Overweight/ObesityNCT07291726
Composite Dietary Antioxidant Index and Metabolic Health in Overweight/Obesity in U.S. Adults
An observational study of Overweight/Obesity and Metabolic Health, run by University-Town Hospital of Chongqing Medical University at 1 site in China.
Trial summary
This cross-sectional study draws on data from the National Health and Nutrition Examination Survey (NHANES) database. The primary objective is to investigate the associations between the Composite Dietary Antioxidant Index (CDAI) and overweight/obesity, as well as the related metabolic abnormalities, among the U.S. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Overweight/Obesity, Metabolic Health
- What is being tested?
- None (Observational)
- How many people
- 0 participants
- Where
- 1 siteChina
- Study dates
- 1 Apr 2024to 6 Aug 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Adult, Older adult
Study population: The study population consists of individuals from the National Health and Nutrition Examination Survey (NHANES) database. It includes participants aged 18 and above with complete data on dietary antioxidant index and body mass index, representing a nationally representative sample of the U.S. population.
Who may be able to join
- Participants with complete data on composite dietary antioxidant index from the NHANES database
- Participants with complete body mass index (BMI) data from the NHANES database
- Individuals aged 18 years and older
Who cannot join
- Participants with missing key data (composite dietary antioxidant index or BMI)
- Individuals who are pregnant
Trial locations and contacts
1 site in 1 country.
China1 site
University Town Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 401331
About this study
Official title: Composite Dietary Antioxidant Index and Metabolic Health in Overweight/Obesity in U.S. Adults: Evidence From NHANES: 2003-2020
This cross-sectional study draws on data from the National Health and Nutrition Examination Survey (NHANES) database. The primary objective is to investigate the associations between the Composite Dietary Antioxidant Index (CDAI) and overweight/obesity, as well as the related metabolic abnormalities, among the U.S. general population. By analyzing this large-scale, nationally representative dataset, the investigators seek to generate evidence that can inform public health policies and clinical practice-ultimately contributing to a deeper understanding of population-level health challenges and the development of targeted strategies to address them.
- Conditions
- Overweight/Obesity, Metabolic Health
- Being tested
- None (Observational)
- Medical subject headings
- Overweight, Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
None (Observational)Other
This is an observational study with no active intervention implemented. Its primary aim is to analyze the relationship between the Composite Dietary Antioxidant Index (CDAI) and overweight/obesity, as well as the associated metabolic abnormalities, using the dataset-with no experimental manipulation involved.
| Study group | Role | What they receive |
|---|---|---|
| CDAI Q1 (Lowest Quartile) | Not described Receives: Other: None (Observational) | |
| CDAI Q2 (Second Quartile) | Not described Receives: Other: None (Observational) | |
| CDAI Q3 (Third Quartile) | Not described Receives: Other: None (Observational) | |
| CDAI Q4 (Highest Quartile) | Not described Receives: Other: None (Observational) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Overweight/Obesity Assessed by Body Mass Index (BMI)
Body Mass Index (BMI) will be calculated as weight (in kilograms) divided by the square of height (in meters). According to the World Health Organization's classification, a BMI of 25.0 - 29.9 kg/m² is considered overweight, and a BMI of 30.0 kg/m² or higher is considered obese. Data on weight and height will be obtained from the NHANES dataset.
Measured: Baseline: Data collection for calculating BMI occurs during the specific NHANES survey cycle relevant to this study (single - time - point cross - sectional assessment).
Metabolic Phenotype Classification (Metabolically Healthy vs. Unhealthy) Assessed by NCEP ATP III Metabolic Syndrome Components
Metabolic phenotypes are classified as metabolically healthy or unhealthy based on the components of metabolic syndrome defined in the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Waist circumference data is not used in this classification due to its high correlation with BMI.
A participant is defined as metabolically healthy if they have none or only one of the following four metabolic abnormalities: (1) Serum triglycerides (TG) ≥ 150 mg/dL; (2) Serum high-density lipoprotein cholesterol (HDL-C) < 40 mg/dL in men or < 50 mg/dL in women; (3) Fasting glucose ≥ 100 mg/dL or use of hypoglycemic drugs; (4) Blood pressure ≥ 130/85 mmHg or use of antihypertensive drugs.
A participant is defined as metabolically unhealthy if they have two or more of the above metabolic abnormalities. Relevant data will be retrieved from the NHANES database.
Measured: Baseline: Data on metabolic components for phenotype classification will be collected during the corresponding NHANES survey cycle for this study, reflecting a single-time-point cross-sectional assessment.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Dec 2025
- Study start1 Apr 2024
- Primary completion4 Jul 2024
- Study completion6 Aug 2024
Why it stopped: This study is a retrospective analysis of de-identified public database data. As no participants were ever enrolled, the status is updated to Withdrawn to accurately reflect that no enrollment occurred.
