study testing Pericapsular nerve group (PENG) block and Lateral Femoral Cutaneous Nerve (LFCN) Block in people with HİP FRACTURE and Hip Surgery (Lateral Incision), run by Başakşehir Çam & Sakura City Hospital at 1 site in Turkey (Türkiye).
Trial summary
This study is designed to find the best way to control pain after hip surgery performed through a side (lateral) incision. Two different types of nerve blocks used before the operation will be compared. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- HİP FRACTURE, Hip Surgery (Lateral Incision), Postoperative Pain Management
- What is being tested?
- Pericapsular nerve group (PENG) block and Lateral Femoral Cutaneous Nerve (LFCN) Block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 72 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Nov 2025to 1 Jul 2026
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients aged between 18 and 80 years
- Patients scheduled for elective or trauma-related hip surgery performed through a lateral incision under spinal anesthesia
- Patients receiving a preoperative ultrasound-guided Pericapsular Nerve Group (PENG) block or a PENG block combined with a Lateral Femoral Cutaneous Nerve (LFCN) block
- American Society of Anesthesiologists (ASA) physical status I-III
- Patients with full orientation and the ability to cooperate
- Ability to understand the study procedures and provide written informed consent
Who cannot join
- Contraindications to regional anesthesia, including coagulopathy or local infection at the injection site
- Presence of neuropathic disorders or conditions that may affect pain perception, including chronic analgesic use
- Requirement for conversion to general anesthesia
- Postoperative admission to the intensive care unit
- Known allergy or hypersensitivity to opioids or local anesthetics
- American Society of Anesthesiologists (ASA) physical status IV-V
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Basaksehir Çam and Sakura City Hospital
Istanbul, BASAKSEHİR, 34490
About this study
Official title: Comparison of Postoperative Analgesic Efficacy of Preoperative Pericapsular Nerve Group (PENG) Block With PENG Block and Lateral Femoral Cutaneous Nerve Block in Lateral Incision Hip Surgery
This study is designed to find the best way to control pain after hip surgery performed through a side (lateral) incision. Two different types of nerve blocks used before the operation will be compared.
In one group, patients will receive a Pericapsular Nerve Group (PENG) block, which numbs the main nerves that carry pain signals from the hip joint. In the other group, patients will receive a PENG block together with a Lateral Femoral Cutaneous Nerve (LFCN) block, which adds extra pain relief for the skin and outer part of the thigh.
Read more
A total of 72 patients between 18 and 80 years old will take part in this study. All operations will be done under spinal anesthesia. Pain levels will be measured several times during the first 24 hours after surgery using a simple 0-10 pain scale. Patients will receive pain medicine through a pump that allows them to press a button when they feel pain. The total amount of medicine used will be recorded.
The researchers will also monitor when patients first need pain medicine, when they can start walking, how satisfied they are with pain control, and if they experience side effects such as nausea or dizziness.
By comparing the two methods, the study aims to see whether adding the LFCN block to the PENG block provides better pain control, lower drug use, faster recovery, and higher patient comfort after hip surgery.
Read the detailed description
Postoperative pain following hip surgery remains a significant clinical challenge, particularly in procedures performed through a lateral incision, where both deep articular and superficial cutaneous pain components contribute to patient discomfort. Effective regional anesthesia techniques are essential to optimize postoperative analgesia, facilitate early mobilization, and reduce opioid-related adverse effects.
The Pericapsular Nerve Group (PENG) block has been introduced as a motor-sparing regional anesthesia technique targeting the articular branches of the femoral, obturator, and accessory obturator nerves, providing effective analgesia for hip joint-related pain. However, due to its limited coverage of cutaneous innervation, patients undergoing lateral incision hip surgery may continue to experience residual superficial pain.
The Lateral Femoral Cutaneous Nerve (LFCN) block selectively targets the sensory innervation of the anterolateral thigh and may complement the PENG block by addressing the cutaneous component of postoperative pain. The combined use of PENG and LFCN blocks has the potential to provide more comprehensive analgesia without compromising motor function.
This study is designed to evaluate whether the addition of an LFCN block to a standard PENG block enhances postoperative pain control and recovery outcomes in patients undergoing hip surgery via a lateral approach. By comparing these two regional anesthesia strategies, the study aims to contribute evidence-based guidance for optimizing multimodal analgesia protocols in hip surgery.
