IgA Nephropathy (IgAN)Phase 2NCT07305974
A Phase IIa Clinical Study of RG002C0106 Injection in Subjects With Primary IgA Nephropathy
A Phase 2 study testing RG002C0106 in people with IgA Nephropathy (IgAN), run by Rigerna Therapeutics Co., Ltd.; Rigerna Therapeutics (Beijing) Co., Ltd. at 1 site in China.
Trial summary
This study looks at how well and safely RG002C0106 works for patients with certain kidney disease: primary IgA nephropathy. It's a phase IIa trial done at several locations where both patients and doctors unknow what treatment is being given. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- IgA Nephropathy (IgAN)
- What is being tested?
- RG002C0106
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 30 participants
- Where
- 1 siteChina
- Study dates
- 8 Sep 2025to 31 Mar 2029
- Phase
- Phase 2
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Voluntarily participate in the clinical trial and sign the informed consent form (ICF);
- Male or female participants aged 18 to 65 years (inclusive) at the time of signing the ICF;
- Body weight ≥ 40 kg;
- Negative blood pregnancy test result at screening for female participants of childbearing potential;
- Renal biopsy pathology results within 10 years prior to screening confirming a diagnosis of primary IgA nephropathy;
- 24-hour urinary protein ≥ 0.75 g/24 h during the screening period;
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- Estimated glomerular filtration rate (eGFR) (calculated using the creatinine-based CKD-EPI formula) ≥ 30 mL/min/1.73 m² during the screening period;
- Must have received vaccination against Neisseria meningitidis (serogroups A, C, W, Y) and Streptococcus pneumoniae infections at least 2 weeks prior to the first dose of the investigational product and provide proof of such vaccination;
- Participants must agree and require their partners to use adequate contraception from the time of signing the ICF, throughout the study, and for at least 3 months after the study ends . Male participants must not donate sperm for at least 6 months after the last dose of the investigational product.
Who cannot join
- Patients with secondary IgA nephropathy ;
- Renal biopsy pathology shows renal tubular atrophy or interstitial fibrosis ≥ 50%; or crescent formation in ≥ 50% of glomeruli ;
- Acute kidney injury or rapidly progressive glomerulonephritis within 4 weeks prior to screening ;
- Patients with nephrotic syndrome, defined as: 24-hour urinary protein (24h-UP) >3.5 g with hypoalbuminemia (serum albumin <3.0 g/dL), hypercholesterolemia (total cholesterol >350 mg/dL), and edema;
- Any of the following abnormal laboratory results at screening:
- Alanine aminotransferase (ALT) > 2 × upper limit of normal (ULN);
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- Total bilirubin (TB) > 1.5 × ULN. However, for patients with a confirmed diagnosis of Gilbert's syndrome, if TB > 1.5 × ULN but conjugated bilirubin < ULN, they may be enrolled;
- Positive test results at screening for HBsAg, HCV Ab,HIV-IgG, or TP-Ab;
- Poorly controlled type 1 or type 2 diabetes during the screening period ;
- Persistent clinically significant elevated blood pressure during the screening period ;
- Patients with immunodeficiency diseases;
- Patients with splenic insufficiency (e.g., asplenia or history of splenectomy);
- History of kidney transplantation or organ transplantation (including bone marrow transplantation, stem cell transplantation, etc.);
- Suspected or confirmed history of hereditary complement deficiency;
- History of any tumor within 5 years before screening, except for the following: basal cell carcinoma of the skin, carcinoma in situ of the cervix, carcinoma in situ of the breast, and squamous cell carcinoma of the skin that have been completely cured after treatment;
- History of meningococcal infection within 12 months before screening;
- Active or suspected viral, bacterial, fungal, or parasitic infection within 14 days prior to investigational product administration;
- History of allergic reactions to oligonucleotides or N-acetylgalactosamine (GalNAc);
- History of intolerance to subcutaneous injections or significant abdominal scarring that may impede administration or local tolerance assessment of the investigational product;
- Treatment with small-molecule complement inhibitors (e.g., iptacopan) within 3 months prior to investigational product administration, or previous treatment failure or intolerance;
- History of clinically significant severe infection within 3 months prior to screening, as determined by the investigator;
- Major surgery or severe trauma within 3 months prior to investigational product administration, incomplete recovery, or planned surgery during the study;
- Participation in any investigational drug or medical device clinical trial within 1 month prior to investigational product administration (excluding screen failures);
- Any other condition considered by the investigator to make the participant unsuitable for inclusion.
Trial locations and contacts
1 site in 1 country.
China1 site
Peking University First Hospital
Beijing, Beijing Municipality, 100034
About this study
Official title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase IIa Clinical Study to Evaluate the Safety, Preliminary Efficacy, and Pharmacokinetic/Pharmacodynamic Characteristics of RG002C0106 Injection in Subjects With Primary IgA Nephropathy
This study looks at how well and safely RG002C0106 works for patients with certain kidney disease: primary IgA nephropathy. It's a phase IIa trial done at several locations where both patients and doctors unknow what treatment is being given.
Read the detailed description
This is a Phase IIa, multicenter, double-blind clinical trial designed to evaluate the efficacy and safety of RG002C0106 in patients with primary IgA nephropathy. The primary objective is to assess the efficacy of RG002C0106 in reducing urinary protein excretion and preserving renal function in these patients. Secondary objectives include characterization of the safety profile, pharmacokinetics, and pharmacodynamics of the treatment
- Conditions
- IgA Nephropathy (IgAN)
- Being tested
- RG002C0106, placebo subcutaneous administration
- Keywords
- IgAN
- Medical subject headings
- Glomerulonephritis, IGA
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
RG002C0106Drug
RG002C0106 for subcutaneous (SC) injection
placebo subcutaneous administrationDrug
The placebo is made of normal saline.
| Study group | Role | What they receive |
|---|---|---|
| Experimental: RG002C0106 | Experimental | Randomly enrolled subjects receiving the investigational drug will receive subcutaneous injection for administration Receives: Drug: RG002C0106 |
| Placebo Comparator: placebo | Placebo comparator | Randomly enrolled subjects receiving placebo will receive subcutaneous injection for administration Receives: Drug: placebo subcutaneous administration |
What is being measured
The primary outcome is the main question the study is designed to answer.
The percentage change from baseline in the mean 24hUPCR)at Week 24 after the first subcutaneous admini;
Measured: up to 169 days
Incidence of adverse events (AEs) and serious adverse events (SAEs) related to the investigational drug.
Measured: up to 169 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Dec 2025
- Study start8 Sep 2025
- Primary completion31 Mar 2029 (estimated)
- Study completion31 Mar 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for IgA Nephropathy (IgAN)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 2
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Rigerna Therapeutics Co., Ltd.; Rigerna Therapeutics (Beijing) Co., Ltd.
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07305974
- Sponsor's protocol ID
- RG002C0106-201
- Status last verified
- Oct 2026
- First submitted
- 7 Dec 2025
- Last updated
- 13 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No