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Overweight/ObesityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Ecologic or community
- Time perspective
- Cross-sectional
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- University-Town Hospital of Chongqing Medical University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jiang Peng, University-Town Hospital of Chongqing Medical University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07291726
- Sponsor's protocol ID
- NHANES_CrossSec_2025_01
- Status last verified
- Feb 2026
- First submitted
- 29 Sep 2025
- Last updated
- 17 Feb 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Composite Dietary Antioxidant Index and Metabolic Health in Overweight/Obesity in U.S. Adults: Evidence From NHANES: 2003-2020
- ClinicalTrials.gov ID
- NCT07291726
- Acronym / sponsor ID
- NHANES_CrossSec_2025_01
- Conditions
- Overweight/Obesity, Metabolic Health
- Study type
- Observational
- Recruitment status
- WithdrawnReason stopped: This study is a retrospective analysis of de-identified public database data. As no participants were ever enrolled, the status is updated to Withdrawn to accurately reflect that no enrollment occurred.
- Enrolment
- 0 participants (actual)
- Lead sponsor
- University-Town Hospital of Chongqing Medical UniversityUniversity, hospital or other
- Study start
- 1 Apr 2024 (actual)
- Primary completion
- 4 Jul 2024 (actual)
- Study completion
- 6 Aug 2024 (actual)
- First posted
- 18 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This cross-sectional study draws on data from the National Health and Nutrition Examination Survey (NHANES) database. The primary objective is to investigate the associations between the Composite Dietary Antioxidant Index (CDAI) and overweight/obesity, as well as the related metabolic abnormalities, among the U.S. general population. By analyzing this large-scale, nationally representative dataset, the investigators seek to generate evidence that can inform public health policies and clinical practice-ultimately contributing to a deeper understanding of population-level health challenges and the development of targeted strategies to address them.
Study design
- Observational model
- Ecologic or community
- Time perspective
- Cross-sectional
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| CDAI Q1 (Lowest Quartile) | – | Other: None (Observational) |
| CDAI Q2 (Second Quartile) | – | Other: None (Observational) |
| CDAI Q3 (Third Quartile) | – | Other: None (Observational) |
| CDAI Q4 (Highest Quartile) | – | Other: None (Observational) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- The study population consists of individuals from the National Health and Nutrition Examination Survey (NHANES) database. It includes participants aged 18 and above with complete data on dietary antioxidant index and body mass index, representing a nationally representative sample of the U.S. population.
Key inclusion criteria (3 listed)
- Participants with complete data on composite dietary antioxidant index from the NHANES database
- Participants with complete body mass index (BMI) data from the NHANES database
- Individuals aged 18 years and older
Key exclusion criteria (2 listed)
- Participants with missing key data (composite dietary antioxidant index or BMI)
- Individuals who are pregnant
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| None (Observational)This is an observational study with no active intervention implemented. Its primary aim is to analyze the relationship between the Composite Dietary Antioxidant Index (CDAI) and overweight/obesity, as well as the associated metabolic abnormalities, using the dataset-with no experimental manipulation involved. | Other | CDAI Q1 (Lowest Quartile), CDAI Q2 (Second Quartile), CDAI Q3 (Third Quartile), CDAI Q4 (Highest Quartile) |
Primary outcome
Overweight/Obesity Assessed by Body Mass Index (BMI)
Time frame: Baseline: Data collection for calculating BMI occurs during the specific NHANES survey cycle relevant to this study (single - time - point cross - sectional assessment).
Body Mass Index (BMI) will be calculated as weight (in kilograms) divided by the square of height (in meters). According to the World Health Organization's classification, a BMI of 25.0 - 29.9 kg/m² is considered overweight, and a BMI of 30.0 kg/m² or higher is considered obese. Data on weight and height will be obtained from the NHANES dataset.
Metabolic Phenotype Classification (Metabolically Healthy vs. Unhealthy) Assessed by NCEP ATP III Metabolic Syndrome Components
Time frame: Baseline: Data on metabolic components for phenotype classification will be collected during the corresponding NHANES survey cycle for this study, reflecting a single-time-point cross-sectional assessment.
Metabolic phenotypes are classified as metabolically healthy or unhealthy based on the components of metabolic syndrome defined in the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Waist circumference data is not used in this classification due to its high correlation with BMI. A participant is defined as metabolically healthy if they have none or only one of the following four metabolic abnormalities: (1) Serum triglycerides (TG) ≥ 150 mg/dL; (2) Serum high-density lipoprotein cholesterol (HDL-C) < 40 mg/dL in men or < 50 mg/dL in women; (3) Fasting glucose ≥ 100 mg/dL or use of hypoglycemic drugs; (4) Blood pressure ≥ 130/85 mmHg or use of antihypertensive drugs. A participant is defined as metabolically unhealthy if they have two or more of the above metabolic abnormalities. Relevant data will be retrieved from the NHANES database.
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Overweight/Obesity and Metabolic Health, run by University-Town Hospital of Chongqing Medical University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 17 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Overweight/Obesity Assessed by Body Mass Index (BMI) (time frame: Baseline: Data collection for calculating BMI occurs during the specific NHANES survey cycle relevant to this study (single - time - point cross - sectional assessment).). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Feb 2026.