Osteoarthritis (OA)REACTNCT07320118
Does Surgical Treatment of Cartilage Defects Prevent Osteoarthritis in Later Life?
An observational study of Osteoarthritis (OA), run by Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust at 2 sites in United Kingdom.
Trial summary
Observational study to assess the effectiveness of cell therapy for the treatment of osteoarthritis Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Osteoarthritis (OA)
- How many people
- 650 participants
- Where
- 2 sitesUnited Kingdom
- Study dates
- 13 Apr 2010to 12 Jan 2030
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients based in the United Kingdom treated at RJAH orthopaedic hospital
Who may be able to join
- ACI patients or patients receiving an alternative treatment
Who cannot join
- Anyone who does not meet the inclusion criteria
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
United Kingdom2 sites, 2 recruiting
- Recruiting
The Robert Jones and Agnes Hunt Orthopaedic Hospital
Oswestry, Sy10 7AG
Karina Wright, +441691404022, karina.wright1@nhs.net
Wright
- Recruiting
Robert Jones and Agnes Hunt Orthopaedic hospital
Oswestry
Wright, +441691404022, karina.wright1@nhs.net
About this study
Official title: Cell Therapy for Osteoarthritis
Observational study to assess the effectiveness of cell therapy for the treatment of osteoarthritis
- Conditions
- Osteoarthritis (OA)
- Medical subject headings
- Osteoarthritis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| ACI patiients | Patient must have had ACI surgery at least 10 months prior | |
| Non ACI Patients | Control group of patients who did not have ACI |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cell Therapy Questionnaire
Cell Therapy Questionnaire CTQ
Measured: At least fifteen months post operation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Jan 2026
- Study start13 Apr 2010
- Primary completion12 Jan 2030 (estimated)
- Study completion12 Jan 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Osteoarthritis (OA)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 650 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
- Sponsor type
- Other government
- Collaborators
- Keele University
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07320118
- Sponsor's protocol ID
- RL1 418
- Acronym
- REACT
- Status last verified
- Dec 2025
- First submitted
- 21 Dec 2025
- Last updated
- 8 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cell Therapy for Osteoarthritis
- ClinicalTrials.gov ID
- NCT07320118
- Acronym / sponsor ID
- REACT / RL1 418
- Conditions
- Osteoarthritis (OA)
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 650 participants (estimated)
- Lead sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS TrustOther government
- Collaborators
- Keele University
- Study start
- 13 Apr 2010 (actual)
- Primary completion
- 12 Jan 2030 (estimated)
- Study completion
- 12 Jan 2030 (estimated)
- First posted
- 6 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Observational study to assess the effectiveness of cell therapy for the treatment of osteoarthritis
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ACI patiients | – | –Patient must have had ACI surgery at least 10 months prior |
| Non ACI Patients | – | –Control group of patients who did not have ACI |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients based in the United Kingdom treated at RJAH orthopaedic hospital
Key inclusion criteria (1 listed)
- ACI patients or patients receiving an alternative treatment
Key exclusion criteria (1 listed)
- Anyone who does not meet the inclusion criteria
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Cell Therapy Questionnaire
Time frame: At least fifteen months post operation
Cell Therapy Questionnaire CTQ
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jan 2026.
Related trials for Osteoarthritis (OA)
Not yet recruiting
Holistic Healing for Knee Osteoarthritis
Knee Osteoarthritis (Knee OA)
Active, not recruiting
Effectiveness of Therapeutic Exercises on Spinopelvic Mobility
Osteoarthritis (OA) of the Hip
Not yet recruiting
The Feasibility of a Virtual/Home-based OA Treatment Program in Older Adults With OA and Multimorbidity
Osteoarthritis of the Knee
RecruitingPhase 3
A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)
Obesity, Overweight
RecruitingPhase 3
A Study to Learn About Berobenatide Given Once Weekly in Adults With Knee Osteoarthritis and Overweight or Obesity With or Without Type 2 Diabetes (VESPER-OA 2)
Obesity, Overweight and/or Obesity
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The Robert Jones and Agnes Hunt Orthopaedic Hospital
Oswestry, United Kingdom
Robert Jones and Agnes Hunt Orthopaedic hospital
Oswestry, United Kingdom
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Osteoarthritis (OA), run by Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust at 2 sites in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 8 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cell Therapy Questionnaire (time frame: At least fifteen months post operation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jan 2026.