Joint HypermobilityAISNCT07249541
Hypermobility, Foot Posture, and Scoliosis Severity
An observational study of Joint Hypermobility and Adolescent Idiopathic Scoliosis, run by Istinye University at 1 site in Turkey (Türkiye).
Trial summary
Adolescent Idiopathic Scoliosis is a three-dimensional spinal deformity that may also affect joint mobility, lower limb alignment, and overall posture. Joint hypermobility and foot posture abnormalities, including pronation or supination, are commonly observed in adolescents and may contribute to postural imbalance or… Read more about this study
- Who is it for?
- Ages 10 to 19 years
- Conditions the study is for
- Joint Hypermobility, Adolescent Idiopathic Scoliosis, Foot Posture
- What is being tested?
- Assessment
- How many people
- 22 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Dec 2025to 30 Apr 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 10 to 19 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: The study population consists of adolescents aged 10 to 19 years who have been clinically and radiographically diagnosed with Adolescent Idiopathic Scoliosis. Participants must have a Cobb angle of at least 10° and be able to complete physical assessments, including hypermobility and foot posture evaluations.
Who may be able to join
- Diagnosis of Adolescent Idiopathic Scoliosis
- Age 10-19 years
- Cobb angle ≥ 10° on standing Anterior-Posterior radiograph
- Ability to participate in physical assessments
- Voluntary consent to participate
Who cannot join
- Neuromuscular, syndromic, or congenital scoliosis
- Previous spinal surgery
- Lower extremity orthopedic conditions affecting foot posture
- Neurological or rheumatological disorders affecting joint mobility
- Communication or cognitive difficulties limiting participate
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Investigation of the Relationship Between Hypermobility, Foot Posture, and Scoliosis Severity in Adolescents With Idiopathic Scoliosis
Adolescent Idiopathic Scoliosis is a three-dimensional spinal deformity that may also affect joint mobility, lower limb alignment, and overall posture. Joint hypermobility and foot posture abnormalities, including pronation or supination, are commonly observed in adolescents and may contribute to postural imbalance or altered biomechanical loading. However, the relationship between hypermobility, foot posture, and the severity of scoliosis remains unclear.
The aim of this study is to examine whether generalized joint hypermobility and foot posture characteristics are associated with Cobb angle severity in adolescents diagnosed with Adolescent Idiopathic Scoliosis. Hypermobility will be assessed using the Beighton Score, and foot posture will be evaluated with the Foot Posture Index. Understanding these associations may help clinicians better evaluate biomechanical factors related to scoliosis and guide future preventive or therapeutic approaches.
- Being tested
- Assessment
- Medical subject headings
- Joint Instability
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AssessmentOther
Participants diagnosed with Adolescent Idiopathic Scoliosis will undergo assessments of hypermobility (Beighton Score), foot posture (Foot Posture Index), and scoliosis severity (Cobb angle).
| Study group | Role | What they receive |
|---|---|---|
| Adolescent Idiopathic Scoliosis Group | Participants diagnosed with Adolescent Idiopathic Scoliosis will undergo assessments of hypermobility (Beighton Score), foot posture (Foot Posture Index), and scoliosis severity (Cobb angle). Receives: Other: Assessment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Foot Posture Index-6
The Foot Posture Index-6 is a reliable and valid clinical assessment tool used to objectively evaluate foot posture in the pronation-supination spectrum. The assessment is performed with the individual in a relaxed standing position and is based on six observational criteria. The total score ranges from -12 to +12, where higher scores indicate a more pronated foot posture, while lower scores reflect a more supinated posture. A score close to 0 represents a neutral foot posture.
Measured: 4 weeks
The Beighton Test
This is a standardized and easily applicable clinical assessment method used to determine joint hypermobility. The total score for the nine-item test ranges from 0 to 9. A total score of ≥4 indicates the presence of hypermobility. It is scored out of 9 points; each positive finding is evaluated as 1 point.
Measured: 4 weeks
Secondary outcomes (2)
Feiss Line Test
Used to evaluate the structural characteristics of the arch of the foot. In this test, the position of the navicular tubercle above or below a line drawn by aligning the medial malleolus, navicular tubercle, and first metatarsal head indicates the presence of pes planus or pes cavus.
Measured: 4 weeks
Sit-Reach Test
This is a common field test that evaluates the flexibility of the hamstring and lumbar muscles. The participant sits in a straight position, knees straight, and the soles of their feet touching the test box, reaching forward; the distance between their toes indicates the level of flexibility.
