Stimulant Use DisorderLDARTNCT07221396
LDART for Stimulant Use Disorder
A study testing LDART and Psychoeducational booklet in people with Stimulant Use Disorder and Cocaine Use Disorder, run by Yale University at 1 site in United States.
Trial summary
The goal of this study is to evaluate the feasibility, acceptability, and preliminary efficacy of a digital intervention called LDART in adults with stimulant use disorder. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Stimulant Use Disorder, Cocaine Use Disorder, Methamphetamine Use Disorder
- What is being tested?
- LDART and Psychoeducational booklet
- Type of treatment
- Medical device, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteUnited States
- Study dates
- 29 Apr 2026to 1 Apr 2027
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- 18 years of age or older
- Currently reside in Connecticut, USA
- Have a smartphone that can send and receive text messages and have internet access that can be access over the course of a month
- Substance (Stimulant) Use Symptom Checklist ≥2, indicating past-year stimulant use disorder
- Had high frequency of cocaine use (≥5 days) in the past 28 days
- Have some self-reported desire to cut down or quit stimulants
Who cannot join
- Unable to provide informed consent, as assessed by the consent quiz
- Unable to speak, read, or write in English
- Vulnerable population status
- Unlikely to be able to complete study procedures in the next 2 months
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Pilot Study of the Digital Intervention LDART for Stimulant Use Disorder
The goal of this study is to evaluate the feasibility, acceptability, and preliminary efficacy of a digital intervention called LDART in adults with stimulant use disorder.
- Being tested
- LDART, Psychoeducational booklet
- Keywords
- social support, digital intervention, mutual-help groups, stimulant use disorder, addiction recovery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
LDARTDevice
Let's Do Addiction Recovery Together! (LDART) is a web-based intervention grounded in social cognitive theory that is designed to reduce hazardous alcohol use. It has three active ingredients: 1) daily recovery goal setting and tracking, 2) motivational video, audio, and written messages from individuals in recovery, and 3) information on several community-based recovery groups (e.g., mutual-help groups, recovery community centers) that provide free, publicly available meetings and activities. Participants receive a text message reminder each night to go to the website to complete the activities, and a text message reminder each morning of the goal they set for themselves, with the option to change it. It only takes a few minutes to use LDART each day over the 4-week intervention period.
Psychoeducational bookletBehavioural
This is a 10-page PDF on stimulant use disorder created by the American Society of Addiction Medicine and American Academy of Addiction Psychiatry. It contains information about stimulant intoxication and withdrawal and treatment options. Participants will be encouraged to access this booklet for a few minutes each night over the 4-week intervention period.
| Study group | Role | What they receive |
|---|---|---|
| LDART | Experimental | Participants will be given access to LDART for 28 days. Receives: Device: LDART |
| Psychoeducational booklet | Active comparator | Participants will be sent a PDF of this booklet. Receives: Behavioral: Psychoeducational booklet |
What is being measured
The primary outcome is the main question the study is designed to answer.
Recruitment rate
The percentage of eligible participants who are enrolled relative to the total number of eligible potential participants who completed the screening.
Measured: From enrollment to the final assessment time point (Day 56)
Accrual rate
The rate of enrollment, defined as number of participants enrolled per month.
Measured: From enrollment to the final assessment time point (Day 56)
Retention rate
The percentage of enrolled participants who complete all study-related procedures (i.e., all three assessments).
Measured: From enrollment to the final assessment time point (Day 56)
Intervention engagement
Number of nights enrolled participants completed the activities on the LDART website, out of 28 nights.
Measured: From beginning the intervention (Day 1) to the end of the intervention period (Day 28)
Intervention acceptability
Rating scores on the end-user version of the Mobile App Rating Scale (uMARS). Total score range 1-5 with higher scores indicating a better quality app.
Measured: The second assessment time point (post-intervention, Day 28)
Secondary outcomes (2)
Change from baseline in stimulant use frequency
Change in self-reported number of days when any stimulants were used in the past 28 days, as measured using the Timeline Follow-back.
Measured: Baseline (Day 0), Post-intervention (Day 28), 1-month post-intervention (Day 56)
Change from baseline in number of hours spent engaging with recovery groups
Self-reported number of hours spent engaging with recovery groups in the past 28 days, as measured using a modified Timeline Follow-back
Measured: Baseline (Day 0), Post-intervention (Day 28), 1-month post-intervention (Day 56)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Oct 2025
- Study start29 Apr 2026
- Primary completion1 Apr 2027 (estimated)
- Study completion1 Apr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Stimulant Use DisorderStudies of the same condition, open and under way.
- More trials run by Yale UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Yale University
- Sponsor type
- University, hospital or other
- Collaborators
- College on Problems of Drug Dependence
- Responsible party
- Sponsor
- Investigators
- Li Yan McCurdy, PhD, Principal investigator, Yale University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07221396
- Sponsor's protocol ID
- 2000040872
- Other IDs
- EarlyCareer Investigator grant
- Acronym
- LDART
- Status last verified
- Apr 2026
- First submitted
- 23 Oct 2025
- Last updated
- 1 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No