- Conditions
- HİP FRACTURE, Hip Surgery (Lateral Incision), Postoperative Pain Management, Analgesia, Postoperative, Regional Anesthesia Success
- Being tested
- Pericapsular nerve group (PENG) block, Lateral Femoral Cutaneous Nerve (LFCN) Block
- Keywords
- Pericapsular Nerve Group Block (PENG Block), Lateral Femoral Cutaneous Nerve Block (LFCN Block), Hip Surgery, Regional Anesthesia, Postoperative Analgesia, Pain Control, Opioid Consumption, Early Mobilization
- Medical subject headings
- Hip Fractures, Agnosia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Pericapsular nerve group (PENG) blockProcedure or surgery
An ultrasound-guided Pericapsular Nerve Group (PENG) block will be performed preoperatively using standard local anesthetic techniques to provide postoperative analgesia in patients undergoing lateral incision hip surgery.
Lateral Femoral Cutaneous Nerve (LFCN) BlockProcedure or surgery
An ultrasound-guided Lateral Femoral Cutaneous Nerve (LFCN) block will be performed preoperatively as an adjunct to the PENG block to enhance postoperative analgesia in patients undergoing lateral incision hip surgery.
| Study group | Role | What they receive |
|---|---|---|
| PENG BLOCK GROUP | Experimental | An ultrasound-guided Pericapsular Nerve Group (PENG) block will be performed preoperatively using standard local anesthetic techniques to provide postoperative analgesia in patients undergoing lateral incision hip surgery. Receives: Procedure: Pericapsular nerve group (PENG) block |
| PENG + LFCN BLOCK GROUP | Experimental | Patients in this group will receive a preoperative ultrasound-guided Pericapsular Nerve Group (PENG) block combined with a Lateral Femoral Cutaneous Nerve (LFCN) block for postoperative analgesia prior to lateral incision hip surgery under spinal anesthesia. Receives: Procedure: Pericapsular nerve group (PENG) block; Procedure: Lateral Femoral Cutaneous Nerve (LFCN) Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative Pain Intensity (NRS Score)
Postoperative pain intensity will be assessed using the Numeric Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain), both at rest and during movement.
Measured: 2, 6, 12, and 24 hours postoperatively
Secondary outcomes (3)
Total Postoperative Opioid Consumption
Total opioid consumption during the first 24 hours postoperatively will be recorded using a patient-controlled analgesia (PCA) device and converted to morphine equivalent dose (mg).
Measured: First 24 hours postoperatively
Patient Satisfaction Score
Patient satisfaction with postoperative pain management will be assessed using a 5-point Likert Satisfaction Scale, ranging from 1 (very dissatisfied) to 5 (very satisfied), where higher scores indicate greater patient satisfaction.
Measured: Within the first 24 hours postoperatively
Time to First Mobilization
Time to first mobilization after surgery will be recorded in hours.
Measured: Within the first 24 hours postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jan 2026
- Study start1 Nov 2025
- Primary completion1 Feb 2026 (estimated)
- Study completion1 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for HİP FRACTUREStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 72 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Başakşehir Çam & Sakura City Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Muzaffer GENCER, Başakşehir Çam & Sakura City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07329829
- Sponsor's protocol ID
- BSH-ANES-MG-01
- Status last verified
- Jul 2025
- First submitted
- 27 Dec 2025
- Last updated
- 12 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Roy R, Agarwal G, Pradhan C, Kuanar D. Total postoperative analgesia for hip surgeries, PENG block with LFCN block. Reg Anesth Pain Med. 2019 Mar 28:rapm-2019-100454. doi: 10.1136/rapm-2019-100454. Online ahead of print. No abstract available.
PubMed 30923252Yoo SH, Lee MJ, Beak MH, Kim WJ. Efficacy of Supplemental Ultrasound-Guided Pericapsular Nerve Group (PENG) Block Combined with Lateral Femoral Cutaneous Nerve Block in Patients Receiving Local Infiltration Analgesia after Hip Fracture Surgery: A Prospective Randomized Controlled Trial. Medicina (Kaunas). 2024 Feb 12;60(2):315. doi: 10.3390/medicina60020315.
PubMed 38399602Pascarella G, Costa F, Strumia A, Ruggiero A, Remore LM, Lanteri T, Hazboun A, Longo F, Gargano F, Schiavoni L, Mattei A, Agro FE, Carassiti M, Cataldo R. Lateral Femoral Cutaneous Nerve Block or Wound Infiltration Combined with Pericapsular Nerve Group (PENG) Block for Postoperative Analgesia following Total Hip Arthroplasty through Posterior Approach: A Randomized Controlled Trial. J Clin Med. 2024 May 2;13(9):2674. doi: 10.3390/jcm13092674.
PubMed 38731203Liang L, Zhang C, Dai W, He K. Comparison between pericapsular nerve group (PENG) block with lateral femoral cutaneous nerve block and supra-inguinal fascia iliaca compartment block (S-FICB) for total hip arthroplasty: a randomized controlled trial. J Anesth. 2023 Aug;37(4):503-510. doi: 10.1007/s00540-023-03192-6. Epub 2023 Apr 12.
PubMed 37043081