Measured: 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Nov 2025
- Study start15 Dec 2025
- Primary completion15 Mar 2026
- Study completion30 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Joint HypermobilityStudies of the same condition, open and under way.
- More trials run by Istinye UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istinye University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tuğçe Yavuz, Istinye University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07249541
- Sponsor's protocol ID
- 25-121
- Acronym
- AIS
- Status last verified
- Jun 2026
- First submitted
- 18 Nov 2025
- Last updated
- 26 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of the Relationship Between Hypermobility, Foot Posture, and Scoliosis Severity in Adolescents With Idiopathic Scoliosis
- ClinicalTrials.gov ID
- NCT07249541
- Acronym / sponsor ID
- AIS / 25-121
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- Istinye UniversityUniversity, hospital or other
- Study start
- 15 Dec 2025 (actual)
- Primary completion
- 15 Mar 2026 (actual)
- Study completion
- 30 Apr 2026 (actual)
- First posted
- 25 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Adolescent Idiopathic Scoliosis is a three-dimensional spinal deformity that may also affect joint mobility, lower limb alignment, and overall posture. Joint hypermobility and foot posture abnormalities, including pronation or supination, are commonly observed in adolescents and may contribute to postural imbalance or altered biomechanical loading. However, the relationship between hypermobility, foot posture, and the severity of scoliosis remains unclear.
The aim of this study is to examine whether generalized joint hypermobility and foot posture characteristics are associated with Cobb angle severity in adolescents diagnosed with Adolescent Idiopathic Scoliosis. Hypermobility will be assessed using the Beighton Score, and foot posture will be evaluated with the Foot Posture Index. Understanding these associations may help clinicians better evaluate biomechanical factors related to scoliosis and guide future preventive or therapeutic approaches.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Adolescent Idiopathic Scoliosis Group | – | Other: AssessmentParticipants diagnosed with Adolescent Idiopathic Scoliosis will undergo assessments of hypermobility (Beighton Score), foot posture (Foot Posture Index), and scoliosis severity (Cobb angle). |
Who may qualify
- Ages
- 10 to 19 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
- Study population
- The study population consists of adolescents aged 10 to 19 years who have been clinically and radiographically diagnosed with Adolescent Idiopathic Scoliosis. Participants must have a Cobb angle of at least 10° and be able to complete physical assessments, including hypermobility and foot posture evaluations.
Key inclusion criteria (5 listed)
- Diagnosis of Adolescent Idiopathic Scoliosis
- Age 10-19 years
- Cobb angle ≥ 10° on standing Anterior-Posterior radiograph
- Ability to participate in physical assessments
- Voluntary consent to participate
Key exclusion criteria (5 listed)
- Neuromuscular, syndromic, or congenital scoliosis
- Previous spinal surgery
- Lower extremity orthopedic conditions affecting foot posture
- Neurological or rheumatological disorders affecting joint mobility
- Communication or cognitive difficulties limiting participate
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AssessmentParticipants diagnosed with Adolescent Idiopathic Scoliosis will undergo assessments of hypermobility (Beighton Score), foot posture (Foot Posture Index), and scoliosis severity (Cobb angle). | Other | Adolescent Idiopathic Scoliosis Group |
Primary outcome
Foot Posture Index-6
Time frame: 4 weeks
The Foot Posture Index-6 is a reliable and valid clinical assessment tool used to objectively evaluate foot posture in the pronation-supination spectrum. The assessment is performed with the individual in a relaxed standing position and is based on six observational criteria. The total score ranges from -12 to +12, where higher scores indicate a more pronated foot posture, while lower scores reflect a more supinated posture. A score close to 0 represents a neutral foot posture.
The Beighton Test
Time frame: 4 weeks
This is a standardized and easily applicable clinical assessment method used to determine joint hypermobility. The total score for the nine-item test ranges from 0 to 9. A total score of ≥4 indicates the presence of hypermobility. It is scored out of 9 points; each positive finding is evaluated as 1 point.
2 secondary outcomes
Feiss Line Test
Time frame: 4 weeks
Sit-Reach Test
Time frame: 4 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Jun 2026.
- Individual participant dataSharing planned: No
Related trials for Joint Hypermobility
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A Study on Associations Between Multidimensional Human Phenotypic Traits and Human Growth and Development
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Joint Hypermobility and Adolescent Idiopathic Scoliosis, run by Istinye University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Foot Posture Index-6 (time frame: 4 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Jun 2026.