Anterior Cruciate Ligament InjuryNCT07269522
Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma
A study testing ACL reconstruction by hamstring graft with PRP and ACL reconstruction by hamstring graft in people with Anterior Cruciate Ligament Injury, run by Muhammad Aamir Latif at 1 site in Pakistan.
Trial summary
No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma. This study aimed to compare the functional outcomes of arthroscopic anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma. Read more about this study
- Who is it for?
- Ages 18 to 40 years
- Conditions the study is for
- Anterior Cruciate Ligament Injury
- What is being tested?
- ACL reconstruction by hamstring graft with PRP and ACL reconstruction by hamstring graft
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 sitePakistan
- Study dates
- 15 Jan 2022to 30 Jun 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Any gender
- Aged 18-40 years
- With clinically and radiologically confirmed arthroscopic evidence of ACL injury
Who cannot join
- With comprised bilateral ACL tears
- Lack of fitness due to associated comorbidity
- Fractures of lower limb bones and/or spine/neurovascular injuries
- Injuries to other knee ligaments
- Significant knee joint arthritis
- Local skin infections
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Functional Outcomes of Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma
No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma. This study aimed to compare the functional outcomes of arthroscopic anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma.
Read the detailed description
In animal studies, platelet-rich plasma has shown excellent results in accelerating the healing of the anterior cruciate ligament, but studies on human have shown varying clinical outcomes when investigating platelet-rich plasma for its effects on anterior cruciate ligament reconstruction. The findings of this study could provide important insights about the possible role of platelet-rich plasma in arthroscopic anterior cruciate ligament reconstruction by hamstring graft. to enhance early graft healing and reduce early complications, though its long-term effectiveness remains inconsistent. Studies suggest PRP may improve short-to-medium term outcomes like reduced pain and enhanced knee function,
- Conditions
- Anterior Cruciate Ligament Injury
- Being tested
- ACL reconstruction by hamstring graft with PRP, ACL reconstruction by hamstring graft
- Medical subject headings
- Anterior Cruciate Ligament Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ACL reconstruction by hamstring graft with PRPProcedure or surgery
Patients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.
ACL reconstruction by hamstring graftProcedure or surgery
Patients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.
| Study group | Role | What they receive |
|---|---|---|
| ACL reconstruction by hamstring graft with PRP group | Experimental | Patients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique. Receives: Procedure: ACL reconstruction by hamstring graft with PRP |
| ACL reconstruction by hamstring graft group | Experimental | Patients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique. Receives: Procedure: ACL reconstruction by hamstring graft |
What is being measured
The primary outcome is the main question the study is designed to answer.
Anterior Drawer's test
Number of patients having grade-1 on the Anterior Drawer's test
Measured: 12 weeks
Lachman's test
Number of patients having grade-1 on the Lysholm knee score
Measured: 12 weeks
Lysholm knee score
A higher Lysholm knee score was labeled as effectiveness of the treatment.
Measured: 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Dec 2025
- Study start15 Jan 2022
- Primary completion30 Jun 2023
- Study completion30 Jun 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Anterior Cruciate Ligament InjuryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Muhammad Aamir Latif
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Muhammad Aamir Latif, RESnTEC, Institute of Research
- Investigators
- Naveed Ali, FCPS, Principal investigator, Lahore General Hospital, Lahore, PakistanMuhammad Hanif, FCPS, Study director, Lahore General Hospital, Lahore, Pakistan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07269522
- Sponsor's protocol ID
- DR-NAVEED-LGH
- Status last verified
- Nov 2025
- First submitted
- 25 Nov 2025
- Last updated
- 8 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Data can be shared on a reasonable request.
Study at a glance
From the registry record, last updated by the sponsor on 8 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Functional Outcomes of Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma
- ClinicalTrials.gov ID
- NCT07269522
- Acronym / sponsor ID
- DR-NAVEED-LGH
- Conditions
- Anterior Cruciate Ligament Injury
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Muhammad Aamir LatifUniversity, hospital or other
- Study start
- 15 Jan 2022 (actual)
- Primary completion
- 30 Jun 2023 (actual)
- Study completion
- 30 Jun 2023 (actual)
- First posted
- 8 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma. This study aimed to compare the functional outcomes of arthroscopic anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma.
Detailed description
In animal studies, platelet-rich plasma has shown excellent results in accelerating the healing of the anterior cruciate ligament, but studies on human have shown varying clinical outcomes when investigating platelet-rich plasma for its effects on anterior cruciate ligament reconstruction. The findings of this study could provide important insights about the possible role of platelet-rich plasma in arthroscopic anterior cruciate ligament reconstruction by hamstring graft. to enhance early graft healing and reduce early complications, though its long-term effectiveness remains inconsistent. Studies suggest PRP may improve short-to-medium term outcomes like reduced pain and enhanced knee function,
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ACL reconstruction by hamstring graft with PRP group | Experimental | Procedure: ACL reconstruction by hamstring graft with PRPPatients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique. |
| ACL reconstruction by hamstring graft group | Experimental | Procedure: ACL reconstruction by hamstring graftPatients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Any gender
- Aged 18-40 years
- With clinically and radiologically confirmed arthroscopic evidence of ACL injury
Key exclusion criteria (6 listed)
- With comprised bilateral ACL tears
- Lack of fitness due to associated comorbidity
- Fractures of lower limb bones and/or spine/neurovascular injuries
- Injuries to other knee ligaments
- Significant knee joint arthritis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ACL reconstruction by hamstring graft with PRPPatients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique. | Procedure or surgery | ACL reconstruction by hamstring graft with PRP group |
| ACL reconstruction by hamstring graftPatients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique. | Procedure or surgery | ACL reconstruction by hamstring graft group |
Primary outcome
Anterior Drawer's test
Time frame: 12 weeks
Number of patients having grade-1 on the Anterior Drawer's test
Lachman's test
Time frame: 12 weeks
Number of patients having grade-1 on the Lysholm knee score
Lysholm knee score
Time frame: 12 weeks
A higher Lysholm knee score was labeled as effectiveness of the treatment.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Dec 2025.
- Individual participant dataSharing planned: No. Data can be shared on a reasonable request.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Naveed Ali, FCPS principal investigator
Lahore General Hospital, Lahore, Pakistan
Muhammad Hanif, FCPS study director
Lahore General Hospital, Lahore, Pakistan
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ACL reconstruction by hamstring graft with PRP and ACL reconstruction by hamstring graft in people with Anterior Cruciate Ligament Injury, run by Muhammad Aamir Latif at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Anterior Drawer's test (time frame: 12 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Dec 2025.